CA2908954C - Combination therapy comprising a tor kinase inhibitor and an imid compound for treating cancer - Google Patents
Combination therapy comprising a tor kinase inhibitor and an imid compound for treating cancer Download PDFInfo
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- CA2908954C CA2908954C CA2908954A CA2908954A CA2908954C CA 2908954 C CA2908954 C CA 2908954C CA 2908954 A CA2908954 A CA 2908954A CA 2908954 A CA2908954 A CA 2908954A CA 2908954 C CA2908954 C CA 2908954C
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US201361908859P | 2013-11-26 | 2013-11-26 | |
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| PCT/US2014/034312 WO2014172429A1 (en) | 2013-04-17 | 2014-04-16 | Combination therapy comprising a tor kinase inhibitor and an imid compound for treating cancer |
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| CN107445940A (zh) | 2006-09-26 | 2017-12-08 | 细胞基因公司 | 作为抗肿瘤剂的5‑取代的喹唑酮衍生物 |
| SG10201501062SA (en) | 2010-02-11 | 2015-04-29 | Celgene Corp | Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same |
| UA113512C2 (xx) | 2011-03-11 | 2017-02-10 | Тверда форма 3-(5-аміно-2-метил-4-оксо-4h-хіназолін-3-іл)піперидин-2,6-діону і її фармацевтична композиція та застосування | |
| WO2014039421A1 (en) | 2012-09-04 | 2014-03-13 | Celgene Corporation | Isotopologues of 3-(5-amino-2-methyl-4-oxoquinazolin-3(4h)-yl) piperidine-2-6-dione and methods of preparation thereof |
| US9126950B2 (en) | 2012-12-21 | 2015-09-08 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| WO2014116573A1 (en) | 2013-01-22 | 2014-07-31 | Celgene Corporation | Processes for the preparation of isotopologues of 3-(4-((4-(morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione and pharmaceutically acceptable salts thereof |
| UA115805C2 (uk) | 2013-04-17 | 2017-12-26 | Сігнал Фармасьютікалз, Елелсі | Комбінована терапія, яка включає сполуку дигідропіразинопіразину й антагоніст рецептора андрогену, для лікування раку простати |
| PH12021552945B1 (en) | 2013-04-17 | 2024-02-28 | Signal Pharm Llc | Treatment of cancer with dihydropyrazino-pyrazines |
| EA037683B1 (ru) | 2013-04-17 | 2021-04-29 | СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Фармацевтические составы, способы, твердые формы и способы применения, относящиеся к 1-этил-7-(2-метил-6-(1h-1,2,4-триазол-3-ил)пиридин-3-ил)-3,4-дигидропиразино[2,3-b] пиразин-2(1h)-ону |
| KR102221029B1 (ko) | 2013-04-17 | 2021-02-26 | 시그날 파마소티칼 엘엘씨 | 디하이드로피라지노-피라진을 사용한 암의 치료 |
| WO2014172436A1 (en) * | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer |
| CN105407892B (zh) | 2013-05-29 | 2019-05-07 | 西格诺药品有限公司 | 一种化合物的药物组合物、其固体形式及它们的使用方法 |
| AU2014360328B2 (en) | 2013-12-06 | 2021-04-01 | Celgene Corporation | Methods for determining drug efficacy for the treatment of diffuse large B-cell lymphoma, multiple myeloma, and myeloid cancers |
| US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| NZ714742A (en) | 2014-04-16 | 2017-04-28 | Signal Pharm Llc | Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use |
| WO2015160868A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | Methods for treating cancer using tor kinase inhibitor combination therapy |
| WO2015160880A1 (en) | 2014-04-16 | 2015-10-22 | Signal Pharmaceuticals, Llc | SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF |
| WO2016007854A1 (en) * | 2014-07-11 | 2016-01-14 | Celgene Corporation | Combination therapy for cancer |
| EP3204008A4 (en) * | 2014-10-07 | 2018-03-07 | Celgene Corporation | Use of biomarkers for predicting clinical sensitivity to cancer treatment |
| US9717745B2 (en) | 2015-03-19 | 2017-08-01 | Zhejiang DTRM Biopharma Co. Ltd. | Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases |
| CN106146508A (zh) * | 2015-03-19 | 2016-11-23 | 浙江导明医药科技有限公司 | 优化的联合用药及其治疗癌症和自身免疫疾病的用途 |
| KR20240090657A (ko) * | 2015-06-29 | 2024-06-21 | 아브락시스 바이오사이언스, 엘엘씨 | 나노입자 mTOR 억제제 조합 요법을 사용하여 고형 종양을 치료하는 방법 |
| EP3313409A4 (en) * | 2015-06-29 | 2018-12-26 | Abraxis BioScience, LLC | Methods of treating hematological malignancy using nanoparticle mtor inhibitor combination therapy |
| LT3313401T (lt) | 2015-06-29 | 2022-01-10 | Abraxis Bioscience, Llc | Nanodalelės, apimančios sirolimą ir albuminą, skirtos naudoti epitelioidinių ląstelių navikų gydymui |
| CN106769807A (zh) * | 2016-12-07 | 2017-05-31 | 王兰英 | 一种利用流式细胞仪检测HeLa细胞凋亡的方法 |
| IL271491B2 (en) | 2017-06-22 | 2023-09-01 | Celgene Corp | Treatment of carcinoma of the liver characterized by hepatitis b virus infection |
| TW201922256A (zh) | 2017-10-27 | 2019-06-16 | 中國大陸商浙江導明醫藥科技有限公司 | 治療淋巴樣惡性疾病之方法 |
| AU2019284608A1 (en) | 2018-06-13 | 2020-12-17 | Biotheryx, Inc. | Aminoamide compounds |
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| KR20230027082A (ko) * | 2020-06-25 | 2023-02-27 | 셀진 코포레이션 | 조합 요법을 사용한 암의 치료 방법 |
| EP4217352A4 (en) | 2020-09-23 | 2024-04-10 | St. Jude Children's Research Hospital, Inc. | Substituted n-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)arylsulfonamide analogs as modulators of cereblon protein |
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| KR102382576B1 (ko) | 2022-04-08 |
| KR102223060B1 (ko) | 2021-03-05 |
| WO2014172429A1 (en) | 2014-10-23 |
| MX2015014596A (es) | 2016-03-03 |
| BR112015026006B1 (pt) | 2022-10-18 |
| BR112015026006A2 (pt) | 2017-07-25 |
| JP2016516817A (ja) | 2016-06-09 |
| HK1221148A1 (zh) | 2017-05-26 |
| MX2020003174A (es) | 2020-07-28 |
| CA2908954A1 (en) | 2014-10-23 |
| US20140314752A1 (en) | 2014-10-23 |
| NZ629456A (en) | 2017-06-30 |
| AU2014254056B2 (en) | 2019-06-06 |
| CN105358177A (zh) | 2016-02-24 |
| BR112015026006A8 (pt) | 2020-01-14 |
| AU2014254056A1 (en) | 2015-11-05 |
| TW201526897A (zh) | 2015-07-16 |
| MX373803B (es) | 2020-03-24 |
| ZA201507735B (en) | 2017-06-28 |
| EP2986318A1 (en) | 2016-02-24 |
| KR20160002791A (ko) | 2016-01-08 |
| CN105358177B (zh) | 2018-11-23 |
| JP6389241B2 (ja) | 2018-09-12 |
| KR20210024231A (ko) | 2021-03-04 |
| US20200113896A1 (en) | 2020-04-16 |
| IL241964B (en) | 2020-01-30 |
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