AU2014254056B2 - Combination therapy comprising a TOR kinase inhibitor and an IMiD compound for treating cancer - Google Patents

Combination therapy comprising a TOR kinase inhibitor and an IMiD compound for treating cancer Download PDF

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Publication number
AU2014254056B2
AU2014254056B2 AU2014254056A AU2014254056A AU2014254056B2 AU 2014254056 B2 AU2014254056 B2 AU 2014254056B2 AU 2014254056 A AU2014254056 A AU 2014254056A AU 2014254056 A AU2014254056 A AU 2014254056A AU 2014254056 B2 AU2014254056 B2 AU 2014254056B2
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alkyl
another embodiment
substituted
lymphoma
cancer
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AU2014254056A1 (en
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Rajesh Chopra
Kristen Mae Hege
Antonia Lopez-Girona
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Signal Pharmaceuticals LLC
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Signal Pharmaceuticals LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2014254056A 2013-04-17 2014-04-16 Combination therapy comprising a TOR kinase inhibitor and an IMiD compound for treating cancer Active AU2014254056B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361813094P 2013-04-17 2013-04-17
US61/813,094 2013-04-17
US201361908859P 2013-11-26 2013-11-26
US61/908,859 2013-11-26
PCT/US2014/034312 WO2014172429A1 (en) 2013-04-17 2014-04-16 Combination therapy comprising a tor kinase inhibitor and an imid compound for treating cancer

Publications (2)

Publication Number Publication Date
AU2014254056A1 AU2014254056A1 (en) 2015-11-05
AU2014254056B2 true AU2014254056B2 (en) 2019-06-06

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AU2014254056A Active AU2014254056B2 (en) 2013-04-17 2014-04-16 Combination therapy comprising a TOR kinase inhibitor and an IMiD compound for treating cancer

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US (2) US20140314752A1 (enExample)
EP (1) EP2986318A1 (enExample)
JP (1) JP6389241B2 (enExample)
KR (2) KR102223060B1 (enExample)
CN (1) CN105358177B (enExample)
AU (1) AU2014254056B2 (enExample)
BR (1) BR112015026006B1 (enExample)
CA (1) CA2908954C (enExample)
HK (1) HK1221148A1 (enExample)
IL (1) IL241964B (enExample)
MX (2) MX373803B (enExample)
NZ (1) NZ629456A (enExample)
TW (1) TW201526897A (enExample)
WO (1) WO2014172429A1 (enExample)
ZA (1) ZA201507735B (enExample)

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Publication number Publication date
KR102382576B1 (ko) 2022-04-08
KR102223060B1 (ko) 2021-03-05
WO2014172429A1 (en) 2014-10-23
MX2015014596A (es) 2016-03-03
BR112015026006B1 (pt) 2022-10-18
BR112015026006A2 (pt) 2017-07-25
JP2016516817A (ja) 2016-06-09
HK1221148A1 (zh) 2017-05-26
MX2020003174A (es) 2020-07-28
CA2908954A1 (en) 2014-10-23
US20140314752A1 (en) 2014-10-23
NZ629456A (en) 2017-06-30
CN105358177A (zh) 2016-02-24
BR112015026006A8 (pt) 2020-01-14
AU2014254056A1 (en) 2015-11-05
TW201526897A (zh) 2015-07-16
MX373803B (es) 2020-03-24
ZA201507735B (en) 2017-06-28
EP2986318A1 (en) 2016-02-24
KR20160002791A (ko) 2016-01-08
CN105358177B (zh) 2018-11-23
JP6389241B2 (ja) 2018-09-12
KR20210024231A (ko) 2021-03-04
US20200113896A1 (en) 2020-04-16
IL241964B (en) 2020-01-30
CA2908954C (en) 2021-08-03

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