IL235978B - Oligonucleotide synthesis method utilizing liquid support in high dispersive phase - Google Patents
Oligonucleotide synthesis method utilizing liquid support in high dispersive phaseInfo
- Publication number
- IL235978B IL235978B IL235978A IL23597814A IL235978B IL 235978 B IL235978 B IL 235978B IL 235978 A IL235978 A IL 235978A IL 23597814 A IL23597814 A IL 23597814A IL 235978 B IL235978 B IL 235978B
- Authority
- IL
- Israel
- Prior art keywords
- synthesis method
- oligonucleotide synthesis
- phase support
- highly dispersible
- dispersible liquid
- Prior art date
Links
- 239000007791 liquid phase Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002515 oligonucleotide synthesis Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
- C07H1/04—Introducing polyphosphoric acid radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2012/063921 WO2013179412A1 (ja) | 2012-05-30 | 2012-05-30 | 高分散性液相支持体を用いたオリゴヌクレオチド合成法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL235978A0 IL235978A0 (en) | 2015-02-01 |
| IL235978B true IL235978B (en) | 2018-02-28 |
Family
ID=49672666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL235978A IL235978B (en) | 2012-05-30 | 2014-11-27 | Oligonucleotide synthesis method utilizing liquid support in high dispersive phase |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9284344B2 (enExample) |
| EP (1) | EP2857412B1 (enExample) |
| DK (1) | DK2857412T3 (enExample) |
| IL (1) | IL235978B (enExample) |
| IN (1) | IN2014DN10144A (enExample) |
| SG (1) | SG11201407967TA (enExample) |
| WO (1) | WO2013179412A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010064146A2 (en) | 2008-12-02 | 2010-06-10 | Chiralgen, Ltd. | Method for the synthesis of phosphorus atom modified nucleic acids |
| CA2767253A1 (en) | 2009-07-06 | 2011-01-13 | Ontorii, Inc. | Novel nucleic acid prodrugs and methods of use thereof |
| WO2012039448A1 (ja) | 2010-09-24 | 2012-03-29 | 株式会社キラルジェン | 不斉補助基 |
| CN103796657B (zh) | 2011-07-19 | 2017-07-11 | 波涛生命科学有限公司 | 合成官能化核酸的方法 |
| US8846885B2 (en) | 2012-02-17 | 2014-09-30 | Ajinomoto Co., Inc. | Oligonucleotide with protected base |
| JP6237237B2 (ja) * | 2012-02-17 | 2017-11-29 | 味の素株式会社 | 塩基部保護オリゴヌクレオチド |
| CA2879066C (en) | 2012-07-13 | 2019-08-13 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
| WO2014010250A1 (en) | 2012-07-13 | 2014-01-16 | Chiralgen, Ltd. | Asymmetric auxiliary group |
| JP6453212B2 (ja) | 2012-07-13 | 2019-01-16 | ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． | キラル制御 |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| JPWO2015108046A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| KR20230152178A (ko) | 2014-01-16 | 2023-11-02 | 웨이브 라이프 사이언시스 리미티드 | 키랄 디자인 |
| TWI729028B (zh) * | 2015-11-17 | 2021-06-01 | 日商日產化學工業股份有限公司 | 寡核苷酸的製造方法 |
| JP7027889B2 (ja) * | 2015-12-16 | 2022-03-02 | 味の素株式会社 | オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド |
| WO2017111137A1 (ja) * | 2015-12-22 | 2017-06-29 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| WO2020166705A1 (ja) | 2019-02-15 | 2020-08-20 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| WO2020175472A1 (ja) | 2019-02-28 | 2020-09-03 | 富士フイルム株式会社 | ペプチド化合物の製造方法、保護基形成用試薬、及び、縮合多環芳香族炭化水素化合物 |
| WO2020175473A1 (ja) | 2019-02-28 | 2020-09-03 | 富士フイルム株式会社 | ペプチド化合物の製造方法、保護基形成用試薬、及び、芳香族複素環化合物 |
| EP3950698A4 (en) * | 2019-03-28 | 2023-01-25 | Ajinomoto Co., Inc. | METHOD OF PREPARING AN OLIGONUCLEOTIDE WITH PHOSPHOROTHIOATE SITE |
| MA55891A (fr) | 2019-05-08 | 2022-03-16 | Ajinomoto Kk | Synthèses en phase liquide convergente d'oligonucléotides |
| WO2021039935A1 (ja) * | 2019-08-29 | 2021-03-04 | 富士フイルム株式会社 | 核酸化合物の製造方法、及び、核酸化合物 |
| WO2021198883A1 (en) | 2020-03-31 | 2021-10-07 | Janssen Biopharma, Inc. | Synthesis of oligonucleotides and related compounds |
| FR3111896A1 (fr) * | 2020-06-24 | 2021-12-31 | Strainchem | Procédés de synthèses en solution de macromolécules à partir d’unités de dérivés de glucides |
| CN113583069B (zh) * | 2021-09-09 | 2023-06-06 | 北京大学 | 核苷磷脂类化合物及其化学合成方法和在核酸递送中的应用 |
| WO2024083746A1 (en) | 2022-10-17 | 2024-04-25 | Bachem Holding Ag | Method and composition for oligonucleotide synthesis |
| WO2024137756A1 (en) * | 2022-12-23 | 2024-06-27 | Hongene Biotech Corporation | Compounds and methods for liquid phase oligonucleotide synthesis |
| WO2025082632A1 (en) | 2023-10-16 | 2025-04-24 | Bachem Holding Ag | Method and composition for oligonucleotide synthesis |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7094943B2 (en) | 1998-04-27 | 2006-08-22 | Hubert Köster | Solution phase biopolymer synthesis |
| JP2003002895A (ja) | 2001-05-30 | 2003-01-08 | Tokyo Inst Of Technol | 核酸の合成法 |
| JP4963665B2 (ja) | 2007-11-27 | 2012-06-27 | 株式会社ミツバ | 扁平型コミュテータ及びその製造方法 |
| JP5548852B2 (ja) * | 2009-05-29 | 2014-07-16 | 国立大学法人東京農工大学 | 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法 |
| WO2012157723A1 (ja) | 2011-05-17 | 2012-11-22 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| JP6237237B2 (ja) * | 2012-02-17 | 2017-11-29 | 味の素株式会社 | 塩基部保護オリゴヌクレオチド |
-
2012
- 2012-05-30 US US14/404,562 patent/US9284344B2/en active Active
- 2012-05-30 SG SG11201407967TA patent/SG11201407967TA/en unknown
- 2012-05-30 WO PCT/JP2012/063921 patent/WO2013179412A1/ja not_active Ceased
- 2012-05-30 DK DK12877844.6T patent/DK2857412T3/en active
- 2012-05-30 IN IN10144DEN2014 patent/IN2014DN10144A/en unknown
- 2012-05-30 EP EP12877844.6A patent/EP2857412B1/en active Active
-
2014
- 2014-11-27 IL IL235978A patent/IL235978B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US20150112053A1 (en) | 2015-04-23 |
| EP2857412A4 (en) | 2015-10-21 |
| DK2857412T3 (en) | 2017-04-03 |
| US9284344B2 (en) | 2016-03-15 |
| SG11201407967TA (en) | 2015-01-29 |
| WO2013179412A1 (ja) | 2013-12-05 |
| EP2857412B1 (en) | 2017-01-11 |
| IN2014DN10144A (enExample) | 2015-08-21 |
| EP2857412A1 (en) | 2015-04-08 |
| IL235978A0 (en) | 2015-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |