IL232652A - A method for the preparation and isolation of Vardenafil salts with acids - Google Patents

A method for the preparation and isolation of Vardenafil salts with acids

Info

Publication number
IL232652A
IL232652A IL232652A IL23265214A IL232652A IL 232652 A IL232652 A IL 232652A IL 232652 A IL232652 A IL 232652A IL 23265214 A IL23265214 A IL 23265214A IL 232652 A IL232652 A IL 232652A
Authority
IL
Israel
Prior art keywords
vardenafil
isolation
salts
acids
preparation
Prior art date
Application number
IL232652A
Other languages
English (en)
Hebrew (he)
Other versions
IL232652A0 (en
Inventor
Halama Ales
Strelec Ivo
Dammer Ondrej
Original Assignee
Zentiva Ks
Halama Ales
Strelec Ivo
Dammer Ondrej
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva Ks, Halama Ales, Strelec Ivo, Dammer Ondrej filed Critical Zentiva Ks
Publication of IL232652A0 publication Critical patent/IL232652A0/en
Publication of IL232652A publication Critical patent/IL232652A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL232652A 2011-11-24 2014-05-15 A method for the preparation and isolation of Vardenafil salts with acids IL232652A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20110767A CZ303877B6 (cs) 2011-11-24 2011-11-24 Zpusob prípravy a izolace solí vardenafilu s kyselinami
PCT/CZ2012/000120 WO2013075680A1 (en) 2011-11-24 2012-11-26 A method for the preparation and isolation of salts of vardenafil with acids

Publications (2)

Publication Number Publication Date
IL232652A0 IL232652A0 (en) 2014-06-30
IL232652A true IL232652A (en) 2017-05-29

Family

ID=47435673

Family Applications (1)

Application Number Title Priority Date Filing Date
IL232652A IL232652A (en) 2011-11-24 2014-05-15 A method for the preparation and isolation of Vardenafil salts with acids

Country Status (7)

Country Link
CN (1) CN103946225B (ko)
BR (1) BR112014012430A2 (ko)
CZ (1) CZ303877B6 (ko)
HU (1) HUP1400334A3 (ko)
IL (1) IL232652A (ko)
IN (1) IN2014KN01308A (ko)
WO (1) WO2013075680A1 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160317542A1 (en) 2013-12-09 2016-11-03 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
PL223869B1 (pl) 2013-12-16 2016-11-30 Starogardzkie Zakłady Farm Polpharma Spółka Akcyjna Sposób otrzymywania wardenafilu i jego soli
CN107445964A (zh) * 2017-07-29 2017-12-08 合肥创新医药技术有限公司 一种盐酸伐地那非杂质的合成方法
JP2021506986A (ja) 2017-12-20 2021-02-22 クラリア・ファルマ・ホールディング・アクチボラグ バルデナフィルを含むフィルム配合物、その調製法、およびその使用
MX2021005892A (es) * 2018-11-28 2021-06-23 Topadur Pharma Ag Novedosos activadores de guanilato ciclasa soluble e inhibidores de fosfodiesterasa con modo de accion dual y usos de estos.
CN114085225A (zh) * 2021-06-04 2022-02-25 广东西捷药业有限公司 一种伐地那非类似物及其合成方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA46166C2 (uk) * 1997-11-12 2002-05-15 Баєр Акцієнгезельшафт 2-фенілзаміщені імідазотриазинони як інгібітори фосфодіестерази, спосіб їх одержання та лікарський засіб на їх основі
DE10063108A1 (de) 2000-12-18 2002-06-20 Bayer Ag Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
DE102004023069A1 (de) 2004-05-11 2005-12-08 Bayer Healthcare Ag Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil
US7977478B2 (en) * 2006-03-13 2011-07-12 Dr. Reddy's Laboratories Limited Polymorphic forms of vardenafil
DE102007027067A1 (de) 2007-06-12 2008-12-18 Ratiopharm Gmbh Verfahren zur Herstellung eines Arzneimittels enthaltend Vardenafil Hydrochlorid Trihydrat
WO2009030095A1 (en) 2007-09-06 2009-03-12 Topharman Shanghai Co., Ltd. Process for preparing vardenafil and its intermediates
ES2388371T3 (es) 2007-12-28 2012-10-15 Topharman Shanghai Co., Ltd. N-{1-[3-(2-etoxi-5-(4-etilpiperazinil)bencenosulfonil)-4,5-dihidro-5-oxo-1,2,4-triazin-6-il]etil}-butiramida, método de preparación y uso
DE102009020888A1 (de) 2009-05-12 2010-11-18 Ratiopharm Gmbh Schmelztablette, enthaltend ein Vardenafil-Salz
PL390079A1 (pl) * 2009-12-30 2011-07-04 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Sposób otrzymywania wardenafilu i jego izolacji jako soli z kwasem cytrynowym oraz krystaliczna postać tej soli
CN101870698B (zh) * 2010-04-02 2012-10-17 漆又毛 磺酰苯基咪唑并三嗪衍生物及制备方法

Also Published As

Publication number Publication date
CZ2011767A3 (cs) 2013-06-05
WO2013075680A1 (en) 2013-05-30
CN103946225B (zh) 2016-06-15
CN103946225A (zh) 2014-07-23
CZ303877B6 (cs) 2013-06-05
HUP1400334A3 (en) 2014-12-29
IN2014KN01308A (ko) 2015-10-16
IL232652A0 (en) 2014-06-30
HUP1400334A2 (hu) 2014-10-28
BR112014012430A2 (pt) 2017-06-06

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Legal Events

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FF Patent granted
MM9K Patent not in force due to non-payment of renewal fees