IL231351A - Imidazopyridazines are conserved in amino acids - Google Patents

Imidazopyridazines are conserved in amino acids

Info

Publication number
IL231351A
IL231351A IL231351A IL23135114A IL231351A IL 231351 A IL231351 A IL 231351A IL 231351 A IL231351 A IL 231351A IL 23135114 A IL23135114 A IL 23135114A IL 231351 A IL231351 A IL 231351A
Authority
IL
Israel
Prior art keywords
amino
substituted imidazopyridazines
imidazopyridazines
substituted
Prior art date
Application number
IL231351A
Other languages
English (en)
Hebrew (he)
Other versions
IL231351A0 (en
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47831558&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL231351(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of IL231351A0 publication Critical patent/IL231351A0/en
Publication of IL231351A publication Critical patent/IL231351A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)
  • Fats And Perfumes (AREA)
IL231351A 2011-09-06 2014-03-06 Imidazopyridazines are conserved in amino acids IL231351A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP11180129 2011-09-06
EP11182440 2011-09-23
EP12179902 2012-08-09
PCT/EP2012/067264 WO2013034570A1 (en) 2011-09-06 2012-09-05 Amino-substituted imidazopyridazines

Publications (2)

Publication Number Publication Date
IL231351A0 IL231351A0 (en) 2014-04-30
IL231351A true IL231351A (en) 2017-01-31

Family

ID=47831558

Family Applications (1)

Application Number Title Priority Date Filing Date
IL231351A IL231351A (en) 2011-09-06 2014-03-06 Imidazopyridazines are conserved in amino acids

Country Status (36)

Country Link
US (1) US9499547B2 (member.php)
EP (1) EP2758401B1 (member.php)
JP (1) JP6174583B2 (member.php)
KR (1) KR20140059268A (member.php)
CN (1) CN103958515B (member.php)
AP (1) AP2014007496A0 (member.php)
AU (1) AU2012306422B2 (member.php)
BR (1) BR112014004687A2 (member.php)
CA (1) CA2847514A1 (member.php)
CL (1) CL2014000543A1 (member.php)
CO (1) CO6900146A2 (member.php)
CR (1) CR20140113A (member.php)
CY (1) CY1119433T1 (member.php)
DK (1) DK2758401T3 (member.php)
DO (1) DOP2014000051A (member.php)
EA (1) EA025688B1 (member.php)
EC (1) ECSP14013231A (member.php)
ES (1) ES2638319T3 (member.php)
GT (1) GT201400043A (member.php)
HR (1) HRP20171248T1 (member.php)
IL (1) IL231351A (member.php)
LT (1) LT2758401T (member.php)
MA (1) MA35422B1 (member.php)
ME (1) ME02951B (member.php)
MX (1) MX348064B (member.php)
MY (1) MY168413A (member.php)
PE (1) PE20141593A1 (member.php)
PH (1) PH12014500501A1 (member.php)
PL (1) PL2758401T3 (member.php)
PT (1) PT2758401T (member.php)
RS (1) RS56179B1 (member.php)
SG (1) SG11201400219PA (member.php)
SI (1) SI2758401T1 (member.php)
UA (1) UA117092C2 (member.php)
WO (1) WO2013034570A1 (member.php)
ZA (1) ZA201402498B (member.php)

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UA117092C2 (uk) 2011-09-06 2018-06-25 Байєр Інтеллектуал Проперті Гмбх Амінозаміщені імідазопіридазини
US9320737B2 (en) * 2011-09-23 2016-04-26 Bayer Intellectual Property Gmbh Substituted imidazopyridazines
US9643974B2 (en) 2011-12-12 2017-05-09 Bayer Intellectual Property Gmbh Amino-substituted imidazopyridazines
US9777004B2 (en) 2012-03-29 2017-10-03 Bayer Intellectual Property Gmbh Amino-substituted imidazopyridazines
EP2834245B1 (en) 2012-04-04 2017-12-13 Bayer Pharma Aktiengesellschaft Amino-substituted imidazopyridazines
CN104797585B (zh) 2012-11-19 2017-08-15 拜耳医药股份公司 氨基咪唑并哒嗪
ES2649156T3 (es) 2013-01-14 2018-01-10 Incyte Holdings Corporation Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim
US9200004B2 (en) 2013-01-15 2015-12-01 Incyte Holdings Corporation Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors
CN105008363A (zh) * 2013-01-30 2015-10-28 拜耳医药股份公司 作为mknk-1激酶抑制剂的酰氨基咪唑并哒嗪
HK1212699A1 (zh) * 2013-02-20 2016-06-17 拜耳医药股份公司 作为mknk1抑制剂的取代的咪唑并[1，2-b]哒嗪类化合物
PE20160532A1 (es) 2013-08-23 2016-05-21 Incyte Corp Compuesto de carboxamida de furo y tienopiridina utiles como inhibidores de cinasas pim
JP2017503809A (ja) 2014-01-09 2017-02-02 バイエル・ファルマ・アクティエンゲゼルシャフト アミド置換イミダゾピリダジン
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
CN107108636A (zh) * 2014-12-23 2017-08-29 拜耳医药股份公司 6‑羟基苯并呋喃基‑和6‑烷氧基苯并呋喃基‑取代的咪唑并哒嗪
US10702526B2 (en) 2015-04-20 2020-07-07 Effector Therapeutics Inc. Inhibitors of immune checkpoint modulators and related methods
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
AR105967A1 (es) 2015-09-09 2017-11-29 Incyte Corp Sales de un inhibidor de pim quinasa
WO2017059251A1 (en) 2015-10-02 2017-04-06 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
WO2017117052A1 (en) * 2015-12-31 2017-07-06 Effector Therapeutics, Inc. Mnk biomarkers and uses thereof
WO2017157418A1 (en) 2016-03-15 2017-09-21 Bayer Pharma Aktiengesellschaft Combination of mknk1-inhibitors
TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法

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JP6121991B2 (ja) * 2011-05-17 2017-04-26 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ Ｍｋｎｋ１キナーゼ阻害剤としてのアミノ置換イミダゾピリダジン
US9730929B2 (en) 2011-06-01 2017-08-15 Bayer Intellectual Property Gmbh Substituted aminoimidazopyridazines
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AR087701A1 (es) 2011-08-31 2014-04-09 Japan Tobacco Inc Derivados de pirazol con actividad inhibidora de sglt1
JO3192B1 (ar) 2011-09-06 2018-03-08 Novartis Ag مركب بنزوثيازولون
UA117092C2 (uk) 2011-09-06 2018-06-25 Байєр Інтеллектуал Проперті Гмбх Амінозаміщені імідазопіридазини
US9320737B2 (en) 2011-09-23 2016-04-26 Bayer Intellectual Property Gmbh Substituted imidazopyridazines
US9353081B2 (en) 2011-09-23 2016-05-31 Hoffmann-La Roche Inc. Bicyclic dihydroquinoline-2-one derivatives
US9643974B2 (en) 2011-12-12 2017-05-09 Bayer Intellectual Property Gmbh Amino-substituted imidazopyridazines
US9777004B2 (en) 2012-03-29 2017-10-03 Bayer Intellectual Property Gmbh Amino-substituted imidazopyridazines
EP2834245B1 (en) 2012-04-04 2017-12-13 Bayer Pharma Aktiengesellschaft Amino-substituted imidazopyridazines
CN104797585B (zh) 2012-11-19 2017-08-15 拜耳医药股份公司 氨基咪唑并哒嗪
CN105008363A (zh) 2013-01-30 2015-10-28 拜耳医药股份公司 作为mknk-1激酶抑制剂的酰氨基咪唑并哒嗪
HK1212699A1 (zh) 2013-02-20 2016-06-17 拜耳医药股份公司 作为mknk1抑制剂的取代的咪唑并[1，2-b]哒嗪类化合物
JP2017503809A (ja) 2014-01-09 2017-02-02 バイエル・ファルマ・アクティエンゲゼルシャフト アミド置換イミダゾピリダジン

Also Published As

Publication number Publication date
NZ622129A (en) 2016-06-24
UA117092C2 (uk) 2018-06-25
SG11201400219PA (en) 2014-03-28
HRP20171248T1 (hr) 2017-10-20
RS56179B1 (sr) 2017-11-30
DOP2014000051A (es) 2014-06-01
AU2012306422A1 (en) 2014-03-27
EP2758401A1 (en) 2014-07-30
GT201400043A (es) 2015-04-06
CY1119433T1 (el) 2018-03-07
PE20141593A1 (es) 2014-11-12
CN103958515B (zh) 2016-11-09
PH12014500501A1 (en) 2021-06-02
CA2847514A1 (en) 2013-03-14
KR20140059268A (ko) 2014-05-15
AP2014007496A0 (en) 2014-03-31
ECSP14013231A (es) 2014-04-30
US20140296231A1 (en) 2014-10-02
MX348064B (es) 2017-05-26
HK1199732A1 (en) 2015-07-17
BR112014004687A2 (pt) 2017-03-28
CL2014000543A1 (es) 2014-09-26
EP2758401B1 (en) 2017-05-31
US9499547B2 (en) 2016-11-22
AP3853A (member.php) 2016-09-30
MY168413A (en) 2018-11-09
MX2014002697A (es) 2014-04-25
ME02951B (me) 2018-07-20
DK2758401T3 (en) 2017-09-11
CR20140113A (es) 2014-05-02
PL2758401T3 (pl) 2017-11-30
CN103958515A (zh) 2014-07-30
EA201400311A1 (ru) 2014-09-30
AU2012306422B2 (en) 2017-10-26
WO2013034570A1 (en) 2013-03-14
JP2014525469A (ja) 2014-09-29
MA35422B1 (fr) 2014-09-01
PT2758401T (pt) 2017-08-30
SI2758401T1 (sl) 2017-10-30
ZA201402498B (en) 2017-09-27
IL231351A0 (en) 2014-04-30
JP6174583B2 (ja) 2017-08-02
CO6900146A2 (es) 2014-03-20
ES2638319T3 (es) 2017-10-19
LT2758401T (lt) 2017-08-25
EA025688B1 (ru) 2017-01-30

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