IL230358B - Identification of human antibodies in cell-specificity - Google Patents

Identification of human antibodies in cell-specificity

Info

Publication number
IL230358B
IL230358B IL230358A IL23035814A IL230358B IL 230358 B IL230358 B IL 230358B IL 230358 A IL230358 A IL 230358A IL 23035814 A IL23035814 A IL 23035814A IL 230358 B IL230358 B IL 230358B
Authority
IL
Israel
Prior art keywords
human antibodies
matured human
identifying affinity
affinity
identifying
Prior art date
Application number
IL230358A
Other languages
English (en)
Hebrew (he)
Original Assignee
Xbiotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xbiotech Inc filed Critical Xbiotech Inc
Publication of IL230358B publication Critical patent/IL230358B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1037Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1096Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515Complete light chain, i.e. VL + CL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL230358A 2011-07-12 2014-01-07 Identification of human antibodies in cell-specificity IL230358B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161506749P 2011-07-12 2011-07-12
PCT/US2012/046431 WO2013009967A2 (en) 2011-07-12 2012-07-12 Identifying affinity-matured human antibodies

Publications (1)

Publication Number Publication Date
IL230358B true IL230358B (en) 2018-11-29

Family

ID=47506915

Family Applications (2)

Application Number Title Priority Date Filing Date
IL230358A IL230358B (en) 2011-07-12 2014-01-07 Identification of human antibodies in cell-specificity
IL262977A IL262977B (en) 2011-07-12 2018-11-13 Identification of human antibodies in cell-specificity

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL262977A IL262977B (en) 2011-07-12 2018-11-13 Identification of human antibodies in cell-specificity

Country Status (11)

Country Link
US (6) US9234030B2 (enExample)
EP (2) EP2731965A4 (enExample)
JP (1) JP6731702B2 (enExample)
KR (1) KR102139388B1 (enExample)
CN (2) CN103687873B (enExample)
AU (2) AU2012281078B2 (enExample)
CA (1) CA2841475C (enExample)
IL (2) IL230358B (enExample)
MX (2) MX361600B (enExample)
RU (2) RU2636045C2 (enExample)
WO (1) WO2013009967A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102139388B1 (ko) * 2011-07-12 2020-07-30 엑스바이오테크, 인크. 친화성 성숙 인간 항체의 동정
US10119134B2 (en) 2013-03-15 2018-11-06 Abvitro Llc Single cell bar-coding for antibody discovery
GB201316644D0 (en) * 2013-09-19 2013-11-06 Kymab Ltd Expression vector production & High-Throughput cell screening
JP6647197B2 (ja) * 2014-05-30 2020-02-14 国立大学法人富山大学 TCR cDNAの増幅方法
WO2015187779A1 (en) 2014-06-03 2015-12-10 Xbiotech, Inc. Compositions and methods for treating and preventing staphylococcus aureus infections
SG10201911069WA (en) 2014-09-15 2020-01-30 Abvitro Llc High-throughput nucleotide library sequencing
US10975146B2 (en) 2018-06-29 2021-04-13 Cedars-Sinai Medical Center Interleukin-1 inhibition for combination treatment of pancreatic cancer
US20200392578A1 (en) * 2019-06-14 2020-12-17 The Regents Of The University Of California Methods of sequencing antibody chains from hybridomas and kits for practicing same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001212019B2 (en) 2000-03-10 2006-12-14 Large Scale Biology Corporation Self antigen vaccines for treating b cell lymphomas and other cancers
AU2002953381A0 (en) * 2002-12-18 2003-01-09 Diatech Pty Ltd In vivo affinity maturation scheme
CN1860367B (zh) * 2003-07-29 2010-05-26 健泰科生物技术公司 人抗cd20抗体的测定法及其用途
TWI333977B (en) * 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
PE20071101A1 (es) 2005-08-31 2007-12-21 Amgen Inc Polipeptidos y anticuerpos
JP5205597B2 (ja) * 2007-06-01 2013-06-05 静岡県 1細胞レベルでの抗体遺伝子の解析・同定方法
US8404445B2 (en) * 2008-09-30 2013-03-26 Abbvie Inc. Antibody libraries
ES2570460T3 (es) * 2009-02-20 2016-05-18 Hoffmann La Roche Método de obtención de ácido nucleico que codifica inmunoglobulina
KR102139388B1 (ko) * 2011-07-12 2020-07-30 엑스바이오테크, 인크. 친화성 성숙 인간 항체의 동정

Also Published As

Publication number Publication date
EP3034513A2 (en) 2016-06-22
AU2012281078A1 (en) 2014-01-23
AU2012281078B2 (en) 2017-05-04
US9394536B2 (en) 2016-07-19
WO2013009967A3 (en) 2013-04-04
WO2013009967A2 (en) 2013-01-17
RU2762685C2 (ru) 2021-12-22
US20160060618A1 (en) 2016-03-03
CA2841475C (en) 2021-02-09
EP3034513B1 (en) 2020-09-02
RU2014102617A (ru) 2015-08-20
RU2017134418A (ru) 2019-02-07
JP2014521316A (ja) 2014-08-28
JP6731702B2 (ja) 2020-07-29
US20130018173A1 (en) 2013-01-17
CN107090459A (zh) 2017-08-25
EP3034513A3 (en) 2016-08-10
RU2636045C2 (ru) 2017-11-17
KR20140044905A (ko) 2014-04-15
MX361600B (es) 2018-12-11
US9670483B2 (en) 2017-06-06
MX2014000431A (es) 2014-09-04
KR102139388B1 (ko) 2020-07-30
CN103687873A (zh) 2014-03-26
US20170233457A1 (en) 2017-08-17
MX2018015450A (es) 2021-11-16
CN103687873B (zh) 2016-10-19
IL262977B (en) 2020-07-30
EP2731965A4 (en) 2015-06-03
RU2017134418A3 (enExample) 2021-06-10
US9453217B2 (en) 2016-09-27
IL262977A (en) 2018-12-31
US20200071388A1 (en) 2020-03-05
CA2841475A1 (en) 2013-01-17
AU2017210585B2 (en) 2019-07-25
US20160362679A1 (en) 2016-12-15
AU2017210585A1 (en) 2017-08-24
EP2731965A2 (en) 2014-05-21
US9234030B2 (en) 2016-01-12
US20160060619A1 (en) 2016-03-03

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