IL228252A - Preparations for the preparation of drugs for the treatment of diseases and lung injury - Google Patents
Preparations for the preparation of drugs for the treatment of diseases and lung injuryInfo
- Publication number
- IL228252A IL228252A IL228252A IL22825213A IL228252A IL 228252 A IL228252 A IL 228252A IL 228252 A IL228252 A IL 228252A IL 22825213 A IL22825213 A IL 22825213A IL 228252 A IL228252 A IL 228252A
- Authority
- IL
- Israel
- Prior art keywords
- nucleic acid
- tlr2
- sequence
- tlr4
- lung
- Prior art date
Links
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
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| PCT/US2012/027169 WO2012118910A2 (en) | 2011-03-03 | 2012-03-01 | Compositions and methods for treating lung disease and injury |
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| CN103492572A (zh) | 2011-03-03 | 2014-01-01 | 夸克医药公司 | 用于治疗肺疾病和损伤的组合物和方法 |
| ES2555160B1 (es) * | 2014-06-24 | 2016-10-25 | Aptus Biotech, S.L. | Aptámeros específicos de TLR-4 y usos de los mismos |
| EP3423568A4 (en) | 2016-03-04 | 2019-11-13 | University Of Louisville Research Foundation, Inc. | METHOD AND COMPOSITIONS FOR EX-VIVO REPRODUCTION OF VERY SMALL EMBRYONAL STEM CELLS (VSELS) |
| JP2019535839A (ja) | 2016-11-29 | 2019-12-12 | ピュアテック ヘルス エルエルシー | 治療剤の送達のためのエクソソーム |
| US10975167B2 (en) | 2017-04-14 | 2021-04-13 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Method to reduce pulmonary arterial hypertension by administering inhibitors of nicotinamide phosphoribotransferase |
| CA3060080C (en) * | 2017-04-14 | 2024-01-23 | The United States Of America As Represented By The Department Of Veterans Affairs | Compositions and methods for treating pulmonary fibrosis |
| WO2020011869A2 (en) | 2018-07-11 | 2020-01-16 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides targeting tlr2 |
| KR102562955B1 (ko) | 2021-07-08 | 2023-08-03 | 렉스소프트 주식회사 | 폐 기능 저하 위험 예측용 단일염기다형성 및 이의 용도 |
| CN114796273A (zh) * | 2022-07-01 | 2022-07-29 | 中国人民解放军总医院第一医学中心 | Tlr4激动的外泌体或外泌体制剂在制备防治放射性肺损伤药物中的应用 |
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| WO2012118911A1 (en) | 2011-03-03 | 2012-09-07 | Quark Pharmaceuticals, Inc. | Oligonucleotide modulators of the toll-like receptor pathway |
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| AU2012223365A1 (en) | 2013-09-12 |
| NZ708151A (en) | 2015-10-30 |
| EP2681314A2 (en) | 2014-01-08 |
| WO2012118910A3 (en) | 2013-01-03 |
| CA2828002A1 (en) | 2012-09-07 |
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| SG192961A1 (en) | 2013-09-30 |
| US9822362B2 (en) | 2017-11-21 |
| WO2012118910A2 (en) | 2012-09-07 |
| US9205100B2 (en) | 2015-12-08 |
| AU2012223365B2 (en) | 2016-11-10 |
| EP2681314B1 (en) | 2017-11-01 |
| JP6000287B2 (ja) | 2016-09-28 |
| CN103492572A (zh) | 2014-01-01 |
| NZ614556A (en) | 2015-06-26 |
| KR20140042792A (ko) | 2014-04-07 |
| US20140005253A1 (en) | 2014-01-02 |
| US20160215284A1 (en) | 2016-07-28 |
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