IL224121A - Use of Matrix-9 and 2 Matrix Protease Inhibitors for the Treatment of Disease - Google Patents

Use of Matrix-9 and 2 Matrix Protease Inhibitors for the Treatment of Disease

Info

Publication number
IL224121A
IL224121A IL224121A IL22412113A IL224121A IL 224121 A IL224121 A IL 224121A IL 224121 A IL224121 A IL 224121A IL 22412113 A IL22412113 A IL 22412113A IL 224121 A IL224121 A IL 224121A
Authority
IL
Israel
Prior art keywords
mmp
antibodies
antibody
ser
pro
Prior art date
Application number
IL224121A
Other languages
English (en)
Hebrew (he)
Inventor
Shanzer Abraham
Sagi Irit
Danon Tamar
Sela Netta
Kikkeri Raghavendra
Arad-Yellin Rina
Original Assignee
Yeda Res & Dev
Shanzer Abraham
Sagi Irit
Danon Tamar
Sela Netta
Kikkeri Raghavendra
Arad-Yellin Rina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev, Shanzer Abraham, Sagi Irit, Danon Tamar, Sela Netta, Kikkeri Raghavendra, Arad-Yellin Rina filed Critical Yeda Res & Dev
Publication of IL224121A publication Critical patent/IL224121A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/06Zinc compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL224121A 2007-02-23 2013-01-06 Use of Matrix-9 and 2 Matrix Protease Inhibitors for the Treatment of Disease IL224121A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90285407P 2007-02-23 2007-02-23
PCT/IL2008/000230 WO2008102359A1 (fr) 2007-02-23 2008-02-21 Anticorps et compositions pharmaceutiques contenant ces anticorps utiles pour inhiber l'activité des métalloprotéines

Publications (1)

Publication Number Publication Date
IL224121A true IL224121A (en) 2016-05-31

Family

ID=39534848

Family Applications (2)

Application Number Title Priority Date Filing Date
IL224120A IL224120A (en) 2007-02-23 2013-01-06 A compound for the production of inhibitors for meteloproteins
IL224121A IL224121A (en) 2007-02-23 2013-01-06 Use of Matrix-9 and 2 Matrix Protease Inhibitors for the Treatment of Disease

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL224120A IL224120A (en) 2007-02-23 2013-01-06 A compound for the production of inhibitors for meteloproteins

Country Status (11)

Country Link
US (5) US8324355B2 (fr)
EP (1) EP2155691B1 (fr)
JP (2) JP5513130B2 (fr)
KR (1) KR20090113908A (fr)
CN (1) CN101702906B (fr)
BR (1) BRPI0807256A2 (fr)
CA (1) CA2678304A1 (fr)
IL (2) IL224120A (fr)
MX (1) MX2009008914A (fr)
RU (1) RU2503682C2 (fr)
WO (1) WO2008102359A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0807256A2 (pt) 2007-02-23 2014-07-22 Yeda Res & Dev "composição com fórmula geral i, composto com a fórmula ii, anticorpo, método de produção de inibidor de metaloproteinase,composição farmacêutica, método de tratamento de doença associada a atividade incompatível ou anormal de metaloproteinas, método de inibição da atividade da metaloproteinase matriz em uma célula"
WO2009079585A2 (fr) 2007-12-17 2009-06-25 Dyax Corp. Compositions et procédés pour traiter des troubles ostéolytiques comprenant des protéines de liaison à mmp-14
WO2009111508A2 (fr) * 2008-03-03 2009-09-11 Dyax Corp. Protéines de liaison à la métalloprotéinase 9 et à la métalloprotéinase 2
WO2010101628A2 (fr) * 2009-03-02 2010-09-10 Massachusetts Institute Of Technology Procédés et produits pour établir un profil enzymatique in vivo
CN102822202B (zh) * 2010-01-27 2015-07-22 耶达研究及发展有限公司 抑制金属蛋白的抗体
KR101930179B1 (ko) 2010-08-27 2018-12-17 길리아드 바이오로직스, 인크. 매트릭스 메탈로프로테이나제 9에 대한 항체
ES2688457T3 (es) * 2010-10-28 2018-11-02 Yeda Research And Development Co. Ltd. Métodos de generación de anticuerpos contra metaloenzimas
WO2013059439A2 (fr) 2011-10-21 2013-04-25 Dyax Corp. Polythérapie comprenant une protéine de liaison à la mmp-14
CN107184974A (zh) 2012-02-29 2017-09-22 吉利德生物制剂公司 抗基质金属蛋白酶9的抗体
US10527619B2 (en) 2013-06-07 2020-01-07 Massachusetts Institute Of Technology Affinity-based detection of ligand-encoded synthetic biomarkers
DK3125942T3 (da) 2014-04-03 2021-12-20 Csl Behring Ag Forstøvning af immunoglobulin
US11357022B2 (en) 2014-05-19 2022-06-07 Qualcomm Incorporated Apparatus and method for interference mitigation utilizing thin control
US10278178B2 (en) 2014-05-19 2019-04-30 Qualcomm Incorporated Apparatus and method for inter-band pairing of carriers for time division duplex transmit- and receive-switching
EP2985296A1 (fr) * 2014-08-13 2016-02-17 Calypso Biotech SA Anticorps spécifiques de MMP9
US10305637B2 (en) * 2016-04-04 2019-05-28 Samsung Electronics Co., Ltd. Method and apparatus for transmitting and receiving feedback in wireless communication system
WO2018148595A1 (fr) * 2017-02-10 2018-08-16 Washington University Anticorps dirigés contre tip1 et leurs procédés d'utilisation
KR102657653B1 (ko) 2017-07-18 2024-04-16 다이이찌 산쿄 가부시키가이샤 활성형 mmp-9 결합 펩티드
EP3911753A1 (fr) 2019-01-17 2021-11-24 Massachusetts Institute of Technology Capteurs pour détecter et imager une métastase cancéreuse
IL264768A (en) 2019-02-10 2020-08-31 Sagi Irit ANTI-MATRIX METALLOPROTEINASE 7 (MMP-7) inhibitory antibody and its use
US11332546B2 (en) 2019-05-21 2022-05-17 The Regents Of The University Of California Protease inhibitory antibodies and methods of use thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595700A (en) * 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
DE69309047T2 (de) 1992-04-07 1997-09-11 British Biotech Pharm Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren
GB9320660D0 (en) 1993-10-07 1993-11-24 British Bio Technology Inhibition of cytokine production
WO1995029689A1 (fr) 1994-04-28 1995-11-09 Merck & Co., Inc. Derives de n-carboxyalkyle utilises comme agents antidegeneratifs
AU2394795A (en) 1994-04-28 1995-11-29 Du Pont Merck Pharmaceutical Company, The Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents
GB9416897D0 (en) 1994-08-20 1994-10-12 British Biotech Pharm Metalloproteinase inhibitors
KR100231230B1 (ko) 1995-08-08 1999-11-15 우에노 도시오 히드록삼산 유도체(hydroxamic acid derivatives)
IL116126A0 (en) * 1995-11-24 1996-01-31 Yeda Res & Dev Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them
DK0780386T3 (da) 1995-12-20 2003-02-03 Hoffmann La Roche Matrixmetalloproteaseinhibitorer
DK0871439T3 (da) 1996-01-02 2004-08-02 Aventis Pharma Inc Substituerede (aryl, heteroaryl, arylmethyl eller heteroarylmethyl) hydroxamsyreforbindelser
WO1997049679A1 (fr) 1996-06-27 1997-12-31 Ono Pharmaceutical Co., Ltd. Derives d'aryle (sulfure, oxyde sulfonique et sulfone) et medicaments les contenant en tant que principe actif
US6174915B1 (en) * 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
KR20010072089A (ko) * 1998-07-30 2001-07-31 로즈 암스트롱, 크리스틴 에이. 트러트웨인 매트릭스 메탈로프로테이나제 억제제로서 트리시클릭술폰아미드 및 그의 유도체
IL132105A0 (en) * 1998-12-24 2001-03-19 Yeda Res & Dev Caspase-8 interacting proteins
EP2330132B1 (fr) * 2003-04-04 2013-08-14 Yeda Research and Development Co. Ltd. Anticorps contre MMP2 ou MMP9 et compositions pharmaceutiques contenant ces anticorps utiles pour inhiber l'activité de cettes métalloprotéines
BRPI0807256A2 (pt) 2007-02-23 2014-07-22 Yeda Res & Dev "composição com fórmula geral i, composto com a fórmula ii, anticorpo, método de produção de inibidor de metaloproteinase,composição farmacêutica, método de tratamento de doença associada a atividade incompatível ou anormal de metaloproteinas, método de inibição da atividade da metaloproteinase matriz em uma célula"
CN102822202B (zh) 2010-01-27 2015-07-22 耶达研究及发展有限公司 抑制金属蛋白的抗体

Also Published As

Publication number Publication date
US8324355B2 (en) 2012-12-04
RU2503682C2 (ru) 2014-01-10
US9416195B2 (en) 2016-08-16
IL224120A (en) 2016-05-31
JP2013241435A (ja) 2013-12-05
KR20090113908A (ko) 2009-11-02
JP5513130B2 (ja) 2014-06-04
US20130030158A1 (en) 2013-01-31
US20100233188A1 (en) 2010-09-16
WO2008102359A9 (fr) 2009-05-22
US20130224225A1 (en) 2013-08-29
EP2155691B1 (fr) 2016-01-13
CA2678304A1 (fr) 2008-08-28
AU2008218525A1 (en) 2008-08-28
US9902783B2 (en) 2018-02-27
JP2010519289A (ja) 2010-06-03
RU2009132006A (ru) 2011-02-27
CN101702906B (zh) 2014-02-12
US8486653B2 (en) 2013-07-16
MX2009008914A (es) 2009-08-28
BRPI0807256A2 (pt) 2014-07-22
WO2008102359A1 (fr) 2008-08-28
JP5792231B2 (ja) 2015-10-07
US20160257765A1 (en) 2016-09-08
EP2155691A1 (fr) 2010-02-24
US20180134808A1 (en) 2018-05-17
CN101702906A (zh) 2010-05-05

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