IL224121A - Use of Matrix-9 and 2 Matrix Protease Inhibitors for the Treatment of Disease - Google Patents
Use of Matrix-9 and 2 Matrix Protease Inhibitors for the Treatment of DiseaseInfo
- Publication number
- IL224121A IL224121A IL224121A IL22412113A IL224121A IL 224121 A IL224121 A IL 224121A IL 224121 A IL224121 A IL 224121A IL 22412113 A IL22412113 A IL 22412113A IL 224121 A IL224121 A IL 224121A
- Authority
- IL
- Israel
- Prior art keywords
- mmp
- antibodies
- antibody
- ser
- pro
- Prior art date
Links
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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
- C07F3/06—Zinc compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
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- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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US90285407P | 2007-02-23 | 2007-02-23 | |
PCT/IL2008/000230 WO2008102359A1 (fr) | 2007-02-23 | 2008-02-21 | Anticorps et compositions pharmaceutiques contenant ces anticorps utiles pour inhiber l'activité des métalloprotéines |
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IL224121A IL224121A (en) | 2007-02-23 | 2013-01-06 | Use of Matrix-9 and 2 Matrix Protease Inhibitors for the Treatment of Disease |
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EP (1) | EP2155691B1 (fr) |
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CN (1) | CN101702906B (fr) |
BR (1) | BRPI0807256A2 (fr) |
CA (1) | CA2678304A1 (fr) |
IL (2) | IL224120A (fr) |
MX (1) | MX2009008914A (fr) |
RU (1) | RU2503682C2 (fr) |
WO (1) | WO2008102359A1 (fr) |
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BRPI0807256A2 (pt) | 2007-02-23 | 2014-07-22 | Yeda Res & Dev | "composição com fórmula geral i, composto com a fórmula ii, anticorpo, método de produção de inibidor de metaloproteinase,composição farmacêutica, método de tratamento de doença associada a atividade incompatível ou anormal de metaloproteinas, método de inibição da atividade da metaloproteinase matriz em uma célula" |
WO2009079585A2 (fr) | 2007-12-17 | 2009-06-25 | Dyax Corp. | Compositions et procédés pour traiter des troubles ostéolytiques comprenant des protéines de liaison à mmp-14 |
WO2009111508A2 (fr) * | 2008-03-03 | 2009-09-11 | Dyax Corp. | Protéines de liaison à la métalloprotéinase 9 et à la métalloprotéinase 2 |
WO2010101628A2 (fr) * | 2009-03-02 | 2010-09-10 | Massachusetts Institute Of Technology | Procédés et produits pour établir un profil enzymatique in vivo |
CN102822202B (zh) * | 2010-01-27 | 2015-07-22 | 耶达研究及发展有限公司 | 抑制金属蛋白的抗体 |
KR101930179B1 (ko) | 2010-08-27 | 2018-12-17 | 길리아드 바이오로직스, 인크. | 매트릭스 메탈로프로테이나제 9에 대한 항체 |
ES2688457T3 (es) * | 2010-10-28 | 2018-11-02 | Yeda Research And Development Co. Ltd. | Métodos de generación de anticuerpos contra metaloenzimas |
WO2013059439A2 (fr) | 2011-10-21 | 2013-04-25 | Dyax Corp. | Polythérapie comprenant une protéine de liaison à la mmp-14 |
CN107184974A (zh) | 2012-02-29 | 2017-09-22 | 吉利德生物制剂公司 | 抗基质金属蛋白酶9的抗体 |
US10527619B2 (en) | 2013-06-07 | 2020-01-07 | Massachusetts Institute Of Technology | Affinity-based detection of ligand-encoded synthetic biomarkers |
DK3125942T3 (da) | 2014-04-03 | 2021-12-20 | Csl Behring Ag | Forstøvning af immunoglobulin |
US11357022B2 (en) | 2014-05-19 | 2022-06-07 | Qualcomm Incorporated | Apparatus and method for interference mitigation utilizing thin control |
US10278178B2 (en) | 2014-05-19 | 2019-04-30 | Qualcomm Incorporated | Apparatus and method for inter-band pairing of carriers for time division duplex transmit- and receive-switching |
EP2985296A1 (fr) * | 2014-08-13 | 2016-02-17 | Calypso Biotech SA | Anticorps spécifiques de MMP9 |
US10305637B2 (en) * | 2016-04-04 | 2019-05-28 | Samsung Electronics Co., Ltd. | Method and apparatus for transmitting and receiving feedback in wireless communication system |
WO2018148595A1 (fr) * | 2017-02-10 | 2018-08-16 | Washington University | Anticorps dirigés contre tip1 et leurs procédés d'utilisation |
KR102657653B1 (ko) | 2017-07-18 | 2024-04-16 | 다이이찌 산쿄 가부시키가이샤 | 활성형 mmp-9 결합 펩티드 |
EP3911753A1 (fr) | 2019-01-17 | 2021-11-24 | Massachusetts Institute of Technology | Capteurs pour détecter et imager une métastase cancéreuse |
IL264768A (en) | 2019-02-10 | 2020-08-31 | Sagi Irit | ANTI-MATRIX METALLOPROTEINASE 7 (MMP-7) inhibitory antibody and its use |
US11332546B2 (en) | 2019-05-21 | 2022-05-17 | The Regents Of The University Of California | Protease inhibitory antibodies and methods of use thereof |
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US4595700A (en) * | 1984-12-21 | 1986-06-17 | G. D. Searle & Co. | Thiol based collagenase inhibitors |
GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
DE69309047T2 (de) | 1992-04-07 | 1997-09-11 | British Biotech Pharm | Hydroxamsäure enthaltende collagenase-inhibitoren und cytokinaktivitätsinhibitoren |
GB9320660D0 (en) | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
WO1995029689A1 (fr) | 1994-04-28 | 1995-11-09 | Merck & Co., Inc. | Derives de n-carboxyalkyle utilises comme agents antidegeneratifs |
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KR20010072089A (ko) * | 1998-07-30 | 2001-07-31 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 매트릭스 메탈로프로테이나제 억제제로서 트리시클릭술폰아미드 및 그의 유도체 |
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BRPI0807256A2 (pt) | 2007-02-23 | 2014-07-22 | Yeda Res & Dev | "composição com fórmula geral i, composto com a fórmula ii, anticorpo, método de produção de inibidor de metaloproteinase,composição farmacêutica, método de tratamento de doença associada a atividade incompatível ou anormal de metaloproteinas, método de inibição da atividade da metaloproteinase matriz em uma célula" |
CN102822202B (zh) | 2010-01-27 | 2015-07-22 | 耶达研究及发展有限公司 | 抑制金属蛋白的抗体 |
-
2008
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- 2008-02-21 WO PCT/IL2008/000230 patent/WO2008102359A1/fr active Application Filing
- 2008-02-21 RU RU2009132006/04A patent/RU2503682C2/ru not_active IP Right Cessation
- 2008-02-21 CN CN200880012673.1A patent/CN101702906B/zh not_active Expired - Fee Related
- 2008-02-21 EP EP08710230.7A patent/EP2155691B1/fr active Active
- 2008-02-21 KR KR1020097019866A patent/KR20090113908A/ko not_active Application Discontinuation
- 2008-02-21 JP JP2009550773A patent/JP5513130B2/ja not_active Expired - Fee Related
- 2008-02-21 US US12/449,728 patent/US8324355B2/en active Active
- 2008-02-21 CA CA002678304A patent/CA2678304A1/fr not_active Abandoned
- 2008-02-21 MX MX2009008914A patent/MX2009008914A/es not_active Application Discontinuation
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2012
- 2012-08-28 US US13/596,090 patent/US8486653B2/en active Active
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2013
- 2013-01-06 IL IL224120A patent/IL224120A/en active IP Right Grant
- 2013-01-06 IL IL224121A patent/IL224121A/en active IP Right Grant
- 2013-04-29 US US13/872,265 patent/US9416195B2/en not_active Expired - Fee Related
- 2013-07-19 JP JP2013150040A patent/JP5792231B2/ja not_active Expired - Fee Related
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2016
- 2016-05-23 US US15/161,375 patent/US9902783B2/en active Active
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- 2018-01-09 US US15/865,479 patent/US20180134808A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US8324355B2 (en) | 2012-12-04 |
RU2503682C2 (ru) | 2014-01-10 |
US9416195B2 (en) | 2016-08-16 |
IL224120A (en) | 2016-05-31 |
JP2013241435A (ja) | 2013-12-05 |
KR20090113908A (ko) | 2009-11-02 |
JP5513130B2 (ja) | 2014-06-04 |
US20130030158A1 (en) | 2013-01-31 |
US20100233188A1 (en) | 2010-09-16 |
WO2008102359A9 (fr) | 2009-05-22 |
US20130224225A1 (en) | 2013-08-29 |
EP2155691B1 (fr) | 2016-01-13 |
CA2678304A1 (fr) | 2008-08-28 |
AU2008218525A1 (en) | 2008-08-28 |
US9902783B2 (en) | 2018-02-27 |
JP2010519289A (ja) | 2010-06-03 |
RU2009132006A (ru) | 2011-02-27 |
CN101702906B (zh) | 2014-02-12 |
US8486653B2 (en) | 2013-07-16 |
MX2009008914A (es) | 2009-08-28 |
BRPI0807256A2 (pt) | 2014-07-22 |
WO2008102359A1 (fr) | 2008-08-28 |
JP5792231B2 (ja) | 2015-10-07 |
US20160257765A1 (en) | 2016-09-08 |
EP2155691A1 (fr) | 2010-02-24 |
US20180134808A1 (en) | 2018-05-17 |
CN101702906A (zh) | 2010-05-05 |
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