IL219759A0 - Novel compounds as receptor modulators with therapeutic utility - Google Patents

Novel compounds as receptor modulators with therapeutic utility

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Publication number
IL219759A0
IL219759A0 IL219759A IL21975912A IL219759A0 IL 219759 A0 IL219759 A0 IL 219759A0 IL 219759 A IL219759 A IL 219759A IL 21975912 A IL21975912 A IL 21975912A IL 219759 A0 IL219759 A0 IL 219759A0
Authority
IL
Israel
Prior art keywords
novel compounds
receptor modulators
therapeutic utility
therapeutic
utility
Prior art date
Application number
IL219759A
Other languages
English (en)
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of IL219759A0 publication Critical patent/IL219759A0/en

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    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140048874A (ko) * 2011-04-14 2014-04-24 알러간, 인코포레이티드 스핑고신-1 포스페이트 수용체 조절제로서의 페닐 이환식 메틸 아민 유도체
AU2013222574A1 (en) * 2012-02-21 2014-09-18 Allergan, Inc. Phenoxy-azetidine derivatives as sphingosine 1-phosphate (S1P) receptor modulators
US20140171393A1 (en) * 2012-12-13 2014-06-19 Allergan, Inc. Novel aromatic thio compounds as receptor modulators
DK2958913T3 (en) * 2013-02-20 2018-11-05 Lg Chemical Ltd SPHINGOSIN-1 PHOSPHATRECEPTOR AGONISTS, PROCEDURES FOR PREPARING IT AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AS AN ACTIVE AGENT
WO2014138075A1 (en) * 2013-03-07 2014-09-12 Allergan, Inc. Phosphonic acid compounds as sphingosine-1-phosphate receptor modulators
WO2015021112A1 (en) * 2013-08-08 2015-02-12 Allergan, Inc. Disubstituted aryl oxy derivatives as sphingosine-1- phosphate receptors modulators
WO2015021109A1 (en) * 2013-08-08 2015-02-12 Allergan, Inc. Disubstituted aryl azetidine derivatives as sphingosine-1-phosphate receptors modulators
WO2015073547A1 (en) * 2013-11-13 2015-05-21 Allergan, Inc. Disubstituted phenoxy azetidine derivatives as sphingosine-1-phosphate (s1p) receptor modulators
MX2020007948A (es) 2018-02-02 2020-12-10 Univ Kyoto Medicamento para prevenir o tratar una enfermedad oftalmica asociada con neovascularizacion intraocular mejorada y/o permeabilidad vascular intraocular.
KR102658762B1 (ko) * 2021-04-14 2024-04-19 주식회사 엘지화학 스핑고신-1-인산 수용체 효능제 합성을 위한 중간체의 제조방법
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Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0146810A3 (de) 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten
US5110987A (en) 1988-06-17 1992-05-05 Emory University Method of preparing sphingosine derivatives
NZ233285A (en) * 1989-04-18 1992-06-25 Duphar Int Res Imidazole-substituted carbamoyl-indoles and condensed analogues thereof and pharmaceutical compositions
US5294722A (en) 1992-04-16 1994-03-15 E. R. Squibb & Sons, Inc. Process for the preparation of imidazoles useful in angiotensin II antagonism
US5403851A (en) 1994-04-05 1995-04-04 Interneuron Pharmaceuticals, Inc. Substituted tryptamines, phenalkylamines and related compounds
EP1002790B1 (en) * 1997-03-12 2005-12-28 Takara Bio Inc. Sphingosine analogues
DE69835223T2 (de) * 1997-09-11 2007-05-31 Takara Bio Inc., Otsu Sphingosinderivate und medizinische zubereitung
DE10010067A1 (de) * 2000-03-02 2001-09-06 Bayer Ag Neue Imidazotriazinone und ihre Verwendung
PT1397130E (pt) 2001-06-20 2007-11-13 Wyeth Corp Derivados ácidos de indole substituído como inibidores de inibidor 1 do activador de plasminogénio (pai-1)
ATE441654T1 (de) * 2002-01-18 2009-09-15 Merck & Co Inc Edg-rezeptoragonisten
CA2472680A1 (en) * 2002-01-18 2003-07-31 Merck & Co., Inc. Selective s1p1/edg1 receptor agonists
DE60330047D1 (en) * 2002-01-18 2009-12-24 Merck & Co Inc "n-(benzyl)aminoalkyl carboxylate, phosphinate, phosphonate und tetrazole als edg rezeptoragonisten"
SI1638551T1 (sl) * 2003-05-19 2012-04-30 Irm Llc Imunosupresivne spojine in sestavki
CN1874991A (zh) * 2003-08-29 2006-12-06 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途
BRPI0515209A (pt) * 2004-08-17 2008-07-08 Galderma Reseach & Dev S N C compostos, composição cosmética, usos de uma composição e composição farmacêutica
GB0612721D0 (en) * 2006-06-27 2006-08-09 Novartis Ag Organic compounds
WO2008030838A2 (en) * 2006-09-07 2008-03-13 Allergan, Inc. Heteroaromatic compounds having sphingosine-1-phosphate (s1p) receptor agonist biological activity
BRPI0716815A2 (pt) * 2006-09-07 2013-11-05 Allergan Inc Co posto heteroatomáticos tendo atividade biológia agonista e/ou antagonista de receptor de esfinfosina-1-fosfato (s1p)
US8614103B2 (en) * 2006-10-27 2013-12-24 Lpath, Inc. Compositions and methods for treating sphingosine-1-phosphate (S1P) related ocular diseases and conditions
TW200827346A (en) * 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
US8633245B2 (en) 2008-04-11 2014-01-21 Institute Of Medicinal Molecular Design, Inc. PAI-1 inhibitor

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MX2012006028A (es) 2012-06-19
WO2011066179A1 (en) 2011-06-03
CN102712618B (zh) 2014-11-26
US8440644B2 (en) 2013-05-14
JP2013512243A (ja) 2013-04-11
CA2780987C (en) 2018-03-06
IN2012DN05125A (Sortimente) 2015-10-23
KR20120098796A (ko) 2012-09-05
KR20120101686A (ko) 2012-09-14
CA2780908A1 (en) 2011-06-03
JP2013512244A (ja) 2013-04-11
EP2504328A1 (en) 2012-10-03
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IL219758A0 (en) 2012-07-31
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US20110152241A1 (en) 2011-06-23
RU2012122615A (ru) 2013-12-27
US8653062B2 (en) 2014-02-18
CA2780987A1 (en) 2011-06-03
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AU2010324988B2 (en) 2016-05-26
BR112012012259A2 (pt) 2019-09-24
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AU2010324983A1 (en) 2012-06-07
CL2012001352A1 (es) 2012-08-31
WO2011066184A1 (en) 2011-06-03
CN102712607A (zh) 2012-10-03
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