IL215483A - 6,4,2-Triple fluoro-n- [6- (1-methyl-piperidine-4-carbonyl) -pyrimidine-2-yl] -benzamide and its use in the preparation of a drug to treat or prevent migraines - Google Patents

6,4,2-Triple fluoro-n- [6- (1-methyl-piperidine-4-carbonyl) -pyrimidine-2-yl] -benzamide and its use in the preparation of a drug to treat or prevent migraines

Info

Publication number
IL215483A
IL215483A IL215483A IL21548311A IL215483A IL 215483 A IL215483 A IL 215483A IL 215483 A IL215483 A IL 215483A IL 21548311 A IL21548311 A IL 21548311A IL 215483 A IL215483 A IL 215483A
Authority
IL
Israel
Prior art keywords
ylcarbonyl
benzamide
piperidin
trifluoro
pyridin
Prior art date
Application number
IL215483A
Other languages
English (en)
Hebrew (he)
Other versions
IL215483A0 (en
Original Assignee
Colucid Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42826711&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL215483(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Colucid Pharmaceuticals Inc filed Critical Colucid Pharmaceuticals Inc
Publication of IL215483A0 publication Critical patent/IL215483A0/en
Publication of IL215483A publication Critical patent/IL215483A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
    • Y02E60/10—Energy storage using batteries

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL215483A 2009-04-02 2011-10-02 6,4,2-Triple fluoro-n- [6- (1-methyl-piperidine-4-carbonyl) -pyrimidine-2-yl] -benzamide and its use in the preparation of a drug to treat or prevent migraines IL215483A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16609709P 2009-04-02 2009-04-02
PCT/US2010/029810 WO2010115125A2 (en) 2009-04-02 2010-04-02 Composition of 2,4,6-trifluoro-n-[6-(1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-benzamide

Publications (2)

Publication Number Publication Date
IL215483A0 IL215483A0 (en) 2011-12-29
IL215483A true IL215483A (en) 2017-07-31

Family

ID=42826711

Family Applications (1)

Application Number Title Priority Date Filing Date
IL215483A IL215483A (en) 2009-04-02 2011-10-02 6,4,2-Triple fluoro-n- [6- (1-methyl-piperidine-4-carbonyl) -pyrimidine-2-yl] -benzamide and its use in the preparation of a drug to treat or prevent migraines

Country Status (26)

Country Link
US (3) US20100256187A1 (enExample)
EP (1) EP2413933B2 (enExample)
JP (9) JP5727457B2 (enExample)
KR (1) KR101697801B1 (enExample)
CN (2) CN102753171A (enExample)
AU (1) AU2010232497B2 (enExample)
CA (1) CA2757019C (enExample)
CY (2) CY1119785T1 (enExample)
DK (1) DK2413933T4 (enExample)
ES (1) ES2655881T5 (enExample)
FI (1) FIC20230001I1 (enExample)
FR (1) FR23C1002I2 (enExample)
HK (1) HK1243923A1 (enExample)
HR (1) HRP20171742T4 (enExample)
HU (2) HUE037261T2 (enExample)
IL (1) IL215483A (enExample)
LT (2) LT2413933T (enExample)
LU (1) LUC00295I2 (enExample)
MX (1) MX2011010359A (enExample)
NL (1) NL301214I2 (enExample)
NO (2) NO2413933T3 (enExample)
NZ (1) NZ596161A (enExample)
PL (1) PL2413933T5 (enExample)
PT (1) PT2413933T (enExample)
SI (1) SI2413933T2 (enExample)
WO (1) WO2010115125A2 (enExample)

Families Citing this family (10)

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TWI263497B (en) 2002-03-29 2006-10-11 Lilly Co Eli Pyridinoylpiperidines as 5-HT1F agonists
KR101683042B1 (ko) 2008-04-04 2016-12-06 포사이트 비젼4, 인크. 통증 관리 및 시력을 위한 치료 장치
JP5727457B2 (ja) * 2009-04-02 2015-06-03 コルーシッド ファーマシューティカルズ， インコーポレイテッド ２，４，６−トリフルオロ−ｎ−［６−（１−メチル−ピペリジン−４−カルボニル）−ピリジン−２−イル］−ベンズアミドの組成物
US8697876B2 (en) 2010-04-02 2014-04-15 Colucid Pharmaceuticals, Inc. Compositions and methods of synthesis of pyridinolypiperidine 5-HT1F agonists
US12044905B2 (en) 2011-04-28 2024-07-23 Journey1 Inc Contact lenses for refractive correction
JP6310072B2 (ja) 2013-06-26 2018-04-11 ネクシスビジョン， インコーポレイテッド 屈折矯正のためのコンタクトレンズ
UA124433C2 (uk) 2016-12-06 2021-09-15 Колюсід Фармасьютікалз, Інк. Піридиноїлпіперидин, його застосування для лікування мігрені та фармацевтична композиція на його основі
TWI826514B (zh) 2018-09-04 2023-12-21 美商美國禮來大藥廠 用於預防偏頭痛之拉米迪坦(lasmiditan)長期夜間投藥
AR119319A1 (es) 2019-07-09 2021-12-09 Lilly Co Eli Procesos e intermediario para la preparación a gran escala de hemisuccinato de 2,4,6-trifluoro-n-[6-(1-metil-piperidina-4-carbonil)-piridin-2-il]-benzamida y preparación de acetato de 2,4,6-trifluoro-n-[6-(1-metil-piperidina-4-carbonil)-piridin-2-il]-benzamida
WO2022086756A1 (en) 2020-10-19 2022-04-28 Journey1, Inc. Astigmatism correcting contact lenses

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JP5727457B2 (ja) 2009-04-02 2015-06-03 コルーシッド ファーマシューティカルズ， インコーポレイテッド ２，４，６−トリフルオロ−ｎ−［６−（１−メチル−ピペリジン−４−カルボニル）−ピリジン−２−イル］−ベンズアミドの組成物
US8697876B2 (en) 2010-04-02 2014-04-15 Colucid Pharmaceuticals, Inc. Compositions and methods of synthesis of pyridinolypiperidine 5-HT1F agonists
UA124433C2 (uk) 2016-12-06 2021-09-15 Колюсід Фармасьютікалз, Інк. Піридиноїлпіперидин, його застосування для лікування мігрені та фармацевтична композиція на його основі
TWI754772B (zh) 2017-09-06 2022-02-11 美商美國禮來大藥廠 用於治療偏頭痛之拉米迪坦(lasmiditan)與cgrp拮抗劑之組合療法
TWI826514B (zh) 2018-09-04 2023-12-21 美商美國禮來大藥廠 用於預防偏頭痛之拉米迪坦(lasmiditan)長期夜間投藥
AR119319A1 (es) 2019-07-09 2021-12-09 Lilly Co Eli Procesos e intermediario para la preparación a gran escala de hemisuccinato de 2,4,6-trifluoro-n-[6-(1-metil-piperidina-4-carbonil)-piridin-2-il]-benzamida y preparación de acetato de 2,4,6-trifluoro-n-[6-(1-metil-piperidina-4-carbonil)-piridin-2-il]-benzamida

Also Published As

Publication number Publication date
LT2413933T (lt) 2018-02-26
US20250228839A1 (en) 2025-07-17
HK1243923A1 (zh) 2018-07-27
NO2023002I1 (no) 2023-01-05
JP2016188241A (ja) 2016-11-04
SI2413933T2 (sl) 2021-09-30
HUE037261T2 (hu) 2018-08-28
CY2023001I2 (el) 2023-06-09
JP7110446B2 (ja) 2022-08-01
ES2655881T5 (es) 2021-11-25
PL2413933T5 (pl) 2021-10-18
CN102753171A (zh) 2012-10-24
JP5727457B2 (ja) 2015-06-03
JP2018087247A (ja) 2018-06-07
LUC00295I2 (enExample) 2025-09-22
LTC2413933I2 (enExample) 2025-03-10
US20210401822A1 (en) 2021-12-30
JP2025020117A (ja) 2025-02-12
US20100256187A1 (en) 2010-10-07
DK2413933T3 (da) 2018-01-29
FR23C1002I2 (fr) 2023-11-24
IL215483A0 (en) 2011-12-29
HRP20171742T1 (hr) 2018-02-09
MX2011010359A (es) 2012-02-23
AU2010232497A1 (en) 2011-11-24
EP2413933B1 (en) 2017-11-01
NL301214I1 (enExample) 2023-01-25
CA2757019C (en) 2018-05-15
JP2012522805A (ja) 2012-09-27
CN107412230A (zh) 2017-12-01
SI2413933T1 (en) 2018-04-30
FR23C1002I1 (fr) 2023-03-10
CY2023001I1 (el) 2023-03-24
JP2021152008A (ja) 2021-09-30
JP7566996B2 (ja) 2024-10-15
AU2010232497B2 (en) 2016-05-19
ES2655881T3 (es) 2018-02-22
WO2010115125A2 (en) 2010-10-07
JP2022163049A (ja) 2022-10-25
NO2413933T3 (enExample) 2018-03-31
JP2023175694A (ja) 2023-12-12
EP2413933A4 (en) 2012-09-19
WO2010115125A3 (en) 2011-02-17
EP2413933B2 (en) 2021-06-09
JP6887462B2 (ja) 2021-06-16
CY1119785T1 (el) 2018-06-27
NZ596161A (en) 2013-11-29
KR101697801B1 (ko) 2017-01-18
DK2413933T4 (da) 2021-08-23
JP2015013903A (ja) 2015-01-22
PT2413933T (pt) 2017-12-12
KR20110136893A (ko) 2011-12-21
HUS2300004I1 (hu) 2023-02-28
HRP20171742T4 (hr) 2021-08-06
LTPA2023502I1 (enExample) 2023-01-25
CA2757019A1 (en) 2010-10-07
EP2413933A2 (en) 2012-02-08
NL301214I2 (nl) 2023-04-19
US12257246B2 (en) 2025-03-25
FIC20230001I1 (fi) 2023-01-10
PL2413933T3 (pl) 2018-04-30
JP2019189617A (ja) 2019-10-31
JP7335397B2 (ja) 2023-08-29

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