IL213674A - Synthesis of radiolabelled pyridines on f18, tosylate precursors and their stable medical preparations - Google Patents
Synthesis of radiolabelled pyridines on f18, tosylate precursors and their stable medical preparationsInfo
- Publication number
- IL213674A IL213674A IL213674A IL21367411A IL213674A IL 213674 A IL213674 A IL 213674A IL 213674 A IL213674 A IL 213674A IL 21367411 A IL21367411 A IL 21367411A IL 213674 A IL213674 A IL 213674A
- Authority
- IL
- Israel
- Prior art keywords
- styrylpyridines
- radiolabeled
- synthesis
- pharmaceutical compositions
- stable pharmaceutical
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14188508P | 2008-12-31 | 2008-12-31 | |
| PCT/US2009/069741 WO2010078370A1 (en) | 2008-12-31 | 2009-12-29 | Synthesis of 18f-radiolabeled styrylpyridines from tosylate precursors and stable pharmaceutical compositions thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL213674A0 IL213674A0 (en) | 2011-07-31 |
| IL213674A true IL213674A (en) | 2016-04-21 |
Family
ID=42310197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL213674A IL213674A (en) | 2008-12-31 | 2011-06-20 | Synthesis of radiolabelled pyridines on f18, tosylate precursors and their stable medical preparations |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US20100172836A1 (OSRAM) |
| EP (1) | EP2381967B1 (OSRAM) |
| JP (1) | JP5717650B2 (OSRAM) |
| KR (1) | KR20110119670A (OSRAM) |
| CN (1) | CN102271716B (OSRAM) |
| AU (1) | AU2009335049B2 (OSRAM) |
| BR (1) | BRPI0923890A2 (OSRAM) |
| CA (1) | CA2748705C (OSRAM) |
| CO (1) | CO6341578A2 (OSRAM) |
| CR (1) | CR20110410A (OSRAM) |
| CY (1) | CY1118658T1 (OSRAM) |
| DK (1) | DK2381967T3 (OSRAM) |
| DO (1) | DOP2011000210A (OSRAM) |
| EA (1) | EA023014B1 (OSRAM) |
| EC (1) | ECSP11011242A (OSRAM) |
| ES (1) | ES2620402T3 (OSRAM) |
| HN (1) | HN2011001810A (OSRAM) |
| HR (1) | HRP20170453T1 (OSRAM) |
| HU (1) | HUE033649T2 (OSRAM) |
| IL (1) | IL213674A (OSRAM) |
| LT (1) | LT2381967T (OSRAM) |
| MA (1) | MA33004B1 (OSRAM) |
| MX (1) | MX2011007063A (OSRAM) |
| MY (1) | MY162312A (OSRAM) |
| NZ (1) | NZ593848A (OSRAM) |
| PE (1) | PE20120007A1 (OSRAM) |
| PL (1) | PL2381967T3 (OSRAM) |
| PT (1) | PT2381967T (OSRAM) |
| RS (1) | RS55674B1 (OSRAM) |
| SG (1) | SG172439A1 (OSRAM) |
| SI (1) | SI2381967T1 (OSRAM) |
| TN (1) | TN2011000318A1 (OSRAM) |
| UA (1) | UA105914C2 (OSRAM) |
| WO (1) | WO2010078370A1 (OSRAM) |
| ZA (1) | ZA201104824B (OSRAM) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9987379B2 (en) * | 2008-09-30 | 2018-06-05 | Case Western Reserve University | Molecular probes for imaging of myelin |
| CN103269724B (zh) | 2010-06-04 | 2017-06-23 | 皮拉马影像股份公司 | 生产F‑18标记的β‑淀粉样蛋白配体的方法 |
| US20130217920A1 (en) * | 2010-06-04 | 2013-08-22 | Piramal Imaging Sa | Method for production of f-18 labeled amyloid beta ligands |
| TWI504414B (zh) * | 2010-06-04 | 2015-10-21 | Bayer Schering Pharma Ag | 生產Ｆ－１８標記之Ａβ配位體之方法 |
| KR20140012732A (ko) * | 2011-04-21 | 2014-02-03 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 작용화된 자성 나노입자, 그리고 아밀로이드 침착물 및 신경섬유매듭의 영상화에서의 용도 |
| SI2723394T1 (sl) * | 2011-06-21 | 2018-10-30 | Piramal Imaging Sa | Formulacije fluoriranega stilbena, primerne za PET slikanje |
| IN2014MN00875A (OSRAM) | 2011-10-19 | 2015-04-17 | Piramal Imaging Sa | |
| CN102432529B (zh) * | 2011-11-14 | 2014-03-26 | 江苏省原子医学研究所 | 一种苯乙烯基吡啶二硫二氮衍生物的制备方法 |
| CN104136420A (zh) * | 2011-12-15 | 2014-11-05 | 通用电气健康护理有限公司 | 作为tau病理学的成像探针的杂环化合物 |
| CN102526765B (zh) * | 2011-12-31 | 2014-07-30 | 郑州泰基鸿诺药物科技有限公司 | 一种Aβ斑块显像剂及其制备方法 |
| CN103965105A (zh) * | 2013-01-29 | 2014-08-06 | 中山大学 | 苯乙烯基喹啉衍生物及其在治疗阿尔茨海默病症中的应用 |
| CN103645254B (zh) * | 2013-11-28 | 2015-01-07 | 江苏省原子医学研究所 | 一种Aβ斑块显像剂前体AV45的含量分析方法 |
| WO2017014599A1 (ko) * | 2015-07-22 | 2017-01-26 | 주식회사 씨코헬스케어 | [18f]플루오로-도파의 방사화학적 순도를 안정화시키는 조성물 및 이의 제조방법 |
| BR112018006969B1 (pt) * | 2015-11-13 | 2022-04-26 | Eli Lilly And Company | Derivados de azetidina para formação de imagem de tau, seu intermediário, seu uso e seu processo de preparação, e composição |
| WO2017156303A1 (en) * | 2016-03-09 | 2017-09-14 | Case Western Reserve University | Radioligands for myelin |
| CN107198780A (zh) * | 2016-03-18 | 2017-09-26 | 南京江原安迪科正电子研究发展有限公司 | 放射性药物组合物及其制备方法、应用 |
| CN106018575B (zh) * | 2016-05-05 | 2018-10-19 | 江苏省原子医学研究所 | 一种PET显像剂前体TsOP-(+)-DTBZ及其光学异构体的分离测定方法 |
| US10695450B2 (en) * | 2016-07-26 | 2020-06-30 | Laboratoires Cyclopharma | Synthesis of a radioactive agent composition |
| CN109922837A (zh) * | 2016-11-08 | 2019-06-21 | 加利福尼亚大学董事会 | 用于临床应用的[f-18]fddnp的多剂量合成方法 |
| TW201906818A (zh) * | 2017-05-31 | 2019-02-16 | 美商５１１製藥公司 | 新穎氘取代之正子發射斷層掃描（ｐｅｔ）顯影劑及其藥理應用 |
| WO2019145293A1 (en) * | 2018-01-24 | 2019-08-01 | Ac Immune Sa | Diagnostic compositions for pet imaging, a method for manufacturing the diagnostic composition and its use in diagnostics |
| CN111499544B (zh) * | 2019-01-31 | 2022-12-02 | 中国医学科学院放射医学研究所 | 一种一锅法制备N-Boc-N-甲基-4-氨基苯乙烯的合成方法 |
| CN111499570B (zh) * | 2019-01-31 | 2023-05-16 | 中国医学科学院放射医学研究所 | 一种av-45中间体的合成方法 |
| US20220175973A1 (en) * | 2019-03-29 | 2022-06-09 | National Institutes for Quantum Science and Technology | Method for producing radiopharmaceutical and radiopharmaceutical |
| CN115403434A (zh) * | 2021-05-26 | 2022-11-29 | 汉中汉核医疗科技有限公司 | 一种放射性药物的合成方法 |
| CN115400232A (zh) * | 2021-05-26 | 2022-11-29 | 汉中汉核医疗科技有限公司 | 一种放射性药物合成方法 |
| CN113582885B (zh) * | 2021-08-30 | 2023-04-21 | 南京克米斯璀新能源科技有限公司 | 一种烷基磺酸钠的生产方法 |
| CN114805190A (zh) * | 2022-06-08 | 2022-07-29 | 吉林大学第一医院 | 一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法 |
| AU2023381809A1 (en) * | 2022-11-14 | 2025-05-22 | Eli Lilly And Company | Polymorphic forms of florbetapir precursor av-105 |
| CN119080714A (zh) * | 2024-09-12 | 2024-12-06 | 四川大学 | 一种偶氮苯磺酸酯化合物及其制备方法和应用、放射性探针的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005067391A2 (en) * | 2004-01-19 | 2005-07-28 | Technion Research & Development Foundation Ltd. | Diagnostic test for parkinson's disease |
| EP1838298A4 (en) * | 2004-12-17 | 2009-03-04 | Univ Pennsylvania | STYLENE DERIVATIVES AND THEIR USE OF THE BINDING AND IMAGE DISPLAY OF AMYLOID PLAQUE |
| JP5290954B2 (ja) * | 2006-03-30 | 2013-09-18 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | スチリルピリジン誘導体及びアミロイド斑を結合させ画像化するためのその使用 |
-
2009
- 2009-12-29 UA UAA201109307A patent/UA105914C2/uk unknown
- 2009-12-29 HU HUE09837135A patent/HUE033649T2/en unknown
- 2009-12-29 DK DK09837135.4T patent/DK2381967T3/en active
- 2009-12-29 EA EA201170911A patent/EA023014B1/ru not_active IP Right Cessation
- 2009-12-29 LT LTEP09837135.4T patent/LT2381967T/lt unknown
- 2009-12-29 SI SI200931600A patent/SI2381967T1/sl unknown
- 2009-12-29 KR KR1020117017636A patent/KR20110119670A/ko not_active Ceased
- 2009-12-29 EP EP09837135.4A patent/EP2381967B1/en active Active
- 2009-12-29 BR BRPI0923890-5A patent/BRPI0923890A2/pt active Search and Examination
- 2009-12-29 MA MA34065A patent/MA33004B1/fr unknown
- 2009-12-29 CN CN200980153414.5A patent/CN102271716B/zh active Active
- 2009-12-29 MX MX2011007063A patent/MX2011007063A/es active IP Right Grant
- 2009-12-29 ES ES09837135.4T patent/ES2620402T3/es active Active
- 2009-12-29 RS RS20170117A patent/RS55674B1/sr unknown
- 2009-12-29 US US12/648,869 patent/US20100172836A1/en not_active Abandoned
- 2009-12-29 JP JP2011543721A patent/JP5717650B2/ja active Active
- 2009-12-29 AU AU2009335049A patent/AU2009335049B2/en active Active
- 2009-12-29 NZ NZ593848A patent/NZ593848A/xx unknown
- 2009-12-29 PL PL09837135T patent/PL2381967T3/pl unknown
- 2009-12-29 WO PCT/US2009/069741 patent/WO2010078370A1/en not_active Ceased
- 2009-12-29 MY MYPI2011003056A patent/MY162312A/en unknown
- 2009-12-29 PE PE2011001294A patent/PE20120007A1/es not_active Application Discontinuation
- 2009-12-29 PT PT98371354T patent/PT2381967T/pt unknown
- 2009-12-29 HR HRP20170453TT patent/HRP20170453T1/hr unknown
- 2009-12-29 CA CA2748705A patent/CA2748705C/en active Active
- 2009-12-29 SG SG2011048055A patent/SG172439A1/en unknown
-
2011
- 2011-06-20 IL IL213674A patent/IL213674A/en active IP Right Grant
- 2011-06-24 TN TN2011000318A patent/TN2011000318A1/fr unknown
- 2011-06-29 HN HN2011001810A patent/HN2011001810A/es unknown
- 2011-06-29 DO DO2011000210A patent/DOP2011000210A/es unknown
- 2011-06-29 ZA ZA2011/04824A patent/ZA201104824B/en unknown
- 2011-07-11 CO CO11086470A patent/CO6341578A2/es active IP Right Grant
- 2011-07-29 CR CR20110410A patent/CR20110410A/es unknown
- 2011-07-29 EC EC2011011242A patent/ECSP11011242A/es unknown
-
2017
- 2017-02-24 CY CY20171100253T patent/CY1118658T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |