IL213648A - וריאנטים אופטימליים של fc ושימושיהם - Google Patents
וריאנטים אופטימליים של fc ושימושיהםInfo
- Publication number
- IL213648A IL213648A IL213648A IL21364811A IL213648A IL 213648 A IL213648 A IL 213648A IL 213648 A IL213648 A IL 213648A IL 21364811 A IL21364811 A IL 21364811A IL 213648 A IL213648 A IL 213648A
- Authority
- IL
- Israel
- Prior art keywords
- variants
- optimized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US46760603P | 2003-05-02 | 2003-05-02 | |
US47783903P | 2003-06-12 | 2003-06-12 | |
US10/672,280 US20040132101A1 (en) | 2002-09-27 | 2003-09-26 | Optimized Fc variants and methods for their generation |
PCT/US2004/009298 WO2004099249A2 (en) | 2003-05-02 | 2004-03-26 | Optimized fc variants and methods for their generation |
Publications (2)
Publication Number | Publication Date |
---|---|
IL213648A0 IL213648A0 (en) | 2011-07-31 |
IL213648A true IL213648A (he) | 2017-01-31 |
Family
ID=38312218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL213648A IL213648A (he) | 2003-05-02 | 2011-06-19 | וריאנטים אופטימליים של fc ושימושיהם |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP5226613B2 (he) |
KR (1) | KR100973564B1 (he) |
CA (1) | CA2766627C (he) |
IL (1) | IL213648A (he) |
RU (1) | RU2337107C2 (he) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2592271T3 (es) | 2005-03-31 | 2016-11-29 | Chugai Seiyaku Kabushiki Kaisha | Métodos de producción de polipéptidos mediante la regulación de la asociación de los polipéptidos |
KR101818274B1 (ko) | 2010-05-27 | 2018-01-12 | 머크 샤프 앤드 돔 코포레이션 | 개선된 특성을 갖는 항체의 제조 방법 |
KR102385507B1 (ko) | 2010-11-30 | 2022-04-12 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자 |
CN103492565B (zh) | 2011-02-25 | 2021-01-29 | 中外制药株式会社 | FcγRIIb特异性Fc抗体 |
MX340498B (es) | 2011-06-30 | 2016-07-11 | Chugai Pharmaceutical Co Ltd | Polipeptido heterodimerizado. |
EP3939996A1 (en) | 2011-09-30 | 2022-01-19 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
TW201817745A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之FcRn結合域的治療性抗原結合分子 |
US20150056182A1 (en) | 2011-11-30 | 2015-02-26 | Chugai Seiyaku Kabushiki Kaisha | Drug containing carrier into cell for forming immune complex |
NZ702241A (en) * | 2012-08-07 | 2018-04-27 | Roche Glycart Ag | Composition comprising two antibodies engineered to have reduced and increased effector function |
EP2889377B1 (en) * | 2012-08-24 | 2020-01-08 | Chugai Seiyaku Kabushiki Kaisha | Fcyriib-specific fc region variant |
WO2014104165A1 (ja) | 2012-12-27 | 2014-07-03 | 中外製薬株式会社 | ヘテロ二量化ポリペプチド |
ES2759061T3 (es) * | 2013-03-15 | 2020-05-07 | Biomolecular Holdings Llc | Inmunoglobulina híbrida que contiene unión no peptidílica |
TR201809571T4 (tr) | 2013-03-15 | 2018-07-23 | Hoffmann La Roche | Ll-22 polipeptidleri ile ıl-22 fc füzyon proteinleri ve kullanım yöntemleri. |
WO2014145000A2 (en) * | 2013-03-15 | 2014-09-18 | Abbvie Biotherapeutics Inc. | Anti-cd25 antibodies and their uses |
AU2014250434B2 (en) | 2013-04-02 | 2019-08-08 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
LT3027651T (lt) * | 2013-08-01 | 2019-04-10 | Five Prime Therapeutics, Inc. | Afukozilinti anti-fgfr2iiib antikūnai |
AU2015244814B2 (en) | 2014-04-07 | 2020-12-24 | Chugai Seiyaku Kabushiki Kaisha | Immunoactivating antigen-binding molecule |
AU2015260230A1 (en) | 2014-05-13 | 2016-11-17 | Chugai Seiyaku Kabushiki Kaisha | T cell-redirected antigen-binding molecule for cells having immunosuppression function |
US20170211876A1 (en) * | 2014-06-12 | 2017-07-27 | Hoffmann-La Roche Inc. | Method for selecting antibodies with modified fcrn interaction |
MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
TWI831538B (zh) | 2014-12-19 | 2024-02-01 | 日商中外製藥股份有限公司 | 抗肌抑素之抗體、含變異Fc區域之多胜肽及使用方法 |
EA201791754A1 (ru) | 2015-02-05 | 2019-01-31 | Чугаи Сейяку Кабусики Кайся | АНТИТЕЛА, СОДЕРЖАЩИЕ ЗАВИСЯЩИЙ ОТ КОНЦЕНТРАЦИИ ИОНОВ АНТИГЕНСВЯЗЫВАЮЩИЙ ДОМЕН, ВАРИАНТЫ Fc-ОБЛАСТИ, IL-8-СВЯЗЫВАЮЩИЕ АНТИТЕЛА И ИХ ПРИМЕНЕНИЯ |
WO2017086367A1 (ja) | 2015-11-18 | 2017-05-26 | 中外製薬株式会社 | 免疫抑制機能を有する細胞に対するt細胞リダイレクト抗原結合分子を用いた併用療法 |
EP3378488A4 (en) | 2015-11-18 | 2019-10-30 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR ENHANCING THE HUMORAL IMMUNE RESPONSE |
EP3394098A4 (en) | 2015-12-25 | 2019-11-13 | Chugai Seiyaku Kabushiki Kaisha | ANTI-MYOSTATIN ANTIBODIES AND METHODS OF USE |
IL264626B (he) | 2016-08-05 | 2022-07-01 | Chugai Pharmaceutical Co Ltd | תכשיר למניעה או טיפול במחלות הקשורות ל– il–8 |
CN106872713A (zh) * | 2016-12-27 | 2017-06-20 | 许洋 | 一种微量蛋白质原位检测的免疫质谱试剂盒及制备方法 |
KR20200099807A (ko) * | 2019-02-15 | 2020-08-25 | 아주대학교산학협력단 | 항체의 불변부위로만 구성된 항체 단편 및 이의 용도 |
CN112397159B (zh) * | 2019-08-19 | 2024-03-22 | 金色熊猫有限公司 | 临床试验报告自动录入方法及装置、电子设备、存储介质 |
WO2024085632A1 (ko) * | 2022-10-18 | 2024-04-25 | 고려대학교 산학협력단 | 인간 항체 fc 도메인 변이체 및 그 용도 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA01007170A (es) * | 1999-01-15 | 2002-07-30 | Genentech Inc | Variantes de polipeptidos con funcion efectora alterada. |
EP2345671B8 (en) * | 2002-09-27 | 2023-01-11 | Xencor, Inc. | Optimized fc variants and methods for their generation |
-
2004
- 2004-03-26 KR KR1020097009022A patent/KR100973564B1/ko active IP Right Review Request
- 2004-03-26 CA CA2766627A patent/CA2766627C/en not_active Expired - Lifetime
- 2004-03-26 RU RU2005137578/13A patent/RU2337107C2/ru active
-
2009
- 2009-05-25 JP JP2009141638A patent/JP5226613B2/ja not_active Expired - Fee Related
-
2011
- 2011-06-19 IL IL213648A patent/IL213648A/he active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
RU2005137578A (ru) | 2007-06-10 |
JP5226613B2 (ja) | 2013-07-03 |
KR20090059170A (ko) | 2009-06-10 |
IL213648A0 (en) | 2011-07-31 |
JP2009209150A (ja) | 2009-09-17 |
RU2337107C2 (ru) | 2008-10-27 |
CA2766627C (en) | 2019-12-03 |
CA2766627A1 (en) | 2004-11-18 |
KR100973564B1 (ko) | 2010-08-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
KB | Patent renewed |