IL204285A - Ambroxol and bromhexine for the treatment of Gaucher disease - Google Patents
Ambroxol and bromhexine for the treatment of Gaucher diseaseInfo
- Publication number
- IL204285A IL204285A IL204285A IL20428510A IL204285A IL 204285 A IL204285 A IL 204285A IL 204285 A IL204285 A IL 204285A IL 20428510 A IL20428510 A IL 20428510A IL 204285 A IL204285 A IL 204285A
- Authority
- IL
- Israel
- Prior art keywords
- ambroxol
- gcase
- compound
- glucocerebrosidase
- activity
- Prior art date
Links
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- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- C—CHEMISTRY; METALLURGY
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- C12Y—ENZYMES
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- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01045—Glucosylceramidase (3.2.1.45), i.e. beta-glucocerebrosidase
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| US6568408P | 2008-02-13 | 2008-02-13 | |
| PCT/US2008/010768 WO2009038695A1 (en) | 2007-09-17 | 2008-09-16 | Method of treating gaucher disease |
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Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE102004021992A1 (de) * | 2004-05-03 | 2005-11-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Topische Zubereitung enthaltend Ambroxol |
| EP3366688B1 (en) | 2010-12-08 | 2022-02-09 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Substituted pyrazolopyrimidines as glucocerebrosidase activators |
| KR102076585B1 (ko) * | 2011-12-22 | 2020-02-12 | 센토제너 아이피 게엠베하 | 리소좀 효소를 재배열하는 능력을 갖는 화합물 및 암브록솔 및/또는 암브록솔의 유도체의 조합물 |
| KR102227473B1 (ko) | 2013-04-15 | 2021-03-15 | 삼성디스플레이 주식회사 | 박막 증착 장치 및 이를 이용한 박막 형성 방법 |
| CN106455661A (zh) * | 2014-05-21 | 2017-02-22 | 雀巢产品技术援助有限公司 | 营养物质的个性化补充 |
| US20190254992A1 (en) * | 2016-06-29 | 2019-08-22 | Hadasit Medical Research Services & Development Limited | Combinations of beta-glycolipides and 4-[(2-amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol, compositions and uses thereof in the treatment of disorders associated with protein misfolding and protein aggregations |
| WO2018089797A1 (en) | 2016-11-14 | 2018-05-17 | Mingwu Wang | Formulations for the treatment of ocular surface diseases and related methods |
| CN110325516A (zh) | 2016-12-29 | 2019-10-11 | 米尼奥尔克斯治疗有限公司 | 杂芳基化合物和它们的用途 |
| JP7369716B2 (ja) * | 2018-01-26 | 2023-10-26 | ノイレ， エルエルシー | 皮膚バリア機能を改善するためのアンブロキソールの使用 |
| WO2019211205A1 (en) | 2018-04-30 | 2019-11-07 | Dorphan S.A. | Pharmaceutical compositions for use in the treatment of lysosomal diseases |
| US20220184185A1 (en) | 2018-07-25 | 2022-06-16 | Modernatx, Inc. | Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders |
| WO2020046132A1 (en) | 2018-08-31 | 2020-03-05 | Leiden University | Pharmacological chaperones for enzyme treatment therapy |
| NL2021840B1 (en) | 2018-10-19 | 2020-05-13 | Univ Leiden | Pharmacological Chaperones For Enzyme Treatment Therapy |
| KR20210148101A (ko) | 2019-02-04 | 2021-12-07 | 프리라인 테라퓨틱스 리미티드 | 폴리뉴클레오티드 |
| WO2025153714A1 (en) * | 2024-01-19 | 2025-07-24 | Scenic Biotech Bv | Pla2g15 inhibitors for use in the treatment of lysosomal storage diseases, hiv, alzheimer's disease or parkinson's disease |
| CN118086341B (zh) * | 2024-04-25 | 2024-08-02 | 上海凌医生物科技有限公司 | 在肝脏中高表达人源葡萄糖脑苷脂酶基因的表达框 |
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| ID28460A (id) | 1998-07-08 | 2001-05-24 | Lipogenics Inc | Komposisi dan metoda untuk perlakuan dan pencegahan penyakit tulang dengan menggunakan tocotrienol |
| MXPA04002066A (es) * | 2001-09-04 | 2005-02-17 | Techno Network Shinoku Co Ltd | Farmacos contra influenza. |
| US20030171391A1 (en) * | 2002-01-25 | 2003-09-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ambroxol for the treatment of chronic pain |
| DE10303229B4 (de) * | 2003-01-28 | 2007-07-26 | Keyneurotek Ag | Ambroxol und Inhibitoren des Angiotensin Converting-Enzyms (ACE) umfassende Arzneimittel Arzneimittel-Zubereitung und ihre Verwendung zur Behandlung von neurodegenerativen Erkrankungen |
| DE10332472A1 (de) * | 2003-07-16 | 2005-02-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ambroxol für die Behandlung von Tinnitus |
| US7488721B2 (en) * | 2004-05-13 | 2009-02-10 | Mcmaster University | Real time methylumbelliferone-based assay |
| EP1850840A2 (en) * | 2005-01-13 | 2007-11-07 | Sirtris Pharmaceuticals, Inc. | Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders |
| JP2008528510A (ja) * | 2005-01-20 | 2008-07-31 | サートリス ファーマシューティカルズ， インコーポレイテッド | 紅潮および／または薬物誘発性体重増加を処置するためのサーチュイン活性化化合物の使用 |
| US20070149466A1 (en) * | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| US8795668B2 (en) * | 2005-12-23 | 2014-08-05 | The Regents Of The University Of Michigan | Methods for treating pulmonary fibrosis |
| US20070244184A1 (en) * | 2006-01-09 | 2007-10-18 | Simon Fraser University | Glycosidase inhibitors and methods of synthesizing same |
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