IL202131A - Polymeric Polyphide Synthase Pufa Systems and a Method to Increase Non-Saturated Acid (Pufas) Acid and Change the Omega-3 to Omega-6 Ratio of the Pufas Produced - Google Patents
Polymeric Polyphide Synthase Pufa Systems and a Method to Increase Non-Saturated Acid (Pufas) Acid and Change the Omega-3 to Omega-6 Ratio of the Pufas ProducedInfo
- Publication number
- IL202131A IL202131A IL202131A IL20213109A IL202131A IL 202131 A IL202131 A IL 202131A IL 202131 A IL202131 A IL 202131A IL 20213109 A IL20213109 A IL 20213109A IL 202131 A IL202131 A IL 202131A
- Authority
- IL
- Israel
- Prior art keywords
- omega
- pufas
- chimeric pufa
- polyunsaturated fatty
- chimeric
- Prior art date
Links
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 title abstract 8
- 108010030975 Polyketide Synthases Proteins 0.000 title 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108091005461 Nucleic proteins Proteins 0.000 abstract 1
- 241000233671 Schizochytrium Species 0.000 abstract 1
- 241000233675 Thraustochytrium Species 0.000 abstract 1
- 235000003869 genetically modified organism Nutrition 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6434—Docosahexenoic acids [DHA]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8273—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for drought, cold, salt resistance
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- C12N9/93—Ligases (6)
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- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C12P7/625—Polyesters of hydroxy carboxylic acids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hematology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/749,686 US8003772B2 (en) | 1999-01-14 | 2007-05-16 | Chimeric PUFA polyketide synthase systems and uses thereof |
| PCT/US2008/063835 WO2008144473A2 (en) | 2007-05-16 | 2008-05-16 | Chimeric pufa polyketide synthase systems and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL202131A0 IL202131A0 (en) | 2010-06-16 |
| IL202131A true IL202131A (en) | 2013-09-30 |
Family
ID=40122412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL202131A IL202131A (en) | 2007-05-16 | 2009-11-15 | Polymeric Polyphide Synthase Pufa Systems and a Method to Increase Non-Saturated Acid (Pufas) Acid and Change the Omega-3 to Omega-6 Ratio of the Pufas Produced |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US8003772B2 (OSRAM) |
| EP (1) | EP2160470B1 (OSRAM) |
| JP (1) | JP5551584B2 (OSRAM) |
| KR (1) | KR101539470B1 (OSRAM) |
| CN (1) | CN101849014B (OSRAM) |
| AU (1) | AU2008254837B2 (OSRAM) |
| BR (1) | BRPI0810302A2 (OSRAM) |
| CA (1) | CA2687523C (OSRAM) |
| ES (1) | ES2467918T3 (OSRAM) |
| IL (1) | IL202131A (OSRAM) |
| MX (1) | MX2009012395A (OSRAM) |
| WO (1) | WO2008144473A2 (OSRAM) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566583B1 (en) * | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
| US20070244192A1 (en) * | 1999-01-14 | 2007-10-18 | Martek Biosciences Corporation | Plant seed oils containing polyunsaturated fatty acids |
| US8003772B2 (en) * | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
| US7247461B2 (en) * | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
| US7217856B2 (en) * | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7211418B2 (en) | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| TWI350854B (en) | 2001-04-16 | 2011-10-21 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| CA3023314C (en) | 2004-04-22 | 2019-12-10 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| US7807849B2 (en) | 2004-04-22 | 2010-10-05 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| US7759548B2 (en) * | 2006-03-15 | 2010-07-20 | Martek Biosciences Corporation | Polyunsaturated fatty acid production in heterologous organisms using PUFA polyketide synthase systems |
| RU2009111266A (ru) | 2006-08-29 | 2010-10-10 | Коммонвелт Сайентифик энд Индастриал Рисерч Организейшн (AU) | Синтез жирных кислот |
| CA2722466A1 (en) | 2008-04-29 | 2009-11-05 | Tariq Ghayur | Dual variable domain immunoglobulins and uses thereof |
| SG191639A1 (en) | 2008-06-03 | 2013-07-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| ES2644883T3 (es) | 2008-11-18 | 2017-11-30 | Commonwealth Scientific And Industrial Research Organisation | Enzimas y métodos para producir ácidos grasos omega-3 |
| CA2755667C (en) * | 2009-03-16 | 2018-06-12 | Martek Biosciences Corporation | Protein production in microorganisms of the phylum labyrinthulomycota |
| ES2717102T3 (es) | 2009-03-19 | 2019-06-19 | Dsm Ip Assets Bv | Moléculas de ácido nucleico de ácido graso poliinsaturado sintasas, y polipéptidos, composiciones y métodos de preparación y usos de los mismos |
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| JP5894794B2 (ja) | 2009-09-24 | 2016-03-30 | 国立大学法人九州大学 | ストラメノパイルの形質転換方法 |
| EP4130273B1 (en) | 2009-12-28 | 2024-06-12 | Sanofi Vaccine Technologies, S.A.S. | Production of heterologous polypeptides in microalgae, microalgal extracellular bodies, compositions, and methods of making and uses thereof |
| ES2651313T3 (es) * | 2009-12-28 | 2018-01-25 | Dsm Ip Assets B.V. | Traustoquítridos recombinantes que crecen en xilosa, y composiciones, métodos de preparación y usos de los mismos |
| US10633667B2 (en) | 2009-12-28 | 2020-04-28 | Boehringer Ingelheim Animal Health USA Inc. | Recombinant NDV antigen and uses thereof |
| US20110195449A1 (en) | 2009-12-28 | 2011-08-11 | Martek Biosciences Corporation | Recombinant Thraustochytrids that Grow on Sucrose, and Compositions, Methods of Making, and Uses Thereof |
| US9012197B2 (en) * | 2009-12-28 | 2015-04-21 | Merial, Inc. | Production of hemagglutinin-neuraminidase protein in microalgae |
| EP4056708A1 (en) * | 2010-01-19 | 2022-09-14 | DSM IP Assets B.V. | Isolated biomass from schizochytrium or thraustochytrium comprising epa and dha and its use in animal feed |
| CA2792118C (en) | 2010-03-12 | 2022-07-12 | Merial Limited | Bluetongue virus recombinant vaccines and uses thereof |
| US11236351B2 (en) * | 2010-05-17 | 2022-02-01 | Dow Agrosciences Llc | Production of DHA and other LC PUFAs in plants |
| TW201144442A (en) * | 2010-05-17 | 2011-12-16 | Dow Agrosciences Llc | Production of DHA and other LC-PUFAs in plants |
| UY33492A (es) | 2010-07-09 | 2012-01-31 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| EP2601218A4 (en) | 2010-08-03 | 2015-02-18 | Abbvie Inc | VARIABLE DOUBLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF |
| JP6259187B2 (ja) * | 2010-10-01 | 2018-01-10 | 国立大学法人九州大学 | ストラメノパイルの形質転換方法 |
| US9133463B2 (en) * | 2011-03-07 | 2015-09-15 | Dsm Nutritional Products Ag | Engineering microorganisms |
| AU2012285806B2 (en) | 2011-07-21 | 2017-09-14 | Dsm Ip Assets B.V. | Fatty acid compositions |
| TW201307553A (zh) | 2011-07-26 | 2013-02-16 | Dow Agrosciences Llc | 在植物中生產二十二碳六烯酸(dha)及其他長鏈多元不飽和脂肪酸(lc-pufa)之技術 |
| CA3082388A1 (en) | 2012-06-15 | 2013-12-19 | Commonwealth Scientific And Industrial Research Organisation | Genetic constructs for producing long chain polyunsaturated fatty acids in plant cells |
| TW201525136A (zh) | 2013-11-26 | 2015-07-01 | Dow Agrosciences Llc | 利用破囊壺菌PUFA合成酶於油籽作物中生成ω-3長鏈多不飽和脂肪酸 |
| CA3241340A1 (en) | 2013-12-18 | 2015-06-25 | Grains Research And Development Corporation | Lipid comprising long chain polyunsaturated fatty acids |
| CA2953008C (en) | 2014-06-27 | 2024-03-19 | Nuseed Pty Ltd | Lipid comprising docosapentaenoic acid |
| CA2977271A1 (en) | 2015-03-02 | 2016-09-09 | Synthetic Genomics, Inc. | Regulatory elements from labyrinthulomycetes microorganisms |
| CA2978770A1 (en) * | 2015-03-12 | 2016-09-15 | Synthetic Genomics, Inc. | Microorganisms for fatty acid production using elongase and desaturase enzymes |
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| AU2008254837A1 (en) | 2008-11-27 |
| US20080022422A1 (en) | 2008-01-24 |
| WO2008144473A2 (en) | 2008-11-27 |
| US8859855B2 (en) | 2014-10-14 |
| CN101849014A (zh) | 2010-09-29 |
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| EP2160470A4 (en) | 2012-02-22 |
| JP2010527244A (ja) | 2010-08-12 |
| HK1143403A1 (en) | 2010-12-31 |
| US8309796B2 (en) | 2012-11-13 |
| EP2160470B1 (en) | 2014-03-05 |
| BRPI0810302A2 (pt) | 2020-10-06 |
| CA2687523A1 (en) | 2008-11-27 |
| AU2008254837B2 (en) | 2013-09-12 |
| IL202131A0 (en) | 2010-06-16 |
| ES2467918T3 (es) | 2014-06-13 |
| US8003772B2 (en) | 2011-08-23 |
| KR101539470B1 (ko) | 2015-07-24 |
| US20130143281A1 (en) | 2013-06-06 |
| MX2009012395A (es) | 2010-02-10 |
| CN101849014B (zh) | 2015-08-19 |
| KR20100020963A (ko) | 2010-02-23 |
| WO2008144473A3 (en) | 2009-01-15 |
| US20120021470A1 (en) | 2012-01-26 |
| CA2687523C (en) | 2016-09-13 |
| JP5551584B2 (ja) | 2014-07-16 |
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