IL197869A

IL197869A - Compounds of 1chk inhibitors

Compounds of 1chk inhibitors

Info

Publication number: IL197869A
Authority: IL; Israel
Prior art keywords: cancer; group; cyclodextrin; hydrogen; composition
Prior art date: 2006-10-20

Application number

IL197869A

Other languages

English (en)

Hebrew (he)

Other versions

IL197869A0 (en

Original Assignee

Icos Corp

Priority date

2006-10-20

Filing date

2009-03-26

Publication date

2013-11-28

2009-03-26 Application filed by Icos Corp filed Critical Icos Corp

2009-12-24 Publication of IL197869A0 publication Critical patent/IL197869A0/en

2013-11-28 Publication of IL197869A publication Critical patent/IL197869A/en

Links

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239000003112 inhibitor Substances 0.000 title abstract description 158
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206010028980 Neoplasm Diseases 0.000 claims abstract description 82
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims abstract description 68
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238000011282 treatment Methods 0.000 claims abstract description 40
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150000002431 hydrogen Chemical group 0.000 claims description 42
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150000003839 salts Chemical class 0.000 claims description 40
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 39
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WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 32
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NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 5
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TURGQPDWYFJEDY-UHFFFAOYSA-N 1-hydroperoxypropane Chemical compound CCCOO TURGQPDWYFJEDY-UHFFFAOYSA-N 0.000 claims description 3
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