AU2007325576B2 - Compositions of Chk1 inhibitors - Google Patents
Compositions of Chk1 inhibitors Download PDFInfo
- Publication number
- AU2007325576B2 AU2007325576B2 AU2007325576A AU2007325576A AU2007325576B2 AU 2007325576 B2 AU2007325576 B2 AU 2007325576B2 AU 2007325576 A AU2007325576 A AU 2007325576A AU 2007325576 A AU2007325576 A AU 2007325576A AU 2007325576 B2 AU2007325576 B2 AU 2007325576B2
- Authority
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- Australia
- Prior art keywords
- cancer
- alkyl
- group
- aryl
- cyclodextrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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| US85305606P | 2006-10-20 | 2006-10-20 | |
| US60/853,056 | 2006-10-20 | ||
| PCT/US2007/080150 WO2008067027A2 (en) | 2006-10-20 | 2007-10-02 | Compositions of chkl inhibitors and cyclodextrin |
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| AU2007325576A1 AU2007325576A1 (en) | 2008-06-05 |
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| NZ (1) | NZ575394A (enExample) |
| SV (1) | SV2009003227A (enExample) |
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| ZA (1) | ZA200902670B (enExample) |
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| US11020363B2 (en) | 2009-05-29 | 2021-06-01 | Cydex Pharmaceuticals, Inc. | Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same |
| JP5914328B2 (ja) | 2009-05-29 | 2016-05-11 | サイデックス・ファーマシューティカルズ・インコーポレイテッド | シクロデキストリン誘導体を含む注射用メルファラン組成物並びにその製造及び使用方法 |
| GB201008005D0 (en) | 2010-05-13 | 2010-06-30 | Sentinel Oncology Ltd | Pharmaceutical compounds |
| PL2758052T3 (pl) * | 2011-09-18 | 2018-10-31 | Euro-Celtique S.A. | Kompozycja farmaceutyczna zawierająca inhibitor HDAC i cyklopolisacharyd |
| PH12014500547A1 (en) | 2011-10-03 | 2014-04-21 | Respivert Ltd | 1-pyrazolyl-3-(-4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 map kinase inhibitors |
| EP2578582A1 (en) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors |
| TWI573792B (zh) | 2012-02-01 | 2017-03-11 | 歐陸斯迪公司 | 新穎治療劑 |
| EP2836221B1 (en) * | 2012-04-13 | 2023-07-05 | L&F Research LLC | Method of using cyclodextrin |
| US9993460B2 (en) | 2013-07-26 | 2018-06-12 | Race Oncology Ltd. | Compositions to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof |
| JP6586098B2 (ja) | 2014-02-14 | 2019-10-02 | レスピバート・リミテツド | キナーゼ阻害剤としてのピラゾリル尿素 |
| GB201409488D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409485D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB201409471D0 (en) | 2014-05-28 | 2014-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| US9890564B2 (en) * | 2014-10-28 | 2018-02-13 | Sargent Manufacturing Company | Interconnected lock with direct drive for adjustable deadbolt to latchbolt spacing |
| JP2017155023A (ja) * | 2016-03-04 | 2017-09-07 | ジェイファーマ株式会社 | Ｌａｔ１阻害活性を有する芳香族アミノ酸誘導体を含有する注射剤 |
| US20200000840A1 (en) * | 2016-03-20 | 2020-01-02 | Asdera Llc | Use of cyclodextrins to reduce endocytosis in malignant and neurodegenerative disorders |
| WO2018068832A1 (en) | 2016-10-11 | 2018-04-19 | Euro-Celtique S.A. | Hodgkin lymphoma therapy |
| AU2018263924B2 (en) * | 2017-05-03 | 2024-07-04 | Cydex Pharmaceuticals, Inc. | Composition containing cyclodextrin and busulfan |
| GB201709403D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating sarcoma |
| GB201709402D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating t-pll |
| GB201709405D0 (en) | 2017-06-13 | 2017-07-26 | Euro Celtique Sa | Compounds for treating ovarian cancer |
| GB201709406D0 (en) | 2017-06-13 | 2017-07-26 | Euro-Cletique S A | Compounds for treating TNBC |
| WO2019067269A2 (en) | 2017-09-28 | 2019-04-04 | Asdera Llc | USE OF CYCLODEXTRINS IN DISEASES AND DISORDERS INVOLVING PHOSPHOLIPID DISRUPTION |
| CN109078005B (zh) * | 2018-08-07 | 2021-11-26 | 江苏领航生物科技有限公司 | 一种白消安组合物及其制备方法和应用 |
| EP3897625A1 (en) | 2018-12-18 | 2021-10-27 | Mundipharma International Corporation Limited | Compounds for treating lymphoma or a t-cell malignant disease |
| WO2024229406A1 (en) | 2023-05-04 | 2024-11-07 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| WO2024246220A1 (en) * | 2023-05-31 | 2024-12-05 | Institut National de la Santé et de la Recherche Médicale | Methods and compositions for treating lung cancer |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025080946A2 (en) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025217307A1 (en) | 2024-04-09 | 2025-10-16 | Revolution Medicines, Inc. | Methods for predicting response to a ras(on) inhibitor and combination therapies |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
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| WO2003015828A1 (en) * | 2001-08-20 | 2003-02-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Parenteral formulations of 1-(5-tert-butyl-2-p-tolyl-2h-pryrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea and a cyclodextrin |
| WO2006105262A1 (en) * | 2005-03-29 | 2006-10-05 | Icos Corporation | HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl |
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| DE3346123A1 (de) * | 1983-12-21 | 1985-06-27 | Janssen Pharmaceutica, N.V., Beerse | Pharmazeutische praeparate von in wasser schwerloeslichen oder instabilen arzneistoffen und verfahren zu ihrer herstellung |
| HU193933B (en) * | 1984-06-08 | 1987-12-28 | Nitrokemia Ipartelepek | Herbicide or plant growth stimulating agent comprising beta-cyclodextrin complex of benzolsulphonylurea derivative and process for preparing the active substances |
| IE62095B1 (en) * | 1988-03-29 | 1994-12-14 | Univ Florida | Pharmaceutical formulations for parenteral use |
| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| GB9001987D0 (en) | 1990-01-29 | 1990-03-28 | Janssen Pharmaceutica Nv | Improved cyclodextrin based erythropietin formulation |
| US5602112A (en) | 1992-06-19 | 1997-02-11 | Supergen, Inc. | Pharmaceutical formulation |
| US6046177A (en) | 1997-05-05 | 2000-04-04 | Cydex, Inc. | Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations |
| NZ505951A (en) * | 1998-02-23 | 2003-02-28 | Cyclops Ehf | A method for enhancing the complexation efficiency of a heterocyclic drug with cyclodextrin, by subjecting the heterocycloc drug to chemically reversible ring-opening |
| WO2002007772A2 (en) * | 2000-07-24 | 2002-01-31 | Boehringer Ingelheim Pharmaceuticals, Inc. | Improved oral dosage formulations |
| UA76977C2 (en) | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
| SE0201658D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Immediate release pharmaceutical formulation |
| WO2005027907A1 (en) * | 2003-09-17 | 2005-03-31 | Icos Corporation | Use of chk1 inhibitors to control cell proliferation |
| KR20050039573A (ko) * | 2003-10-23 | 2005-04-29 | 주식회사 태평양 | 티오우레아계 유도체의 용해성과 생체이용률이 개선된약제학적 조성물 |
| CN1813739A (zh) | 2005-11-25 | 2006-08-09 | 王颖 | 一种注射用盐酸纳美芬冻干粉针制剂 |
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2007
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- 2007-10-02 BR BRPI0717460-8A2A patent/BRPI0717460A2/pt not_active IP Right Cessation
- 2007-10-02 MY MYPI20091558 patent/MY150649A/en unknown
- 2007-10-02 KR KR1020117017995A patent/KR20110098009A/ko not_active Ceased
- 2007-10-02 EP EP07871106A patent/EP2063879A2/en not_active Withdrawn
- 2007-10-02 AU AU2007325576A patent/AU2007325576B2/en not_active Ceased
- 2007-10-02 KR KR1020097007975A patent/KR20090065537A/ko not_active Ceased
- 2007-10-02 JP JP2009533425A patent/JP2010506942A/ja active Pending
- 2007-10-02 CA CA2673483A patent/CA2673483C/en not_active Expired - Fee Related
- 2007-10-02 NZ NZ575394A patent/NZ575394A/en not_active IP Right Cessation
- 2007-10-02 US US12/442,529 patent/US8455471B2/en not_active Expired - Fee Related
- 2007-10-02 UA UAA200903745A patent/UA95310C2/ru unknown
- 2007-10-02 MX MX2009004214A patent/MX2009004214A/es active IP Right Grant
- 2007-10-02 EA EA200900571A patent/EA200900571A1/ru unknown
- 2007-10-02 WO PCT/US2007/080150 patent/WO2008067027A2/en not_active Ceased
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2009
- 2009-03-20 CR CR10680A patent/CR10680A/es unknown
- 2009-03-26 IL IL197869A patent/IL197869A/en not_active IP Right Cessation
- 2009-04-17 TN TNP2009000146A patent/TN2009000146A1/fr unknown
- 2009-04-17 ZA ZA200902670A patent/ZA200902670B/xx unknown
- 2009-04-17 CO CO09039148A patent/CO6180503A2/es not_active Application Discontinuation
- 2009-04-20 SV SV2009003227A patent/SV2009003227A/es unknown
- 2009-04-20 NO NO20091544A patent/NO20091544L/no not_active Application Discontinuation
- 2009-05-07 MA MA31850A patent/MA30872B1/fr unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003015828A1 (en) * | 2001-08-20 | 2003-02-27 | Boehringer Ingelheim Pharmaceuticals, Inc. | Parenteral formulations of 1-(5-tert-butyl-2-p-tolyl-2h-pryrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea and a cyclodextrin |
| WO2006105262A1 (en) * | 2005-03-29 | 2006-10-05 | Icos Corporation | HETEROARYL UREA DERIVATIVES USEFUL FOR INHIBITING CHKl |
Also Published As
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| ZA200902670B (en) | 2010-06-30 |
| CR10680A (es) | 2009-10-13 |
| WO2008067027A3 (en) | 2009-04-16 |
| KR20090065537A (ko) | 2009-06-22 |
| EP2063879A2 (en) | 2009-06-03 |
| MY150649A (en) | 2014-02-14 |
| UA95310C2 (ru) | 2011-07-25 |
| AU2007325576A1 (en) | 2008-06-05 |
| BRPI0717460A2 (pt) | 2013-12-24 |
| KR20110098009A (ko) | 2011-08-31 |
| CA2673483C (en) | 2014-04-08 |
| IL197869A (en) | 2013-11-28 |
| US8455471B2 (en) | 2013-06-04 |
| NZ575394A (en) | 2012-01-12 |
| EA200900571A1 (ru) | 2009-12-30 |
| CA2673483A1 (en) | 2008-06-05 |
| SV2009003227A (es) | 2010-02-04 |
| CN101528215B (zh) | 2011-10-19 |
| MX2009004214A (es) | 2009-05-11 |
| WO2008067027A2 (en) | 2008-06-05 |
| CN101528215A (zh) | 2009-09-09 |
| MA30872B1 (fr) | 2009-11-02 |
| US20100022512A1 (en) | 2010-01-28 |
| TN2009000146A1 (en) | 2010-10-18 |
| NO20091544L (no) | 2009-06-10 |
| CO6180503A2 (es) | 2010-07-19 |
| IL197869A0 (en) | 2009-12-24 |
| JP2010506942A (ja) | 2010-03-04 |
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