IL193640A - Biodegradable foam - Google Patents
Biodegradable foamInfo
- Publication number
- IL193640A IL193640A IL193640A IL19364008A IL193640A IL 193640 A IL193640 A IL 193640A IL 193640 A IL193640 A IL 193640A IL 19364008 A IL19364008 A IL 19364008A IL 193640 A IL193640 A IL 193640A
- Authority
- IL
- Israel
- Prior art keywords
- foam
- gel
- chitosan
- polysaccharide
- forming
- Prior art date
Links
- 239000006260 foam Substances 0.000 title claims abstract description 326
- 150000004676 glycans Chemical class 0.000 claims abstract description 58
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 58
- 239000005017 polysaccharide Substances 0.000 claims abstract description 58
- 239000002131 composite material Substances 0.000 claims abstract description 46
- 239000011148 porous material Substances 0.000 claims abstract description 42
- 238000000034 method Methods 0.000 claims abstract description 26
- 229920001661 Chitosan Polymers 0.000 claims description 121
- 150000002500 ions Chemical class 0.000 claims description 67
- 235000010443 alginic acid Nutrition 0.000 claims description 42
- 229920000615 alginic acid Polymers 0.000 claims description 42
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 39
- 239000004088 foaming agent Substances 0.000 claims description 39
- 229940072056 alginate Drugs 0.000 claims description 37
- 229920001222 biopolymer Polymers 0.000 claims description 35
- 238000002156 mixing Methods 0.000 claims description 27
- 238000001035 drying Methods 0.000 claims description 20
- 241001465754 Metazoa Species 0.000 claims description 17
- 239000006185 dispersion Substances 0.000 claims description 16
- 238000004132 cross linking Methods 0.000 claims description 15
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 15
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims description 13
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 13
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 13
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 12
- 108010088751 Albumins Proteins 0.000 claims description 11
- 102000009027 Albumins Human genes 0.000 claims description 11
- 239000002250 absorbent Substances 0.000 claims description 11
- 230000002745 absorbent Effects 0.000 claims description 11
- 230000006196 deacetylation Effects 0.000 claims description 10
- 238000003381 deacetylation reaction Methods 0.000 claims description 10
- 229940014041 hyaluronate Drugs 0.000 claims description 9
- 239000004014 plasticizer Substances 0.000 claims description 8
- 239000003431 cross linking reagent Substances 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 6
- 239000011575 calcium Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 239000003002 pH adjusting agent Substances 0.000 claims description 6
- 238000011282 treatment Methods 0.000 claims description 6
- 238000000465 moulding Methods 0.000 claims description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 4
- 229910001424 calcium ion Inorganic materials 0.000 claims description 4
- 229920000609 methyl cellulose Polymers 0.000 claims description 4
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- 235000010981 methylcellulose Nutrition 0.000 claims description 4
- 238000007493 shaping process Methods 0.000 claims description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 3
- 238000013019 agitation Methods 0.000 claims description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
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- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 3
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 2
- 239000000835 fiber Substances 0.000 claims 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
- 229940050528 albumin Drugs 0.000 claims 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 claims 1
- 229910001422 barium ion Inorganic materials 0.000 claims 1
- 239000000679 carrageenan Substances 0.000 claims 1
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- 238000003745 diagnosis Methods 0.000 claims 1
- 238000009940 knitting Methods 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
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- 238000001356 surgical procedure Methods 0.000 claims 1
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 10
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- 239000007943 implant Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 61
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- 239000000499 gel Substances 0.000 description 23
- 150000003839 salts Chemical class 0.000 description 17
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 16
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- 239000007864 aqueous solution Substances 0.000 description 12
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- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 11
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- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 4
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 3
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
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Landscapes
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Colloid Chemistry (AREA)
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| US87417406P | 2006-12-11 | 2006-12-11 | |
| PCT/US2007/005435 WO2007103208A2 (en) | 2006-03-01 | 2007-03-01 | Biodegradable foam |
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| IL193640A0 IL193640A0 (en) | 2009-05-04 |
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| US8668737B2 (en) | 1997-10-10 | 2014-03-11 | Senorx, Inc. | Tissue marking implant |
| US8361082B2 (en) | 1999-02-02 | 2013-01-29 | Senorx, Inc. | Marker delivery device with releasable plug |
| US9820824B2 (en) | 1999-02-02 | 2017-11-21 | Senorx, Inc. | Deployment of polysaccharide markers for treating a site within a patent |
| US7983734B2 (en) | 2003-05-23 | 2011-07-19 | Senorx, Inc. | Fibrous marker and intracorporeal delivery thereof |
| US7877133B2 (en) | 2003-05-23 | 2011-01-25 | Senorx, Inc. | Marker or filler forming fluid |
| GB0508531D0 (en) | 2005-04-27 | 2005-06-01 | Smith & Nephew | Sai with ultrasound |
| US9579077B2 (en) | 2006-12-12 | 2017-02-28 | C.R. Bard, Inc. | Multiple imaging mode tissue marker |
| CN101778891B (zh) * | 2007-06-13 | 2013-01-16 | Fmc有限公司 | 涂覆藻酸盐的含多糖凝胶泡沫复合物,其制备方法及其应用 |
| DE102007037051A1 (de) * | 2007-07-24 | 2009-01-29 | Aesculap Ag | Flächiges Implantat |
| EP2200674A2 (en) * | 2007-09-10 | 2010-06-30 | Boston Scientific Scimed, Inc. | Medical devices with triggerable bioadhesive material |
| US8999377B2 (en) * | 2007-09-19 | 2015-04-07 | Surmodics, Inc. | System for forming a biocompatible foam using polymerizable alpha(1-4)glucopyranose polymers and gas-producing component |
| DE102007051059B4 (de) * | 2007-10-18 | 2014-04-03 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Bioverbundmaterial für die kontrollierte Freisetzung von Wirkstoffen |
| US8673354B2 (en) | 2007-11-05 | 2014-03-18 | Technion Research And Development Foundation Ltd. | Adhesives and methods of applying the same |
| WO2009066106A1 (en) | 2007-11-21 | 2009-05-28 | Smith & Nephew Plc | Wound dressing |
| EP2987510B1 (en) | 2007-11-21 | 2020-10-28 | T.J. Smith & Nephew Limited | Suction device and dressing |
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| US11253399B2 (en) | 2007-12-06 | 2022-02-22 | Smith & Nephew Plc | Wound filling apparatuses and methods |
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| WO2007103208A3 (en) | 2008-12-24 |
| AU2007224137A1 (en) | 2007-09-13 |
| IL193621A (en) | 2013-08-29 |
| CA2643084C (en) | 2015-12-29 |
| US9028872B2 (en) | 2015-05-12 |
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