IL165323A0 - Compounds that abrogate dna-damage-induced cell c ycle g2 checkpoint and/or augment the anti-cancer activity of dna-damaging treatments - Google Patents
Compounds that abrogate dna-damage-induced cell c ycle g2 checkpoint and/or augment the anti-cancer activity of dna-damaging treatmentsInfo
- Publication number
- IL165323A0 IL165323A0 IL16532303A IL16532303A IL165323A0 IL 165323 A0 IL165323 A0 IL 165323A0 IL 16532303 A IL16532303 A IL 16532303A IL 16532303 A IL16532303 A IL 16532303A IL 165323 A0 IL165323 A0 IL 165323A0
- Authority
- IL
- Israel
- Prior art keywords
- dna
- checkpoint
- compounds
- damage
- ycle
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/26—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/36—Esters of dithiocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- General Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38693002P | 2002-06-06 | 2002-06-06 | |
| PCT/IB2003/003164 WO2003104181A2 (en) | 2002-06-06 | 2003-06-06 | Compounds that abrogate dna-damage-induced cell cycle g2 checkpoint and/or augment the anti-cancer activity of dna-damaging treatments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL165323A0 true IL165323A0 (en) | 2006-01-15 |
Family
ID=29736236
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL16532303A IL165323A0 (en) | 2002-06-06 | 2003-06-06 | Compounds that abrogate dna-damage-induced cell c ycle g2 checkpoint and/or augment the anti-cancer activity of dna-damaging treatments |
| IL165323A IL165323A (en) | 2002-06-06 | 2004-11-22 | Compounds that eliminate a 2 g checkpoint in the cell cycle that is attracted by DNA damage And / or aiding anti-cancer activity of DNA-damaging treatments |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL165323A IL165323A (en) | 2002-06-06 | 2004-11-22 | Compounds that eliminate a 2 g checkpoint in the cell cycle that is attracted by DNA damage And / or aiding anti-cancer activity of DNA-damaging treatments |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US7030111B2 (ko) |
| EP (1) | EP1511713B8 (ko) |
| JP (2) | JP4919598B2 (ko) |
| KR (1) | KR100984951B1 (ko) |
| CN (1) | CN100577631C (ko) |
| AT (1) | ATE520653T1 (ko) |
| AU (1) | AU2003247044B8 (ko) |
| CA (1) | CA2487388C (ko) |
| ES (1) | ES2369534T3 (ko) |
| IL (2) | IL165323A0 (ko) |
| NO (1) | NO20045556L (ko) |
| WO (1) | WO2003104181A2 (ko) |
| ZA (1) | ZA200409650B (ko) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL165323A0 (en) * | 2002-06-06 | 2006-01-15 | Canbas Co Ltd | Compounds that abrogate dna-damage-induced cell c ycle g2 checkpoint and/or augment the anti-cancer activity of dna-damaging treatments |
| US7297709B2 (en) | 2003-05-22 | 2007-11-20 | Abbott Laboratories | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors |
| US7358046B2 (en) * | 2003-08-08 | 2008-04-15 | Canbas Co., Ltd. | Sensitivity test to predict efficacy of anti-cancer therapies |
| EP1988171A1 (en) * | 2006-02-21 | 2008-11-05 | The Kitasato Institute | Substance fki-2342 and process for production thereof |
| CA2679955A1 (en) * | 2006-10-13 | 2008-05-29 | Reliance Life Sciences Pvt. Ltd. | Novel chemotherapeutic agents against inflammation and cancer |
| CN101720323A (zh) * | 2007-04-11 | 2010-06-02 | 三井有限公司 | 具有抗癌活性的化合物 |
| EP3578974A1 (en) * | 2018-06-08 | 2019-12-11 | Novagray | Bleomycin for mimicking the effect of ionizing radiations on t cells |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2913483A (en) * | 1958-05-08 | 1959-11-17 | Dow Chemical Co | Lower alkylphenyl 2, 4-dichloro-benzoates |
| DE2049865A1 (en) * | 1970-10-10 | 1972-04-13 | Dynamit Nobel Ag, 5210 Troisdorf | Aromatic acid aryl esters - prepd from aromatic trichloromethyl cpds phenols and water |
| US4394389A (en) * | 1979-03-01 | 1983-07-19 | Riet Bartholomeus Van T | Hydroxybenzohydroxamic acids, benzamides and esters as ribonucleotide reductase inhibitors |
| JPS56110777A (en) * | 1980-02-07 | 1981-09-02 | Chisso Corp | Ester derivative of 4-fluorobenzoic acid |
| US4612386A (en) * | 1980-09-16 | 1986-09-16 | The Dow Chemical Company | Process for making esters |
| JPS58188838A (ja) * | 1982-04-27 | 1983-11-04 | Chisso Corp | ４−（４′−フルオロベンゾイルオキシ）フエノ−ルのエステル誘導体 |
| US4934389A (en) * | 1988-12-06 | 1990-06-19 | Pettiford William L | Dental floss dispenser |
| FR2649977B1 (fr) | 1989-07-18 | 1991-10-04 | Cird | Esters bi-aromatiques, leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique |
| JP2696434B2 (ja) * | 1991-01-23 | 1998-01-14 | 富士写真フイルム株式会社 | 画像形成方法 |
| US5733920A (en) * | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
| US6017958A (en) * | 1996-06-04 | 2000-01-25 | Octamer, Inc. | Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity |
| CA2216559A1 (en) * | 1997-09-25 | 1999-03-25 | Michel Roberge | G2 checkpoint inhibitors and assay |
| DE69911935T3 (de) | 1998-03-13 | 2008-02-07 | The University Of British Columbia, Vancouver | Granulatimide-derivate zur behandlung von krebs |
| JP2002507567A (ja) * | 1998-03-25 | 2002-03-12 | ラージ スケール バイオロジー コーポレイション | 血管形成を阻害するための安息香酸誘導体 |
| WO2001021771A2 (en) | 1999-09-22 | 2001-03-29 | Canbas Co., Ltd. | Compositions and methods for inhibiting g2 cell cycle arrest and sensitizing cells to dna damaging agents |
| US6211164B1 (en) * | 2000-03-10 | 2001-04-03 | Abbott Laboratories | Antisense oligonucleotides of the human chk1 gene and uses thereof |
| SI1483290T1 (sl) | 2002-01-17 | 2009-02-28 | Takeda Pharmaceutical | Peptidi in peptidomimetiki, ki imajo antiproliferacijsko aktivnost in/ali okrepijo sredstva ali obdelave, ki poškodujejo nukleinsko kislino |
| AU2003243318A1 (en) * | 2002-05-29 | 2003-12-19 | Millennium Pharmaceuticals, Inc. | Diarylurea compounds and derivatives as chk-1 inhibitors for the treatment of cancer |
| IL165323A0 (en) * | 2002-06-06 | 2006-01-15 | Canbas Co Ltd | Compounds that abrogate dna-damage-induced cell c ycle g2 checkpoint and/or augment the anti-cancer activity of dna-damaging treatments |
| US6881573B2 (en) * | 2003-09-12 | 2005-04-19 | Allan L. Louderback | Augmented solvent/detergent method for inactivating enveloped and non-enveloped viruses |
-
2003
- 2003-06-06 IL IL16532303A patent/IL165323A0/xx unknown
- 2003-06-06 AT AT03757173T patent/ATE520653T1/de not_active IP Right Cessation
- 2003-06-06 JP JP2004511251A patent/JP4919598B2/ja not_active Expired - Fee Related
- 2003-06-06 EP EP03757173A patent/EP1511713B8/en not_active Expired - Lifetime
- 2003-06-06 KR KR1020047019826A patent/KR100984951B1/ko not_active IP Right Cessation
- 2003-06-06 WO PCT/IB2003/003164 patent/WO2003104181A2/en active Application Filing
- 2003-06-06 CN CN03818476A patent/CN100577631C/zh not_active Expired - Fee Related
- 2003-06-06 CA CA2487388A patent/CA2487388C/en not_active Expired - Fee Related
- 2003-06-06 AU AU2003247044A patent/AU2003247044B8/en not_active Ceased
- 2003-06-06 US US10/457,029 patent/US7030111B2/en not_active Expired - Fee Related
- 2003-06-06 ES ES03757173T patent/ES2369534T3/es not_active Expired - Lifetime
-
2004
- 2004-11-22 IL IL165323A patent/IL165323A/en not_active IP Right Cessation
- 2004-11-29 ZA ZA200409650A patent/ZA200409650B/en unknown
- 2004-12-20 NO NO20045556A patent/NO20045556L/no unknown
-
2006
- 2006-01-17 US US11/334,160 patent/US7407985B2/en not_active Expired - Lifetime
-
2008
- 2008-06-02 US US12/131,639 patent/US7629364B2/en not_active Expired - Fee Related
- 2008-06-02 US US12/131,564 patent/US7652042B2/en not_active Expired - Fee Related
-
2010
- 2010-04-22 JP JP2010099281A patent/JP2010168398A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US7652042B2 (en) | 2010-01-26 |
| CA2487388C (en) | 2011-05-10 |
| US7030111B2 (en) | 2006-04-18 |
| EP1511713A2 (en) | 2005-03-09 |
| US7629364B2 (en) | 2009-12-08 |
| JP2010168398A (ja) | 2010-08-05 |
| ATE520653T1 (de) | 2011-09-15 |
| ZA200409650B (en) | 2006-09-27 |
| AU2003247044B8 (en) | 2009-04-09 |
| NO20045556L (no) | 2005-03-04 |
| US20040198727A1 (en) | 2004-10-07 |
| EP1511713B8 (en) | 2012-02-08 |
| AU2003247044B2 (en) | 2009-03-26 |
| US20060122269A1 (en) | 2006-06-08 |
| CN100577631C (zh) | 2010-01-06 |
| US7407985B2 (en) | 2008-08-05 |
| IL165323A (en) | 2015-05-31 |
| US20080227827A1 (en) | 2008-09-18 |
| ES2369534T3 (es) | 2011-12-01 |
| US20080293137A1 (en) | 2008-11-27 |
| WO2003104181A2 (en) | 2003-12-18 |
| KR100984951B1 (ko) | 2010-10-01 |
| AU2003247044A1 (en) | 2003-12-22 |
| JP4919598B2 (ja) | 2012-04-18 |
| KR20050019730A (ko) | 2005-03-03 |
| CA2487388A1 (en) | 2003-12-18 |
| EP1511713B1 (en) | 2011-08-17 |
| JP2005528457A (ja) | 2005-09-22 |
| CN1671644A (zh) | 2005-09-21 |
| WO2003104181A3 (en) | 2004-07-29 |
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| IL165323A0 (en) | Compounds that abrogate dna-damage-induced cell c ycle g2 checkpoint and/or augment the anti-cancer activity of dna-damaging treatments |