IL163996A0 - N3 alkylated benzimidazole derivatives as mek inhibitors - Google Patents

N3 alkylated benzimidazole derivatives as mek inhibitors

Info

Publication number
IL163996A0
IL163996A0 IL16399603A IL16399603A IL163996A0 IL 163996 A0 IL163996 A0 IL 163996A0 IL 16399603 A IL16399603 A IL 16399603A IL 16399603 A IL16399603 A IL 16399603A IL 163996 A0 IL163996 A0 IL 163996A0
Authority
IL
Israel
Prior art keywords
benzimidazole derivatives
mek inhibitors
alkylated benzimidazole
alkylated
mek
Prior art date
Application number
IL16399603A
Other languages
English (en)
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of IL163996A0 publication Critical patent/IL163996A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
IL16399603A 2002-03-13 2003-03-13 N3 alkylated benzimidazole derivatives as mek inhibitors IL163996A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36416402P 2002-03-13 2002-03-13
PCT/US2003/007565 WO2003077855A2 (fr) 2002-03-13 2003-03-13 Derives de benzimidazole n3 alkyles servant d'inhibiteurs de mek

Publications (1)

Publication Number Publication Date
IL163996A0 true IL163996A0 (en) 2005-12-18

Family

ID=28041882

Family Applications (1)

Application Number Title Priority Date Filing Date
IL16399603A IL163996A0 (en) 2002-03-13 2003-03-13 N3 alkylated benzimidazole derivatives as mek inhibitors

Country Status (18)

Country Link
US (2) US20030216460A1 (fr)
EP (1) EP1482944A4 (fr)
JP (1) JP2005526076A (fr)
KR (1) KR20040098013A (fr)
CN (1) CN1652792A (fr)
AR (1) AR038972A1 (fr)
AU (1) AU2003220202A1 (fr)
CA (1) CA2478534A1 (fr)
CO (1) CO5611145A2 (fr)
DO (1) DOP2003000614A (fr)
IL (1) IL163996A0 (fr)
MX (1) MXPA04008894A (fr)
PA (1) PA8569201A1 (fr)
PL (1) PL378635A1 (fr)
RU (1) RU2300528C2 (fr)
TW (1) TW200406203A (fr)
UA (1) UA76837C2 (fr)
WO (1) WO2003077855A2 (fr)

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US7732616B2 (en) * 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
US7517994B2 (en) * 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
AU2004293026B2 (en) 2003-11-21 2012-01-19 Array Biopharma Inc. AKT protein kinase inhibitors
EP1699477A2 (fr) * 2003-12-11 2006-09-13 Theravance, Inc. Compositions a utiliser dans le traitement de maladies proliferatives cellulaires caracterisees par la presence d'une tyrosine kinase receptrice mutante
KR101318012B1 (ko) 2004-10-20 2013-10-14 메르크 세로노 에스.에이. 3-아릴아미노 피리딘 유도체
WO2006058752A1 (fr) * 2004-12-01 2006-06-08 Laboratoires Serono S.A. Dérivés de [1,2,4]triazolo[4,3-a]pyridine pour le traitement de maladies hyperproliférantes
SG177981A1 (en) 2005-05-18 2012-02-28 Array Biopharma Inc 4-(phenylamino)-6-oxo-1, 6-dihydropyridazine-3-carboxamide derivatives as mek inhibitors for the treatment of hyperproliferative diseases
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US8101799B2 (en) 2005-07-21 2012-01-24 Ardea Biosciences Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK
PL1934174T3 (pl) * 2005-10-07 2011-09-30 Exelixis Inc Azetydyny jako inhibitory w leczeniu chorób proliferacyjnych
WO2007071951A1 (fr) * 2005-12-21 2007-06-28 Astrazeneca Ab Sel de tosylate du 6-(4-bromo-2-chlorophenylamino)-7-fluoro-n-(2-hydroxyethoxy)-3-methyl-3h-benzimidazole-5-carboxamide, inhibiteur de mek pouvant etre employe dans le traitement du cancer
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US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
UA99597C2 (ru) 2006-07-06 2012-09-10 Еррей Біофарма Інк. Пиримидилциклопентаны как ингибиторы акт протеинкиназ
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US7893085B2 (en) * 2006-08-21 2011-02-22 Genentech, Inc Aza-benzothiophenyl compounds and methods of use
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Also Published As

Publication number Publication date
US20060106225A1 (en) 2006-05-18
AU2003220202A1 (en) 2003-09-29
UA76837C2 (uk) 2006-09-15
KR20040098013A (ko) 2004-11-18
TW200406203A (en) 2004-05-01
WO2003077855A2 (fr) 2003-09-25
CO5611145A2 (es) 2006-02-28
EP1482944A4 (fr) 2006-04-19
DOP2003000614A (es) 2009-09-30
CN1652792A (zh) 2005-08-10
CA2478534A1 (fr) 2003-09-25
WO2003077855A3 (fr) 2004-03-04
RU2300528C2 (ru) 2007-06-10
PL378635A1 (pl) 2006-05-15
RU2004127925A (ru) 2005-05-27
JP2005526076A (ja) 2005-09-02
PA8569201A1 (es) 2004-05-21
AR038972A1 (es) 2005-02-02
EP1482944A2 (fr) 2004-12-08
MXPA04008894A (es) 2005-06-20
US20030216460A1 (en) 2003-11-20

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