IL159578A0 - Messenchymal cells and osteoblasts from human embryonic stem cell - Google Patents

Messenchymal cells and osteoblasts from human embryonic stem cell

Info

Publication number
IL159578A0
IL159578A0 IL15957802A IL15957802A IL159578A0 IL 159578 A0 IL159578 A0 IL 159578A0 IL 15957802 A IL15957802 A IL 15957802A IL 15957802 A IL15957802 A IL 15957802A IL 159578 A0 IL159578 A0 IL 159578A0
Authority
IL
Israel
Prior art keywords
osteoblasts
stem cell
embryonic stem
human embryonic
messenchymal
Prior art date
Application number
IL15957802A
Other languages
English (en)
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geron Corp filed Critical Geron Corp
Publication of IL159578A0 publication Critical patent/IL159578A0/xx

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0654—Osteocytes, Osteoblasts, Odontocytes; Bones, Teeth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
    • C12N2500/14—Calcium; Ca chelators; Calcitonin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/44—Thiols, e.g. mercaptoethanol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/04—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from germ cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/04—Immortalised cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
IL15957802A 2001-07-06 2002-07-03 Messenchymal cells and osteoblasts from human embryonic stem cell IL159578A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30373201P 2001-07-06 2001-07-06
PCT/US2002/020998 WO2003004605A2 (fr) 2001-07-06 2002-07-03 Osteoblastes et cellules mesenchymateuses provenant de cellule souche embryonnaire humaine

Publications (1)

Publication Number Publication Date
IL159578A0 true IL159578A0 (en) 2004-06-01

Family

ID=23173436

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15957802A IL159578A0 (en) 2001-07-06 2002-07-03 Messenchymal cells and osteoblasts from human embryonic stem cell
IL159578A IL159578A (en) 2001-07-06 2003-12-25 Differentiated cell population for generating osteoprogenitors or osteoblasts

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL159578A IL159578A (en) 2001-07-06 2003-12-25 Differentiated cell population for generating osteoprogenitors or osteoblasts

Country Status (11)

Country Link
US (4) US20030021771A1 (fr)
EP (1) EP1412481B1 (fr)
JP (1) JP2004535808A (fr)
CN (2) CN101696397B (fr)
AU (1) AU2002322379B2 (fr)
CA (1) CA2453068C (fr)
ES (1) ES2539105T3 (fr)
GB (1) GB2392674B (fr)
HK (1) HK1141552A1 (fr)
IL (2) IL159578A0 (fr)
WO (1) WO2003004605A2 (fr)

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US20040121460A1 (en) * 2001-01-24 2004-06-24 Lumelsky Nadya L Differentiation of stem cells to pancreatic endocrine cells
US20030211605A1 (en) * 2001-05-01 2003-11-13 Lee Sang-Hun Derivation of midbrain dopaminergic neurons from embryonic stem cells
GB0222846D0 (en) 2002-10-03 2002-11-06 Choo Yen Cell culture
PT2457999T (pt) 2002-12-16 2019-01-28 Technion Res & Dev Foundation Sistema de cultura para células estaminais pluripotentes
US20030224411A1 (en) * 2003-03-13 2003-12-04 Stanton Lawrence W. Genes that are up- or down-regulated during differentiation of human embryonic stem cells
JP2005304443A (ja) * 2004-04-26 2005-11-04 Institute Of Physical & Chemical Research 前駆間葉系幹細胞
EP1743023A1 (fr) * 2004-05-07 2007-01-17 Wisconsin Alumni Research Foundation Procede permettant de former des cellules souches mesenchymateuses a partir de cellules souches embryonnaires
EP1745125A1 (fr) * 2004-05-14 2007-01-24 Becton, Dickinson and Company Environnements de culture cellulaire pour la dilatation excempte de serum de cellules souches mesenchymateuses
EP1809739B1 (fr) 2004-07-13 2014-10-15 Asterias Biotherapeutics, Inc. Milieu destine a la croissance de cellules souches embryonnaires humaines
AU2006235211B2 (en) 2005-04-12 2010-10-14 Mesoblast, Inc. Isolation of adult multipotential cells by tissue non-specific alkaline phosphatase
US9074181B2 (en) 2005-06-22 2015-07-07 Asterias Biotherapeutics, Inc. Suspension culture of human embryonic stem cells
JP4714741B2 (ja) * 2005-07-29 2011-06-29 学校法人松本歯科大学 歯の再生方法
SG177946A1 (en) 2005-08-29 2012-02-28 Technion Res & Dev Foundation Media for culturing stem cells
JP2009506769A (ja) * 2005-09-02 2009-02-19 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 間充織幹細胞誘導方法
US9029146B2 (en) * 2005-09-02 2015-05-12 Agency For Science, Technology And Research Mesenchymal stem cell conditioned medium
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JP5170443B2 (ja) * 2006-02-16 2013-03-27 ユニヴェルシテ リブル ドゥ ブリュッセル 骨髄幹細胞（ｂｍｓｃ）を骨分化させる方法およびその使用
WO2007122233A1 (fr) * 2006-04-25 2007-11-01 Vrije Universiteit Brussel PRÉPARATION de cellules PROGÉNITRICES MÉSENCHYMATEUSES, en particulier de cellules PROGÉNITRICES OSTÉOGÉNIQUES
EP3441459B1 (fr) 2006-08-02 2021-03-17 Technion Research & Development Foundation Limited Procédés d'expansion de cellules souches embryonnaires dans une culture en suspension
EP2076770A1 (fr) * 2006-10-02 2009-07-08 Cellartis AB Nouvel essai de toxicité basé sur des cellules souches et des cellules progénitrices dérivées de blastocystes humains
KR100937456B1 (ko) * 2007-08-01 2010-01-19 한국생명공학연구원 인간배아줄기세포를 조골세포 직계열로 분화시키는 방법
EP2408904B1 (fr) * 2009-03-20 2017-10-18 Mesoblast, Inc. Production de cellules pluripotentes reprogrammées
EP2446021A4 (fr) * 2009-06-25 2013-11-13 Geron Corp Descendance de cellules souches pluripotentes différenciées appauvrie en phénotypes étrangers
KR101135636B1 (ko) * 2009-10-27 2012-04-17 서울대학교산학협력단 인간 만능줄기세포로부터 중배엽 줄기세포를 생산하는 방법 및 이에 의해 생성된 중배엽 줄기세포
ES2932664T3 (es) 2009-11-12 2023-01-23 Technion Res & Dev Foundation Medios de cultivo, cultivos celulares y métodos de cultivo de células madre pluripotentes en estado no diferenciado
US9029145B2 (en) 2010-04-08 2015-05-12 The University Court Of The University Of Edinburgh Chondrogenic progenitor cells, protocol for derivation of cells and uses thereof
WO2011124741A1 (fr) * 2010-04-08 2011-10-13 Fundación Progreso Y Salud Utilisation d'un milieu de culture conditionné par des cellules souches mésenchymateuses pour la différenciation de cellules souches pluripotentes humaines
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EP2691512B1 (fr) 2011-03-29 2019-05-01 Asterias Biotherapeutics, Inc. Populations enrichies de cellules de lignée cardiomyocytaire issues de cellules souches pluripotentes
CN103083653B (zh) * 2011-10-28 2015-07-22 辽宁成大动物药业有限公司 一种采用微载体高密度细胞培养技术生产猪瘟活疫苗的方法
CN103777009B (zh) * 2012-10-18 2016-03-02 辽宁成大动物药业有限公司 一种使用辣根过氧化物酶标抗体检测猪瘟弱毒病毒滴度的方法
KR20200138445A (ko) 2014-04-24 2020-12-09 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 입양 세포 요법 생성물을 생성하기 위한 유도 만능 줄기 세포의 응용
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CN108570448B (zh) * 2018-01-26 2019-04-02 皓昇莱生物制药有限公司 一种高效的hPSCs向MSCs分化的方法
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Also Published As

Publication number Publication date
US20030036194A1 (en) 2003-02-20
GB2392674B (en) 2005-08-10
GB2392674A (en) 2004-03-10
US20060057720A1 (en) 2006-03-16
CN1636054A (zh) 2005-07-06
EP1412481A2 (fr) 2004-04-28
ES2539105T3 (es) 2015-06-26
CN101696397B (zh) 2015-07-08
EP1412481A4 (fr) 2005-01-05
EP1412481B1 (fr) 2015-04-01
WO2003004605A2 (fr) 2003-01-16
JP2004535808A (ja) 2004-12-02
WO2003004605A3 (fr) 2003-11-13
AU2002322379B2 (en) 2007-02-15
CA2453068A1 (fr) 2003-01-16
GB0400481D0 (en) 2004-02-11
IL159578A (en) 2010-11-30
US20030021771A1 (en) 2003-01-30
CA2453068C (fr) 2018-02-20
US20050282274A1 (en) 2005-12-22
CN101696397A (zh) 2010-04-21
HK1141552A1 (en) 2010-11-12

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