IL157541A0 - METHOD FOR PROTECTING CELLS AND TISSUES FORM IONIZING RADIATION TOXICITY WITH alpha, beta UNSATURATED ARYL SULFONES - Google Patents

METHOD FOR PROTECTING CELLS AND TISSUES FORM IONIZING RADIATION TOXICITY WITH alpha, beta UNSATURATED ARYL SULFONES

Info

Publication number
IL157541A0
IL157541A0 IL15754102A IL15754102A IL157541A0 IL 157541 A0 IL157541 A0 IL 157541A0 IL 15754102 A IL15754102 A IL 15754102A IL 15754102 A IL15754102 A IL 15754102A IL 157541 A0 IL157541 A0 IL 157541A0
Authority
IL
Israel
Prior art keywords
alpha
beta unsaturated
unsaturated aryl
ionizing radiation
radiation
Prior art date
Application number
IL15754102A
Other languages
English (en)
Original Assignee
Univ Temple
Onconova Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Temple, Onconova Therapeutics Inc filed Critical Univ Temple
Publication of IL157541A0 publication Critical patent/IL157541A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IL15754102A 2001-02-28 2002-02-28 METHOD FOR PROTECTING CELLS AND TISSUES FORM IONIZING RADIATION TOXICITY WITH alpha, beta UNSATURATED ARYL SULFONES IL157541A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27199001P 2001-02-28 2001-02-28
PCT/US2002/006107 WO2002069892A2 (en) 2001-02-28 2002-02-28 METHOD FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY WITH α, β UNSATURATED ARYL SULFONES

Publications (1)

Publication Number Publication Date
IL157541A0 true IL157541A0 (en) 2004-03-28

Family

ID=23037934

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15754102A IL157541A0 (en) 2001-02-28 2002-02-28 METHOD FOR PROTECTING CELLS AND TISSUES FORM IONIZING RADIATION TOXICITY WITH alpha, beta UNSATURATED ARYL SULFONES
IL157541A IL157541A (en) 2001-02-28 2003-08-21 Use of alpha, beta unsaturated aryl sulfone compounds for preparing radioprotective compositions

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL157541A IL157541A (en) 2001-02-28 2003-08-21 Use of alpha, beta unsaturated aryl sulfone compounds for preparing radioprotective compositions

Country Status (10)

Country Link
US (1) US6667346B2 (OSRAM)
EP (1) EP1370253B8 (OSRAM)
JP (1) JP4302986B2 (OSRAM)
KR (1) KR100850331B1 (OSRAM)
AT (1) ATE406881T1 (OSRAM)
AU (1) AU2002305942B2 (OSRAM)
CA (1) CA2439288C (OSRAM)
DE (1) DE60228692D1 (OSRAM)
IL (2) IL157541A0 (OSRAM)
WO (1) WO2002069892A2 (OSRAM)

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WO2002028828A1 (en) 2000-10-05 2002-04-11 Temple University - Of The Commonwealth System Of Higher Education Substituted (e)-styryl benzylsulfones for treating proliferative disorders
MXPA04008356A (es) * 2002-02-28 2005-09-12 Univ Temple (e)-2,6-dialcoxiestiril bencilsulfonas sustituidas con un grupo amino y en la posicion 4 para tratar trastornos poliferativos.
IL163608A0 (en) * 2002-02-28 2005-12-18 Univ Temple Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders
US7744889B2 (en) * 2003-11-14 2010-06-29 Temple University - Of The Commonwealth System Of Higher Education Alpha, beta-unsaturated sulfoxides for treating proliferative disorders
US7649013B2 (en) * 2003-11-26 2010-01-19 Arqule, Inc. Methods of protecting against radiation injury
EP1740530B8 (en) * 2004-03-16 2017-03-01 Temple University - Of The Commonwealth System of Higher Education Substituted phenoxy- and phenylthio-derivatives for treating proliferative disorders
EP1773310B9 (en) 2004-06-24 2012-04-25 Temple University - Of The Commonwealth System of Higher Education Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof
ATE497768T1 (de) * 2004-07-19 2011-02-15 Onconova Therapeutics Inc Formulierungen für die parenterale verabreichung von (e)-2,6-dialkoxystryryl 4-substituierten benzylsulfonen
US7537572B2 (en) 2004-10-22 2009-05-26 General Patent, Llc Treatment or pre-treatment for radiation/chemical exposure
EP1841420B1 (en) * 2005-01-05 2011-12-07 Temple University - Of The Commonwealth System of Higher Education Treatment of drug-resistant proliferative disorders
AU2006216544B2 (en) * 2005-02-25 2012-04-05 Onconova Therapeutics, Inc. Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis
US8106033B2 (en) * 2005-03-11 2012-01-31 Temple University - Of The Commonwealth System Of Higher Education Composition and methods for the treatment of proliferative diseases
WO2007016201A2 (en) 2005-07-29 2007-02-08 Onconova Therapeutics, Inc. FORMULATION OF RADIOPROTECTIVE α, β UNSATURATED ARYL SULFONES
EP1864692A1 (en) * 2006-06-07 2007-12-12 Biotempt B.V. Use of peptides for the control of radiation injury
JP2007302640A (ja) * 2006-05-15 2007-11-22 Natl Inst Of Radiological Sciences 抗放射線被ばく障害剤
EP2046343B1 (en) * 2006-07-28 2014-05-14 Onconova Therapeutics, Inc. Formulations of radioprotective alpha, beta unsaturated aryl sulfones
JP5278968B2 (ja) 2006-08-30 2013-09-04 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法
CA2663375A1 (en) * 2006-09-15 2008-03-20 Onconova Therapeutics, Inc. Activated cytotoxic compounds for attachment to targeting molecules for the treatment of mammalian disease conditions
WO2008076270A2 (en) * 2006-12-13 2008-06-26 Temple University-Of The Commonwealth System Of Higher Education Sulfide, sulfoxide and sulfone chalcone analogues, derivatives thereof and therapeutic uses thereof
US20100049284A1 (en) * 2008-05-15 2010-02-25 The Catholic University Of America Use of heat to treat biological systems exposed to damaging radiation
CN102231984A (zh) * 2008-10-01 2011-11-02 北卡罗来纳大学查珀尔希尔分校 使用选择性细胞周期蛋白依赖性激酶4/6抑制剂对抗化疗化合物的造血防护
JP2012504645A (ja) * 2008-10-01 2012-02-23 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 健康な細胞に対する電離放射線の影響を低下させる又は防止するための医薬組成物
WO2010075026A2 (en) * 2008-12-16 2010-07-01 Onconova Therapeutics Inc Methods for determining efficacy of a therapeutic regimen against deleterious effects of cytotoxic agents in human
WO2010132725A2 (en) 2009-05-13 2010-11-18 The University Of North Carolina At Chapel Hill Cyclin dependent kinase inhibitors and methods of use
JP5882296B2 (ja) * 2010-03-24 2016-03-09 オンコノバ・セラピューティックス・インコーポレーテッド 創傷の予防及び治療のための組成物及び方法
EA023535B9 (ru) * 2010-03-26 2016-11-30 Онконова Терапьютикс, Инк. Композиция водного радиопротекторного фармацевтического раствора и способ предотвращения, снижения или исключения эффектов ионизирующей радиации
GB201010359D0 (en) 2010-06-21 2010-08-04 Univ Nottingham Compounds for treating proliferative disorders
CA2818046A1 (en) 2010-11-17 2012-05-24 The University Of North Carolina At Chapel Hill Protection of renal tissues from ischemia through inhibition of the proliferative kinases cdk4 and cdk6
CN110776447A (zh) 2012-09-20 2020-02-11 坦普尔大学 取代的烷基二芳基衍生物、制备方法和用途
CN107417691B (zh) 2013-03-15 2020-06-26 G1治疗公司 高效的抗赘生剂和抗增生剂
US9464092B2 (en) 2013-03-15 2016-10-11 G1 Therapeutics, Inc. Transient protection of normal cells during chemotherapy
CN104230770B (zh) * 2013-06-17 2017-11-21 华夏生生药业(北京)有限公司 苯乙烯基砜类化合物、其制备方法以及其作为神经保护剂的应用
AU2015204239B2 (en) * 2014-01-06 2018-04-19 Hackensack University Medical Center Method for treating skin cancer using radiation therapy
WO2015161288A1 (en) 2014-04-17 2015-10-22 G1 Therapeutics, Inc. Tricyclic lactams for use as anti-neoplastic and anti-proliferative agents
WO2016040848A1 (en) 2014-09-12 2016-03-17 G1 Therapeutics, Inc. Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors
EP3191098A4 (en) 2014-09-12 2018-04-25 G1 Therapeutics, Inc. Combinations and dosing regimes to treat rb-positive tumors
US10383831B2 (en) 2015-08-03 2019-08-20 Temple University—Of the Commonwealth System of Higher Education 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use
CN106432011B (zh) * 2016-09-18 2018-11-02 中国医学科学院放射医学研究所 一类具有辐射防护作用的新化合物、其制备方法及其药物应用
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CA3078232A1 (en) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. Use of p38 inhibitors to reduce expression of dux4
JP7324930B2 (ja) * 2019-07-18 2023-08-10 フアシアシェンシェン ファーマシューティカル ベイジン カンパニー リミテッド カルバメート置換スチリルスルホン類化合物及びその製造方法ならびにその使用
US10988479B1 (en) 2020-06-15 2021-04-27 G1 Therapeutics, Inc. Morphic forms of trilaciclib and methods of manufacture thereof

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CZ299718B6 (cs) 1997-10-03 2008-10-29 Temple University - Of The Commonwealth System Ofhigher Education Styrylsulfonová sloucenina a farmaceutický prostredek ji obsahující
US6201154B1 (en) 1999-03-31 2001-03-13 Temple University-Of The Commonwealth Of Higher Education Z-styryl sulfone anticancer agents
JP4596651B2 (ja) 1999-04-02 2010-12-08 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション （ｅ）−スチリルスルホン抗癌剤
AU3381399A (en) * 1999-04-02 2000-10-23 Temple University - Of The Commonwealth System Of Higher Education Styryl sulfone anticancer agents
AU780844B2 (en) * 1999-10-12 2005-04-21 Temple University-Of The Commonwealth System Of Higher Education Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
US6664287B2 (en) * 2000-03-15 2003-12-16 Bethesda Pharmaceuticals, Inc. Antioxidants
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US6486210B2 (en) 2000-04-14 2002-11-26 Temple University—Of the Commonwealth System of Higher Education Substituted styryl benzylsulfones for treating proliferative disorders
CA2439255C (en) * 2001-02-28 2011-01-04 Temple University Of The Commonwealth System Of Higher Education N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof

Also Published As

Publication number Publication date
US6667346B2 (en) 2003-12-23
EP1370253B1 (en) 2008-09-03
KR100850331B1 (ko) 2008-08-04
ATE406881T1 (de) 2008-09-15
JP2004525908A (ja) 2004-08-26
CA2439288C (en) 2011-08-09
JP4302986B2 (ja) 2009-07-29
EP1370253A2 (en) 2003-12-17
IL157541A (en) 2010-05-31
CA2439288A1 (en) 2002-09-12
EP1370253A4 (en) 2005-08-17
AU2002305942B2 (en) 2006-10-26
US20030060505A1 (en) 2003-03-27
WO2002069892A3 (en) 2002-11-07
DE60228692D1 (de) 2008-10-16
KR20030086596A (ko) 2003-11-10
WO2002069892A2 (en) 2002-09-12
EP1370253B8 (en) 2008-11-26

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