IL154729A0 - SYNTHESIS OF 4alpha-ARYLEPICATECHINS - Google Patents

SYNTHESIS OF 4alpha-ARYLEPICATECHINS

Info

Publication number
IL154729A0
IL154729A0 IL15472901A IL15472901A IL154729A0 IL 154729 A0 IL154729 A0 IL 154729A0 IL 15472901 A IL15472901 A IL 15472901A IL 15472901 A IL15472901 A IL 15472901A IL 154729 A0 IL154729 A0 IL 154729A0
Authority
IL
Israel
Prior art keywords
4alpha
epicatechin
resulting
synthesis
hydride
Prior art date
Application number
IL15472901A
Other languages
English (en)
Original Assignee
Mars Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mars Inc filed Critical Mars Inc
Publication of IL154729A0 publication Critical patent/IL154729A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL15472901A 2000-09-05 2001-08-21 SYNTHESIS OF 4alpha-ARYLEPICATECHINS IL154729A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/655,360 US6476241B1 (en) 2000-09-05 2000-09-05 Synthesis of 4α-arylepicatechins
PCT/US2001/026175 WO2002020506A2 (en) 2000-09-05 2001-08-21 SYNTHESIS OF 4α-ARYLEPICATECHINS

Publications (1)

Publication Number Publication Date
IL154729A0 true IL154729A0 (en) 2003-10-31

Family

ID=24628579

Family Applications (1)

Application Number Title Priority Date Filing Date
IL15472901A IL154729A0 (en) 2000-09-05 2001-08-21 SYNTHESIS OF 4alpha-ARYLEPICATECHINS

Country Status (11)

Country Link
US (4) US6476241B1 (zh)
EP (1) EP1317437B1 (zh)
JP (1) JP2004508362A (zh)
CN (1) CN100358885C (zh)
AT (1) ATE374759T1 (zh)
AU (2) AU2001283472B2 (zh)
CA (1) CA2421513A1 (zh)
DE (1) DE60130785D1 (zh)
IL (1) IL154729A0 (zh)
RU (1) RU2281942C2 (zh)
WO (1) WO2002020506A2 (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207842B1 (en) 1997-10-09 2001-03-27 Mars Incorporated Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
US7015338B1 (en) 1999-04-15 2006-03-21 Mars Incorporated Synthetic methods for preparing procyanidin oligomers
US6476241B1 (en) * 2000-09-05 2002-11-05 Mars Incorporated Synthesis of 4α-arylepicatechins
ES2349633T3 (es) * 2002-10-01 2011-01-07 Nellcor Puritan Bennett Llc Uso de una cinta para la cabeza para indicar la tensión y sistema que comprende un sensor de oximetría y una cinta para la cabeza.
US7067679B2 (en) * 2002-10-02 2006-06-27 Mars, Inc. Synthesis of dimeric, trimeric, tetrameric pentameric, and higher oligomeric epicatechin-derived procyanidins having 4,8-interflavan linkages and their use to inhibit cancer cell growth through cell cycle arrest
WO2005089262A2 (en) 2004-03-12 2005-09-29 University Of Georgia Research Foundation, Inc. Novel peanut skin extract as a vaccine adjuvant
EP2522347A1 (en) 2005-06-29 2012-11-14 Mars Incorporated Flavonols and procyanidins for inducing peripheral blood vessel vasodilation
US20070004796A1 (en) * 2005-06-29 2007-01-04 Romanczyk Leo Jr Processes for the preparation of protected-(+)-catechin and (-)-epicatechin monomers, for coupling the protected monomers with an activated, protected epicatechin monomer, and for the preparation of epicatechin-(4B,8)-epicatechin or -catechin dimers and their digallates
US20100048920A1 (en) * 2005-06-29 2010-02-25 Mars, Incorporated Preparation of (+)-Catechin, (-)-Epicatechin, (-)-Catechin, and (+)-Epicatechin and Their 5,7,3',4'-Tetra-O-Benzyl Analogues
US20080145919A1 (en) * 2006-12-18 2008-06-19 Franklin Thomas D Portable organ and tissue preservation apparatus, kit and methods
JP5290558B2 (ja) * 2007-10-10 2013-09-18 株式会社エヌ・ティー・エイチ ナチュラルヘナ抽出物とその用途
US20120095063A1 (en) * 2009-04-17 2012-04-19 Francisco Villareal Methods and compositions for treatment of ischemic conditions and conditions related to mitochondrial function
MX2012012567A (es) 2010-04-28 2012-11-21 Kimberly Clark Co Metodo para aumentar la permeabilidad de una barrera epitelial.
JP5890846B2 (ja) * 2011-01-27 2016-03-22 スファエラ ファーマ ピーティーイー リミテッド ポリフェノールの新規合成方法
WO2014115174A2 (en) * 2013-01-26 2014-07-31 Sphaera Pharma Pvt. Ltd. Novel approach for synthesis of catechins

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1493976C3 (de) 1964-01-18 1973-09-13 Merck Patent Gmbh, 6100 Darmstadt Substituierte Flavandenvate sowie Verfahren zu ihrer Herstellung
US4255336A (en) 1977-11-25 1981-03-10 Ciba-Geigy Corporation Process for the preparation of O-substituted derivatives of (+)-cyanidan-3-01
GB2122608B (en) * 1982-06-01 1985-10-02 Zyma Sa (+)-cyanidan-3-ol derivatives
ES2078339T3 (es) 1989-05-12 1995-12-16 Cariel Leon Composiciones a base de proantocianidoles; su aplicacion farmacologica.
US5554645A (en) 1994-10-03 1996-09-10 Mars, Incorporated Antineoplastic cocoa extracts and methods for making and using the same
US6207842B1 (en) * 1997-10-09 2001-03-27 Mars Incorporated Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
EP1026164A1 (en) 1999-02-02 2000-08-09 ADM Cocoa B.V. Process for extracting polyphenolic antioxidants from purine-containing plants
US6156912A (en) * 1999-04-09 2000-12-05 Mars, Incorporated 88, 66, and 68 catechin and epicatechin dimers and methods for their preparation
US7015338B1 (en) * 1999-04-15 2006-03-21 Mars Incorporated Synthetic methods for preparing procyanidin oligomers
US6476241B1 (en) * 2000-09-05 2002-11-05 Mars Incorporated Synthesis of 4α-arylepicatechins
US6420972B1 (en) * 2000-10-18 2002-07-16 Wms Gaming, Inc. Door monitor for a gaming machine
US7067679B2 (en) * 2002-10-02 2006-06-27 Mars, Inc. Synthesis of dimeric, trimeric, tetrameric pentameric, and higher oligomeric epicatechin-derived procyanidins having 4,8-interflavan linkages and their use to inhibit cancer cell growth through cell cycle arrest
CA2499549C (en) * 2002-10-11 2012-01-24 Proteotech, Inc. Isolation, purification and synthesis of procyanidin b2 and uses thereof
US7756362B2 (en) * 2005-01-28 2010-07-13 Canon Kabushiki Kaisha Image processing apparatus, control method therefor, computer program, and computer-readable storage medium

Also Published As

Publication number Publication date
US20030100775A1 (en) 2003-05-29
US7126014B2 (en) 2006-10-24
ATE374759T1 (de) 2007-10-15
CA2421513A1 (en) 2002-03-14
EP1317437B1 (en) 2007-10-03
AU2001283472B9 (en) 2002-03-22
CN100358885C (zh) 2008-01-02
AU2001283472B2 (en) 2007-05-24
EP1317437A2 (en) 2003-06-11
US6720432B2 (en) 2004-04-13
RU2281942C2 (ru) 2006-08-20
US6476241B1 (en) 2002-11-05
US20070197804A1 (en) 2007-08-23
AU8347201A (en) 2002-03-22
WO2002020506A2 (en) 2002-03-14
US20050014958A1 (en) 2005-01-20
DE60130785D1 (de) 2007-11-15
JP2004508362A (ja) 2004-03-18
WO2002020506A3 (en) 2003-02-06
CN1473159A (zh) 2004-02-04

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