IL154456A - S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomiting - Google Patents

S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomiting

Info

Publication number
IL154456A
IL154456A IL154456A IL15445603A IL154456A IL 154456 A IL154456 A IL 154456A IL 154456 A IL154456 A IL 154456A IL 15445603 A IL15445603 A IL 15445603A IL 154456 A IL154456 A IL 154456A
Authority
IL
Israel
Prior art keywords
migraine
headache
compound
nausea
ethylisothiouronium
Prior art date
Application number
IL154456A
Other languages
English (en)
Hebrew (he)
Inventor
Raphael Barkan
Alexander Mirimsky
Original Assignee
Raphael Barkan
Alexander Mirimsky
Meditor Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL14463201A external-priority patent/IL144632A0/xx
Application filed by Raphael Barkan, Alexander Mirimsky, Meditor Pharmaceuticals Ltd filed Critical Raphael Barkan
Priority to IL154456A priority Critical patent/IL154456A/en
Publication of IL154456A publication Critical patent/IL154456A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
IL154456A 2000-09-05 2003-02-13 S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomiting IL154456A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL154456A IL154456A (en) 2000-09-05 2003-02-13 S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomiting

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22981200P 2000-09-05 2000-09-05
IL14463201A IL144632A0 (en) 2001-07-30 2001-07-30 Method and pharmaceutical compositions for treating headache, nausea and migraine
PCT/IL2001/000817 WO2002019961A2 (en) 2000-09-05 2001-08-30 Pharmaceutical compositions for headache, migraine, nausea and emesis
IL154456A IL154456A (en) 2000-09-05 2003-02-13 S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomiting

Publications (1)

Publication Number Publication Date
IL154456A true IL154456A (en) 2013-05-30

Family

ID=26324036

Family Applications (1)

Application Number Title Priority Date Filing Date
IL154456A IL154456A (en) 2000-09-05 2003-02-13 S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomiting

Country Status (22)

Country Link
US (2) US7148208B2 (pt)
EP (1) EP1315505B1 (pt)
JP (1) JP2004508311A (pt)
KR (1) KR100849999B1 (pt)
CN (1) CN100448439C (pt)
AT (1) ATE375797T1 (pt)
AU (2) AU2001286178B2 (pt)
BR (1) BR0113698A (pt)
CA (1) CA2420410C (pt)
CY (1) CY1107270T1 (pt)
DE (1) DE60131004T2 (pt)
DK (1) DK1315505T3 (pt)
ES (1) ES2296792T3 (pt)
HK (1) HK1058009A1 (pt)
HU (1) HUP0302362A3 (pt)
IL (1) IL154456A (pt)
MD (1) MD2447G2 (pt)
MX (1) MXPA03001737A (pt)
NO (1) NO20031902L (pt)
NZ (1) NZ524903A (pt)
PT (1) PT1315505E (pt)
WO (1) WO2002019961A2 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0302362A3 (en) * 2000-09-05 2005-05-30 Meditor Pharmaceuticals Ltd Pharmaceutical compositions for headache, migraine, nausea and emesis
US20090186854A1 (en) * 2006-03-23 2009-07-23 Meditor Pharmaceuticals Ltd. S-alkylisothiouronium derivatives for the treatment of inflammatory diseases
WO2008152619A1 (en) * 2007-06-13 2008-12-18 Meditor Pharmaceuticals Ltd. Taste masked pharmaceutical compositions of s-alkylisothiouronium derivatives
WO2009060451A2 (en) * 2007-11-06 2009-05-14 Barkan-Farma S.R.L. S-alkylisothiouronium derivatives for treating uterine hypercontractility disorders
MD3619G2 (ro) * 2007-11-06 2009-01-31 Рафаэль Баркан Remediu medicamentos nazal cu acţiune anticongestivă
US12011423B2 (en) 2007-11-06 2024-06-18 Foraviset Ltd. S-alkylisothiouronium derivatives for treating uterine hypercontractility disorders
US20100063368A1 (en) * 2008-04-24 2010-03-11 Searete Llc, A Limited Liability Corporation Computational system and method for memory modification
US9449150B2 (en) 2008-04-24 2016-09-20 The Invention Science Fund I, Llc Combination treatment selection methods and systems
US20100130811A1 (en) * 2008-04-24 2010-05-27 Searete Llc Computational system and method for memory modification
US9662391B2 (en) 2008-04-24 2017-05-30 The Invention Science Fund I Llc Side effect ameliorating combination therapeutic products and systems
US9282927B2 (en) 2008-04-24 2016-03-15 Invention Science Fund I, Llc Methods and systems for modifying bioactive agent use
US20100069724A1 (en) * 2008-04-24 2010-03-18 Searete Llc Computational system and method for memory modification
US8930208B2 (en) 2008-04-24 2015-01-06 The Invention Science Fund I, Llc Methods and systems for detecting a bioactive agent effect
US9560967B2 (en) 2008-04-24 2017-02-07 The Invention Science Fund I Llc Systems and apparatus for measuring a bioactive agent effect
US8606592B2 (en) 2008-04-24 2013-12-10 The Invention Science Fund I, Llc Methods and systems for monitoring bioactive agent use
US8682687B2 (en) 2008-04-24 2014-03-25 The Invention Science Fund I, Llc Methods and systems for presenting a combination treatment
US8876688B2 (en) 2008-04-24 2014-11-04 The Invention Science Fund I, Llc Combination treatment modification methods and systems
US9649469B2 (en) 2008-04-24 2017-05-16 The Invention Science Fund I Llc Methods and systems for presenting a combination treatment
US9064036B2 (en) 2008-04-24 2015-06-23 The Invention Science Fund I, Llc Methods and systems for monitoring bioactive agent use
US8615407B2 (en) 2008-04-24 2013-12-24 The Invention Science Fund I, Llc Methods and systems for detecting a bioactive agent effect
US20090270687A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for modifying bioactive agent use
US9239906B2 (en) 2008-04-24 2016-01-19 The Invention Science Fund I, Llc Combination treatment selection methods and systems
US9026369B2 (en) 2008-04-24 2015-05-05 The Invention Science Fund I, Llc Methods and systems for presenting a combination treatment
US7974787B2 (en) * 2008-04-24 2011-07-05 The Invention Science Fund I, Llc Combination treatment alteration methods and systems
US8357117B2 (en) * 2008-08-06 2013-01-22 Family Health International Device and method for delivering an agent into breast milk while breastfeeding
WO2012018341A1 (en) * 2010-08-05 2012-02-09 Family Health International Device and method for delivering an agent into breast milk while breastfeeding
CN109523244B (zh) * 2018-11-02 2023-06-27 创新先进技术有限公司 一种基于母子账户的用于转移款项数据的方法和系统

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2419675A1 (fr) * 1978-03-16 1979-10-12 Philagro Sa Compositions fongicides a base de phosphites d'isothiouronium
GB9418912D0 (en) * 1994-09-20 1994-11-09 Fisons Corp Pharmaceutically active compounds
MD263C2 (ro) * 1995-03-01 1995-12-31 Виктор ГИКАВЫЙ Remediu cu acţiune antihipotensivă "IZOTURON"
MD586C2 (ro) * 1995-05-25 1997-03-31 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Substanţă medicamentoasă cu acţiune antihipotensivă "Difetur"
FR2753098B1 (fr) * 1996-09-06 1998-11-27 Sod Conseils Rech Applic Composition pharmaceutique comprenant au moins un inhibiteur de no synthase et au moins un piegeur des formes reactives de l'oxygene
DK0928191T3 (da) * 1996-09-26 2002-12-30 Meditor Pharmaceuticals Ltd Farmaceutiske præparater indeholdende S-alkylisothiouroniumderivater
WO1998019674A2 (en) * 1996-11-05 1998-05-14 Head Explorer Aps A method for treating tension-type headache
MD1138C2 (ro) * 1997-02-17 1999-07-31 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Izopropilfosfit-S-izopropilizotiuroniu- substanţă cu acţiune hipertensivă
MD1223C2 (ro) * 1997-07-15 2000-01-31 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Aplicarea dimetilfosfatului de S-metil-izo-tiouroniu în calitate de substanţă vasoconstrictoare şi preparat farmaceutic pe baza lui
US6127420A (en) * 1997-08-22 2000-10-03 The Medical College Of Wisconsin Research Foundation, Inc. L-N5 -(1-imino-3-alkenyl) ornithine and related compounds and use thereof
MD1431G2 (ro) * 1998-01-16 2001-02-28 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Remedii antihipotensive
US6093743A (en) * 1998-06-23 2000-07-25 Medinox Inc. Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor
FR2788771B1 (fr) * 1999-01-22 2001-04-13 Pf Medicament Nouvelles 1,2-alcoyl-1-[1-[aryl (alcoyl) oxyalcoyl] piperidin-4-yl]-3-aryl isothiourees substituees, leur preparation et leur application en therapeutique
WO2000051623A2 (en) * 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
CN101850120A (zh) * 1999-07-21 2010-10-06 奥默罗斯公司 用于抑制疼痛,炎症和软骨退化的溶液及方法
HUP0302362A3 (en) * 2000-09-05 2005-05-30 Meditor Pharmaceuticals Ltd Pharmaceutical compositions for headache, migraine, nausea and emesis

Also Published As

Publication number Publication date
BR0113698A (pt) 2003-12-09
MD20020139A (en) 2002-11-30
HUP0302362A3 (en) 2005-05-30
EP1315505A2 (en) 2003-06-04
WO2002019961A3 (en) 2002-08-15
CN1464788A (zh) 2003-12-31
CA2420410A1 (en) 2002-03-14
AU2001286178B2 (en) 2006-09-14
HK1058009A1 (en) 2004-04-30
EP1315505A4 (en) 2006-02-22
WO2002019961A2 (en) 2002-03-14
CY1107270T1 (el) 2012-11-21
NZ524903A (en) 2004-11-26
HUP0302362A2 (hu) 2003-11-28
US8673979B2 (en) 2014-03-18
CA2420410C (en) 2011-04-26
CN100448439C (zh) 2009-01-07
DE60131004D1 (de) 2007-11-29
NO20031902D0 (no) 2003-04-28
EP1315505B1 (en) 2007-10-17
DE60131004T2 (de) 2008-07-31
AU8617801A (en) 2002-03-22
US7148208B2 (en) 2006-12-12
JP2004508311A (ja) 2004-03-18
KR20030055257A (ko) 2003-07-02
KR100849999B1 (ko) 2008-08-01
MD2447G2 (ro) 2005-12-31
ATE375797T1 (de) 2007-11-15
MD2447F2 (en) 2004-05-31
US20040006044A1 (en) 2004-01-08
DK1315505T3 (da) 2008-03-03
ES2296792T3 (es) 2008-05-01
US20070088005A1 (en) 2007-04-19
NO20031902L (no) 2003-06-09
PT1315505E (pt) 2008-01-28
MXPA03001737A (es) 2004-09-10

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees