MD1223C2 - Aplicarea dimetilfosfatului de S-metil-izo-tiouroniu în calitate de substanţă vasoconstrictoare şi preparat farmaceutic pe baza lui - Google Patents
Aplicarea dimetilfosfatului de S-metil-izo-tiouroniu în calitate de substanţă vasoconstrictoare şi preparat farmaceutic pe baza lui Download PDFInfo
- Publication number
- MD1223C2 MD1223C2 MD97-0201A MD970201A MD1223C2 MD 1223 C2 MD1223 C2 MD 1223C2 MD 970201 A MD970201 A MD 970201A MD 1223 C2 MD1223 C2 MD 1223C2
- Authority
- MD
- Moldova
- Prior art keywords
- base
- pharmaceutical preparation
- compound
- dimethyl phosphate
- application
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000005526 vasoconstrictor agent Substances 0.000 title abstract 3
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- YFEHFLUEQSONBX-UHFFFAOYSA-N [amino(methylsulfanyl)methylidene]azanium;dimethyl phosphate Chemical compound CSC(N)=N.COP(O)(=O)OC YFEHFLUEQSONBX-UHFFFAOYSA-N 0.000 title 1
- KKUKTXOBAWVSHC-UHFFFAOYSA-N Dimethylphosphate Chemical compound COP(O)(=O)OC KKUKTXOBAWVSHC-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000036543 hypotension Effects 0.000 abstract 1
- 231100001231 less toxic Toxicity 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 229960003733 phenylephrine hydrochloride Drugs 0.000 abstract 1
- OCYSGIYOVXAGKQ-FVGYRXGTSA-N phenylephrine hydrochloride Chemical compound [H+].[Cl-].CNC[C@H](O)C1=CC=CC(O)=C1 OCYSGIYOVXAGKQ-FVGYRXGTSA-N 0.000 abstract 1
- 150000003585 thioureas Chemical class 0.000 abstract 1
- 230000003639 vasoconstrictive effect Effects 0.000 abstract 1
- 230000024883 vasodilation Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Invenţia se referă la farmacologie şi poate fi folosită în tratamentul diferitelor afecţiuni patologice însoţite de vasodilataţie.Esenþa invenþiei constã în faptul cã în calitate de substanþã vasoconstrictoare miotropã se propune un derivat de tiouree - dimetilfosfatul de S-metilizotiouroniu, de asemenea se propune ºi un preparat farmaceutic pe baza lui.Compusul dat posedã o acþiune vasoconstrictoare asemãnãtoare dupã intensitatea efectului cu difeturul sau izoturonul ºi mezatonul, dar având corespunzãtor o duratã de acþiune de 5 ºi 6 ori mai mare. Totodatã substanþa propusã este mai puþin toxicã (DL = 478 mg/kilocorp), nu provoacã hipotensiune secundarã.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD97-0201A MD1223C2 (ro) | 1997-07-15 | 1997-07-15 | Aplicarea dimetilfosfatului de S-metil-izo-tiouroniu în calitate de substanţă vasoconstrictoare şi preparat farmaceutic pe baza lui |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MD97-0201A MD1223C2 (ro) | 1997-07-15 | 1997-07-15 | Aplicarea dimetilfosfatului de S-metil-izo-tiouroniu în calitate de substanţă vasoconstrictoare şi preparat farmaceutic pe baza lui |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MD1223B1 MD1223B1 (ro) | 1999-05-31 |
| MD1223C2 true MD1223C2 (ro) | 2000-01-31 |
Family
ID=19739036
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MD97-0201A MD1223C2 (ro) | 1997-07-15 | 1997-07-15 | Aplicarea dimetilfosfatului de S-metil-izo-tiouroniu în calitate de substanţă vasoconstrictoare şi preparat farmaceutic pe baza lui |
Country Status (1)
| Country | Link |
|---|---|
| MD (1) | MD1223C2 (ro) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD1431G2 (ro) * | 1998-01-16 | 2001-02-28 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Remedii antihipotensive |
| MD2228G2 (ro) * | 2003-01-21 | 2004-02-29 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Utilizarea derivaţiilor izotiouronici în tratamentul şi profilaxia atoniei intestinale |
| MD3644G2 (ro) * | 2008-03-17 | 2009-02-28 | Рафаэль Баркан | Preparat pentru tratamentul algodismenoreei |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2296792T3 (es) * | 2000-09-05 | 2008-05-01 | Meditor Pharmaceuticals Ltd. | Composiciones farmaceuticas para cefalea, ,migraña, nauseas y emesis. |
| MD2850G2 (ro) * | 2005-02-18 | 2006-07-31 | Валентин ФРИПТУ | Metodă de inducere a avortului medicamentos |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD185B1 (ro) * | 1989-05-12 | 1995-04-30 | Univ De Stat De Medinica N Tes | Metoda de tratament al socului |
| MD586B1 (ro) * | 1995-05-25 | 1996-07-31 | Univ Nicolae Testemitanu | Substanta medicamentoasa cu actiune antihipotensiva "Difetur" |
-
1997
- 1997-07-15 MD MD97-0201A patent/MD1223C2/ro unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD185B1 (ro) * | 1989-05-12 | 1995-04-30 | Univ De Stat De Medinica N Tes | Metoda de tratament al socului |
| MD586B1 (ro) * | 1995-05-25 | 1996-07-31 | Univ Nicolae Testemitanu | Substanta medicamentoasa cu actiune antihipotensiva "Difetur" |
Non-Patent Citations (1)
| Title |
|---|
| Мухин Е.А., Гикавый В.И., Парий Б.И. Гипертензивные средства. 1983, Штиинца (Кишинев) * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD1431G2 (ro) * | 1998-01-16 | 2001-02-28 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Remedii antihipotensive |
| MD2228G2 (ro) * | 2003-01-21 | 2004-02-29 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Utilizarea derivaţiilor izotiouronici în tratamentul şi profilaxia atoniei intestinale |
| MD3644G2 (ro) * | 2008-03-17 | 2009-02-28 | Рафаэль Баркан | Preparat pentru tratamentul algodismenoreei |
Also Published As
| Publication number | Publication date |
|---|---|
| MD1223B1 (ro) | 1999-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PD99 | Pending application |