HUP0302362A2 - Fejfájás, migrén, émelygés és hányás kezelésére alkalmas gyógyászati készítmény - Google Patents
Fejfájás, migrén, émelygés és hányás kezelésére alkalmas gyógyászati készítményInfo
- Publication number
- HUP0302362A2 HUP0302362A2 HU0302362A HUP0302362A HUP0302362A2 HU P0302362 A2 HUP0302362 A2 HU P0302362A2 HU 0302362 A HU0302362 A HU 0302362A HU P0302362 A HUP0302362 A HU P0302362A HU P0302362 A2 HUP0302362 A2 HU P0302362A2
- Authority
- HU
- Hungary
- Prior art keywords
- alkyl
- straight
- nausea
- headache
- vomiting
- Prior art date
Links
- 206010019233 Headaches Diseases 0.000 title abstract 4
- 208000019695 Migraine disease Diseases 0.000 title abstract 4
- 206010047700 Vomiting Diseases 0.000 title abstract 4
- 231100000869 headache Toxicity 0.000 title abstract 4
- 206010027599 migraine Diseases 0.000 title abstract 3
- 206010028813 Nausea Diseases 0.000 title 1
- 230000008693 nausea Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 nitro, amino Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000008051 alkyl sulfates Chemical group 0.000 abstract 1
- 125000005360 alkyl sulfoxide group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 125000005362 aryl sulfone group Chemical group 0.000 abstract 1
- 125000005361 aryl sulfoxide group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- CTYRPMDGLDAWRQ-UHFFFAOYSA-N phenyl hydrogen sulfate Chemical group OS(=O)(=O)OC1=CC=CC=C1 CTYRPMDGLDAWRQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003138 primary alcohols Chemical class 0.000 abstract 1
- 150000003141 primary amines Chemical class 0.000 abstract 1
- CSYSULGPHGCBQD-UHFFFAOYSA-N s-ethylisothiouronium diethylphosphate Chemical compound CCSC(N)=N.CCOP(O)(=O)OCC CSYSULGPHGCBQD-UHFFFAOYSA-N 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 150000003333 secondary alcohols Chemical class 0.000 abstract 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 150000003456 sulfonamides Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
- 150000003509 tertiary alcohols Chemical class 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
- 125000005309 thioalkoxy group Chemical group 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
- 230000008673 vomiting Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Otolaryngology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A találmány tárgya S-alkil-izo-tio-urónium származékok, nem korlátozómódon ideértve az S-etil-izo-tio-urónium-dietil-foszfátot, a fejfájás(beleértve a migrént, de nem korlátozódva arra), illetve a hányásmegelőzésére, illetve kezelésére, különösen a migrénes tünetek, nemkorlátozó módon ideértve a fejfájást, émelygést és hányást,enyhítésére. A gyógyászati kompozíció hatékony fejfájás, migrén,émelygés, illetve hányás kezelésére, amely aktív hatóanyagként az (I)általános képletű vegyületet tartalmazza. A képletben R1 jelentése 1-8szénatomos, egyenes vagy elágazó láncú, telített vagy telítetlenalkiléncsoport, amely az alábbi csoportok közül lehet eggyel vagytöbbel helyettesítve: halogénatom, primer, szekunder vagy tercieramin, primer, szekunder vagy tercier alkohol, s a láncbanelőfordulhatnak az alábbi heteroatomok: O, N, S; R2, R3, R4 és R5jelentése egymástól függetlenül hidrogén, hidroxil, egyenes vagyelágazó szénláncú alacsonyabb szénatomszámú alkil, egyenes vagyelágazó szénláncú alacsonyabb szénatomszámú alkenil, egyenes vagyelágazó szénláncú alacsonyabb szénatomszámú alkinil, alacsonyabbszénatomszámú alkoxi, alkoxi-alkil, cikloalkil, cikloalkil-alkil,alacsony szénatomszámú tio-alkoxi, nitro, amino, ciano, szulfonil,halogénalkil, karbo-ariloxi, karbo-alkil-aril-oxi, alkil-szulfoxid,aril-szulfoxid, alkil-szulfon, aril-szulfon, alkil-szulfát, aril-szulfát, szulfonamid, tio-alkil, amely adott esetben halogénatommalvan szubsztituálva; A- jelentése fiziológiailag elviselhető anion. Ó
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22981200P | 2000-09-05 | 2000-09-05 | |
IL14463201A IL144632A0 (en) | 2001-07-30 | 2001-07-30 | Method and pharmaceutical compositions for treating headache, nausea and migraine |
PCT/IL2001/000817 WO2002019961A2 (en) | 2000-09-05 | 2001-08-30 | Pharmaceutical compositions for headache, migraine, nausea and emesis |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0302362A2 true HUP0302362A2 (hu) | 2003-11-28 |
HUP0302362A3 HUP0302362A3 (en) | 2005-05-30 |
Family
ID=26324036
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0302362A HUP0302362A3 (en) | 2000-09-05 | 2001-08-30 | Pharmaceutical compositions for headache, migraine, nausea and emesis |
Country Status (22)
Country | Link |
---|---|
US (2) | US7148208B2 (hu) |
EP (1) | EP1315505B1 (hu) |
JP (1) | JP2004508311A (hu) |
KR (1) | KR100849999B1 (hu) |
CN (1) | CN100448439C (hu) |
AT (1) | ATE375797T1 (hu) |
AU (2) | AU2001286178B2 (hu) |
BR (1) | BR0113698A (hu) |
CA (1) | CA2420410C (hu) |
CY (1) | CY1107270T1 (hu) |
DE (1) | DE60131004T2 (hu) |
DK (1) | DK1315505T3 (hu) |
ES (1) | ES2296792T3 (hu) |
HK (1) | HK1058009A1 (hu) |
HU (1) | HUP0302362A3 (hu) |
IL (1) | IL154456A (hu) |
MD (1) | MD2447G2 (hu) |
MX (1) | MXPA03001737A (hu) |
NO (1) | NO20031902L (hu) |
NZ (1) | NZ524903A (hu) |
PT (1) | PT1315505E (hu) |
WO (1) | WO2002019961A2 (hu) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ524903A (en) * | 2000-09-05 | 2004-11-26 | Meditor Pharmaceuticals Ltd | Pharmaceutical compositions comprising S-alkylisothiouronium derivatives for headache, migraine, nausea and emesis |
WO2007108004A2 (en) * | 2006-03-23 | 2007-09-27 | Meditor Pharmaceuticals Ltd. | S-alkylisothiouronium derivatives for the treatment of inflammatory diseases |
EA200901591A1 (ru) * | 2007-06-13 | 2010-06-30 | Медитор Фармасьютикалс Лтд. | Фармацевтические композиции производных s-алкилизотиоурония с маскированным вкусом |
EP2219447B1 (en) * | 2007-11-06 | 2013-07-03 | Barkan-Farma S.r.l. | S-alkylisothiouronium derivatives for treating uterine hypercontractility disorders |
MD3619G2 (ro) * | 2007-11-06 | 2009-01-31 | Рафаэль Баркан | Remediu medicamentos nazal cu acţiune anticongestivă |
US9560967B2 (en) | 2008-04-24 | 2017-02-07 | The Invention Science Fund I Llc | Systems and apparatus for measuring a bioactive agent effect |
US9282927B2 (en) | 2008-04-24 | 2016-03-15 | Invention Science Fund I, Llc | Methods and systems for modifying bioactive agent use |
US20100069724A1 (en) * | 2008-04-24 | 2010-03-18 | Searete Llc | Computational system and method for memory modification |
US8682687B2 (en) | 2008-04-24 | 2014-03-25 | The Invention Science Fund I, Llc | Methods and systems for presenting a combination treatment |
US9449150B2 (en) | 2008-04-24 | 2016-09-20 | The Invention Science Fund I, Llc | Combination treatment selection methods and systems |
US20100063368A1 (en) * | 2008-04-24 | 2010-03-11 | Searete Llc, A Limited Liability Corporation | Computational system and method for memory modification |
US8876688B2 (en) | 2008-04-24 | 2014-11-04 | The Invention Science Fund I, Llc | Combination treatment modification methods and systems |
US8615407B2 (en) | 2008-04-24 | 2013-12-24 | The Invention Science Fund I, Llc | Methods and systems for detecting a bioactive agent effect |
US8930208B2 (en) | 2008-04-24 | 2015-01-06 | The Invention Science Fund I, Llc | Methods and systems for detecting a bioactive agent effect |
US8606592B2 (en) | 2008-04-24 | 2013-12-10 | The Invention Science Fund I, Llc | Methods and systems for monitoring bioactive agent use |
US9662391B2 (en) | 2008-04-24 | 2017-05-30 | The Invention Science Fund I Llc | Side effect ameliorating combination therapeutic products and systems |
US9239906B2 (en) | 2008-04-24 | 2016-01-19 | The Invention Science Fund I, Llc | Combination treatment selection methods and systems |
US9649469B2 (en) | 2008-04-24 | 2017-05-16 | The Invention Science Fund I Llc | Methods and systems for presenting a combination treatment |
US9064036B2 (en) | 2008-04-24 | 2015-06-23 | The Invention Science Fund I, Llc | Methods and systems for monitoring bioactive agent use |
US7974787B2 (en) * | 2008-04-24 | 2011-07-05 | The Invention Science Fund I, Llc | Combination treatment alteration methods and systems |
US9026369B2 (en) | 2008-04-24 | 2015-05-05 | The Invention Science Fund I, Llc | Methods and systems for presenting a combination treatment |
US20100130811A1 (en) * | 2008-04-24 | 2010-05-27 | Searete Llc | Computational system and method for memory modification |
US20090270687A1 (en) * | 2008-04-24 | 2009-10-29 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Methods and systems for modifying bioactive agent use |
US8357117B2 (en) * | 2008-08-06 | 2013-01-22 | Family Health International | Device and method for delivering an agent into breast milk while breastfeeding |
WO2012018341A1 (en) * | 2010-08-05 | 2012-02-09 | Family Health International | Device and method for delivering an agent into breast milk while breastfeeding |
CN109523244B (zh) * | 2018-11-02 | 2023-06-27 | 创新先进技术有限公司 | 一种基于母子账户的用于转移款项数据的方法和系统 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2419675A1 (fr) * | 1978-03-16 | 1979-10-12 | Philagro Sa | Compositions fongicides a base de phosphites d'isothiouronium |
GB9418912D0 (en) * | 1994-09-20 | 1994-11-09 | Fisons Corp | Pharmaceutically active compounds |
MD263C2 (ro) * | 1995-03-01 | 1995-12-31 | Виктор ГИКАВЫЙ | Remediu cu acţiune antihipotensivă "IZOTURON" |
MD586C2 (ro) * | 1995-05-25 | 1997-03-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Substanţă medicamentoasă cu acţiune antihipotensivă "Difetur" |
FR2753098B1 (fr) * | 1996-09-06 | 1998-11-27 | Sod Conseils Rech Applic | Composition pharmaceutique comprenant au moins un inhibiteur de no synthase et au moins un piegeur des formes reactives de l'oxygene |
EP0928191B1 (en) * | 1996-09-26 | 2002-08-28 | Meditor Pharmaceuticals Ltd. | Pharmaceutical compositions comprising s-alkylisothiouronium derivatives |
WO1998019674A2 (en) * | 1996-11-05 | 1998-05-14 | Head Explorer Aps | A method for treating tension-type headache |
MD1138C2 (ro) * | 1997-02-17 | 1999-07-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Izopropilfosfit-S-izopropilizotiuroniu- substanţă cu acţiune hipertensivă |
MD1223C2 (ro) * | 1997-07-15 | 2000-01-31 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Aplicarea dimetilfosfatului de S-metil-izo-tiouroniu în calitate de substanţă vasoconstrictoare şi preparat farmaceutic pe baza lui |
US6127420A (en) * | 1997-08-22 | 2000-10-03 | The Medical College Of Wisconsin Research Foundation, Inc. | L-N5 -(1-imino-3-alkenyl) ornithine and related compounds and use thereof |
MD1431G2 (ro) * | 1998-01-16 | 2001-02-28 | Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова | Remedii antihipotensive |
US6093743A (en) * | 1998-06-23 | 2000-07-25 | Medinox Inc. | Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor |
FR2788771B1 (fr) * | 1999-01-22 | 2001-04-13 | Pf Medicament | Nouvelles 1,2-alcoyl-1-[1-[aryl (alcoyl) oxyalcoyl] piperidin-4-yl]-3-aryl isothiourees substituees, leur preparation et leur application en therapeutique |
US6489308B1 (en) * | 1999-03-05 | 2002-12-03 | Trustees Of University Of Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of nitric-oxide-induced clinical conditions |
ATE399025T1 (de) * | 1999-07-21 | 2008-07-15 | Omeros Corp | Spüllösungen und verfahren zur schmerzhemmung, entzündungshemmung und hemmung des knorpelabbaus |
NZ524903A (en) * | 2000-09-05 | 2004-11-26 | Meditor Pharmaceuticals Ltd | Pharmaceutical compositions comprising S-alkylisothiouronium derivatives for headache, migraine, nausea and emesis |
-
2001
- 2001-08-30 NZ NZ524903A patent/NZ524903A/en not_active IP Right Cessation
- 2001-08-30 HU HU0302362A patent/HUP0302362A3/hu unknown
- 2001-08-30 AU AU2001286178A patent/AU2001286178B2/en not_active Ceased
- 2001-08-30 JP JP2002524446A patent/JP2004508311A/ja active Pending
- 2001-08-30 KR KR1020037003277A patent/KR100849999B1/ko not_active IP Right Cessation
- 2001-08-30 CA CA2420410A patent/CA2420410C/en not_active Expired - Fee Related
- 2001-08-30 DE DE60131004T patent/DE60131004T2/de not_active Expired - Lifetime
- 2001-08-30 CN CNB018151795A patent/CN100448439C/zh not_active Expired - Fee Related
- 2001-08-30 MD MDA20020139A patent/MD2447G2/ro not_active IP Right Cessation
- 2001-08-30 AU AU8617801A patent/AU8617801A/xx active Pending
- 2001-08-30 DK DK01965546T patent/DK1315505T3/da active
- 2001-08-30 AT AT01965546T patent/ATE375797T1/de active
- 2001-08-30 WO PCT/IL2001/000817 patent/WO2002019961A2/en active IP Right Grant
- 2001-08-30 EP EP01965546A patent/EP1315505B1/en not_active Expired - Lifetime
- 2001-08-30 PT PT01965546T patent/PT1315505E/pt unknown
- 2001-08-30 MX MXPA03001737A patent/MXPA03001737A/es active IP Right Grant
- 2001-08-30 ES ES01965546T patent/ES2296792T3/es not_active Expired - Lifetime
- 2001-08-30 BR BR0113698-4A patent/BR0113698A/pt not_active Application Discontinuation
-
2003
- 2003-02-13 IL IL154456A patent/IL154456A/en not_active IP Right Cessation
- 2003-03-05 US US10/382,217 patent/US7148208B2/en not_active Expired - Lifetime
- 2003-04-28 NO NO20031902A patent/NO20031902L/no not_active Application Discontinuation
-
2004
- 2004-02-11 HK HK04100896.1A patent/HK1058009A1/xx not_active IP Right Cessation
-
2006
- 2006-10-18 US US11/550,548 patent/US8673979B2/en not_active Expired - Fee Related
-
2008
- 2008-01-17 CY CY20081100071T patent/CY1107270T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |