IL154456A - S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomiting - Google Patents

S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomiting

Info

Publication number
IL154456A
IL154456A IL154456A IL15445603A IL154456A IL 154456 A IL154456 A IL 154456A IL 154456 A IL154456 A IL 154456A IL 15445603 A IL15445603 A IL 15445603A IL 154456 A IL154456 A IL 154456A
Authority
IL
Israel
Prior art keywords
migraine
headache
compound
nausea
ethylisothiouronium
Prior art date
Application number
IL154456A
Other languages
English (en)
Hebrew (he)
Inventor
Raphael Barkan
Alexander Mirimsky
Original Assignee
Raphael Barkan
Alexander Mirimsky
Meditor Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL14463201A external-priority patent/IL144632A0/xx
Application filed by Raphael Barkan, Alexander Mirimsky, Meditor Pharmaceuticals Ltd filed Critical Raphael Barkan
Priority to IL154456A priority Critical patent/IL154456A/en
Publication of IL154456A publication Critical patent/IL154456A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
IL154456A 2000-09-05 2003-02-13 S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomiting IL154456A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL154456A IL154456A (en) 2000-09-05 2003-02-13 S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomiting

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US22981200P 2000-09-05 2000-09-05
IL14463201A IL144632A0 (en) 2001-07-30 2001-07-30 Method and pharmaceutical compositions for treating headache, nausea and migraine
PCT/IL2001/000817 WO2002019961A2 (en) 2000-09-05 2001-08-30 Pharmaceutical compositions for headache, migraine, nausea and emesis
IL154456A IL154456A (en) 2000-09-05 2003-02-13 S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomiting

Publications (1)

Publication Number Publication Date
IL154456A true IL154456A (en) 2013-05-30

Family

ID=26324036

Family Applications (1)

Application Number Title Priority Date Filing Date
IL154456A IL154456A (en) 2000-09-05 2003-02-13 S-alkylisothiouronium derivatives for the treatment of headache, migraine, nausea and vomiting

Country Status (22)

Country Link
US (2) US7148208B2 (es)
EP (1) EP1315505B1 (es)
JP (1) JP2004508311A (es)
KR (1) KR100849999B1 (es)
CN (1) CN100448439C (es)
AT (1) ATE375797T1 (es)
AU (2) AU2001286178B2 (es)
BR (1) BR0113698A (es)
CA (1) CA2420410C (es)
CY (1) CY1107270T1 (es)
DE (1) DE60131004T2 (es)
DK (1) DK1315505T3 (es)
ES (1) ES2296792T3 (es)
HK (1) HK1058009A1 (es)
HU (1) HUP0302362A3 (es)
IL (1) IL154456A (es)
MD (1) MD2447G2 (es)
MX (1) MXPA03001737A (es)
NO (1) NO20031902L (es)
NZ (1) NZ524903A (es)
PT (1) PT1315505E (es)
WO (1) WO2002019961A2 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ524903A (en) * 2000-09-05 2004-11-26 Meditor Pharmaceuticals Ltd Pharmaceutical compositions comprising S-alkylisothiouronium derivatives for headache, migraine, nausea and emesis
WO2007108004A2 (en) * 2006-03-23 2007-09-27 Meditor Pharmaceuticals Ltd. S-alkylisothiouronium derivatives for the treatment of inflammatory diseases
EA200901591A1 (ru) * 2007-06-13 2010-06-30 Медитор Фармасьютикалс Лтд. Фармацевтические композиции производных s-алкилизотиоурония с маскированным вкусом
EP2219447B1 (en) * 2007-11-06 2013-07-03 Barkan-Farma S.r.l. S-alkylisothiouronium derivatives for treating uterine hypercontractility disorders
MD3619G2 (ro) * 2007-11-06 2009-01-31 Рафаэль Баркан Remediu medicamentos nazal cu acţiune anticongestivă
US9560967B2 (en) 2008-04-24 2017-02-07 The Invention Science Fund I Llc Systems and apparatus for measuring a bioactive agent effect
US9282927B2 (en) 2008-04-24 2016-03-15 Invention Science Fund I, Llc Methods and systems for modifying bioactive agent use
US20100069724A1 (en) * 2008-04-24 2010-03-18 Searete Llc Computational system and method for memory modification
US8682687B2 (en) 2008-04-24 2014-03-25 The Invention Science Fund I, Llc Methods and systems for presenting a combination treatment
US9449150B2 (en) 2008-04-24 2016-09-20 The Invention Science Fund I, Llc Combination treatment selection methods and systems
US20100063368A1 (en) * 2008-04-24 2010-03-11 Searete Llc, A Limited Liability Corporation Computational system and method for memory modification
US8876688B2 (en) 2008-04-24 2014-11-04 The Invention Science Fund I, Llc Combination treatment modification methods and systems
US8615407B2 (en) 2008-04-24 2013-12-24 The Invention Science Fund I, Llc Methods and systems for detecting a bioactive agent effect
US8930208B2 (en) 2008-04-24 2015-01-06 The Invention Science Fund I, Llc Methods and systems for detecting a bioactive agent effect
US8606592B2 (en) 2008-04-24 2013-12-10 The Invention Science Fund I, Llc Methods and systems for monitoring bioactive agent use
US9662391B2 (en) 2008-04-24 2017-05-30 The Invention Science Fund I Llc Side effect ameliorating combination therapeutic products and systems
US9239906B2 (en) 2008-04-24 2016-01-19 The Invention Science Fund I, Llc Combination treatment selection methods and systems
US9649469B2 (en) 2008-04-24 2017-05-16 The Invention Science Fund I Llc Methods and systems for presenting a combination treatment
US9064036B2 (en) 2008-04-24 2015-06-23 The Invention Science Fund I, Llc Methods and systems for monitoring bioactive agent use
US7974787B2 (en) * 2008-04-24 2011-07-05 The Invention Science Fund I, Llc Combination treatment alteration methods and systems
US9026369B2 (en) 2008-04-24 2015-05-05 The Invention Science Fund I, Llc Methods and systems for presenting a combination treatment
US20100130811A1 (en) * 2008-04-24 2010-05-27 Searete Llc Computational system and method for memory modification
US20090270687A1 (en) * 2008-04-24 2009-10-29 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems for modifying bioactive agent use
US8357117B2 (en) * 2008-08-06 2013-01-22 Family Health International Device and method for delivering an agent into breast milk while breastfeeding
WO2012018341A1 (en) * 2010-08-05 2012-02-09 Family Health International Device and method for delivering an agent into breast milk while breastfeeding
CN109523244B (zh) * 2018-11-02 2023-06-27 创新先进技术有限公司 一种基于母子账户的用于转移款项数据的方法和系统

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2419675A1 (fr) * 1978-03-16 1979-10-12 Philagro Sa Compositions fongicides a base de phosphites d'isothiouronium
GB9418912D0 (en) * 1994-09-20 1994-11-09 Fisons Corp Pharmaceutically active compounds
MD263C2 (ro) * 1995-03-01 1995-12-31 Виктор ГИКАВЫЙ Remediu cu acţiune antihipotensivă "IZOTURON"
MD586C2 (ro) * 1995-05-25 1997-03-31 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Substanţă medicamentoasă cu acţiune antihipotensivă "Difetur"
FR2753098B1 (fr) * 1996-09-06 1998-11-27 Sod Conseils Rech Applic Composition pharmaceutique comprenant au moins un inhibiteur de no synthase et au moins un piegeur des formes reactives de l'oxygene
EP0928191B1 (en) * 1996-09-26 2002-08-28 Meditor Pharmaceuticals Ltd. Pharmaceutical compositions comprising s-alkylisothiouronium derivatives
WO1998019674A2 (en) * 1996-11-05 1998-05-14 Head Explorer Aps A method for treating tension-type headache
MD1138C2 (ro) * 1997-02-17 1999-07-31 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Izopropilfosfit-S-izopropilizotiuroniu- substanţă cu acţiune hipertensivă
MD1223C2 (ro) * 1997-07-15 2000-01-31 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Aplicarea dimetilfosfatului de S-metil-izo-tiouroniu în calitate de substanţă vasoconstrictoare şi preparat farmaceutic pe baza lui
US6127420A (en) * 1997-08-22 2000-10-03 The Medical College Of Wisconsin Research Foundation, Inc. L-N5 -(1-imino-3-alkenyl) ornithine and related compounds and use thereof
MD1431G2 (ro) * 1998-01-16 2001-02-28 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Remedii antihipotensive
US6093743A (en) * 1998-06-23 2000-07-25 Medinox Inc. Therapeutic methods employing disulfide derivatives of dithiocarbamates and compositions useful therefor
FR2788771B1 (fr) * 1999-01-22 2001-04-13 Pf Medicament Nouvelles 1,2-alcoyl-1-[1-[aryl (alcoyl) oxyalcoyl] piperidin-4-yl]-3-aryl isothiourees substituees, leur preparation et leur application en therapeutique
US6489308B1 (en) * 1999-03-05 2002-12-03 Trustees Of University Of Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of nitric-oxide-induced clinical conditions
ATE399025T1 (de) * 1999-07-21 2008-07-15 Omeros Corp Spüllösungen und verfahren zur schmerzhemmung, entzündungshemmung und hemmung des knorpelabbaus
NZ524903A (en) * 2000-09-05 2004-11-26 Meditor Pharmaceuticals Ltd Pharmaceutical compositions comprising S-alkylisothiouronium derivatives for headache, migraine, nausea and emesis

Also Published As

Publication number Publication date
KR20030055257A (ko) 2003-07-02
KR100849999B1 (ko) 2008-08-01
MD2447F2 (en) 2004-05-31
BR0113698A (pt) 2003-12-09
NO20031902L (no) 2003-06-09
CY1107270T1 (el) 2012-11-21
CN100448439C (zh) 2009-01-07
US20070088005A1 (en) 2007-04-19
MXPA03001737A (es) 2004-09-10
AU2001286178B2 (en) 2006-09-14
MD2447G2 (ro) 2005-12-31
HUP0302362A3 (en) 2005-05-30
ATE375797T1 (de) 2007-11-15
MD20020139A (en) 2002-11-30
ES2296792T3 (es) 2008-05-01
HUP0302362A2 (hu) 2003-11-28
WO2002019961A2 (en) 2002-03-14
US20040006044A1 (en) 2004-01-08
NZ524903A (en) 2004-11-26
WO2002019961A3 (en) 2002-08-15
EP1315505B1 (en) 2007-10-17
DE60131004D1 (de) 2007-11-29
CA2420410A1 (en) 2002-03-14
EP1315505A2 (en) 2003-06-04
CN1464788A (zh) 2003-12-31
HK1058009A1 (en) 2004-04-30
PT1315505E (pt) 2008-01-28
DE60131004T2 (de) 2008-07-31
JP2004508311A (ja) 2004-03-18
US7148208B2 (en) 2006-12-12
US8673979B2 (en) 2014-03-18
DK1315505T3 (da) 2008-03-03
NO20031902D0 (no) 2003-04-28
EP1315505A4 (en) 2006-02-22
CA2420410C (en) 2011-04-26
AU8617801A (en) 2002-03-22

Similar Documents

Publication Publication Date Title
US8673979B2 (en) Pharmaceutical compositions for headache, migraine, nausea and emesis
AU2001286178A1 (en) Pharmaceutical compositions for headache, migraine, nausea and emesis
MERHOFF et al. Ergot intoxication: historical review and description of unusual clinical manifestations
CA2260943C (en) Formulation of 5-ht agonists
EP1578412B1 (en) Pharmaceutical compositions and method of treating parkinson&#39;s disease
JP2000508341A (ja) 片頭痛の治療法及び薬効の強化組成物
US4804669A (en) Treatment of pain with a piperidine
CA1157379A (en) Method of preparation of pharmaceutical composition for treating peripheral orthostatic hypotention
NZ506020A (en) Use of pharmaceutical combinations containing tramadol and an antiemetic
AU2007229791A1 (en) Terguride/proterguride for the treatment of chronic pain (e.g. migraine)
IE61612B1 (en) Antiparkinson ergoline derivatives
KR100367792B1 (ko) 테트라하이드로벤즈[cd]인돌-6-카복스아미드를 포함하는 성기능부전 치료용 약제
US4481206A (en) Spiro succinimide derivative in the treatment of dementia of the Alzheimer type
CA2066834A1 (en) Use of glycine/nmda receptor ligands for the treatment of drug dependence and withdrawal
KR100692235B1 (ko) 안지오텐신 ⅱ 길항물질의 신규한 용도
JP4864259B2 (ja) 性機能障害および血管収縮に関する疾患の予防および治療におけるイカリンの使用
US3644643A (en) Method of reducing intraocular pressure using glycine
US4687771A (en) Method for treatment of male impotence
RU2275905C2 (ru) Фармацевтические композиции от головной боли, мигрени, тошноты и рвоты
NZ207411A (en) Pharmaceutical compositions containing paracetamol and tizanidine
JPS63132834A (ja) 鎮静剤製剤
JPS60500016A (ja) 鎮痛薬組成物類
Blackwell et al. Antidepressant drugs
EP0342211B1 (en) Treatment of arteriosclerosis by administration of l-tryptophan or l-5-hydroxytryptophan
UA28717U (en) Method for preventing or alleviating nausea or vomiting

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees