IL151583A0 - A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities - Google Patents
A process for purifying lovastatin and simvastatin with reduced levels of dimeric impuritiesInfo
- Publication number
- IL151583A0 IL151583A0 IL15158301A IL15158301A IL151583A0 IL 151583 A0 IL151583 A0 IL 151583A0 IL 15158301 A IL15158301 A IL 15158301A IL 15158301 A IL15158301 A IL 15158301A IL 151583 A0 IL151583 A0 IL 151583A0
- Authority
- IL
- Israel
- Prior art keywords
- simvastatin
- reduced levels
- dimeric impurities
- lovastatin
- purifying
- Prior art date
Links
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 title 1
- RYMZZMVNJRMUDD-UHFFFAOYSA-N SJ000286063 Natural products C12C(OC(=O)C(C)(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 RYMZZMVNJRMUDD-UHFFFAOYSA-N 0.000 title 1
- 239000012535 impurity Substances 0.000 title 1
- 229960004844 lovastatin Drugs 0.000 title 1
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 title 1
- QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 title 1
- 229960002855 simvastatin Drugs 0.000 title 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18686800P | 2000-03-03 | 2000-03-03 | |
| PCT/US2001/006334 WO2001066538A1 (en) | 2000-03-03 | 2001-02-27 | A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL151583A0 true IL151583A0 (en) | 2003-04-10 |
Family
ID=22686591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15158301A IL151583A0 (en) | 2000-03-03 | 2001-02-27 | A process for purifying lovastatin and simvastatin with reduced levels of dimeric impurities |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6521762B2 (cs) |
| EP (1) | EP1265884A4 (cs) |
| JP (1) | JP2003525935A (cs) |
| KR (1) | KR20030069790A (cs) |
| CN (1) | CN1443182A (cs) |
| AU (1) | AU4183301A (cs) |
| CA (1) | CA2402061A1 (cs) |
| CZ (1) | CZ20023201A3 (cs) |
| DE (1) | DE01913139T1 (cs) |
| HR (1) | HRP20020730A2 (cs) |
| HU (1) | HUP0301214A2 (cs) |
| IL (1) | IL151583A0 (cs) |
| IS (1) | IS6533A (cs) |
| PL (1) | PL357533A1 (cs) |
| SK (1) | SK13782002A3 (cs) |
| TR (1) | TR200403001T3 (cs) |
| WO (1) | WO2001066538A1 (cs) |
| ZA (1) | ZA200207023B (cs) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100435078B1 (ko) * | 2002-02-08 | 2004-06-09 | 종근당바이오 주식회사 | 심바스타틴의 정제방법 |
| WO2005054253A1 (en) * | 2003-12-05 | 2005-06-16 | Biocon Limited | Process for the purification of macrolides |
| US7199126B2 (en) * | 2004-04-29 | 2007-04-03 | Pharmix Corporation | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase |
| US7183285B2 (en) * | 2004-04-29 | 2007-02-27 | Pharmix Corp. | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase |
| US20050272770A1 (en) * | 2004-04-29 | 2005-12-08 | John Griffin | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase |
| US20050282883A1 (en) * | 2004-04-29 | 2005-12-22 | John Griffin | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase |
| US8012498B2 (en) | 2004-07-12 | 2011-09-06 | Sandhya Goyal | Topical gel formulation comprising organophosphate insecticide and preparation thereof |
| US8158139B2 (en) * | 2004-07-12 | 2012-04-17 | Taro Pharmaceuticals North America, Inc. | Topical gel formulation comprising organophosphate insecticide and preparation thereof |
| US20070015779A1 (en) * | 2005-04-29 | 2007-01-18 | John Griffin | Compositions and treatments for inhibiting kinase and/or hmg-coa reductase |
| US7560445B2 (en) | 2005-07-06 | 2009-07-14 | Taro Pharmaceuticals North America, Inc. | Process for preparing malathion for pharmaceutical use |
| WO2007061849A2 (en) * | 2005-11-23 | 2007-05-31 | Merck & Co., Inc. | Method of generating amorphous solid for water-insoluble pharmaceuticals |
| WO2008147807A2 (en) | 2007-05-23 | 2008-12-04 | Amcol International Corporation | Cholesterol-interacting layered phyllosilicates and methods of reducing hypercholesteremia in a mammal |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5925599B2 (ja) | 1979-02-20 | 1984-06-19 | 三共株式会社 | 新生理活性物質モナコリンｋおよびその製造法 |
| US4319039A (en) * | 1979-06-15 | 1982-03-09 | Merck & Co., Inc. | Preparation of ammonium salt of hypocholesteremic fermentation product |
| US4294926A (en) | 1979-06-15 | 1981-10-13 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4294846A (en) | 1979-09-21 | 1981-10-13 | Merck & Co., Inc. | Hypocholesteremic fermentation products and products of preparation |
| US4342767A (en) | 1980-01-23 | 1982-08-03 | Merck & Co., Inc. | Hypocholesteremic fermentation products |
| US4444784A (en) | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4420491A (en) | 1980-05-28 | 1983-12-13 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| US4582915A (en) | 1983-10-11 | 1986-04-15 | Merck & Co., Inc. | Process for C-methylation of 2-methylbutyrates |
| US4820850A (en) | 1987-07-10 | 1989-04-11 | Merck & Co., Inc. | Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof |
| US4916239A (en) | 1988-07-19 | 1990-04-10 | Merck & Co., Inc. | Process for the lactonization of mevinic acids and analogs thereof |
| US5202029A (en) * | 1991-03-13 | 1993-04-13 | Caron Kabushiki Kaisha | Process for purification of hmg-coa reductase inhibitors |
| HU210867B (en) * | 1992-11-04 | 1995-10-30 | Biogal Gyogyszergyar | Method for extraction and purification of mevinolin from culture medium |
| SI9300047A (en) | 1993-01-29 | 1994-09-30 | Krka | Microbiological method for preparation of lovostatin and/or mevinoline acid |
| US5409820A (en) | 1993-08-06 | 1995-04-25 | Apotex, Inc. | Process for the production of lovastatin using Coniothyrium fuckelii |
| UA44922C2 (uk) * | 1995-12-06 | 2002-03-15 | Балканфарма-Разград Ад | Спосіб одержання ловастатину |
| IN186880B (cs) | 1997-10-28 | 2001-12-01 | Ranbaxy Lab Ltd | |
| IN186879B (cs) | 1997-10-28 | 2001-12-01 | Ranbaxy Lab Ltd | |
| SI9800046A (sl) | 1998-02-18 | 1999-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti |
| SI20072A (sl) * | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
| US6380401B1 (en) | 1999-10-27 | 2002-04-30 | Merck & Co., Inc. | Lactonization process |
-
2001
- 2001-02-27 TR TR2004/03001T patent/TR200403001T3/xx unknown
- 2001-02-27 US US09/793,946 patent/US6521762B2/en not_active Expired - Fee Related
- 2001-02-27 CN CN01808689A patent/CN1443182A/zh active Pending
- 2001-02-27 CZ CZ20023201A patent/CZ20023201A3/cs unknown
- 2001-02-27 IL IL15158301A patent/IL151583A0/xx unknown
- 2001-02-27 DE DE01913139T patent/DE01913139T1/de active Pending
- 2001-02-27 SK SK1378-2002A patent/SK13782002A3/sk not_active Application Discontinuation
- 2001-02-27 EP EP01913139A patent/EP1265884A4/en not_active Withdrawn
- 2001-02-27 PL PL01357533A patent/PL357533A1/xx not_active Application Discontinuation
- 2001-02-27 CA CA002402061A patent/CA2402061A1/en not_active Abandoned
- 2001-02-27 KR KR1020027011541A patent/KR20030069790A/ko not_active Withdrawn
- 2001-02-27 JP JP2001565354A patent/JP2003525935A/ja active Pending
- 2001-02-27 AU AU4183301A patent/AU4183301A/xx active Pending
- 2001-02-27 HR HRP20020730 patent/HRP20020730A2/hr not_active Application Discontinuation
- 2001-02-27 WO PCT/US2001/006334 patent/WO2001066538A1/en not_active Ceased
- 2001-02-27 HU HU0301214A patent/HUP0301214A2/hu unknown
-
2002
- 2002-08-29 IS IS6533A patent/IS6533A/is unknown
- 2002-09-02 ZA ZA200207023A patent/ZA200207023B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK13782002A3 (sk) | 2004-02-03 |
| US20020002288A1 (en) | 2002-01-03 |
| HUP0301214A2 (hu) | 2003-08-28 |
| AU4183301A (en) | 2001-09-17 |
| WO2001066538A1 (en) | 2001-09-13 |
| CN1443182A (zh) | 2003-09-17 |
| IS6533A (is) | 2002-08-29 |
| US6521762B2 (en) | 2003-02-18 |
| EP1265884A1 (en) | 2002-12-18 |
| KR20030069790A (ko) | 2003-08-27 |
| JP2003525935A (ja) | 2003-09-02 |
| EP1265884A4 (en) | 2003-05-21 |
| PL357533A1 (en) | 2004-07-26 |
| TR200403001T3 (tr) | 2005-02-21 |
| HRP20020730A2 (en) | 2004-12-31 |
| ZA200207023B (en) | 2003-09-02 |
| CA2402061A1 (en) | 2001-09-13 |
| CZ20023201A3 (cs) | 2003-09-17 |
| DE01913139T1 (de) | 2005-03-31 |
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