HRP970435B1 - Process for manufacturing simvastatin from lovastatin or mevinolinic acid - Google Patents

Process for manufacturing simvastatin from lovastatin or mevinolinic acid

Info

Publication number
HRP970435B1
HRP970435B1 HR970435A HRP970435A HRP970435B1 HR P970435 B1 HRP970435 B1 HR P970435B1 HR 970435 A HR970435 A HR 970435A HR P970435 A HRP970435 A HR P970435A HR P970435 B1 HRP970435 B1 HR P970435B1
Authority
HR
Croatia
Prior art keywords
lovastatin
mevinolinic acid
simvastatin
manufacturing
manufacturing simvastatin
Prior art date
Application number
HR970435A
Inventor
Yatendra Kumar
Rajesh Kumar Thaper
Satyananda Misra
S M Dileep Kumar
Jag Mohan Khanna
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IN175DE1997 external-priority patent/IN184969B/en
Priority claimed from US08/816,573 external-priority patent/US5763646A/en
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of HRP970435A2 publication Critical patent/HRP970435A2/en
Publication of HRP970435B1 publication Critical patent/HRP970435B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/02—Preparation of carboxylic acid esters by interreacting ester groups, i.e. transesterification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HR970435A 1997-01-24 1997-08-07 Process for manufacturing simvastatin from lovastatin or mevinolinic acid HRP970435B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN175DE1997 IN184969B (en) 1997-01-24 1997-01-24
US08/816,573 US5763646A (en) 1997-03-13 1997-03-13 Process for manufacturing simvastatin from lovastatin or mevinolinic acid

Publications (2)

Publication Number Publication Date
HRP970435A2 HRP970435A2 (en) 1998-12-31
HRP970435B1 true HRP970435B1 (en) 2001-12-31

Family

ID=26324532

Family Applications (1)

Application Number Title Priority Date Filing Date
HR970435A HRP970435B1 (en) 1997-01-24 1997-08-07 Process for manufacturing simvastatin from lovastatin or mevinolinic acid

Country Status (4)

Country Link
KR (1) KR100263699B1 (en)
CN (1) CN1102588C (en)
HR (1) HRP970435B1 (en)
SK (1) SK283319B6 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100361833B1 (en) * 2000-06-20 2002-11-22 주식회사 엘지생명과학 Process for manufacturing simvastatin
KR20020017162A (en) * 2000-08-29 2002-03-07 구광시 New process for producing simvastatin
KR100502833B1 (en) * 2002-03-25 2005-07-25 보령제약 주식회사 Improved preparation method of simvastatin and their intermediates
CN105147659A (en) * 2013-12-24 2015-12-16 深圳华润九新药业有限公司 Application of acid lovastatin hydroxyl compound
CN104744416A (en) * 2015-03-25 2015-07-01 河南师范大学 Preparation method of simvastatin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5393893A (en) * 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof

Also Published As

Publication number Publication date
KR100263699B1 (en) 2000-08-01
HRP970435A2 (en) 1998-12-31
CN1188763A (en) 1998-07-29
SK283319B6 (en) 2003-06-03
CN1102588C (en) 2003-03-05
KR19980069782A (en) 1998-10-26
SK116797A3 (en) 1998-09-09

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
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Payment date: 20040812

Year of fee payment: 8

PBON Lapse due to non-payment of renewal fee

Effective date: 20050808