IL148428A0 - Pyrimidine derivatives - Google Patents

Pyrimidine derivatives

Info

Publication number
IL148428A0
IL148428A0 IL14842800A IL14842800A IL148428A0 IL 148428 A0 IL148428 A0 IL 148428A0 IL 14842800 A IL14842800 A IL 14842800A IL 14842800 A IL14842800 A IL 14842800A IL 148428 A0 IL148428 A0 IL 148428A0
Authority
IL
Israel
Prior art keywords
halogeno
pyrimidine derivatives
trifluoromethyl
cyano
hydroxy
Prior art date
Application number
IL14842800A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of IL148428A0 publication Critical patent/IL148428A0/xx

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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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IL14842800A 1999-10-13 2000-10-10 Pyrimidine derivatives IL148428A0 (en)

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Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9816837D0 (en) 1998-08-04 1998-09-30 Zeneca Ltd Amide derivatives
US7772432B2 (en) 1991-09-19 2010-08-10 Astrazeneca Ab Amidobenzamide derivatives which are useful as cytokine inhibitors
NZ502702A (en) 1997-09-23 2002-10-25 Astrazeneca Ab Amide derivatives for the treatment of diseases mediated by TNF, IL-1, IL-6 or IL-8
CA2328699A1 (en) 1998-05-15 1999-11-25 Dearg Sutherland Brown Benzamide derivatives for the treatment of diseases mediated by cytokines
EP1102750A1 (de) 1998-08-04 2001-05-30 AstraZeneca AB Amid-derivate verwendbar als inhibitoren der cytokinproduktion
ES2211172T3 (es) 1998-09-25 2004-07-01 Astrazeneca Ab Derivados de benzamida y su utilizacion como inhibidores de citoquinas.
NZ513726A (en) 1999-03-17 2001-09-28 Astrazeneca Ab Amide derivatives
PT1163237E (pt) 1999-03-17 2004-08-31 Astrazeneca Ab Derivados de amida
GB9906566D0 (en) 1999-03-23 1999-05-19 Zeneca Ltd Chemical compounds
US6943161B2 (en) 1999-12-28 2005-09-13 Pharmacopela Drug Discovery, Inc. Pyrimidine and triazine kinase inhibitors
WO2001047921A1 (en) * 1999-12-28 2001-07-05 Pharmacopeia, Inc. Pyrimidine and triazine kinase inhibitors
US6867300B2 (en) 2000-11-17 2005-03-15 Bristol-Myers Squibb Company Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
US6670357B2 (en) 2000-11-17 2003-12-30 Bristol-Myers Squibb Company Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
US7122544B2 (en) 2000-12-06 2006-10-17 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
US7129242B2 (en) 2000-12-06 2006-10-31 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto
US6716851B2 (en) 2000-12-12 2004-04-06 Cytovia, Inc. Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators or caspases and inducers of apoptosis and the use thereof
CA2451128A1 (en) 2001-06-26 2003-01-09 Bristol-Myers Squibb Company N-heterocyclic inhibitors of tnf-alpha expression
GB0124939D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124933D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0124934D0 (en) 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
GB0202873D0 (en) 2002-02-07 2002-03-27 Novartis Ag Organic compounds
AU2003245711A1 (en) * 2002-02-11 2003-09-04 Pfizer Inc. Nicotinamide derivatives useful as pde4 inhibitors
DK1474395T3 (da) 2002-02-12 2008-02-11 Smithkline Beecham Corp Nicotinamidderivater, der er nyttige som p38-inhibitorer
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
US7388009B2 (en) 2002-04-23 2008-06-17 Bristol-Myers Squibb Company Heteroaryl-substituted pyrrolo-triazine compounds useful as kinase inhibitors
DE60325469D1 (de) 2002-04-23 2009-02-05 Bristol Myers Squibb Co Als kinase inhibitoren geeignete arylketonpyrrolotriazin-verbindungen
EP1497019B1 (de) 2002-04-23 2015-05-20 Bristol-Myers Squibb Company Pyrrolo-triazin-anilin-verbindungen als kinaseinhibitoren
TW200400034A (en) 2002-05-20 2004-01-01 Bristol Myers Squibb Co Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
EP1707205A2 (de) 2002-07-09 2006-10-04 Boehringer Ingelheim Pharma GmbH & Co. KG Pharazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege
GB0308186D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
GB0308201D0 (en) 2003-04-09 2003-05-14 Smithkline Beecham Corp Novel compounds
CA2528438A1 (en) 2003-06-03 2005-01-06 Novartis Ag P-38 inhibitors
JP2006527230A (ja) * 2003-06-13 2006-11-30 ノバルティス アクチエンゲゼルシャフト Ｒａｆキナーゼ阻害剤としての２−アミノピリミジン誘導体
PT1641764E (pt) 2003-06-26 2011-10-27 Novartis Ag Inibidores de p38 quinase a base de heterociclo de 5 elementos
ES2315703T3 (es) 2003-07-25 2009-04-01 Novartis Ag Inhibidores de la quinasa p-38.
GB0318814D0 (en) 2003-08-11 2003-09-10 Smithkline Beecham Corp Novel compounds
US7419978B2 (en) 2003-10-22 2008-09-02 Bristol-Myers Squibb Company Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
GB0324790D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Amide derivatives
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
EP1867646A1 (de) * 2004-05-03 2007-12-19 Boehringer Ingelheim Pharmaceuticals, Inc. Cytokin-Inhibitoren
EP1745036A2 (de) 2004-05-03 2007-01-24 Boehringer Ingelheim Pharmaceuticals Inc. Cytokininhibitoren
ATE434614T1 (de) 2004-06-28 2009-07-15 Bayer Schering Pharma Ag 4,6-disubstitutierte pyrimidine und deren verwendung als proteinkinase-hemmer
US7504521B2 (en) 2004-08-05 2009-03-17 Bristol-Myers Squibb Co. Methods for the preparation of pyrrolotriazine compounds
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
US7148348B2 (en) 2004-08-12 2006-12-12 Bristol-Myers Squibb Company Process for preparing pyrrolotriazine aniline compounds useful as kinase inhibitors
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
US20060178388A1 (en) 2005-02-04 2006-08-10 Wrobleski Stephen T Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
US7473784B2 (en) 2005-08-01 2009-01-06 Bristol-Myers Squibb Company Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors
US7754717B2 (en) * 2005-08-15 2010-07-13 Amgen Inc. Bis-aryl amide compounds and methods of use
BR122021011787B1 (pt) * 2005-11-01 2022-01-25 Impact Biomedicines, Inc Inibidores de biaril meta pirimidina de cinases, composição farmacêutica e processo para preparar uma composição farmacêutica
CN101374941A (zh) 2005-12-29 2009-02-25 人类起源公司 采集和保存胎盘干细胞的改良组合物及其使用方法
CN101395158A (zh) 2006-03-07 2009-03-25 百时美施贵宝公司 可作为激酶抑制剂的吡咯并三嗪苯胺前体药物化合物
EP2054392A2 (de) * 2006-06-15 2009-05-06 Boehringer Ingelheim International GmbH 2-anilino-4-(heterocyclische)amino-pyrimidine als proteinkinase-c-alpha-hemmer
CN101616667A (zh) 2006-10-27 2009-12-30 百时美施贵宝公司 可用作激酶抑制剂的杂环酰胺化合物
US7943617B2 (en) 2006-11-27 2011-05-17 Bristol-Myers Squibb Company Heterobicyclic compounds useful as kinase inhibitors
EP1992344A1 (de) 2007-05-18 2008-11-19 Institut Curie P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind
TWI552752B (zh) 2007-10-19 2016-10-11 賽基艾維洛米斯研究股份有限公司 雜芳基化合物及其用途
US20100015708A1 (en) * 2008-06-18 2010-01-21 Mdrna, Inc. Ribonucleic acids with non-standard bases and uses thereof
CN102131805A (zh) 2008-06-20 2011-07-20 百时美施贵宝公司 用作激酶抑制剂的咪唑并吡啶和咪唑并吡嗪化合物
EP2307411B1 (de) 2008-06-20 2014-01-01 Bristol-Myers Squibb Company Als kinaseinhibitoren geeignete triazolopyridinverbindungen
WO2010120963A1 (en) * 2009-04-16 2010-10-21 Bristol-Myers Squibb Company Tablet formulation for p38 inhibitor and method
EP2477630A4 (de) * 2009-09-17 2013-05-01 Univ Vanderbilt Substituierte benzamidanaloga als negative allosterische mglur5-modulatoren sowie verfahren zu ihrer herstellung und verwendung
WO2012031057A1 (en) 2010-09-01 2012-03-08 Bristol-Myers Squibb Company Bms- 582949 for the treatment of resistant rheumatic disease
UY34305A (es) 2011-09-01 2013-04-30 Novartis Ag Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar
NZ731797A (en) 2012-04-24 2018-08-31 Vertex Pharma Dna-pk inhibitors
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
ME03336B (de) 2013-03-12 2019-10-20 Vertex Pharma Dna-pk-hemmer
RU2675270C2 (ru) 2013-10-17 2018-12-18 Вертекс Фармасьютикалз Инкорпорейтед Сокристаллы и содержащие их фармацевтические композиции
WO2015077246A1 (en) 2013-11-19 2015-05-28 Vanderbilt University Substituted imidazopyridine and triazolopyridine compounds as negative allosteric modulators of mglur5
US9533982B2 (en) 2014-03-20 2017-01-03 Vanderbilt University Substituted bicyclic heteroaryl carboxamide analogs as mGluR5 negative allosteric modulators
US9550778B2 (en) 2014-10-03 2017-01-24 Vanderbilt University Substituted 6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analogs as negative allosteric modulators of mGluR5
CA3038657A1 (en) 2016-09-27 2018-04-05 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of dna-damaging agents and dna-pk inhibitors
BR112020015743A2 (pt) 2018-02-08 2020-12-15 Enyo Pharma Derivados de tiofeno não fundido e seus usos
CA3133964A1 (en) * 2019-03-18 2020-09-24 The Council Of The Queensland Institute Of Medical Research Cardiomyocyte proliferation
AU2021226349A1 (en) * 2020-02-28 2022-08-18 Dana-Farber Cancer Institute, Inc. Map kinase kinase (MKK7) inhibitors and uses thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9816837D0 (en) 1998-08-04 1998-09-30 Zeneca Ltd Amide derivatives
GB9300059D0 (en) * 1992-01-20 1993-03-03 Zeneca Ltd Quinazoline derivatives
JP2000506532A (ja) * 1996-03-13 2000-05-30 スミスクライン・ビーチャム・コーポレイション サイトカイン介在疾患の治療にて有用な新規ピリミジン化合物
GB9623833D0 (en) 1996-11-16 1997-01-08 Zeneca Ltd Chemical compound
EP0994860A1 (de) * 1997-07-03 2000-04-26 Du Pont Pharmaceuticals Company Aryl- und arylamino-substituierte heteroringen als corticotropin freisetzende hormon antagonisten
NZ502702A (en) 1997-09-23 2002-10-25 Astrazeneca Ab Amide derivatives for the treatment of diseases mediated by TNF, IL-1, IL-6 or IL-8
AU751573C (en) 1998-03-27 2003-10-09 Janssen Pharmaceutica N.V. HIV inhibiting pyrimidine derivatives
CA2328699A1 (en) 1998-05-15 1999-11-25 Dearg Sutherland Brown Benzamide derivatives for the treatment of diseases mediated by cytokines
BR9910474A (pt) 1998-05-15 2001-01-02 Astrazeneca Ab Composto derivado de amida, processo para preparação do mesmo, composição farmacêutica, e, uso de um composto derivado de amida
EP1102750A1 (de) 1998-08-04 2001-05-30 AstraZeneca AB Amid-derivate verwendbar als inhibitoren der cytokinproduktion
DE69917469T2 (de) 1998-08-27 2005-05-12 Sumitomo Pharmaceuticals Co., Ltd. Pyrimidin derivate
WO2000012485A1 (en) 1998-08-29 2000-03-09 Astrazeneca Ab Pyrimidine compounds
EP1107958B1 (de) 1998-08-29 2006-08-16 AstraZeneca AB Pyrimidine verbindungen
ES2211172T3 (es) 1998-09-25 2004-07-01 Astrazeneca Ab Derivados de benzamida y su utilizacion como inhibidores de citoquinas.
WO2000020402A1 (en) * 1998-10-01 2000-04-13 Astrazeneca Ab Chemical compounds
NZ513726A (en) 1999-03-17 2001-09-28 Astrazeneca Ab Amide derivatives
PT1163237E (pt) 1999-03-17 2004-08-31 Astrazeneca Ab Derivados de amida
GB9906566D0 (en) 1999-03-23 1999-05-19 Zeneca Ltd Chemical compounds

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WO2001027089A1 (en) 2001-04-19
ZA200201557B (en) 2003-07-30
ATE286501T1 (de) 2005-01-15
US6846827B1 (en) 2005-01-25
EP1226126A1 (de) 2002-07-31
IL148428A (en) 2006-12-10
HK1045511B (zh) 2005-06-03
NO322808B1 (no) 2006-12-11
AU7804200A (en) 2001-04-23
CN1378537A (zh) 2002-11-06
HK1045511A1 (en) 2002-11-29
NO20021728L (no) 2002-06-12
JP2003511442A (ja) 2003-03-25
DE60017279D1 (en) 2005-02-10
EP1226126B1 (de) 2005-01-05
KR100738862B1 (ko) 2007-07-13
CN100415724C (zh) 2008-09-03
NO20021728D0 (no) 2002-04-12
BR0014596A (pt) 2002-06-11
AU772293B2 (en) 2004-04-22
KR20020091830A (ko) 2002-12-06
CA2382605A1 (en) 2001-04-19
NZ517572A (en) 2003-11-28
DE60017279T2 (de) 2005-12-08
MXPA02003533A (es) 2002-08-20
GB9924092D0 (en) 1999-12-15

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