IL147575A - Method for purifying keratinocyte growth factors - Google Patents
Method for purifying keratinocyte growth factorsInfo
- Publication number
- IL147575A IL147575A IL14757595A IL14757595A IL147575A IL 147575 A IL147575 A IL 147575A IL 14757595 A IL14757595 A IL 14757595A IL 14757595 A IL14757595 A IL 14757595A IL 147575 A IL147575 A IL 147575A
- Authority
- IL
- Israel
- Prior art keywords
- kgf
- seq
- solution
- oxidized
- cation exchange
- Prior art date
Links
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- 239000007790 solid phase Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960002175 thyroglobulin Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 108010035534 tyrosyl-leucyl-alanine Proteins 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 239000013585 weight reducing agent Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32333994A | 1994-10-13 | 1994-10-13 | |
| US08/487,830 US6008328A (en) | 1994-10-13 | 1995-06-07 | Method for purifying keratinocyte growth factors |
| IL11560595A IL115605A (en) | 1994-10-13 | 1995-10-12 | Method for purifying keratinocyte growth factors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL147575A true IL147575A (en) | 2004-05-12 |
Family
ID=26983902
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11560595A IL115605A (en) | 1994-10-13 | 1995-10-12 | Method for purifying keratinocyte growth factors |
| IL14757595A IL147575A (en) | 1994-10-13 | 1995-10-12 | Method for purifying keratinocyte growth factors |
| IL14757502A IL147575A0 (en) | 1994-10-13 | 2002-01-10 | Method for purifying keratinocyte growth factors |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL11560595A IL115605A (en) | 1994-10-13 | 1995-10-12 | Method for purifying keratinocyte growth factors |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14757502A IL147575A0 (en) | 1994-10-13 | 2002-01-10 | Method for purifying keratinocyte growth factors |
Country Status (18)
| Country | Link |
|---|---|
| EP (2) | EP0785949B1 (xx) |
| JP (1) | JP3877226B2 (xx) |
| CN (1) | CN1161380C (xx) |
| AT (1) | ATE239038T1 (xx) |
| CA (1) | CA2201762C (xx) |
| CZ (1) | CZ98297A3 (xx) |
| DE (2) | DE69530599T2 (xx) |
| DK (1) | DK0785949T3 (xx) |
| ES (1) | ES2197926T3 (xx) |
| HU (1) | HU220584B1 (xx) |
| IL (3) | IL115605A (xx) |
| LU (1) | LU91235I2 (xx) |
| NL (1) | NL300229I2 (xx) |
| NO (1) | NO971567L (xx) |
| PT (1) | PT785949E (xx) |
| SI (1) | SI0785949T1 (xx) |
| SK (1) | SK43097A3 (xx) |
| WO (1) | WO1996011952A1 (xx) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077692A (en) * | 1995-02-14 | 2000-06-20 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 |
| US6693077B1 (en) | 1995-02-14 | 2004-02-17 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 |
| US7232667B2 (en) | 1995-02-14 | 2007-06-19 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 polynucleotides |
| US6743422B1 (en) | 1996-10-15 | 2004-06-01 | Amgen, Inc. | Keratinocyte growth factor-2 products |
| US6869927B1 (en) | 1997-12-22 | 2005-03-22 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 formulations |
| KR20010033484A (ko) | 1997-12-22 | 2001-04-25 | 휴먼 게놈 사이언시즈, 인크. | 각질세포 성장 인자-2 제제 |
| EP1360201A1 (en) * | 2001-02-06 | 2003-11-12 | MERCK PATENT GmbH | Modified keratinocyte growth factor (kgf) with reduced immunogenicity |
| MXPA04001526A (es) | 2001-08-21 | 2004-05-31 | Chiron Corp | Composiciones de polipetidos kgf. |
| CN102242124B (zh) * | 2010-05-10 | 2013-05-22 | 齐鲁制药有限公司 | 改造的角化细胞生长因子基因及其在酵母中的表达 |
| CN102675449B (zh) * | 2011-03-17 | 2016-06-08 | 重庆富进生物医药有限公司 | 缺失型人角质细胞生长因子-ⅰ二硫键变构体及其用途 |
| CN109402130A (zh) * | 2018-11-23 | 2019-03-01 | 成都中医药大学附属医院 | 一种重组人角质细胞生长因子-1及其制备方法和用途 |
| CN110183529B (zh) * | 2019-05-23 | 2023-06-02 | 重庆派金生物科技有限公司 | 一种缺失型人角质细胞生长因子-1的重组制备方法 |
| KR20230127721A (ko) * | 2022-02-25 | 2023-09-01 | 한국해양과학기술원 | 온도안정성을 향상시킨 fgf7 폴리펩타이드 및 그 용도 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE197800T1 (de) * | 1989-01-31 | 2000-12-15 | Jeffrey S Rubin | Dns kodierend für einen für epithelzellen spezifischen wachstumsfaktor |
| IE914393A1 (en) * | 1990-12-18 | 1992-07-01 | Amgen Inc | Analogs of acidic fibroblast growth factor having enhanced¹stability and biological activity |
| CZ343795A3 (en) * | 1993-06-29 | 1996-07-17 | Chiron Corp | Shortened keratinocyte growth factor /kgf/ exhibiting increased biological activity |
| NZ274667A (en) * | 1993-09-24 | 1997-03-24 | American Cyanamid Co | Fibroblast growth factor analogue |
| CN1168678A (zh) * | 1994-10-13 | 1997-12-24 | 安姆根有限公司 | 用kgf治疗糖尿病的方法 |
| HUT78069A (hu) * | 1994-10-13 | 1999-08-30 | Amgen Inc. | Keratinocita növekedési faktor analógok |
| HUT77746A (hu) * | 1994-10-13 | 1998-07-28 | Amgen Inc. | Fokozott stabilitással és biológiai aktivitással rendelkező savas fibroblaszt növekedési faktor analógok |
-
1995
- 1995-10-12 ES ES95936309T patent/ES2197926T3/es not_active Expired - Lifetime
- 1995-10-12 CA CA002201762A patent/CA2201762C/en not_active Expired - Lifetime
- 1995-10-12 PT PT95936309T patent/PT785949E/pt unknown
- 1995-10-12 AT AT95936309T patent/ATE239038T1/de active
- 1995-10-12 CN CNB951967959A patent/CN1161380C/zh not_active Expired - Lifetime
- 1995-10-12 HU HU9701514A patent/HU220584B1/hu unknown
- 1995-10-12 EP EP95936309A patent/EP0785949B1/en not_active Expired - Lifetime
- 1995-10-12 DE DE69530599T patent/DE69530599T2/de not_active Expired - Lifetime
- 1995-10-12 SI SI9530657T patent/SI0785949T1/xx unknown
- 1995-10-12 IL IL11560595A patent/IL115605A/xx not_active IP Right Cessation
- 1995-10-12 DE DE1995630599 patent/DE122006000019I1/de active Pending
- 1995-10-12 DK DK95936309T patent/DK0785949T3/da active
- 1995-10-12 CZ CZ97982A patent/CZ98297A3/cs unknown
- 1995-10-12 JP JP51337696A patent/JP3877226B2/ja not_active Expired - Lifetime
- 1995-10-12 SK SK430-97A patent/SK43097A3/sk unknown
- 1995-10-12 EP EP02028624A patent/EP1334981B1/en not_active Expired - Lifetime
- 1995-10-12 IL IL14757595A patent/IL147575A/en not_active IP Right Cessation
- 1995-10-12 WO PCT/US1995/013099 patent/WO1996011952A1/en active IP Right Grant
-
1997
- 1997-04-04 NO NO971567A patent/NO971567L/no unknown
-
2002
- 2002-01-10 IL IL14757502A patent/IL147575A0/xx active IP Right Grant
-
2006
- 2006-04-11 NL NL300229C patent/NL300229I2/nl unknown
- 2006-04-12 LU LU91235C patent/LU91235I2/fr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| EXTF | Application for patent extension filed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |