IL145796A0 - Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences - Google Patents
Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequencesInfo
- Publication number
- IL145796A0 IL145796A0 IL14579600A IL14579600A IL145796A0 IL 145796 A0 IL145796 A0 IL 145796A0 IL 14579600 A IL14579600 A IL 14579600A IL 14579600 A IL14579600 A IL 14579600A IL 145796 A0 IL145796 A0 IL 145796A0
- Authority
- IL
- Israel
- Prior art keywords
- production
- nucleotide sequences
- respiratory syncytial
- syncytial virus
- virus vaccines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18541—Use of virus, viral particle or viral elements as a vector
- C12N2760/18543—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18561—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/291,894 US6689367B1 (en) | 1995-09-27 | 1999-04-13 | Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences |
PCT/US2000/008802 WO2000061611A2 (en) | 1999-04-13 | 2000-03-31 | Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences |
Publications (1)
Publication Number | Publication Date |
---|---|
IL145796A0 true IL145796A0 (en) | 2002-07-25 |
Family
ID=23122324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14579600A IL145796A0 (en) | 1999-04-13 | 2000-03-31 | Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences |
Country Status (10)
Country | Link |
---|---|
EP (2) | EP1690940A1 (de) |
JP (1) | JP2002541785A (de) |
KR (1) | KR100746979B1 (de) |
CN (1) | CN100491530C (de) |
AU (1) | AU4065500A (de) |
BR (1) | BR0011160A (de) |
CA (1) | CA2369200A1 (de) |
IL (1) | IL145796A0 (de) |
MX (1) | MXPA01010320A (de) |
WO (1) | WO2000061611A2 (de) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2342237T3 (es) * | 1995-09-27 | 2010-07-02 | The Usa, As Represented By The Secretary Of The Department Of Health And Human Services | Produccion de virus sinciciales respiratorios infecciosos a partir de secuencias clonadas de nucleotidos. |
US7485440B2 (en) | 1995-09-27 | 2009-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2 |
JP4413999B2 (ja) | 1996-07-15 | 2010-02-10 | アメリカ合衆国 | クローニングされたヌクレオチド配列からの弱毒化呼吸シンシチウムウィルスワクチンの製造 |
US6699476B1 (en) | 1996-07-15 | 2004-03-02 | Peter L. Collins | Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules |
US7201907B1 (en) | 1997-05-23 | 2007-04-10 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines |
US20030082209A1 (en) | 2000-07-05 | 2003-05-01 | Skiadopoulos Mario H. | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
US7951383B2 (en) | 1997-05-23 | 2011-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuated parainfluenza virus (PIV) vaccines |
US7632508B2 (en) | 1997-05-23 | 2009-12-15 | The United States Of America | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
AU2006200619B2 (en) * | 1997-09-26 | 2007-12-13 | Medimmune, Llc | Recombinant RSV virus expression systems and vaccines |
WO2001004335A2 (en) | 1999-07-09 | 2001-01-18 | The Government Of The United States Of America, As Represented By The Department Of Health And Humanservices | Human-bovine chimeric respiratory syncytial virus vaccines |
WO2001004321A1 (en) * | 1999-07-09 | 2001-01-18 | The Government Of The United States Of America, As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines involving modification of m2 orf2 |
EP1572947B1 (de) | 2002-09-18 | 2014-06-25 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | GEWINNUNG VON REKOMBINANTEM HUMANEM PARAINFLUENZA-VIRUS TYP 2 (HPIV2) AUS cDNA UND VERWENDUNG VON REKOMBINANTEM HPIV2 IN IMMUNOGENEN ZUSAMMENSETZUNGEN SOWIE ALS VEKTOREN ZUR HERVORRUFUNG VON IMMUNREAKTIONEN GEGEN PIV UND ANDERE MENSCHLICHE KRANKHEITSERREGER |
JP2007524372A (ja) | 2003-02-28 | 2007-08-30 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンテッド バイ ザ セクレタリー オブ ザ デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 組換えヒトメタニューモウイルスおよびその使用 |
WO2004113517A2 (en) | 2003-06-09 | 2004-12-29 | Wyeth | IMPROVED METHOD FOR THE RECOVERY OF NON-SEGMENTED, NEGATIVE-STRANDED RNA VIRUSES FROM cDNA |
US8597637B1 (en) * | 2010-05-18 | 2013-12-03 | Weidong Zhang | Breast cancer therapy using an engineered respiratory syncytial virus |
PL2954049T3 (pl) | 2013-02-08 | 2023-10-16 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Atenuacja ludzkiego syncytialnego wirusa oddechowego przez deoptymalizację par kodonów w skali genomu |
JP7198759B2 (ja) | 2016-09-23 | 2023-01-04 | ザ・ユナイテッド・ステイツ・オブ・アメリカ・アズ・リプリゼンテッド・バイ・ザ・セクレタリー・デパートメント・オブ・ヘルス・アンド・ヒューマン・サービシーズ | 弱毒化表現型を有するヒト呼吸器多核体ウイルス(rsv)のためのワクチン候補 |
CN107384958B (zh) * | 2017-07-14 | 2020-04-10 | 北京交通大学 | 基于反向遗传学构建的rsv反基因组质粒及其应用 |
CN113462656B (zh) * | 2021-03-24 | 2022-09-30 | 兰州生物制品研究所有限责任公司 | 一种人三型副流感病毒冷适应温度敏感株及其应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US708395A (en) | 1901-04-15 | 1902-09-02 | Oscar Peterson | Device for digging ditches. |
US2177396A (en) | 1936-04-18 | 1939-10-24 | Borden Co | Milk bottle |
US4614197A (en) | 1984-10-15 | 1986-09-30 | Deere & Company | Chaff spreading arrangement for a combine |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4763497A (en) | 1986-09-03 | 1988-08-16 | Clover Co., Ltd. | Lock device for double sliding doors |
US4800078A (en) | 1987-05-28 | 1989-01-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Immunotherapeutic method of treating respiratory disease by intranasal administration of Igb |
IL105456A (en) | 1992-04-21 | 1996-12-05 | American Home Prod | Vaccines of attenuated respiratory syncytial virus |
US20030054505A1 (en) * | 1997-09-26 | 2003-03-20 | Hong Jin | Recombinant rsv expression systems and vaccines |
DK0780475T4 (da) | 1995-08-09 | 2006-10-23 | Schweiz Serum & Impfinst | Fremgangsmåde til fremstilling af infektiöse negativ-streng RNA-virus |
JPH11512609A (ja) | 1995-09-27 | 1999-11-02 | アメリカ合衆国 | クローン化されたヌクレオチド配列からの感染性RSウイルス(respiratory syncytial virus)の生産 |
US6077514A (en) * | 1996-04-04 | 2000-06-20 | The Regents Of The University Of Michigan | Attenuated respiratory syncytial virus |
JP4413999B2 (ja) * | 1996-07-15 | 2010-02-10 | アメリカ合衆国 | クローニングされたヌクレオチド配列からの弱毒化呼吸シンシチウムウィルスワクチンの製造 |
CN1250725C (zh) | 1997-05-23 | 2006-04-12 | 美国政府健康及人类服务部 | 从克隆的核苷酸序列制备减毒副流感病毒疫苗的方法 |
US7208161B1 (en) | 1997-05-23 | 2007-04-24 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences |
UA67845C2 (uk) * | 1999-04-23 | 2004-07-15 | Smithkline Beecham Plc | Поліморф 5-[4-[2- (n-метил-n-(2-піридил)аміно)етокси]бензил]тіазолідин-2,4-діону солі малеїнової кислоти |
-
2000
- 2000-03-31 CA CA002369200A patent/CA2369200A1/en not_active Abandoned
- 2000-03-31 MX MXPA01010320A patent/MXPA01010320A/es active IP Right Grant
- 2000-03-31 JP JP2000611553A patent/JP2002541785A/ja active Pending
- 2000-03-31 EP EP06075156A patent/EP1690940A1/de not_active Ceased
- 2000-03-31 CN CNB00806217XA patent/CN100491530C/zh not_active Expired - Lifetime
- 2000-03-31 IL IL14579600A patent/IL145796A0/xx not_active IP Right Cessation
- 2000-03-31 EP EP00920058A patent/EP1169457A2/de not_active Ceased
- 2000-03-31 AU AU40655/00A patent/AU4065500A/en not_active Abandoned
- 2000-03-31 KR KR1020017013099A patent/KR100746979B1/ko not_active IP Right Cessation
- 2000-03-31 BR BR0011160-0A patent/BR0011160A/pt not_active Application Discontinuation
- 2000-03-31 WO PCT/US2000/008802 patent/WO2000061611A2/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1169457A2 (de) | 2002-01-09 |
CA2369200A1 (en) | 2000-10-19 |
MXPA01010320A (es) | 2003-09-15 |
BR0011160A (pt) | 2002-10-08 |
CN100491530C (zh) | 2009-05-27 |
AU4065500A (en) | 2000-11-14 |
KR20020013526A (ko) | 2002-02-20 |
JP2002541785A (ja) | 2002-12-10 |
WO2000061611A2 (en) | 2000-10-19 |
WO2000061611A9 (en) | 2002-03-28 |
EP1690940A1 (de) | 2006-08-16 |
KR100746979B1 (ko) | 2007-08-07 |
CN1364195A (zh) | 2002-08-14 |
WO2000061611A3 (en) | 2001-01-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM9K | Patent not in force due to non-payment of renewal fees |