IL145589A0 - In vivo stain compounds and methods of use to identify dysplastic tissue - Google Patents

In vivo stain compounds and methods of use to identify dysplastic tissue

Info

Publication number
IL145589A0
IL145589A0 IL14558900A IL14558900A IL145589A0 IL 145589 A0 IL145589 A0 IL 145589A0 IL 14558900 A IL14558900 A IL 14558900A IL 14558900 A IL14558900 A IL 14558900A IL 145589 A0 IL145589 A0 IL 145589A0
Authority
IL
Israel
Prior art keywords
methods
stain compounds
dysplastic tissue
compounds
vivo
Prior art date
Application number
IL14558900A
Other languages
English (en)
Original Assignee
Zila Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zila Inc filed Critical Zila Inc
Publication of IL145589A0 publication Critical patent/IL145589A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/36—[b, e]-condensed, at least one with a further condensed benzene ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Sanitary Thin Papers (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Materials For Medical Uses (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
IL14558900A 2000-01-31 2000-01-31 In vivo stain compounds and methods of use to identify dysplastic tissue IL145589A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2000/002602 WO2001054696A1 (en) 2000-01-31 2000-01-31 In vivo stain compounds and methods of use to identify dysplastic tissue

Publications (1)

Publication Number Publication Date
IL145589A0 true IL145589A0 (en) 2002-06-30

Family

ID=21741026

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14558900A IL145589A0 (en) 2000-01-31 2000-01-31 In vivo stain compounds and methods of use to identify dysplastic tissue

Country Status (23)

Country Link
US (1) US6830743B1 (xx)
EP (1) EP1165087B1 (xx)
JP (1) JP2003520816A (xx)
KR (1) KR100641972B1 (xx)
CN (1) CN1219515C (xx)
AT (1) ATE303810T1 (xx)
AU (1) AU784639B2 (xx)
BR (1) BR0009427A (xx)
CA (1) CA2366759A1 (xx)
CZ (1) CZ20013504A3 (xx)
DE (1) DE60022487T2 (xx)
DK (1) DK1165087T3 (xx)
EA (1) EA003939B1 (xx)
ES (1) ES2248061T3 (xx)
HU (1) HUP0201634A3 (xx)
IL (1) IL145589A0 (xx)
MX (1) MXPA01009797A (xx)
NO (1) NO322012B1 (xx)
PL (1) PL349999A1 (xx)
SK (1) SK13782001A3 (xx)
TR (1) TR200102815T1 (xx)
TW (1) TWI250157B (xx)
WO (1) WO2001054696A1 (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7462346B2 (en) * 2001-08-28 2008-12-09 Zila Biotechnology, Inc. Light-stabilized(in vivo) stain composition and method of manufacture
US20050089472A1 (en) * 2003-10-22 2005-04-28 Shovers Aaron H. Monitoring the status of a condition of an animal through visually observable indicia

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321251A (en) * 1979-12-19 1982-03-23 The United States Of America As Represented By The Department Of Health And Human Services Detection of malignant lesions of the oral cavity utilizing toluidine blue rinse
JPS63187154A (ja) * 1987-01-29 1988-08-02 Kishida Kagaku Kk 酸素検知剤
JP3549880B2 (ja) * 1991-10-31 2004-08-04 ジラ・インコーポレーテッド 生物学的染料組成物、調製方法および上皮癌描写への使用方法
US5942410A (en) * 1997-07-07 1999-08-24 Oncometrics Imaging Corp. Composition and method for staining cellular DNA, comprising thiazine derivative metabisulfite and methanol or ethanol
US6417003B1 (en) * 1993-01-14 2002-07-09 Zila, Inc. Method and kit for epithelial cancer screening
WO1997026018A1 (en) * 1996-01-16 1997-07-24 Zila Pharmaceuticals, Inc. Methods and compositions for in-vivo detection of oral cancers and precancerous conditions
ATE282714T1 (de) * 1997-01-20 2004-12-15 Kyowa Medex Co Ltd Methoden und reagenzien zur quantitativen bestimmung von ascorbinsäure
DE19716586C1 (de) * 1997-04-21 1998-08-06 Continental Ag Verfahren zum Ermitteln der Profiltiefe eines Fahrzeugreifens am fahrenden Fahrzeug
US6194573B1 (en) * 1997-11-13 2001-02-27 Zila, Inc. Process for manufacture of in vivo stain composition
US6649144B1 (en) * 2000-02-28 2003-11-18 Zila, Inc. Method for detecting and killing epithelial cancer cells

Also Published As

Publication number Publication date
ES2248061T3 (es) 2006-03-16
ATE303810T1 (de) 2005-09-15
DE60022487D1 (de) 2005-10-13
BR0009427A (pt) 2002-07-16
PL349999A1 (en) 2002-10-21
JP2003520816A (ja) 2003-07-08
NO20014720D0 (no) 2001-09-28
CA2366759A1 (en) 2001-08-02
AU3695600A (en) 2001-08-07
CN1219515C (zh) 2005-09-21
CN1345241A (zh) 2002-04-17
SK13782001A3 (sk) 2002-02-05
HUP0201634A3 (en) 2009-08-28
HUP0201634A2 (en) 2002-09-28
TR200102815T1 (tr) 2002-05-21
US6830743B1 (en) 2004-12-14
KR20010108431A (ko) 2001-12-07
EA200101028A1 (ru) 2002-02-28
NO20014720L (no) 2001-11-27
NO322012B1 (no) 2006-08-07
DK1165087T3 (da) 2005-11-21
EA003939B1 (ru) 2003-10-30
EP1165087B1 (en) 2005-09-07
WO2001054696A1 (en) 2001-08-02
AU784639B2 (en) 2006-05-18
EP1165087A1 (en) 2002-01-02
KR100641972B1 (ko) 2006-11-02
DE60022487T2 (de) 2006-07-13
EP1165087A4 (en) 2003-04-02
TWI250157B (en) 2006-03-01
MXPA01009797A (es) 2002-11-04
CZ20013504A3 (cs) 2002-04-17

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