IL144867A0 - Method of crystallising n-(4-trifluoromethylphenyl)-5-methyl-isoxazole-4-carboxamide - Google Patents

Method of crystallising n-(4-trifluoromethylphenyl)-5-methyl-isoxazole-4-carboxamide

Info

Publication number
IL144867A0
IL144867A0 IL14486700A IL14486700A IL144867A0 IL 144867 A0 IL144867 A0 IL 144867A0 IL 14486700 A IL14486700 A IL 14486700A IL 14486700 A IL14486700 A IL 14486700A IL 144867 A0 IL144867 A0 IL 144867A0
Authority
IL
Israel
Prior art keywords
crystallising
trifluoromethylphenyl
isoxazole
carboxamide
methyl
Prior art date
Application number
IL14486700A
Other languages
English (en)
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of IL144867A0 publication Critical patent/IL144867A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL14486700A 1999-02-26 2000-02-12 Method of crystallising n-(4-trifluoromethylphenyl)-5-methyl-isoxazole-4-carboxamide IL144867A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19908527A DE19908527C2 (de) 1999-02-26 1999-02-26 Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid
PCT/EP2000/001151 WO2000050411A1 (de) 1999-02-26 2000-02-12 Verfahren zur kristallisation von n- (4-trifluormethylphenyl) -5-methyl- isoxazol- 4-carboxamid

Publications (1)

Publication Number Publication Date
IL144867A0 true IL144867A0 (en) 2002-06-30

Family

ID=7899073

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14486700A IL144867A0 (en) 1999-02-26 2000-02-12 Method of crystallising n-(4-trifluoromethylphenyl)-5-methyl-isoxazole-4-carboxamide
IL144867A IL144867A (en) 1999-02-26 2001-08-13 Method of crystallising n -(4 - trifluoromethylphenyl)- 5-methyl-isoxazole-4 carboxamide

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL144867A IL144867A (en) 1999-02-26 2001-08-13 Method of crystallising n -(4 - trifluoromethylphenyl)- 5-methyl-isoxazole-4 carboxamide

Country Status (22)

Country Link
US (1) US6303792B1 (es)
EP (1) EP1155004B1 (es)
JP (1) JP4625187B2 (es)
KR (1) KR100626110B1 (es)
CN (1) CN1127491C (es)
AR (1) AR022737A1 (es)
AT (1) ATE257828T1 (es)
AU (1) AU762394B2 (es)
BR (1) BR0008566B1 (es)
CA (1) CA2363875C (es)
DE (2) DE19908527C2 (es)
DK (1) DK1155004T3 (es)
ES (1) ES2214259T3 (es)
HK (1) HK1043787B (es)
HU (1) HU228918B1 (es)
IL (2) IL144867A0 (es)
NO (1) NO319830B1 (es)
NZ (1) NZ513777A (es)
PL (1) PL199365B1 (es)
PT (1) PT1155004E (es)
WO (1) WO2000050411A1 (es)
ZA (1) ZA200106973B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19610955A1 (de) * 1996-03-20 1997-09-25 Hoechst Ag Kombinationspräparat, enthaltend 5-Methylisoxazol-4-carbonsäure-(4-trifluormethyl)- anilid und N-(4-Trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid
ES2150808T3 (es) * 1997-08-08 2000-12-01 Aventis Pharma Gmbh Forma cristalina de (4-trifluorometil)-anilida de acido 5-metilisoxazol-4-carboxilico.
CN1411373A (zh) * 1999-12-16 2003-04-16 特瓦制药工业有限公司 制备来氟米特的新方法和新晶形的来氟米特
HUP0301865A3 (en) * 2000-02-15 2005-12-28 Teva Pharma A method for synthesizing leflunomide
CN107311954B (zh) * 2017-05-17 2020-04-07 力赛生物医药科技（厦门）有限公司 来氟米特晶型化合物、制备方法及其应用
CN114436894A (zh) * 2020-11-04 2022-05-06 欣凯医药化工中间体（上海）有限公司 泰瑞米特钠晶型及制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2854439A1 (de) 1978-12-16 1980-07-03 Hoechst Ag Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung
DE3534440A1 (de) * 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
US5494911A (en) * 1990-05-18 1996-02-27 Hoechst Aktiengesellschaft Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use
DE4127737A1 (de) * 1991-08-22 1993-02-25 Hoechst Ag Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen
US5519042A (en) * 1994-01-13 1996-05-21 Hoechst Aktiengesellschaft Method of treating hyperproliferative vascular disease
ES2150808T3 (es) 1997-08-08 2000-12-01 Aventis Pharma Gmbh Forma cristalina de (4-trifluorometil)-anilida de acido 5-metilisoxazol-4-carboxilico.
DE19734438A1 (de) * 1997-08-08 1999-02-11 Hoechst Marion Roussel De Gmbh Kristallform von N-(4-Trifluormethylphenyl)-5-methyl-isoxazole-4-carboxamid

Also Published As

Publication number Publication date
NO20014077L (no) 2001-10-24
NO319830B1 (no) 2005-09-19
NO20014077D0 (no) 2001-08-22
EP1155004A1 (de) 2001-11-21
HK1043787B (zh) 2004-03-05
IL144867A (en) 2006-12-31
CN1127491C (zh) 2003-11-12
DK1155004T3 (da) 2004-04-13
JP2002537388A (ja) 2002-11-05
HUP0200058A2 (hu) 2002-05-29
KR100626110B1 (ko) 2006-09-20
BR0008566B1 (pt) 2011-03-22
PL350422A1 (en) 2002-12-16
ES2214259T3 (es) 2004-09-16
DE19908527A1 (de) 2000-08-31
KR20010103774A (ko) 2001-11-23
CA2363875C (en) 2008-04-29
WO2000050411A1 (de) 2000-08-31
AU3803800A (en) 2000-09-14
JP4625187B2 (ja) 2011-02-02
ZA200106973B (en) 2002-08-22
DE50005025D1 (de) 2004-02-19
PL199365B1 (pl) 2008-09-30
CA2363875A1 (en) 2000-08-31
PT1155004E (pt) 2004-05-31
AU762394B2 (en) 2003-06-26
EP1155004B1 (de) 2004-01-14
HU228918B1 (en) 2013-06-28
US6303792B1 (en) 2001-10-16
DE19908527C2 (de) 2001-08-30
AR022737A1 (es) 2002-09-04
HK1043787A1 (en) 2002-09-27
BR0008566A (pt) 2002-01-22
HUP0200058A3 (en) 2004-07-28
NZ513777A (en) 2004-01-30
CN1341106A (zh) 2002-03-20
ATE257828T1 (de) 2004-01-15

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Legal Events

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