IL144234A0 - Synthesis method of nitroxymethylphenyl esters of aspirin derivatives - Google Patents

Synthesis method of nitroxymethylphenyl esters of aspirin derivatives

Info

Publication number
IL144234A0
IL144234A0 IL14423400A IL14423400A IL144234A0 IL 144234 A0 IL144234 A0 IL 144234A0 IL 14423400 A IL14423400 A IL 14423400A IL 14423400 A IL14423400 A IL 14423400A IL 144234 A0 IL144234 A0 IL 144234A0
Authority
IL
Israel
Prior art keywords
synthesis method
aspirin derivatives
nitroxymethylphenyl
esters
nitroxymethylphenyl esters
Prior art date
Application number
IL14423400A
Other languages
English (en)
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of IL144234A0 publication Critical patent/IL144234A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/86—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
IL14423400A 1999-01-26 2000-01-18 Synthesis method of nitroxymethylphenyl esters of aspirin derivatives IL144234A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI000134A IT1307928B1 (it) 1999-01-26 1999-01-26 Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.
PCT/EP2000/000353 WO2000044705A1 (en) 1999-01-26 2000-01-18 Synthesis method of nitroxymethylphenyl esters of aspirin derivatives

Publications (1)

Publication Number Publication Date
IL144234A0 true IL144234A0 (en) 2002-05-23

Family

ID=11381613

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14423400A IL144234A0 (en) 1999-01-26 2000-01-18 Synthesis method of nitroxymethylphenyl esters of aspirin derivatives

Country Status (18)

Country Link
US (1) US6512137B1 (xx)
EP (1) EP1147074B1 (xx)
JP (1) JP2002535380A (xx)
KR (1) KR100732147B1 (xx)
CN (2) CN1572787A (xx)
AT (1) ATE291567T1 (xx)
AU (1) AU766497B2 (xx)
BR (1) BR0007643A (xx)
CA (1) CA2361454A1 (xx)
DE (1) DE60018902T2 (xx)
ES (1) ES2239588T3 (xx)
HU (1) HUP0105011A3 (xx)
IL (1) IL144234A0 (xx)
IT (1) IT1307928B1 (xx)
PT (1) PT1147074E (xx)
RU (1) RU2232747C2 (xx)
WO (1) WO2000044705A1 (xx)
ZA (1) ZA200105705B (xx)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2348741C (en) 1998-10-30 2010-04-20 Nitromed Inc. Nitrosasted and nitrosylated nonsteroidal antiinflammatory compounds, comositions and methods of use
IT1312115B1 (it) 1999-06-24 2002-04-04 Nicox Sa Composti amorfi e relative composizioni farmaceutiche
ITMI991517A1 (it) * 1999-07-09 2001-01-09 Nicox Sa Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico
IL150368A0 (en) * 1999-12-23 2002-12-01 Nitromed Inc Nitrosated and nitrosylated cyclooxygenase-2-inhibitors, compositions and methods of use
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
DE60122939T2 (de) 2000-12-21 2007-01-11 Nitromed, Inc., Bedford Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
EP1539134A4 (en) 2002-06-11 2007-04-11 Nitromed Inc SELECTIVE INHIBITORS OF CYCLOOXIGENASE-2 NITROSIS AND / OR NITROSYLES, COMPOSITIONS AND METHODS OF USE
EP1539729A4 (en) * 2002-07-03 2008-02-20 Nitromed Inc NITROSED NON-TESTED OXIDE COMPOUNDS, COMPOSITIONS, AND APPLICATION METHODS
AU2003261281A1 (en) * 2002-07-29 2004-02-16 Nicox S.A. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
ATE399757T1 (de) * 2003-11-20 2008-07-15 Nicox Sa Neues verfahren zur herstellung von nitrooxyderivaten von paracetamol
WO2005065361A2 (en) 2003-12-31 2005-07-21 Khosrow Kashfi Compounds and compositions for treating dysproliferative diseases, and methods of use thereof
RU2007110846A (ru) 2004-08-26 2008-10-10 Николас Пайрамал Индия Лимитед (In) Пролекарства, включающие новые биодеградируемые линкеры
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
JP2007275193A (ja) * 2006-04-04 2007-10-25 Fujifilm Corp 光プローブおよび光断層画像化装置
AU2008286954B2 (en) 2007-08-10 2015-01-15 Basil Rigas Anti-inflammatory compounds and uses thereof
ES2362894B1 (es) * 2009-11-16 2012-05-21 Ferrer Internacional S.A. Procedimiento de preparación del �?cido 4-nitro-oxi-metil-benzoico.
CN105658651A (zh) * 2012-09-21 2016-06-08 巴兹尔·里格斯 用于治疗炎症相关的病症、疼痛和发热、皮肤病症、癌症及其癌症前期状况的组合物
WO2014052889A1 (en) * 2012-09-27 2014-04-03 The Board Of Trustees Of The University Of Illinois Anti-inflammatory agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
SV1997000108A (es) * 1997-12-18 1999-11-24 Manufacturas Humberto Bukele E Sintesis de acido acetilsalicilico en presencia de oxido de calcio

Also Published As

Publication number Publication date
ITMI990134A1 (it) 2000-07-26
ATE291567T1 (de) 2005-04-15
US6512137B1 (en) 2003-01-28
KR20010101653A (ko) 2001-11-14
EP1147074A1 (en) 2001-10-24
CA2361454A1 (en) 2000-08-03
HUP0105011A3 (en) 2002-12-28
HUP0105011A2 (hu) 2002-04-29
RU2232747C2 (ru) 2004-07-20
JP2002535380A (ja) 2002-10-22
CN1344244A (zh) 2002-04-10
PT1147074E (pt) 2005-07-29
IT1307928B1 (it) 2001-11-29
CN1191228C (zh) 2005-03-02
ZA200105705B (en) 2002-10-11
WO2000044705A1 (en) 2000-08-03
DE60018902D1 (de) 2005-04-28
BR0007643A (pt) 2001-10-16
AU2664500A (en) 2000-08-18
AU766497B2 (en) 2003-10-16
CN1572787A (zh) 2005-02-02
EP1147074B1 (en) 2005-03-23
KR100732147B1 (ko) 2007-06-25
DE60018902T2 (de) 2006-03-30
ES2239588T3 (es) 2005-10-01

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