IL143805A0 - Combination therapy of radiation and a cox-2 inhibitor for the treatment of neoplasia - Google Patents

Combination therapy of radiation and a cox-2 inhibitor for the treatment of neoplasia

Info

Publication number
IL143805A0
IL143805A0 IL14380599A IL14380599A IL143805A0 IL 143805 A0 IL143805 A0 IL 143805A0 IL 14380599 A IL14380599 A IL 14380599A IL 14380599 A IL14380599 A IL 14380599A IL 143805 A0 IL143805 A0 IL 143805A0
Authority
IL
Israel
Prior art keywords
inhibitor
radiation
neoplasia
cox
treatment
Prior art date
Application number
IL14380599A
Other languages
English (en)
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of IL143805A0 publication Critical patent/IL143805A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Radiation-Therapy Devices (AREA)
IL14380599A 1998-12-23 1999-12-22 Combination therapy of radiation and a cox-2 inhibitor for the treatment of neoplasia IL143805A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11378698P 1998-12-23 1998-12-23
US09/385,214 US6649645B1 (en) 1998-12-23 1999-08-27 Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia
PCT/US1999/030669 WO2000038716A1 (fr) 1998-12-23 1999-12-22 Therapie combinant la radiotherapie et un inhibiteur de la cyclooxygenase-2 permettant de traiter les maladies neoplasiques

Publications (1)

Publication Number Publication Date
IL143805A0 true IL143805A0 (en) 2002-04-21

Family

ID=26811473

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14380599A IL143805A0 (en) 1998-12-23 1999-12-22 Combination therapy of radiation and a cox-2 inhibitor for the treatment of neoplasia
IL143805A IL143805A (en) 1998-12-23 2001-06-17 Use of COX 2 inhibitors for the preparation of drugs for the treatment of neoplasia in a patient treated with radiation

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL143805A IL143805A (en) 1998-12-23 2001-06-17 Use of COX 2 inhibitors for the preparation of drugs for the treatment of neoplasia in a patient treated with radiation

Country Status (19)

Country Link
US (3) US6649645B1 (fr)
EP (2) EP1522313A1 (fr)
JP (1) JP2002535249A (fr)
KR (1) KR100705744B1 (fr)
AT (1) ATE281845T1 (fr)
AU (1) AU769665B2 (fr)
BR (1) BR9916544A (fr)
CA (1) CA2356547A1 (fr)
CY (1) CY1105584T1 (fr)
DE (1) DE69921852T2 (fr)
DK (1) DK1140181T3 (fr)
EA (1) EA200100571A1 (fr)
ES (1) ES2232205T3 (fr)
HU (1) HUP0104669A3 (fr)
IL (2) IL143805A0 (fr)
NO (1) NO20013064L (fr)
PL (1) PL349149A1 (fr)
PT (1) PT1140181E (fr)
WO (1) WO2000038716A1 (fr)

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US20080153894A1 (en) * 2002-12-19 2008-06-26 Pharmacia Corporation Cyclooxygenase-2 inhibitor and antibacterial agent combination for intramammary treatment of mastitis
PT1585743E (pt) 2002-12-19 2007-07-12 Pfizer Compostos de 2- (1h-indazol-6-ilamin)-benzamida como inibidores de proteína-cinases úteis para o tratamento de doenças aftálmicas.
US7259266B2 (en) * 2003-03-31 2007-08-21 Pharmacia Corporation Benzopyran compounds useful for treating inflammatory conditions
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JP2011506277A (ja) * 2007-11-28 2011-03-03 トラガラ ファーマシューティカルズ，インク． Ｃｏｘ−２阻害薬と代謝拮抗物質との組み合わせを使用する癌治療
US20110086850A1 (en) * 2008-04-11 2011-04-14 Board Of Regents, The University Of Texas System Radiosensitization of tumors with indazolpyrrolotriazines for radiotherapy
US8002838B2 (en) * 2008-06-11 2011-08-23 Depuy Products, Inc. Joint prosthesis with positionable head
KR102108226B1 (ko) 2010-02-12 2020-05-08 화이자 인코포레이티드 8-플루오로-2-｛4-［(메틸아미노)메틸］페닐｝-1,3,4,5-테트라하이드로-6ｈ-아제피노［5,4,3-ｃｄ］인돌-6-온의 염 및 다형체
TWI646091B (zh) 2012-12-28 2019-01-01 日商衛斯克慧特股份有限公司 鹽類及晶形
JP6215335B2 (ja) 2013-09-24 2017-10-18 富士フイルム株式会社 新規な含窒素化合物もしくはその塩またはそれらと金属との錯体
JP6621477B2 (ja) 2014-12-18 2019-12-18 ファイザー・インク ピリミジンおよびトリアジン誘導体ならびにａｘｌ阻害薬としてのそれらの使用

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HUP0104669A2 (hu) 2002-05-29
PL349149A1 (en) 2002-07-01
ES2232205T3 (es) 2005-05-16
EA200100571A1 (ru) 2001-12-24
US6649645B1 (en) 2003-11-18
EP1140181B1 (fr) 2004-11-10
IL143805A (en) 2007-03-08
WO2000038716A1 (fr) 2000-07-06
BR9916544A (pt) 2002-01-08
ATE281845T1 (de) 2004-11-15
KR20010109273A (ko) 2001-12-08
AU2713400A (en) 2000-07-31
US20040053934A1 (en) 2004-03-18
AU769665B2 (en) 2004-01-29
EP1140181A1 (fr) 2001-10-10
US20040053935A1 (en) 2004-03-18
WO2000038716A9 (fr) 2000-11-30
JP2002535249A (ja) 2002-10-22
NO20013064D0 (no) 2001-06-20
EP1522313A1 (fr) 2005-04-13
CA2356547A1 (fr) 2000-07-06
DE69921852D1 (de) 2004-12-16
DE69921852T2 (de) 2005-10-27
CY1105584T1 (el) 2010-07-28
NO20013064L (no) 2001-08-23
KR100705744B1 (ko) 2007-04-11
HUP0104669A3 (en) 2002-08-28
PT1140181E (pt) 2005-02-28
DK1140181T3 (da) 2005-02-14

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