CA2161789A1 - Derives de substitution en 2 du 3,4-diarylthiofene, inhibiteurs de la cyclooxygenase - Google Patents
Derives de substitution en 2 du 3,4-diarylthiofene, inhibiteurs de la cyclooxygenaseInfo
- Publication number
- CA2161789A1 CA2161789A1 CA002161789A CA2161789A CA2161789A1 CA 2161789 A1 CA2161789 A1 CA 2161789A1 CA 002161789 A CA002161789 A CA 002161789A CA 2161789 A CA2161789 A CA 2161789A CA 2161789 A1 CA2161789 A1 CA 2161789A1
- Authority
- CA
- Canada
- Prior art keywords
- group
- hydrogen
- thiadiazol
- oxadiazol
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/42—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms
- C07D333/44—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms with nitro or nitroso radicals directly attached to ring carbon atoms attached in position 5
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6135493A | 1993-05-13 | 1993-05-13 | |
US061,354 | 1993-05-13 | ||
PCT/CA1994/000264 WO1994026731A1 (fr) | 1993-05-13 | 1994-05-11 | Inhibiteurs de la cyclogenase |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2161789A1 true CA2161789A1 (fr) | 1994-11-24 |
Family
ID=22035257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002161789A Abandoned CA2161789A1 (fr) | 1993-05-13 | 1994-05-11 | Derives de substitution en 2 du 3,4-diarylthiofene, inhibiteurs de la cyclooxygenase |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU6718494A (fr) |
CA (1) | CA2161789A1 (fr) |
WO (1) | WO1994026731A1 (fr) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6027694A (en) * | 1993-01-15 | 1994-08-15 | G.D. Searle & Co. | Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents |
GB9420616D0 (en) * | 1994-10-12 | 1994-11-30 | Merck Sharp & Dohme | Method, compositions and use |
US5840746A (en) * | 1993-06-24 | 1998-11-24 | Merck Frosst Canada, Inc. | Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases |
US5521213A (en) | 1994-08-29 | 1996-05-28 | Merck Frosst Canada, Inc. | Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2 |
GB2294879A (en) * | 1994-10-19 | 1996-05-15 | Merck & Co Inc | Cylcooxygenase-2 Inhibitors |
JP2636819B2 (ja) | 1994-12-20 | 1997-07-30 | 日本たばこ産業株式会社 | オキサゾール系複素環式芳香族化合物 |
US5643933A (en) * | 1995-06-02 | 1997-07-01 | G. D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
US6515014B2 (en) | 1995-06-02 | 2003-02-04 | G. D. Searle & Co. | Thiophene substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
WO1996038418A1 (fr) | 1995-06-02 | 1996-12-05 | G.D. Searle & Co. | Derives heterocyclo-substitues d'acide hydroxamique utilises comme inhibiteurs de la cyclo-oxygenase-2 et de la 5-lipoxygenase |
US6512121B2 (en) | 1998-09-14 | 2003-01-28 | G.D. Searle & Co. | Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
US5700816A (en) * | 1995-06-12 | 1997-12-23 | Isakson; Peter C. | Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor |
CA2224517A1 (fr) * | 1995-06-12 | 1996-12-27 | G.D. Searle & Co. | Compositions comprenant un inhibiteur de cyclooxygenase-2 et un inhibiteur de 5-lipoxygenase |
EP0833664A1 (fr) | 1995-06-12 | 1998-04-08 | G.D. SEARLE & CO. | Traitement d'inflammations par une combinaison d'un inhibiteur de la cyclooxygenase-2 et d'un antagoniste du recepteur de leukotriene b 4? |
KR19990064310A (ko) * | 1995-10-17 | 1999-07-26 | 윌리암스 로저 에이 | 시클로옥시게나제-2의 검출방법 |
EP0880363B1 (fr) | 1996-02-13 | 2002-09-11 | G.D. SEARLE & CO. | Combinaisons a effets immunosuppresseurs comprenant un inhibiteur de cyclooxygenase-2 et un inhibiteur de la leucotriene a 4 hydrolase |
AU2250097A (en) | 1996-02-13 | 1997-09-02 | G.D. Searle & Co. | Compositions comprising a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist |
DE69709069T2 (de) | 1996-02-13 | 2002-07-04 | G.D. Searle & Co., Chicago | Zusammensetzungen mit immunosuppressiven wirkungen, welche 5-lipoxygenase-inhibitoren und cyclooxygenase-2-inhibitoren enthalten |
WO1997038986A1 (fr) | 1996-04-12 | 1997-10-23 | G.D. Searle & Co. | Derives benzenesulfonamide substitue utilisables comme precurseurs des inhibiteurs du cox-2 |
US6677364B2 (en) | 1998-04-20 | 2004-01-13 | G.D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
US5883267A (en) * | 1996-05-31 | 1999-03-16 | Merck & Co., Inc. | Process for making phenyl heterocycles useful as cox-2 inhibitors |
HRP970289A2 (en) * | 1996-05-31 | 1998-04-30 | Merck & Co Inc | Process for preparing phenyl heterocycles useful as cox-2 inhibitors |
RU2239429C2 (ru) | 1996-10-15 | 2004-11-10 | Джи. Ди. Сирл Энд Ко. | Способ применения ингибиторов циклооксигеназы-2 для лечения и профилактики неоплазии |
CA2308639A1 (fr) * | 1997-10-31 | 1999-05-14 | G.D. Searle & Co. | Methode pour l'utilisation d'inhibiteurs de cyclooxygenase-2 permettant de maintenir le canal arteriel foetal au cours du traitement et de la prevention d'accouchements prematures |
US6025353A (en) * | 1997-11-19 | 2000-02-15 | G.D. Searle & Co. | Method of using cyclooxygenase-2 inhibitors as anti-angiogenic agents |
US6649645B1 (en) | 1998-12-23 | 2003-11-18 | Pharmacia Corporation | Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia |
US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
WO2001017996A1 (fr) * | 1999-09-08 | 2001-03-15 | Merck Frosst Canada & Co. | Thiadiazoles-1,2,3, et leur utilisation comme inhibiteurs de cox-2 |
AU2001253749A1 (en) * | 2000-04-25 | 2001-11-07 | Pharmacia Corporation | 2-fluorobenzenesulfonyl compounds for the treatment of inflammation |
ES2166710B1 (es) * | 2000-04-25 | 2004-10-16 | J. URIACH & CIA, S.A. | Nuevos compuestos heterociclicos con actividad antiinflamatoria. |
US6465509B2 (en) | 2000-06-30 | 2002-10-15 | Merck Frosst Canada & Co. | Pyrones as inhibitors of cyclooxygenase-2 |
US6716829B2 (en) | 2000-07-27 | 2004-04-06 | Pharmacia Corporation | Aldosterone antagonist and cyclooxygenase-2 inhibitor combination therapy to prevent or treat inflammation-related cardiovascular disorders |
US20030105144A1 (en) | 2001-04-17 | 2003-06-05 | Ping Gao | Stabilized oral pharmaceutical composition |
US6673818B2 (en) | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US7067159B2 (en) | 2003-12-05 | 2006-06-27 | New Chapter, Inc. | Methods for treating prostate cancer with herbal compositions |
US7070816B2 (en) | 2003-12-05 | 2006-07-04 | New Chapter, Inc. | Methods for treating prostatic intraepithelial neoplasia with herbal compositions |
WO2005115992A1 (fr) | 2004-05-23 | 2005-12-08 | Housey Pharmaceuticals, Inc. | Modulateurs de theramuteine |
US7622142B2 (en) | 2004-09-14 | 2009-11-24 | New Chapter Inc. | Methods for treating glioblastoma with herbal compositions |
US8067464B2 (en) | 2004-10-04 | 2011-11-29 | Nitromed, Inc. | Compositions and methods using apocynin compounds and nitric oxide donors |
US8431110B2 (en) | 2005-05-23 | 2013-04-30 | Hmi Medical Innovations, Llc. | Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators |
WO2007016677A2 (fr) | 2005-08-02 | 2007-02-08 | Nitromed, Inc. | Composes antimicrobiens promoteurs d'oxyde nitrique, compositions et procedes d'utilisation |
US7838023B2 (en) | 2005-11-16 | 2010-11-23 | Nitromed, Inc. | Furoxan compounds, compositions and methods of use |
EP2007705A4 (fr) | 2006-03-29 | 2011-09-07 | Nicox Sa | Prostaglandines amplificatrices d'oxyde nitrique, compositions et méthodes d'utilisation |
CA3042642A1 (fr) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Comprime extrude anti-abus a liberation immediate |
US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
JP6371463B2 (ja) | 2014-07-17 | 2018-08-08 | ファーマシューティカル マニュファクチュアリング リサーチ サービシズ,インコーポレーテッド | 即時放出性乱用抑止性液体充填剤形 |
US20160106737A1 (en) | 2014-10-20 | 2016-04-21 | Pharmaceutical Manufacturing Research Services, Inc. | Extended Release Abuse Deterrent Liquid Fill Dosage Form |
WO2016177776A1 (fr) | 2015-05-04 | 2016-11-10 | Academisch Medisch Centrum | Biomarqueurs pour la détection de l'insensibilité à l'aspirine |
CN107011320A (zh) * | 2017-05-17 | 2017-08-04 | 广州医科大学 | 环丙基取代噻吩环烷胺类化合物及其应用 |
WO2022195579A1 (fr) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Dipalmitoyl-phosphatidyl-éthanol-amine conjuguée à l'acide hyaluronique en combinaison avec des médicaments anti-inflammatoires non stéroïdiens (ains) pour traiter ou soulager des maladies inflammatoires |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0087629B1 (fr) * | 1982-03-03 | 1986-01-15 | E.I. Du Pont De Nemours And Company | 2,3-Diaryl-5-halo-thiophènes, anti-inflammatoires et/ou analgésiques |
EP0365089A3 (fr) * | 1988-10-18 | 1991-06-05 | Merck & Co. Inc. | 2-Aryl-5(3-méthoxy-5-(hydroxypropylsulphonyl)-4-propoxyphényl) tétrahydrothiophène et analogues |
AU6027694A (en) * | 1993-01-15 | 1994-08-15 | G.D. Searle & Co. | Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents |
-
1994
- 1994-05-11 CA CA002161789A patent/CA2161789A1/fr not_active Abandoned
- 1994-05-11 WO PCT/CA1994/000264 patent/WO1994026731A1/fr active Application Filing
- 1994-05-11 AU AU67184/94A patent/AU6718494A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU6718494A (en) | 1994-12-12 |
WO1994026731A1 (fr) | 1994-11-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |