AU2001253749A1 - 2-fluorobenzenesulfonyl compounds for the treatment of inflammation - Google Patents

2-fluorobenzenesulfonyl compounds for the treatment of inflammation

Info

Publication number
AU2001253749A1
AU2001253749A1 AU2001253749A AU5374901A AU2001253749A1 AU 2001253749 A1 AU2001253749 A1 AU 2001253749A1 AU 2001253749 A AU2001253749 A AU 2001253749A AU 5374901 A AU5374901 A AU 5374901A AU 2001253749 A1 AU2001253749 A1 AU 2001253749A1
Authority
AU
Australia
Prior art keywords
fluorobenzenesulfonyl
inflammation
compounds
treatment
fluorobenzenesulfonyl compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001253749A
Inventor
David L. Brown
Matthew J Graneto
Cindy L. Ludwig
John J Talley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia LLC
Original Assignee
Pharmacia LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia LLC filed Critical Pharmacia LLC
Publication of AU2001253749A1 publication Critical patent/AU2001253749A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/18—Radicals substituted by singly bound hetero atoms other than halogen by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
AU2001253749A 2000-04-25 2001-04-20 2-fluorobenzenesulfonyl compounds for the treatment of inflammation Abandoned AU2001253749A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19953300P 2000-04-25 2000-04-25
US60199533 2000-04-25
US25338000P 2000-11-27 2000-11-27
US60253380 2000-11-27
PCT/US2001/012983 WO2001081332A2 (en) 2000-04-25 2001-04-20 2-fluorobenzenesulfonyl compounds for the treatment of inflammation

Publications (1)

Publication Number Publication Date
AU2001253749A1 true AU2001253749A1 (en) 2001-11-07

Family

ID=26894867

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001253749A Abandoned AU2001253749A1 (en) 2000-04-25 2001-04-20 2-fluorobenzenesulfonyl compounds for the treatment of inflammation
AU2001255600A Abandoned AU2001255600A1 (en) 2000-04-25 2001-04-20 Regioselective synthesis of 3,4-di(carbocyclyl or heterocyclyl)thiophenes

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2001255600A Abandoned AU2001255600A1 (en) 2000-04-25 2001-04-20 Regioselective synthesis of 3,4-di(carbocyclyl or heterocyclyl)thiophenes

Country Status (5)

Country Link
US (2) US20020183362A1 (en)
EP (2) EP1276736A2 (en)
JP (2) JP2003531202A (en)
AU (2) AU2001253749A1 (en)
WO (2) WO2001081332A2 (en)

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RU2002119574A (en) 1999-12-23 2004-01-10 Нитромед, Инк. (Us) Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions based on them and methods for their use
US20040092552A1 (en) * 2000-04-25 2004-05-13 Brown David L 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation
US20020183362A1 (en) * 2000-04-25 2002-12-05 Pharmacia Corporation 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation
US20030232996A1 (en) * 2001-04-20 2003-12-18 Brown David L Regioselective synthesis of 3,4-di{(carboclyl or heterocyclyl)thiophenes
RU2004132721A (en) 2002-04-08 2005-06-27 Глэксо Груп Лимитед (GB) (2-Alcoxy) phenyl) Cyclopent-1-Enyl) Aromatic Carboxylic acid and Heterocyclic Carbonic Acid and its derivatives
GB0221443D0 (en) * 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
CA2505945A1 (en) * 2002-12-02 2004-06-17 Fujisawa Pharmaceutical Co., Ltd. Pyrazole derivatives useful as cox-i inhibitors
EP2067776A1 (en) 2003-07-24 2009-06-10 Euro-Celtique S.A. Piperidine compounds and pharmaceutical compositions containing them
ITMI20040019A1 (en) * 2004-01-12 2004-04-12 Univ Bari ISOSSAZOLIC DERIVATIVES AND THEIR USE AS CYCLOSXYGENASE INHIBITORS
CA2584317A1 (en) * 2004-10-15 2006-04-27 Memory Pharmaceuticals Corporation Pyrazole derivatives as phosphodiesterase 4 inhibitors
WO2007076039A2 (en) * 2005-12-20 2007-07-05 Massachusetts Institute Of Technology Communications and power harvesting system for in-pipe wireless sensor networks
NL2000351C2 (en) 2005-12-22 2007-09-11 Pfizer Prod Inc Estrogen modulators.
AU2007292436A1 (en) * 2006-09-07 2008-03-13 Allergan, Inc. Heteroaromatic compounds having sphingosine-1-phosphate (S1P) receptor agonist biological activity
CA2685266C (en) 2007-04-27 2014-01-28 Purdue Pharma L.P. Trpv1 antagonists and uses thereof for the treatment of prevention of pain, ui and ulcer, ibd, or ibs in an animal
US7989450B2 (en) 2008-01-11 2011-08-02 Universita' Degli Studi Di Bari Functionalized diarylisoxazoles inhibitors of ciclooxygenase
CA2894399A1 (en) 2012-12-06 2014-06-12 Quanticel Pharmaceuticals, Inc. Histone demethylase inhibitors

Family Cites Families (32)

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US4820827A (en) 1982-03-03 1989-04-11 E. I. Du Pont De Nemours And Company 2,3-diaryl-5-bromothiophene compounds of use for the treatment of inflammaton and dysmenorrhea
US5663180A (en) * 1983-10-29 1997-09-02 G.D. Searle & Co. Substituted cyclopentenes for the treatment of inflammation
US5571810A (en) 1990-06-11 1996-11-05 Fujisawa Pharmaceutical Co., Ltd. Thiophene derivatives
GB9012936D0 (en) 1990-06-11 1990-08-01 Fujisawa Pharmaceutical Co Thiophene derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
DK0679157T3 (en) 1993-01-15 1998-07-27 Searle & Co Novel 3,4-diarylthiophenes and analogs thereof for use as anti-inflammatory agents
AU6718494A (en) * 1993-05-13 1994-12-12 Merck Frosst Canada Inc. 2-substituted-3,4-diarylthiophene derivatives as inhibitors of cyclooxygenase
US5380738A (en) * 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
GB9602877D0 (en) 1996-02-13 1996-04-10 Merck Frosst Canada Inc 3,4-Diaryl-2-hydroxy-2,5- dihydrofurans as prodrugs to cox-2 inhibitors
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
DE10075033I2 (en) * 1993-11-30 2001-08-02 Searle & Co substituted pyrazolyl-benzenesulfonamides for the treatment of inflammation.
US5401765A (en) * 1993-11-30 1995-03-28 G. D. Searle 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders
US5393790A (en) * 1994-02-10 1995-02-28 G.D. Searle & Co. Substituted spiro compounds for the treatment of inflammation
AU2424895A (en) * 1994-05-04 1995-11-29 G.D. Searle & Co. Substituted spirodienes for the treatment of inflammation
JPH10504542A (en) * 1994-07-27 1998-05-06 ジー．ディー．サール アンド カンパニー Substituted thiazole compounds for treating inflammation
US5521213A (en) 1994-08-29 1996-05-28 Merck Frosst Canada, Inc. Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
US5908852A (en) * 1994-11-14 1999-06-01 G. D. Searle & Co. 1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
US5739166A (en) * 1994-11-29 1998-04-14 G.D. Searle & Co. Substituted terphenyl compounds for the treatment of inflammation
JP2636819B2 (en) * 1994-12-20 1997-07-30 日本たばこ産業株式会社 Oxazole-based heterocyclic aromatic compounds
US5686470A (en) * 1995-02-10 1997-11-11 Weier; Richard M. 2, 3-substituted pyridines for the treatment of inflammation
CN1107058C (en) * 1995-02-13 2003-04-30 G·D·瑟尔公司 Substituted isoxazoles for the treatment of inflammation
US5886016A (en) * 1995-09-15 1999-03-23 G.D. Searle & Co. Benzopyranopyrazolyl derivatives for the treatment of inflammation
US5756529A (en) * 1995-09-29 1998-05-26 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides for use in veterinary therapies
US5981576A (en) 1995-10-13 1999-11-09 Merck Frosst Canada, Inc. (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors
KR100387658B1 (en) * 1996-04-12 2003-08-19 지.디. 썰 엘엘씨 Substituted benzenesulfonamide derivatives as prodrugs of cox-2 inhibitors
AU5377698A (en) * 1996-12-10 1998-07-03 G.D. Searle & Co. Substituted pyrrolyl compounds for the treatment of inflammation
JPH11180871A (en) * 1997-09-26 1999-07-06 Sankyo Co Ltd Medicine containing 1,2-diphenylpyrrole derivative
FR2769311B1 (en) * 1997-10-07 1999-12-24 Union Pharma Scient Appl NOVEL 3,4-DIARYLTHIAZOLIN-2-ONE OR -2-THIONE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USES
NZ333399A (en) * 1997-12-24 2000-05-26 Sankyo Co Cyclooxygenase-2 inhibitors (COX-2) for the prevention and treatment of tumors, cachexia and tumor-metastasis
TNSN99111A1 (en) * 1998-06-11 2005-11-10 Pfizer NOVEL SULFONYLBENZENE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US6294558B1 (en) * 1999-05-31 2001-09-25 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
US20020183362A1 (en) * 2000-04-25 2002-12-05 Pharmacia Corporation 2-Fluorobenzenesulfonyl compounds for the treatment of inflammation
US6673818B2 (en) * 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation

Also Published As

Publication number Publication date
US6600052B1 (en) 2003-07-29
WO2001081332A2 (en) 2001-11-01
WO2001081332A3 (en) 2002-04-04
EP1276736A2 (en) 2003-01-22
JP2003531202A (en) 2003-10-21
WO2001081333A2 (en) 2001-11-01
JP2003531201A (en) 2003-10-21
EP1296971A2 (en) 2003-04-02
WO2001081333A3 (en) 2002-04-25
US20020183362A1 (en) 2002-12-05
AU2001255600A1 (en) 2001-11-07

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