IL143392A0 - Carboxylic acids and carboxylic acid isosteres of n-heterocyclic compounds - Google Patents
Carboxylic acids and carboxylic acid isosteres of n-heterocyclic compoundsInfo
- Publication number
- IL143392A0 IL143392A0 IL14339299A IL14339299A IL143392A0 IL 143392 A0 IL143392 A0 IL 143392A0 IL 14339299 A IL14339299 A IL 14339299A IL 14339299 A IL14339299 A IL 14339299A IL 143392 A0 IL143392 A0 IL 143392A0
- Authority
- IL
- Israel
- Prior art keywords
- treating
- carboxylic acid
- acid isosteres
- heterocyclic compounds
- carboxylic acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20423798A | 1998-12-03 | 1998-12-03 | |
US09/453,571 US6331537B1 (en) | 1998-06-03 | 1999-12-02 | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds |
PCT/US1999/028663 WO2000032588A2 (fr) | 1998-12-03 | 1999-12-03 | Acides carboxyliques et isosteres d'acides carboxyliques de composes n-heterocycliques |
Publications (1)
Publication Number | Publication Date |
---|---|
IL143392A0 true IL143392A0 (en) | 2002-04-21 |
Family
ID=26899306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14339299A IL143392A0 (en) | 1998-12-03 | 1999-12-03 | Carboxylic acids and carboxylic acid isosteres of n-heterocyclic compounds |
Country Status (20)
Country | Link |
---|---|
US (2) | US6331537B1 (fr) |
EP (1) | EP1135370B1 (fr) |
KR (1) | KR20010086080A (fr) |
CN (1) | CN1213026C (fr) |
AT (1) | ATE252078T1 (fr) |
AU (1) | AU767468B2 (fr) |
BG (1) | BG105643A (fr) |
BR (1) | BR9916461A (fr) |
CA (1) | CA2353460C (fr) |
CZ (1) | CZ20011971A3 (fr) |
DE (1) | DE69912151T2 (fr) |
EA (1) | EA003926B1 (fr) |
HU (1) | HUP0105027A3 (fr) |
IL (1) | IL143392A0 (fr) |
MX (1) | MXPA01005549A (fr) |
NO (1) | NO318909B1 (fr) |
NZ (1) | NZ511673A (fr) |
PL (1) | PL348715A1 (fr) |
SK (1) | SK7442001A3 (fr) |
WO (1) | WO2000032588A2 (fr) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US6274602B1 (en) * | 1998-06-03 | 2001-08-14 | Gpi Nil Holdings, Inc. | Heterocyclic thioester and ketone hair growth compositions and uses |
US20010049381A1 (en) * | 1997-06-04 | 2001-12-06 | Gpl Nil Holdings, Inc., | Pyrrolidine derivative hair growth compositions and uses |
EP1011650A1 (fr) * | 1997-09-24 | 2000-06-28 | Amgen Inc., | Procede utilise pour prevenir les deficits auditifs au moyen de composes sensorineurotrophiques |
HUP0202249A3 (en) | 1999-07-09 | 2003-01-28 | Ortho Mcneil Pharm Inc | Neurotrophic pyrrolidines and piperidines, compositions containing them and use of the compounds |
DOP2000000107A (es) | 1999-12-01 | 2002-09-16 | Agouron Pharmaceutical Inc | Compuestos, composiciones y metodos para estimular el crecimiento y alongamiento de las neuronas |
US6809093B2 (en) * | 2000-10-17 | 2004-10-26 | H. Lee Moffitt Cancer & Research Institute, Inc. | 2-substituted heterocyclic compounds |
US6608196B2 (en) | 2001-05-03 | 2003-08-19 | Galileo Pharmaceuticals, Inc. | Process for solid supported synthesis of pyruvate-derived compounds |
EP1392639B1 (fr) | 2001-05-03 | 2008-09-17 | Galileo Laboratories, Inc. | Derives de pyruvates |
EP1404325A2 (fr) * | 2001-05-29 | 2004-04-07 | Guilford Pharmaceuticals Inc. | Procede de traitement d'accidents nerveux entraines par une operation |
US20100030130A1 (en) * | 2001-11-09 | 2010-02-04 | Cochlear Limited | Pharmaceutical intervention for modulation of neural plasticity |
US20100030301A1 (en) * | 2001-11-09 | 2010-02-04 | Cochlear Limited | Electrical stimulation for modulation of neural plasticity |
AUPR879201A0 (en) * | 2001-11-09 | 2001-12-06 | Cochlear Limited | Subthreshold stimulation of a cochlea |
US20050171579A1 (en) * | 2001-11-09 | 2005-08-04 | Claudia Tasche | Stimulating device |
US7345091B2 (en) | 2002-07-29 | 2008-03-18 | Cardax Pharmaceuticals, Inc. | Carotenoid ether analogs or derivatives for the inhibition and amelioration of disease |
US7763649B2 (en) | 2002-07-29 | 2010-07-27 | Cardax Pharmaceuticals, Inc. | Carotenoid analogs or derivatives for controlling connexin 43 expression |
US20050059635A1 (en) * | 2002-07-29 | 2005-03-17 | Lockwood Samuel Fournier | Carotenoid ester analogs or derivatives for controlling C-reactive protein levels |
US20050148517A1 (en) * | 2002-07-29 | 2005-07-07 | Lockwood Samuel F. | Carotenoid ether analogs or derivatives for controlling connexin 43 expression |
US7723327B2 (en) | 2002-07-29 | 2010-05-25 | Cardax Pharmaceuticals, Inc. | Carotenoid ester analogs or derivatives for the inhibition and amelioration of liver disease |
US20050143475A1 (en) * | 2002-07-29 | 2005-06-30 | Lockwood Samuel F. | Carotenoid analogs or derivatives for the inhibition and amelioration of ischemic reperfusion injury |
KR20050069975A (ko) | 2002-07-29 | 2005-07-05 | 하와이 바이오테크, 인코포레이티드 | 질병의 억제 및 완화를 위한 카로티노이드 구조 유사체 |
US7375133B2 (en) * | 2002-07-29 | 2008-05-20 | Cardax Pharmaceuticals, Inc. | Pharmaceutical compositions including carotenoid ether analogs or derivatives for the inhibition and amelioration of disease |
US7521584B2 (en) * | 2002-07-29 | 2009-04-21 | Cardax Pharmaceuticals, Inc. | Carotenoid analogs or derivatives for the inhibition and amelioration of disease |
US7320997B2 (en) | 2002-07-29 | 2008-01-22 | Cardax Pharmaceuticals, Inc. | Pharmaceutical compositions including carotenoid ester analogs or derivatives for the inhibition and amelioration of disease |
WO2004016167A1 (fr) * | 2002-08-16 | 2004-02-26 | The General Hospital Corporation | Imagerie fonctionnelle non invasive de l'activation du systeme nerveux peripherique chez les humains et les animaux |
EP1546103B1 (fr) * | 2002-10-03 | 2009-03-18 | Vertex Pharmaceuticals Incorporated | Piperazine et derives de piperidine permettant de traiter des maladies neurologiques |
US7691901B2 (en) * | 2004-04-14 | 2010-04-06 | Cardax Pharmaceuticals Inc. | Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation |
US20060058269A1 (en) * | 2004-04-14 | 2006-03-16 | Lockwood Samuel F | Carotenoid analogs or derivatives for the inhibition and amelioration of inflammation |
CA2569724A1 (fr) | 2004-06-15 | 2005-12-29 | Cochlear Americas | Determination automatique du seuil d'une reponse neuronale evoquee |
US20060116423A1 (en) * | 2004-10-18 | 2006-06-01 | Dash Pramod K | Methods and compositions for treatment of central nervous system injury with isothiocyanates |
AU2005311826A1 (en) * | 2004-11-30 | 2006-06-08 | Plexxikon, Inc. | Indole derivatives for use as PPAR active compounds |
CN101277949A (zh) * | 2005-04-22 | 2008-10-01 | 阿兰托斯制药控股公司 | 二肽基肽酶-ⅳ抑制剂 |
WO2006138187A1 (fr) * | 2005-06-13 | 2006-12-28 | Yong-Qian Wu | Promedicaments a penetration renforcee dans les tissus |
KR20080047591A (ko) * | 2005-09-07 | 2008-05-29 | 플렉시콘, 인코퍼레이티드 | Ppar 조절인자로서 사용하기 위한 1,3-이치환된 인돌유도체 |
DE102005050377A1 (de) * | 2005-10-21 | 2007-04-26 | Bayer Healthcare Ag | Heterocyclische Verbindungen und ihre Verwendung |
PE20090159A1 (es) * | 2007-03-08 | 2009-02-21 | Plexxikon Inc | COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs |
CA2690229C (fr) | 2007-06-29 | 2013-10-29 | Acucela, Inc. | Derives d'alcynylphenyle pour traiter les maladies et les affections ophtalmiques |
MX337100B (es) | 2007-10-05 | 2016-02-11 | Acucela Inc | Compuestos alcoxi para el tratamiento de enfermedades. |
TWI446904B (zh) | 2007-11-01 | 2014-08-01 | Acucela Inc | 用於治療眼科疾病及病症之胺衍生化合物 |
ES2535516T3 (es) | 2008-04-24 | 2015-05-12 | F2G Limited | Agentes antifúngicos de pirrol |
WO2010013240A1 (fr) | 2008-07-31 | 2010-02-04 | Dekel Pharmaceuticals Ltd. | Compositions et procédés de traitement de troubles inflammatoires |
CA2740952C (fr) | 2008-10-22 | 2015-12-29 | Ian L. Scott | Composes de traitement de maladies et troubles ophtalmiques |
US20100317711A1 (en) * | 2008-12-17 | 2010-12-16 | Gliamed, Inc. | Stem-like cells and method for reprogramming adult mammalian somatic cells |
WO2011003103A2 (fr) * | 2009-07-02 | 2011-01-06 | Acucela, Inc. | Pharmacologie de modulateurs du cycle visuel |
US9981018B2 (en) * | 2010-06-08 | 2018-05-29 | The Cleveland Clinic Foundation | Compositions and methods for modulating toll-like receptor 2 activation |
JP2015505536A (ja) | 2012-01-20 | 2015-02-23 | アクセラ インク. | 疾患の処置のための置換された複素環化合物 |
US9505728B2 (en) | 2012-03-09 | 2016-11-29 | Inception 2, Inc. | Triazolone compounds and uses thereof |
BR112015013350B1 (pt) | 2012-12-20 | 2022-04-05 | Tempest Therapeutics, Inc | Composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica e respectivos usos |
KR20160048988A (ko) | 2013-09-06 | 2016-05-04 | 인셉션 2 인코퍼레이티드 | 트라이아졸론 화합물 및 이의 용도 |
EP3096755A4 (fr) * | 2014-01-23 | 2017-12-27 | Sova Pharmaceuticals, Inc. | Inhibiteurs de cystathionine- (gamma)-lyase (cse) pour le traitement de la douleur |
EP3415511A1 (fr) | 2014-11-21 | 2018-12-19 | F2G Limited | Agents antifongiques |
US10285977B2 (en) * | 2015-08-13 | 2019-05-14 | David Weinstein Consulting, Inc. | Compositions and methods for treating alopecia |
CA2993829A1 (fr) * | 2015-08-13 | 2017-02-16 | River Town Therapeutics, Inc. | Compositions et procedes pour le traitement de l'alopecie |
JP2019510820A (ja) * | 2016-03-21 | 2019-04-18 | ワインスタイン,デイビッド | 創傷治癒及び瘢痕予防のための方法 |
GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
US10709686B2 (en) * | 2018-03-20 | 2020-07-14 | David Weinstein Consulting, Inc. | Methods for treating pulmonary fibrosis |
US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
Family Cites Families (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA794723B (en) | 1978-09-11 | 1980-08-27 | Univ Miami | Anti-hypertensive agents |
IL58849A (en) | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
IT1148775B (it) | 1980-02-29 | 1986-12-03 | Attilio Pronzati | Bastoncini da sci dotati di rotelle intercambiabili |
US4734420A (en) | 1980-03-05 | 1988-03-29 | University Of Miami | Anti-hypertensive agents |
US4692458A (en) | 1980-03-05 | 1987-09-08 | University Of Miami | Anti-hypertensive agents |
US4950649A (en) | 1980-09-12 | 1990-08-21 | University Of Illinois | Didemnins and nordidemnins |
EP0048159A3 (fr) | 1980-09-17 | 1982-05-12 | University Of Miami | Peptides carboxyalcoyliques, thioéthers et éthers de peptides comme agents antihypertensifs |
LU88621I2 (fr) | 1980-10-23 | 1995-09-01 | Schering Corp | Sandopril |
ZA817261B (en) | 1980-10-23 | 1982-09-29 | Schering Corp | Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them |
US5348944A (en) | 1980-10-23 | 1994-09-20 | Schering Corporation | Carboxyalkyl dipeptides |
ZA826022B (en) | 1981-08-21 | 1983-08-31 | Univ Miami | Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides |
US4766110A (en) * | 1981-08-21 | 1988-08-23 | Ryan James W | Novel complex amido and imido derivatives of carboxyalkyl peptides |
EP0088350B1 (fr) | 1982-03-08 | 1985-02-20 | Schering Corporation | Carboxyalkyl dipeptides, leur procédé de préparation et leurs compositions pharmaceutiques les contenant |
US4431644A (en) | 1982-03-08 | 1984-02-14 | Schering Corporation | Antihypertensive agents |
EP0177581A4 (fr) | 1984-04-06 | 1987-08-10 | Gail S Bazzano | Compositions stimulant la croissance des cheveux. |
US4595766A (en) | 1984-10-26 | 1986-06-17 | Ciba-Geigy Corporation | Process for the preparation of an indoline carboxylic acid |
DE3508251A1 (de) | 1985-03-08 | 1986-09-11 | Merck Patent Gmbh, 6100 Darmstadt | Dipeptide |
CN86101850A (zh) | 1985-03-22 | 1987-02-04 | 森得克斯(美国)有限公司 | N,n′-二烷基胍基二肽的制造方法与用途 |
US5714510A (en) | 1985-07-18 | 1998-02-03 | Proctor; Peter H. | Topical proxyl composition and method |
US5472687A (en) | 1985-07-18 | 1995-12-05 | Proctor; Peter H. | Topical pyridine N-oxides |
WO1988000040A1 (fr) | 1986-07-02 | 1988-01-14 | American Health Products Corporation | Composition et kit servant a promouvoir la croissance topique des cheveux |
US5214034A (en) | 1986-09-26 | 1993-05-25 | Mitsui Toatsu Chemicals, Incorporated | Catechol derivatives, and preventive and remedial preparations for regressive disorders in the central nervous system containing the same |
DE3636278A1 (de) | 1986-10-24 | 1988-05-05 | Hoechst Ag | Herbizide mittel auf der basis von cyclischen (alpha)-iminocarbon-saeureaniliden sowie neue (alpha)-iminocarbonsaeureanilide und verfahren zu ihrer herstellung |
IT1206078B (it) | 1987-06-03 | 1989-04-14 | Polifarma Spa | Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico |
WO1989006234A1 (fr) | 1987-12-28 | 1989-07-13 | Bazzano Gail S | Amines a substitution n,n et utilisation de telles amines en vue de promouvoir la croissance des cheveux |
US5187156A (en) | 1988-03-16 | 1993-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same |
US5232923A (en) | 1988-03-18 | 1993-08-03 | Mitsui Toatsu Chemicals, Incorporated | Catechol derivatives and pharmaceutical preparations containing same |
US5274097A (en) | 1988-04-19 | 1993-12-28 | Bayer Aktiengesellschaft | 1,3-disubstituted pyrrolidines |
IL90872A0 (en) | 1988-07-08 | 1990-02-09 | Smithkline Beckman Corp | Retroviral protease binding peptides |
US5002962A (en) | 1988-07-20 | 1991-03-26 | Health Research, Inc. | Photosensitizing agents |
US5166317A (en) | 1988-10-31 | 1992-11-24 | Houston Biotechnology Incorporated | Neurotrophic factor |
EP0378318A1 (fr) | 1989-01-11 | 1990-07-18 | Merck & Co. Inc. | Procédé pour la préparation de FK-506 ainsi que produits intermédiaires tricarbonyliques |
US5359138A (en) | 1989-04-15 | 1994-10-25 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Poststatin and related compounds or salts thereof |
US5164525A (en) | 1989-06-30 | 1992-11-17 | Merck & Co., Inc. | Synthetic process for fk-506 type macrolide intermediates |
US5128483A (en) | 1989-07-19 | 1992-07-07 | American Cyanamid Company | Dibromovinyl and acetylene-1-pyrrolidinecarboxylic acid intermediates |
US5215969A (en) | 1989-08-11 | 1993-06-01 | Hahnemann University | Dopaminergic neurotrophic factor for treatment of Parkinson's disease |
US5703088A (en) | 1989-08-21 | 1997-12-30 | Beth Israel Deaconess Medical Center, Inc. | Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses |
GB8922026D0 (en) | 1989-09-29 | 1989-11-15 | Pharma Mar Sa | Novel anti-viral and cytotoxic agent |
DE122007000050I1 (de) | 1990-02-19 | 2007-11-08 | Novartis Ag | Acylverbindungen |
US5115098A (en) | 1990-02-28 | 1992-05-19 | President And Fellows Of Harvard College | End-blocked peptides inhibiting binding capacity of gp120 |
JPH04211648A (ja) | 1990-07-27 | 1992-08-03 | Nippon Kayaku Co Ltd | ケト酸アミド誘導体 |
DE4015255A1 (de) | 1990-05-12 | 1991-11-14 | Hoechst Ag | Oxalyl-aminosaeurederivate, verfahren zu ihrer herstellung und ihrer verwendung als arzneimittel zur inhibierung der prolyl-hydroxylase |
US5504197A (en) | 1990-06-20 | 1996-04-02 | The Salk Institute For Biological Studies | DNA encoding neurotrophic growth factors |
US5192773A (en) | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
ES2104597T3 (es) | 1990-08-14 | 1997-10-16 | Kenneth M Hallam | Composicion para la promocion del crecimiento del cabello. |
GB2247456A (en) | 1990-09-03 | 1992-03-04 | Fujisawa Pharmaceutical Co | Tetrahydropyrane compounds, a process for their production and a pharmaceutical composition containing the same |
JPH04124198A (ja) | 1990-09-12 | 1992-04-24 | Sumitomo Pharmaceut Co Ltd | 神経栄養ペプチド誘導体 |
EP0488258B1 (fr) | 1990-11-27 | 1996-04-17 | Fuji Photo Film Co., Ltd. | Dérivés de propenamide, leur polymères, copolymères et leur emploi |
FR2671082B1 (fr) | 1990-12-28 | 1993-04-16 | Oreal | Agent a plusieurs composants ou kit de preparation de la forme sulfo-conjuguee de composes pyrimidino- ou triazino-n-oxyde et procede de mise en óoeuvre. |
US5321009A (en) | 1991-04-03 | 1994-06-14 | American Home Products Corporation | Method of treating diabetes |
US5147877A (en) | 1991-04-18 | 1992-09-15 | Merck & Co. Inc. | Semi-synthetic immunosuppressive macrolides |
US5620971A (en) | 1991-05-09 | 1997-04-15 | Vertex Pharmaceuticals Incorporated | Biologically active acylated amino acid derivatives |
FR2677884B1 (fr) | 1991-06-20 | 1993-07-09 | Oreal | Composition pour freiner la chute des cheveux a base de pyrimidines n-oxyde trisubstitues ou leurs derives sulfoconjugues, nouveaux composes pyrimidines n-oxyde ou leurs derives sulfoconjugues. |
JPH05194235A (ja) | 1991-07-25 | 1993-08-03 | Tanabe Seiyaku Co Ltd | 中枢性カルシウム拮抗剤 |
JPH05178824A (ja) | 1991-08-05 | 1993-07-20 | Takeda Chem Ind Ltd | アスパラギン誘導体およびその用途 |
US5604294A (en) | 1991-09-05 | 1997-02-18 | Luly; Jay R. | Macrocyclic immunomodulators |
CA2091194A1 (fr) | 1992-04-08 | 1993-10-09 | Richard D. Connell | Derives 2-oxoethyliques utilises comme immunosuppresseurs |
US5342942A (en) | 1992-06-09 | 1994-08-30 | Warner-Lambert Company | Pyrazoloquinazolone derivatives as neurotrophic agents |
IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
US5480989A (en) | 1992-10-13 | 1996-01-02 | American Home Products Corporation | Carbamates of rapamycin |
US5536737A (en) | 1992-11-20 | 1996-07-16 | Japan Tobacco Inc. | Compound having prolyl endopeptidase inhibitory activity and pharmaceutical use thereof |
US5646167A (en) | 1993-01-06 | 1997-07-08 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamix acids |
DE69414279T2 (de) | 1993-02-09 | 1999-04-08 | Bayer Corp., Pittsburgh, Pa. | Sulfonamidaminomethylenderivate als Immunsuppressiva |
WO1994021253A1 (fr) | 1993-03-17 | 1994-09-29 | Abbott Laboratories | Immunomodulateurs macrocycliques substitues contenant des amines aliphatiques |
JP3599287B2 (ja) | 1993-04-28 | 2004-12-08 | 三菱化学株式会社 | スルホンアミド誘導体 |
US5319098A (en) * | 1993-05-18 | 1994-06-07 | Celgene Corporation | Process for the stereoselective preparation of L-alanyl-L-proline |
US5798355A (en) | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
US5846981A (en) | 1993-05-28 | 1998-12-08 | Gpi Nil Holdings Inc. | Inhibitors of rotamase enzyme activity |
IT1270882B (it) | 1993-10-05 | 1997-05-13 | Isagro Srl | Oligopeptidi ad attivita' fungicida |
US5527907A (en) | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
US5612350A (en) | 1993-11-30 | 1997-03-18 | Abbott Laboratories | Macrocyclic immunomodulators with novel cyclohexyl ring replacements |
US5744485A (en) | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
US5898029A (en) | 1994-04-12 | 1999-04-27 | The John Hopkins University | Direct influences on nerve growth of agents that interact with immunophilins in combination with neurotrophic factors |
US5463048A (en) | 1994-06-14 | 1995-10-31 | American Home Products Corporation | Rapamycin amidino carbamates |
DE4425950A1 (de) | 1994-07-21 | 1996-01-25 | Bayer Ag | Verwendung von Sulfonylbenzyl-substituierten Imidazolen, Imidazopyridinen und Benzimidazolen |
ATE299145T1 (de) * | 1994-08-18 | 2005-07-15 | Ariad Gene Therapeutics Inc | Neues multimerisierendes reagenz |
US5543423A (en) | 1994-11-16 | 1996-08-06 | Vertex Pharmaceuticals, Incorporated | Amino acid derivatives with improved multi-drug resistance activity |
US6291510B1 (en) * | 1995-06-07 | 2001-09-18 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5614547A (en) | 1995-06-07 | 1997-03-25 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme |
US5859031A (en) | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5696135A (en) | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
US5801197A (en) | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
ATE465149T1 (de) * | 1996-02-28 | 2010-05-15 | Ariad Pharma Inc | Synthetische rapamycinderivate als multimerisierende wirkstoffe für chimere proteine mit von immunophilin abgeleiteten domänen |
US5717092A (en) | 1996-03-29 | 1998-02-10 | Vertex Pharmaceuticals Inc. | Compounds with improved multi-drug resistance activity |
US5629325A (en) | 1996-06-06 | 1997-05-13 | Abbott Laboratories | 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission |
EP0823419A3 (fr) | 1996-08-09 | 2000-08-16 | Takeda Chemical Industries, Ltd. | Composés de diméthylpropanediol |
US5786378A (en) | 1996-09-25 | 1998-07-28 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters |
US5801187A (en) | 1996-09-25 | 1998-09-01 | Gpi-Nil Holdings, Inc. | Heterocyclic esters and amides |
US5840736A (en) | 1996-11-13 | 1998-11-24 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
US5811434A (en) | 1996-11-13 | 1998-09-22 | Vertex Pharmacueticals Incorporated | Methods and compositions for stimulating neurite growth |
US5780484A (en) | 1996-11-13 | 1998-07-14 | Vertex Pharmaceuticals Incorporated | Methods for stimulating neurite growth with piperidine compounds |
US5874449A (en) | 1996-12-31 | 1999-02-23 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of heterocyclic thioesters |
US5721256A (en) | 1997-02-12 | 1998-02-24 | Gpi Nil Holdings, Inc. | Method of using neurotrophic sulfonamide compounds |
US5846979A (en) | 1997-02-28 | 1998-12-08 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
US5945441A (en) * | 1997-06-04 | 1999-08-31 | Gpi Nil Holdings, Inc. | Pyrrolidine carboxylate hair revitalizing agents |
EP1011650A1 (fr) * | 1997-09-24 | 2000-06-28 | Amgen Inc., | Procede utilise pour prevenir les deficits auditifs au moyen de composes sensorineurotrophiques |
BR9815920A (pt) * | 1998-06-03 | 2001-02-20 | Gpi Nil Holding Inc | Compostos aza-heterocìclicos usados para tratar distúrbios neurológicos e queda de cabelo |
US6284779B1 (en) * | 1999-02-03 | 2001-09-04 | Schering Aktiiengesellschaft | Heteroaromatic compounds |
-
1999
- 1999-12-02 US US09/453,571 patent/US6331537B1/en not_active Expired - Fee Related
- 1999-12-03 AU AU18413/00A patent/AU767468B2/en not_active Ceased
- 1999-12-03 AT AT99961930T patent/ATE252078T1/de not_active IP Right Cessation
- 1999-12-03 EP EP99961930A patent/EP1135370B1/fr not_active Expired - Lifetime
- 1999-12-03 HU HU0105027A patent/HUP0105027A3/hu unknown
- 1999-12-03 KR KR1020017007002A patent/KR20010086080A/ko not_active Application Discontinuation
- 1999-12-03 WO PCT/US1999/028663 patent/WO2000032588A2/fr not_active Application Discontinuation
- 1999-12-03 BR BR9916461-2A patent/BR9916461A/pt not_active Application Discontinuation
- 1999-12-03 IL IL14339299A patent/IL143392A0/xx unknown
- 1999-12-03 SK SK744-2001A patent/SK7442001A3/sk unknown
- 1999-12-03 CN CNB998139661A patent/CN1213026C/zh not_active Expired - Fee Related
- 1999-12-03 CZ CZ20011971A patent/CZ20011971A3/cs unknown
- 1999-12-03 NZ NZ511673A patent/NZ511673A/xx unknown
- 1999-12-03 EA EA200100570A patent/EA003926B1/ru not_active IP Right Cessation
- 1999-12-03 CA CA002353460A patent/CA2353460C/fr not_active Expired - Fee Related
- 1999-12-03 PL PL99348715A patent/PL348715A1/xx not_active IP Right Cessation
- 1999-12-03 MX MXPA01005549A patent/MXPA01005549A/es active IP Right Grant
- 1999-12-03 DE DE69912151T patent/DE69912151T2/de not_active Expired - Fee Related
-
2001
- 2001-06-05 NO NO20012765A patent/NO318909B1/no not_active IP Right Cessation
- 2001-06-25 BG BG105643A patent/BG105643A/xx unknown
- 2001-08-02 US US09/920,017 patent/US7153883B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
PL348715A1 (en) | 2002-06-03 |
CN1213026C (zh) | 2005-08-03 |
AU767468B2 (en) | 2003-11-13 |
CA2353460A1 (fr) | 2000-06-08 |
EP1135370B1 (fr) | 2003-10-15 |
NO20012765L (no) | 2001-07-20 |
KR20010086080A (ko) | 2001-09-07 |
CA2353460C (fr) | 2009-11-10 |
US20030186961A1 (en) | 2003-10-02 |
EP1135370A2 (fr) | 2001-09-26 |
SK7442001A3 (en) | 2001-12-03 |
BG105643A (en) | 2002-02-28 |
MXPA01005549A (es) | 2003-07-14 |
CZ20011971A3 (cs) | 2001-09-12 |
WO2000032588A2 (fr) | 2000-06-08 |
DE69912151T2 (de) | 2004-07-08 |
US7153883B2 (en) | 2006-12-26 |
US6331537B1 (en) | 2001-12-18 |
EA003926B1 (ru) | 2003-10-30 |
EA200100570A1 (ru) | 2001-12-24 |
HUP0105027A3 (en) | 2002-10-28 |
CN1330634A (zh) | 2002-01-09 |
ATE252078T1 (de) | 2003-11-15 |
NZ511673A (en) | 2004-03-26 |
WO2000032588A3 (fr) | 2001-02-22 |
AU1841300A (en) | 2000-06-19 |
HUP0105027A2 (hu) | 2002-05-29 |
NO20012765D0 (no) | 2001-06-05 |
NO318909B1 (no) | 2005-05-23 |
DE69912151D1 (de) | 2003-11-20 |
BR9916461A (pt) | 2001-09-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL143392A0 (en) | Carboxylic acids and carboxylic acid isosteres of n-heterocyclic compounds | |
BG105012A (en) | N-linked sulphonamides of n-heterocyclic carboxylic acids or carboxylic isosteres | |
ATE319712T1 (de) | Hydantoin derivate, pharmazeutische zusammensetzungen und verfahren zu ihrer verwendung | |
UA49011C2 (uk) | Похідні циклічної амінокислоти, фармацевтична композиція та спосіб лікування | |
AU2002327378A1 (en) | Treatment of neuropsychiatric disorders by near-diaphragmatic nerve stimulation | |
MX9604985A (es) | Cardiotropina y usos de la misma. | |
ATE362363T1 (de) | Verwendung von tnf-alpha inhibitoren zur behandlung von nervenwurzelschäden | |
EA200500007A1 (ru) | Пролекарства возбуждающих аминокислот | |
ATE325610T1 (de) | Xanthinderivative zur behandlung von hirnischämie | |
CA2198005A1 (fr) | Pyrazolo[3,4-g]quinoxalines, agents inhibiteurs de la proteine tyrosine-kinase des recepteurs pdgf | |
WO1999062879A8 (fr) | Urees et carbamates d'acides carboxyliques n-heterocycliques et d'isosteres d'acide carboxylique | |
ATE409028T1 (de) | Arzneien zur behandlung von nervenerkrankungen | |
NZ508462A (en) | Aza-heterocyclic compounds used to treat neurological disorders and hair loss | |
BR9815919A (pt) | Compostos aza heterocìclicos usados para tratar distúrbios neurológicos e perda de cabelo | |
ATE192923T1 (de) | Verwendung von boswelliasäure zur behandlung von hirntumoren | |
ATE463252T1 (de) | Methode zur behandlung des zentralnervensystems durch applikation von strukturanaloga von igf | |
WO2002055481A8 (fr) | Promedicaments d'aminoacides excitateurs | |
TW200600512A (en) | Carboxylic acids and carboxylic acid isosteres of n-heterocyclic compounds | |
WO2003006489A3 (fr) | Promedicaments d'acides amines excitateurs | |
WO2003037261A3 (fr) | Procedes et compositions pour le traitement et le diagnostic de troubles generant une douleur au moyen de 9805 | |
WO2000061180A3 (fr) | Produits et procedes destines au traitement de maladies associees a ptp lar | |
WO2000011137A8 (fr) | Amphiphiles cationiques instables acides | |
TW200833674A (en) | Prodrugs of excitatory amino acids |