IL143384A0 - New amidino derivatives and their use as thrombin inhibitors - Google Patents
New amidino derivatives and their use as thrombin inhibitorsInfo
- Publication number
- IL143384A0 IL143384A0 IL14338499A IL14338499A IL143384A0 IL 143384 A0 IL143384 A0 IL 143384A0 IL 14338499 A IL14338499 A IL 14338499A IL 14338499 A IL14338499 A IL 14338499A IL 143384 A0 IL143384 A0 IL 143384A0
- Authority
- IL
- Israel
- Prior art keywords
- thrombin inhibitors
- sup
- amidino derivatives
- thrombin
- new amidino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9804313A SE9804313D0 (sv) | 1998-12-14 | 1998-12-14 | New compounds |
| PCT/SE1999/002316 WO2000035869A1 (en) | 1998-12-14 | 1999-12-10 | New amidino derivatives and their use as thrombin inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL143384A0 true IL143384A0 (en) | 2002-04-21 |
Family
ID=20413647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14338499A IL143384A0 (en) | 1998-12-14 | 1999-12-10 | New amidino derivatives and their use as thrombin inhibitors |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US6750243B1 (xx) |
| EP (1) | EP1140820B1 (xx) |
| JP (1) | JP2002532467A (xx) |
| KR (1) | KR20010086105A (xx) |
| AT (1) | ATE261939T1 (xx) |
| AU (1) | AU753290C (xx) |
| BR (1) | BR9916255A (xx) |
| CA (1) | CA2352054C (xx) |
| CZ (1) | CZ20012094A3 (xx) |
| DE (1) | DE69915686T2 (xx) |
| EE (1) | EE200100315A (xx) |
| ID (1) | ID29873A (xx) |
| IL (1) | IL143384A0 (xx) |
| IS (1) | IS5966A (xx) |
| NO (1) | NO20012914L (xx) |
| NZ (1) | NZ512000A (xx) |
| PL (1) | PL348972A1 (xx) |
| SE (1) | SE9804313D0 (xx) |
| TR (1) | TR200101651T2 (xx) |
| WO (1) | WO2000035869A1 (xx) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0001803D0 (sv) * | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
| US6433186B1 (en) | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
| AR035216A1 (es) | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
| US7129233B2 (en) * | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
| JP2004516286A (ja) | 2000-12-18 | 2004-06-03 | メルク エンド カムパニー インコーポレーテッド | ベンジルアミン誘導体およびそれのトロンビン阻害薬としての使用 |
| JP2005504003A (ja) | 2001-02-09 | 2005-02-10 | メルク エンド カムパニー インコーポレーテッド | トロンビン阻害剤 |
| AR034517A1 (es) * | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
| SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
| US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| JP4800216B2 (ja) * | 2003-10-24 | 2011-10-26 | エグゼリクシス， インコーポレイテッド | ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法 |
| US7524354B2 (en) * | 2005-07-07 | 2009-04-28 | Research Foundation Of State University Of New York | Controlled synthesis of highly monodispersed gold nanoparticles |
| TW200827336A (en) * | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
| US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
| CN104327029A (zh) * | 2014-09-21 | 2015-02-04 | 湖南华腾制药有限公司 | 一种含氧杂环化合物的制备方法 |
| CN106632192A (zh) * | 2017-01-10 | 2017-05-10 | 湖南华腾制药有限公司 | 一种含氧杂环化合物的制备方法 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU178398B (en) | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
| HU192646B (en) | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
| AU600226B2 (en) | 1985-02-04 | 1990-08-09 | Merrell Pharmaceuticals Inc. | Novel peptidase inhibitors |
| US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| EP0362002B1 (en) | 1988-09-01 | 1995-07-26 | Merrell Dow Pharmaceuticals Inc. | HIV protease inhibitors |
| ZA897515B (en) | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
| TW201303B (xx) | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
| CA2075154A1 (en) | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
| SE9102462D0 (sv) | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
| CZ333492A3 (en) | 1991-11-12 | 1993-09-15 | Lilly Co Eli | Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised |
| SE9103612D0 (sv) | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
| ATE159030T1 (de) | 1992-03-04 | 1997-10-15 | Gyogyszerkutato Intezet | Neuartige antikoagulierende peptidderivate und arzneimittel die solche enthalten so wie entsprechendes herstellungsverfahren |
| TW223629B (xx) | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
| AU675981B2 (en) | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
| JPH06340619A (ja) | 1993-05-03 | 1994-12-13 | Bristol Myers Squibb Co | グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤 |
| SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| EP0648780A1 (en) | 1993-08-26 | 1995-04-19 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
| TW394760B (en) | 1993-09-07 | 2000-06-21 | Hoffmann La Roche | Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same |
| AU1025795A (en) | 1994-01-27 | 1995-08-03 | Mitsubishi Chemical Corporation | Prolineamide derivatives |
| IL112795A (en) | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Derivatives of peptides as antithrombotic drugs, their preparation, and pharmaceutical preparations containing them |
| US5705487A (en) | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
| US5707966A (en) | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
| US5561146A (en) | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
| DE4421052A1 (de) | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
| US5510369A (en) | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
| US6030972A (en) | 1995-02-17 | 2000-02-29 | Basf Aktiengesellschaft | Dipeptide amidines as thrombin inhibitors |
| US5710130A (en) | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
| CA2216859A1 (en) | 1995-04-04 | 1996-10-10 | Merck & Co., Inc. | Thrombin inhibitors |
| US5629324A (en) * | 1995-04-10 | 1997-05-13 | Merck & Co., Inc. | Thrombin inhibitors |
| SA96170106A (ar) | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
| TWI238827B (en) | 1995-12-21 | 2005-09-01 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
| AU1990197A (en) | 1996-03-12 | 1997-10-01 | Bristol-Myers Squibb Company | Carbamyl guanidine and amidine prodrugs |
| SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
| AU3496297A (en) | 1996-06-25 | 1998-01-14 | Eli Lilly And Company | Anticoagulant agents |
| DE19632772A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Benzamidine |
| AR013084A1 (es) * | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
| SE0001803D0 (sv) * | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
-
1998
- 1998-12-14 SE SE9804313A patent/SE9804313D0/xx unknown
-
1999
- 1999-12-10 CZ CZ20012094A patent/CZ20012094A3/cs unknown
- 1999-12-10 BR BR9916255-5A patent/BR9916255A/pt not_active Application Discontinuation
- 1999-12-10 AU AU20187/00A patent/AU753290C/en not_active Ceased
- 1999-12-10 IL IL14338499A patent/IL143384A0/xx unknown
- 1999-12-10 CA CA002352054A patent/CA2352054C/en not_active Expired - Fee Related
- 1999-12-10 EE EEP200100315A patent/EE200100315A/xx unknown
- 1999-12-10 EP EP99963821A patent/EP1140820B1/en not_active Expired - Lifetime
- 1999-12-10 KR KR1020017007349A patent/KR20010086105A/ko not_active Application Discontinuation
- 1999-12-10 NZ NZ512000A patent/NZ512000A/en not_active IP Right Cessation
- 1999-12-10 DE DE69915686T patent/DE69915686T2/de not_active Expired - Lifetime
- 1999-12-10 JP JP2000588131A patent/JP2002532467A/ja active Pending
- 1999-12-10 US US09/509,032 patent/US6750243B1/en not_active Expired - Fee Related
- 1999-12-10 ID IDW00200101264A patent/ID29873A/id unknown
- 1999-12-10 AT AT99963821T patent/ATE261939T1/de not_active IP Right Cessation
- 1999-12-10 PL PL99348972A patent/PL348972A1/xx not_active Application Discontinuation
- 1999-12-10 TR TR2001/01651T patent/TR200101651T2/xx unknown
- 1999-12-10 WO PCT/SE1999/002316 patent/WO2000035869A1/en not_active Application Discontinuation
-
2001
- 2001-06-13 NO NO20012914A patent/NO20012914L/no not_active Application Discontinuation
- 2001-06-13 IS IS5966A patent/IS5966A/is unknown
-
2004
- 2004-04-02 US US10/815,954 patent/US7241757B2/en not_active Expired - Fee Related
-
2007
- 2007-06-06 US US11/808,122 patent/US20070249578A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2018700A (en) | 2000-07-03 |
| SE9804313D0 (sv) | 1998-12-14 |
| DE69915686D1 (de) | 2004-04-22 |
| NO20012914D0 (no) | 2001-06-13 |
| JP2002532467A (ja) | 2002-10-02 |
| CA2352054C (en) | 2008-12-09 |
| US7241757B2 (en) | 2007-07-10 |
| EP1140820B1 (en) | 2004-03-17 |
| NZ512000A (en) | 2003-11-28 |
| DE69915686T2 (de) | 2005-02-24 |
| PL348972A1 (en) | 2002-06-17 |
| EP1140820A1 (en) | 2001-10-10 |
| US20070249578A1 (en) | 2007-10-25 |
| US20040186090A1 (en) | 2004-09-23 |
| WO2000035869A1 (en) | 2000-06-22 |
| CZ20012094A3 (cs) | 2001-11-14 |
| EE200100315A (et) | 2002-02-15 |
| CA2352054A1 (en) | 2000-06-22 |
| ID29873A (id) | 2001-10-18 |
| BR9916255A (pt) | 2001-10-02 |
| AU753290C (en) | 2004-10-28 |
| US6750243B1 (en) | 2004-06-15 |
| AU753290B2 (en) | 2002-10-17 |
| KR20010086105A (ko) | 2001-09-07 |
| NO20012914L (no) | 2001-08-14 |
| IS5966A (is) | 2001-06-13 |
| TR200101651T2 (tr) | 2001-12-21 |
| ATE261939T1 (de) | 2004-04-15 |
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