IL140438A0 - Polyketides and their synthesis - Google Patents
Polyketides and their synthesisInfo
- Publication number
- IL140438A0 IL140438A0 IL14043899A IL14043899A IL140438A0 IL 140438 A0 IL140438 A0 IL 140438A0 IL 14043899 A IL14043899 A IL 14043899A IL 14043899 A IL14043899 A IL 14043899A IL 140438 A0 IL140438 A0 IL 140438A0
- Authority
- IL
- Israel
- Prior art keywords
- pks
- domain
- loading
- substituted
- acyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Polyesters Or Polycarbonates (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Catalysts (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9814006.4A GB9814006D0 (en) | 1998-06-29 | 1998-06-29 | Polyketides and their synthesis |
| PCT/GB1999/002044 WO2000000618A2 (en) | 1998-06-29 | 1999-06-29 | Polyketides and their synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL140438A0 true IL140438A0 (en) | 2002-02-10 |
Family
ID=10834580
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14043899A IL140438A0 (en) | 1998-06-29 | 1999-06-29 | Polyketides and their synthesis |
| IL14044099A IL140440A0 (en) | 1998-06-29 | 1999-06-29 | Polyketides and ther synthesis |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL14044099A IL140440A0 (en) | 1998-06-29 | 1999-06-29 | Polyketides and ther synthesis |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US7148045B1 (ko) |
| EP (2) | EP1090123B1 (ko) |
| JP (2) | JP2002519014A (ko) |
| KR (2) | KR20010071683A (ko) |
| CN (2) | CN1316001A (ko) |
| AT (2) | ATE321137T1 (ko) |
| AU (2) | AU765257B2 (ko) |
| BR (2) | BR9911712A (ko) |
| CA (2) | CA2335523A1 (ko) |
| CZ (2) | CZ20004913A3 (ko) |
| DE (2) | DE69930510T2 (ko) |
| ES (1) | ES2341403T3 (ko) |
| GB (1) | GB9814006D0 (ko) |
| HK (1) | HK1034536A1 (ko) |
| HU (2) | HUP0102945A2 (ko) |
| ID (2) | ID28285A (ko) |
| IL (2) | IL140438A0 (ko) |
| MX (2) | MXPA00012936A (ko) |
| NZ (2) | NZ509600A (ko) |
| PL (2) | PL345575A1 (ko) |
| TR (2) | TR200003771T2 (ko) |
| WO (2) | WO2000000618A2 (ko) |
| YU (2) | YU82500A (ko) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7738015B2 (en) * | 1997-10-09 | 2010-06-15 | Fotonation Vision Limited | Red-eye filter method and apparatus |
| US7630006B2 (en) * | 1997-10-09 | 2009-12-08 | Fotonation Ireland Limited | Detecting red eye filter and apparatus using meta-data |
| GB9814622D0 (en) * | 1998-07-06 | 1998-09-02 | Biotica Tech Ltd | Polyketides,their preparation,and materials for use therein |
| US6458771B1 (en) | 1999-04-16 | 2002-10-01 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
| US6590083B1 (en) | 1999-04-16 | 2003-07-08 | Ortho-Mcneil Pharmaceutical, Inc. | Ketolide antibacterials |
| GB9912563D0 (en) * | 1999-05-28 | 1999-07-28 | Biotica Tech Ltd | Polyketides and their synthesis |
| US6524841B1 (en) * | 1999-10-08 | 2003-02-25 | Kosan Biosciences, Inc. | Recombinant megalomicin biosynthetic genes and uses thereof |
| US7033818B2 (en) | 1999-10-08 | 2006-04-25 | Kosan Biosciences, Inc. | Recombinant polyketide synthase genes |
| AU2001248588B2 (en) | 2000-04-13 | 2006-02-02 | Biotica Technology Limited | Hybrid glycosylated products and their production and use |
| US20030225006A1 (en) * | 2002-02-19 | 2003-12-04 | Burns Lesley S | Novel spinosyn-producing polyketide synthases |
| DE60315723T2 (de) | 2002-07-16 | 2008-06-19 | Biotica Technology Ltd. | Herstellung von Polyketiden und anderen natürlichen Produkten |
| GB0327720D0 (en) * | 2003-11-28 | 2003-12-31 | Biotica Tech Ltd | Erythromycins and process for their preparation |
| GB0327721D0 (en) * | 2003-11-28 | 2003-12-31 | Biotica Tech Ltd | Polyketides and their synthesis |
| GB0417852D0 (en) | 2004-08-11 | 2004-09-15 | Biotica Tech Ltd | Production of polyketides and other natural products |
| EP2254995A4 (en) | 2008-03-28 | 2011-05-25 | Univ California | PRODUCTION OF DICARBOXYLIC ACIDS USING SYNTHASE POLYCTICIDES |
| EP2268828A4 (en) * | 2008-04-29 | 2012-08-01 | Univ California | PREPARATION OF BIOFUELS USING POLYKETIDE SYNTHESES |
| GB0904540D0 (en) | 2009-03-17 | 2009-04-29 | Biotica Tech Ltd | Novel compounds and methods for their production |
| US8765431B2 (en) * | 2009-07-23 | 2014-07-01 | The Regents Of The University Of Michigan | Method for enzymatic production of decarboxylated polyketides and fatty acids |
| EP2456777A2 (en) | 2009-07-24 | 2012-05-30 | Université Henri Poincaré - Nancy 1 | Stambomycin and derivatives, their production and their use as drugs |
| GB0914589D0 (en) | 2009-08-20 | 2009-09-30 | Biotica Tech Ltd | Novel compounds and methods for their production |
| US8852902B2 (en) | 2010-11-22 | 2014-10-07 | The Regents Of The University Of California | Producing a trimethylpentanoic acid using hybrid polyketide synthases |
| KR102528984B1 (ko) | 2013-04-04 | 2023-05-08 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 매크롤라이드 그리고 그의 제조방법 및 용도 |
| JP2017531663A (ja) * | 2014-10-08 | 2017-10-26 | プレジデント アンド フェローズ オブ ハーバード カレッジ | １４員ケトライドならびにそれらの調製および使用の方法 |
| WO2016154591A1 (en) | 2015-03-25 | 2016-09-29 | President And Fellows Of Harvard College | Macrolides with modified desosamine sugars and uses thereof |
| CN106591388A (zh) * | 2016-10-13 | 2017-04-26 | 中国农业科学院生物技术研究所 | 具有聚酮类化合物合成功能的基因Dr2091 |
| EP3585796B1 (en) | 2017-02-22 | 2021-06-16 | ISR Immune System Regulation Holding AB (publ) | Novel immune stimulating macrolides |
| EP3585795B1 (en) | 2017-02-22 | 2021-06-09 | ISR Immune System Regulation Holding AB (publ) | Novel immune stimulating macrolides |
| WO2018226893A2 (en) | 2017-06-06 | 2018-12-13 | Zymergen Inc. | A high-throughput (htp) genomic engineering platform for improving saccharopolyspora spinosa |
| JP2021523930A (ja) | 2018-03-23 | 2021-09-09 | アイエスアール イミューン システム レギュレイション ホールディング アクチエボラグ（パブル） | マクロライド化合物と免疫チェックポイント阻害剤との組み合わせ |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5141926A (en) * | 1990-04-18 | 1992-08-25 | Abbott Laboratories | Erythromycin derivatives |
| US5672491A (en) * | 1993-09-20 | 1997-09-30 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
| US5712146A (en) * | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
| ATE297992T1 (de) * | 1993-09-20 | 2005-07-15 | Univ Leland Stanford Junior | Recombinante herstellung aromatischer polyketiden |
| IL122859A0 (en) * | 1995-07-06 | 1998-08-16 | Univ Leland Stanford Junior | Cell-free synthesis of polyketides |
| NZ333861A (en) * | 1996-07-05 | 2000-08-25 | Pfizer | Erythromycins and preparation from unnatural starter units in microorganisms |
| JPH10303641A (ja) * | 1997-04-23 | 1998-11-13 | Mitsubishi Electric Corp | 発振器及び無線機 |
| AU732909B2 (en) * | 1997-04-30 | 2001-05-03 | Board Of Trustees Of The Leland Stanford Junior University | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold |
| AP1060A (en) * | 1998-01-02 | 2002-04-23 | Pfizer Prod Inc | Novel erythromycin derivatives. |
-
1998
- 1998-06-29 GB GBGB9814006.4A patent/GB9814006D0/en not_active Ceased
-
1999
- 1999-06-29 AU AU45245/99A patent/AU765257B2/en not_active Ceased
- 1999-06-29 AT AT99928128T patent/ATE321137T1/de not_active IP Right Cessation
- 1999-06-29 YU YU82500A patent/YU82500A/sh unknown
- 1999-06-29 JP JP2000557261A patent/JP2002519014A/ja active Pending
- 1999-06-29 HU HU0102945A patent/HUP0102945A2/hu unknown
- 1999-06-29 AU AU45247/99A patent/AU763230B2/en not_active Ceased
- 1999-06-29 MX MXPA00012936A patent/MXPA00012936A/es not_active IP Right Cessation
- 1999-06-29 WO PCT/GB1999/002044 patent/WO2000000618A2/en active IP Right Grant
- 1999-06-29 KR KR1020007014999A patent/KR20010071683A/ko not_active Application Discontinuation
- 1999-06-29 CA CA002335523A patent/CA2335523A1/en not_active Abandoned
- 1999-06-29 PL PL99345575A patent/PL345575A1/xx not_active Application Discontinuation
- 1999-06-29 EP EP99928128A patent/EP1090123B1/en not_active Expired - Lifetime
- 1999-06-29 HU HU0105179A patent/HUP0105179A2/hu unknown
- 1999-06-29 TR TR2000/03771T patent/TR200003771T2/xx unknown
- 1999-06-29 ES ES99928126T patent/ES2341403T3/es not_active Expired - Lifetime
- 1999-06-29 PL PL99345578A patent/PL345578A1/xx not_active Application Discontinuation
- 1999-06-29 CN CN99810073A patent/CN1316001A/zh active Pending
- 1999-06-29 BR BR9911712-6A patent/BR9911712A/pt not_active Application Discontinuation
- 1999-06-29 JP JP2000557371A patent/JP4489947B2/ja not_active Expired - Fee Related
- 1999-06-29 TR TR2000/03770T patent/TR200003770T2/xx unknown
- 1999-06-29 IL IL14043899A patent/IL140438A0/xx unknown
- 1999-06-29 KR KR1020007015000A patent/KR20010071684A/ko not_active Application Discontinuation
- 1999-06-29 IL IL14044099A patent/IL140440A0/xx unknown
- 1999-06-29 DE DE69930510T patent/DE69930510T2/de not_active Expired - Lifetime
- 1999-06-29 NZ NZ509600A patent/NZ509600A/xx unknown
- 1999-06-29 WO PCT/GB1999/002042 patent/WO2000000500A2/en not_active Application Discontinuation
- 1999-06-29 DE DE69942149T patent/DE69942149D1/de not_active Expired - Lifetime
- 1999-06-29 YU YU82700A patent/YU82700A/sh unknown
- 1999-06-29 CN CN99810052A patent/CN1315956A/zh active Pending
- 1999-06-29 CZ CZ20004913A patent/CZ20004913A3/cs unknown
- 1999-06-29 ID IDW20010219A patent/ID28285A/id unknown
- 1999-06-29 MX MXPA00012885A patent/MXPA00012885A/es not_active IP Right Cessation
- 1999-06-29 NZ NZ509601A patent/NZ509601A/en unknown
- 1999-06-29 EP EP99928126A patent/EP1091971B1/en not_active Expired - Lifetime
- 1999-06-29 US US09/720,840 patent/US7148045B1/en not_active Expired - Fee Related
- 1999-06-29 CZ CZ20004912A patent/CZ20004912A3/cs unknown
- 1999-06-29 BR BR9911710-0A patent/BR9911710A/pt not_active Application Discontinuation
- 1999-06-29 ID IDW20010220A patent/ID27419A/id unknown
- 1999-06-29 AT AT99928126T patent/ATE461289T1/de not_active IP Right Cessation
- 1999-06-29 CA CA002331764A patent/CA2331764C/en not_active Expired - Fee Related
-
2001
- 2001-07-16 HK HK01104954A patent/HK1034536A1/xx not_active IP Right Cessation
-
2004
- 2004-02-19 US US10/782,257 patent/US7198922B2/en not_active Expired - Fee Related
-
2006
- 2006-04-21 US US11/408,536 patent/US20060240528A1/en not_active Abandoned
Also Published As
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