IL138717A0 - A method for identifying small molecule drug lead compounds - Google Patents

A method for identifying small molecule drug lead compounds

Info

Publication number
IL138717A0
IL138717A0 IL13871799A IL13871799A IL138717A0 IL 138717 A0 IL138717 A0 IL 138717A0 IL 13871799 A IL13871799 A IL 13871799A IL 13871799 A IL13871799 A IL 13871799A IL 138717 A0 IL138717 A0 IL 138717A0
Authority
IL
Israel
Prior art keywords
small molecule
lead compounds
molecule drug
identifying small
drug lead
Prior art date
Application number
IL13871799A
Other languages
English (en)
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Priority to IL16297199A priority Critical patent/IL162971A/xx
Publication of IL138717A0 publication Critical patent/IL138717A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/807—Hapten conjugated with peptide or protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IL13871799A 1998-03-27 1999-03-26 A method for identifying small molecule drug lead compounds IL138717A0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IL16297199A IL162971A (en) 1998-03-27 1999-03-26 Library of candidate target binding fragments

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/049,754 US6344330B1 (en) 1998-03-27 1998-03-27 Pharmacophore recombination for the identification of small molecule drug lead compounds
PCT/US1999/006734 WO1999049314A1 (fr) 1998-03-27 1999-03-26 Recombinaison de pharmacophores utile pour l'identification de composes de petites molecules constituant des pistes pour la recherche de medicaments

Publications (1)

Publication Number Publication Date
IL138717A0 true IL138717A0 (en) 2001-10-31

Family

ID=21961533

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13871799A IL138717A0 (en) 1998-03-27 1999-03-26 A method for identifying small molecule drug lead compounds

Country Status (9)

Country Link
US (5) US6344330B1 (fr)
EP (1) EP1066522B1 (fr)
JP (1) JP2002507748A (fr)
AT (1) ATE342507T1 (fr)
AU (1) AU759327B2 (fr)
CA (1) CA2326341C (fr)
DE (1) DE69933549T2 (fr)
IL (1) IL138717A0 (fr)
WO (1) WO1999049314A1 (fr)

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US20050287596A9 (en) * 1998-06-26 2005-12-29 Braisted Andrew C Novel ligands and libraries of ligands
US20030194745A1 (en) * 1998-06-26 2003-10-16 Mcdowell Robert S. Cysteine mutants and methods for detecting ligand binding to biological molecules
US6824987B1 (en) * 1999-05-11 2004-11-30 President And Fellows Of Harvard College Small molecule printing
WO2002042773A2 (fr) * 2000-11-21 2002-05-30 Sunesis Pharmaceuticals, Inc. Methode de fixation etendue pour l'identification rapide de ligands
US20020172967A1 (en) * 2001-02-13 2002-11-21 Gadek Thomas R. Identification of non-covalent complexes by mass spectrometry
US20040017884A1 (en) * 2002-07-25 2004-01-29 Havrilla George J. Flow method and apparatus for screening chemicals using micro x-ray fluorescence
US9157875B2 (en) * 2001-05-16 2015-10-13 Benjamin P. Warner Drug development and manufacturing
US6858148B2 (en) 2003-07-16 2005-02-22 The Regents Of The University Of California Method and apparatus for detecting chemical binding
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IL161409A0 (en) * 2001-11-21 2004-09-27 Sunesis Pharmaceuticals Inc Methods for ligand discovery
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US7519145B2 (en) * 2002-07-25 2009-04-14 Los Alamos National Security, Llc Flow method and apparatus for screening chemicals using micro x-ray fluorescence
EP1558922B1 (fr) * 2002-10-30 2013-02-27 Ampere Life Sciences, Inc. Identification de composes therapeutiques en fonction de leur proprietes physico-chimiques
WO2004057340A1 (fr) 2002-12-23 2004-07-08 Astex Technology Limited Synthese et criblage de ligands par cristallographie a diffraction de rayons x
US7736909B2 (en) * 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
AU2004230519A1 (en) * 2003-04-11 2004-10-28 Sgx Pharmaceuticals, Inc. Compound libraries and methods for drug discovery
US20070003954A1 (en) * 2005-05-12 2007-01-04 The Board Of Regents Of The University Of Texas System Protein and antibody profiling using small molecule microarrays
DK1934388T3 (da) 2005-10-04 2013-02-25 Alchemia Ltd Fremgangsmåde til lægemiddeludvikling
EP1994209A4 (fr) * 2006-01-03 2013-11-13 Harvard College Impression de petites molécules
JP5143841B2 (ja) 2006-10-10 2013-02-13 ロス アラモス ナショナル セキュリティー，エルエルシー 高度な薬物開発及び製造
DE102007023102A1 (de) * 2006-12-19 2008-06-26 Bayer Cropscience Ag Bisoxime als Fungizide
JP5743135B2 (ja) 2007-09-28 2015-07-01 エックスアールプロ・サイエンシーズ・インコーポレーテッド タンパク質翻訳後修飾を測定するための方法及び装置
US10107798B2 (en) 2008-03-25 2018-10-23 Sunesis Pharmaceuticals, Inc. Methods of chemotype evolution
CA2763685A1 (fr) * 2009-05-29 2010-12-02 The Board Of Regents Of The University Of Texas System Ligands peptoides d'isolement et traitement de lymphocytes t auto-immuns
CN102439451B (zh) * 2009-06-02 2014-12-03 德克萨斯大学系统董事会 患神经退行性疾病的对象中抗体所识别的小分子的鉴定
WO2011047257A1 (fr) * 2009-10-16 2011-04-21 The Board Of Regents Of The University Of Texas System Compositions et procédés de production de banques de peptoïdes cycliques
EP2588456A1 (fr) 2010-07-02 2013-05-08 Syngenta Participations AG Nouveaux dérivés microbicides d'éther de dioxime
US20140162980A1 (en) 2010-07-29 2014-06-12 Syngenta Crop Protection Llc Novel microbiocidal dioxime ether derivatives
EP2688911B1 (fr) 2011-03-24 2017-08-02 OPKO Pharmaceuticals, LLC Recherche de biomarqueurs dans un fluide biologique au moyen de banques à base de perles ou de particules
WO2013024040A2 (fr) 2011-08-12 2013-02-21 B.S.R.C. Alexander Fleming Inhibiteurs de trimérisation de la superfamille des tnf
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CN102731450A (zh) * 2012-07-04 2012-10-17 中山大学 一种苯并呋喃或吲哚的制备方法
US10782295B2 (en) 2013-08-13 2020-09-22 The Scripps Research Institute Cysteine-reactive ligand discovery in proteomes
CN104897826B (zh) * 2015-06-16 2016-06-22 广西师范大学 一种用于细胞原位检测小分子化合物与靶蛋白相互作用的方法
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Also Published As

Publication number Publication date
US20020115107A1 (en) 2002-08-22
US20040132100A1 (en) 2004-07-08
WO1999049314A9 (fr) 1999-11-18
CA2326341A1 (fr) 1999-09-30
EP1066522A4 (fr) 2005-02-02
US20040063157A1 (en) 2004-04-01
WO1999049314A1 (fr) 1999-09-30
CA2326341C (fr) 2009-02-17
JP2002507748A (ja) 2002-03-12
DE69933549T2 (de) 2007-06-21
US7001727B2 (en) 2006-02-21
US6344330B1 (en) 2002-02-05
US6344334B1 (en) 2002-02-05
ATE342507T1 (de) 2006-11-15
AU3211399A (en) 1999-10-18
EP1066522B1 (fr) 2006-10-11
DE69933549D1 (de) 2006-11-23
AU759327B2 (en) 2003-04-10
EP1066522A1 (fr) 2001-01-10

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Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees