ATE342507T1 - PHARMAKOPHORE REKOMBINATION ZUR IDENTIFIZIERUNG VON ßLEADß-VERBINDUNGEN VON KLEINMOLEKÜL- MEDIKAMENTEN - Google Patents

PHARMAKOPHORE REKOMBINATION ZUR IDENTIFIZIERUNG VON ßLEADß-VERBINDUNGEN VON KLEINMOLEKÜL- MEDIKAMENTEN

Info

Publication number
ATE342507T1
ATE342507T1 AT99914218T AT99914218T ATE342507T1 AT E342507 T1 ATE342507 T1 AT E342507T1 AT 99914218 T AT99914218 T AT 99914218T AT 99914218 T AT99914218 T AT 99914218T AT E342507 T1 ATE342507 T1 AT E342507T1
Authority
AT
Austria
Prior art keywords
ßleadß
identifying
compounds
small molecule
molecule drugs
Prior art date
Application number
AT99914218T
Other languages
English (en)
Inventor
Jonathan A Ellman
Ingrid Choong
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE342507T1 publication Critical patent/ATE342507T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/807—Hapten conjugated with peptide or protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT99914218T 1998-03-27 1999-03-26 PHARMAKOPHORE REKOMBINATION ZUR IDENTIFIZIERUNG VON ßLEADß-VERBINDUNGEN VON KLEINMOLEKÜL- MEDIKAMENTEN ATE342507T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/049,754 US6344330B1 (en) 1998-03-27 1998-03-27 Pharmacophore recombination for the identification of small molecule drug lead compounds

Publications (1)

Publication Number Publication Date
ATE342507T1 true ATE342507T1 (de) 2006-11-15

Family

ID=21961533

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99914218T ATE342507T1 (de) 1998-03-27 1999-03-26 PHARMAKOPHORE REKOMBINATION ZUR IDENTIFIZIERUNG VON ßLEADß-VERBINDUNGEN VON KLEINMOLEKÜL- MEDIKAMENTEN

Country Status (9)

Country Link
US (5) US6344330B1 (de)
EP (1) EP1066522B1 (de)
JP (1) JP2002507748A (de)
AT (1) ATE342507T1 (de)
AU (1) AU759327B2 (de)
CA (1) CA2326341C (de)
DE (1) DE69933549T2 (de)
IL (1) IL138717A0 (de)
WO (1) WO1999049314A1 (de)

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US6998233B2 (en) 1998-06-26 2006-02-14 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery
US6919178B2 (en) 2000-11-21 2005-07-19 Sunesis Pharmaceuticals, Inc. Extended tethering approach for rapid identification of ligands
US20050287596A9 (en) * 1998-06-26 2005-12-29 Braisted Andrew C Novel ligands and libraries of ligands
US20030194745A1 (en) * 1998-06-26 2003-10-16 Mcdowell Robert S. Cysteine mutants and methods for detecting ligand binding to biological molecules
US6824987B1 (en) * 1999-05-11 2004-11-30 President And Fellows Of Harvard College Small molecule printing
EP1441228B1 (de) * 2000-11-21 2006-06-28 Sunesis Pharmaceuticals, Inc. Erweiterter "thethering" Ansatz zum schnellen Auffinden von Liganden
US20020172967A1 (en) * 2001-02-13 2002-11-21 Gadek Thomas R. Identification of non-covalent complexes by mass spectrometry
US20040017884A1 (en) * 2002-07-25 2004-01-29 Havrilla George J. Flow method and apparatus for screening chemicals using micro x-ray fluorescence
US9157875B2 (en) * 2001-05-16 2015-10-13 Benjamin P. Warner Drug development and manufacturing
US6858148B2 (en) 2003-07-16 2005-02-22 The Regents Of The University Of California Method and apparatus for detecting chemical binding
NZ530811A (en) * 2001-08-07 2005-07-29 Sunesis Pharmaceuticals Inc Disulfide and thiosulfonate ligands and libraries comprising these ligands
AU2002254725A1 (en) * 2001-11-21 2003-06-10 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery
CA2493461C (en) 2002-07-24 2013-01-08 Dror Ofer Drug discovery method
US7519145B2 (en) * 2002-07-25 2009-04-14 Los Alamos National Security, Llc Flow method and apparatus for screening chemicals using micro x-ray fluorescence
US7491312B2 (en) * 2002-10-30 2009-02-17 Edison Pharmaceuticals, Inc. Identifying therapeutic compounds based on their physical-chemical properties
ATE354096T1 (de) 2002-12-23 2007-03-15 Astex Therapeutics Ltd Synthese und screening von liganden mit hilfe von röntgenkristallographie
US7736909B2 (en) * 2003-01-09 2010-06-15 Board Of Regents, The University Of Texas System Methods and compositions comprising capture agents
US20040265909A1 (en) * 2003-04-11 2004-12-30 Jeff Blaney Compound libraries and methods for drug discovery
US20070003954A1 (en) * 2005-05-12 2007-01-04 The Board Of Regents Of The University Of Texas System Protein and antibody profiling using small molecule microarrays
DK1934388T3 (da) * 2005-10-04 2013-02-25 Alchemia Ltd Fremgangsmåde til lægemiddeludvikling
WO2008013569A2 (en) * 2006-01-03 2008-01-31 The President And Fellows Of Harvard College Small molecule printing
EP2084519B1 (de) 2006-10-10 2012-08-01 Los Alamos National Security, LLC Röntgenfluoreszenz-analyseverfahren
DE102007023102A1 (de) * 2006-12-19 2008-06-26 Bayer Cropscience Ag Bisoxime als Fungizide
US20090087919A1 (en) 2007-09-28 2009-04-02 Caldera Pharmaceuticals, Inc. Method and Apparatus for Measuring Protein Post-Translational Modification
US10107798B2 (en) 2008-03-25 2018-10-23 Sunesis Pharmaceuticals, Inc. Methods of chemotype evolution
RU2563822C2 (ru) * 2009-05-29 2015-09-20 Дзе Борд Оф Риджентс Оф Дзе Юниверсити Оф Техас Систем Пептоидные лиганды для выделения и обработки аутоиммунных т-клеток
US9551721B2 (en) * 2009-06-02 2017-01-24 The Board Of Regents Of The University Of Texas System Identification of small molecules recognized by antibodies in subjects with neurodegenerative diseases
WO2011047257A1 (en) * 2009-10-16 2011-04-21 The Board Of Regents Of The University Of Texas System Compositions and methods for producing cyclic peptoid libraries
BR112012033490A2 (pt) 2010-07-02 2015-09-15 Syngenta Participations Ag derivados de éter dioxima microbicida
CA2804355A1 (en) 2010-07-29 2012-02-02 Syngenta Participations Ag Novel microbiocidal dioxime ether derivatives
WO2012129423A2 (en) 2011-03-24 2012-09-27 Opko Pharmaceuticals, Llc Biomarker discovery in complex biological fluid using bead or particle based libraries and diagnostic kits and therapeutics
WO2013024040A2 (en) 2011-08-12 2013-02-21 B.S.R.C. Alexander Fleming Tnf superfamily trimerization inhibitors
WO2013092460A1 (en) 2011-12-20 2013-06-27 Syngenta Participations Ag Cyclic bisoxime microbicides
CN102731450A (zh) * 2012-07-04 2012-10-17 中山大学 一种苯并呋喃或吲哚的制备方法
WO2015023724A1 (en) 2013-08-13 2015-02-19 The Scripps Research Institute Cysteine-reactive ligand discovery in proteomes
CN104897826B (zh) * 2015-06-16 2016-06-22 广西师范大学 一种用于细胞原位检测小分子化合物与靶蛋白相互作用的方法
CA2999800A1 (en) 2015-08-11 2017-02-16 Stephen Mark Robbins Dpep-1 binding compositions and methods of use
EP3365686A4 (de) 2015-10-22 2019-03-27 The Scripps Research Institute Reaktive cysteinsonden und verwendungen davon
US10458995B2 (en) 2016-03-25 2019-10-29 Muralidhar Reddy Moola Combinatorial synthesis and biomarker development
EP3570829A4 (de) 2017-01-18 2021-03-10 The Scripps Research Institute Fotoreaktive liganden und verwendungen davon

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US6344330B1 (en) * 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
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Also Published As

Publication number Publication date
AU759327B2 (en) 2003-04-10
DE69933549D1 (de) 2006-11-23
EP1066522A1 (de) 2001-01-10
EP1066522B1 (de) 2006-10-11
DE69933549T2 (de) 2007-06-21
AU3211399A (en) 1999-10-18
EP1066522A4 (de) 2005-02-02
CA2326341C (en) 2009-02-17
US6344334B1 (en) 2002-02-05
IL138717A0 (en) 2001-10-31
WO1999049314A1 (en) 1999-09-30
JP2002507748A (ja) 2002-03-12
US6344330B1 (en) 2002-02-05
US7001727B2 (en) 2006-02-21
US20020115107A1 (en) 2002-08-22
US20040063157A1 (en) 2004-04-01
CA2326341A1 (en) 1999-09-30
US20040132100A1 (en) 2004-07-08
WO1999049314A9 (en) 1999-11-18

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