IL135584A - Use of dual, non-selective antagonists ß-adrenoreceptor and α1-adrenoreceptor in the preparation of a drug for the treatment of amyloid diseases - Google Patents
Use of dual, non-selective antagonists ß-adrenoreceptor and α1-adrenoreceptor in the preparation of a drug for the treatment of amyloid diseasesInfo
- Publication number
- IL135584A IL135584A IL13558498A IL13558498A IL135584A IL 135584 A IL135584 A IL 135584A IL 13558498 A IL13558498 A IL 13558498A IL 13558498 A IL13558498 A IL 13558498A IL 135584 A IL135584 A IL 135584A
- Authority
- IL
- Israel
- Prior art keywords
- carbon atoms
- hydrogen
- adrenoceptor
- lower alkyl
- selective
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6236697P | 1997-10-15 | 1997-10-15 | |
PCT/US1998/021789 WO1999018794A1 (en) | 1997-10-15 | 1998-10-15 | Method for treating alzheimer's disease |
Publications (2)
Publication Number | Publication Date |
---|---|
IL135584A0 IL135584A0 (en) | 2001-05-20 |
IL135584A true IL135584A (en) | 2005-12-18 |
Family
ID=22042015
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13558498A IL135584A (en) | 1997-10-15 | 1998-10-15 | Use of dual, non-selective antagonists ß-adrenoreceptor and α1-adrenoreceptor in the preparation of a drug for the treatment of amyloid diseases |
Country Status (16)
Country | Link |
---|---|
US (1) | US6358990B1 (ja) |
EP (1) | EP1024697A4 (ja) |
JP (1) | JP2001519364A (ja) |
KR (1) | KR100573352B1 (ja) |
CN (1) | CN1281334A (ja) |
AU (1) | AU751526B2 (ja) |
BR (1) | BR9814075A (ja) |
CA (1) | CA2305262A1 (ja) |
HU (1) | HUP0100024A3 (ja) |
IL (1) | IL135584A (ja) |
NO (1) | NO20001869L (ja) |
NZ (1) | NZ504419A (ja) |
PL (1) | PL339910A1 (ja) |
TR (1) | TR200001018T2 (ja) |
WO (1) | WO1999018794A1 (ja) |
ZA (1) | ZA989365B (ja) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10142175A1 (de) * | 2001-10-09 | 2003-03-27 | Eucro Europe Contract Res Gmbh | Verwendung von ß-Adrenozeptor-Agonisten zur Behandlung von neurodegenerativen Erkrankungen |
US8101209B2 (en) * | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
CA2483054A1 (en) * | 2002-04-30 | 2003-11-13 | Sb Pharmco Puerto Rico Inc. | Carvedilol monocitrate monohydrate |
EP1534270A4 (en) * | 2002-06-27 | 2006-05-17 | Sb Pharmco Inc | CARVEDILOL PHOSPHATE SALTS AND / OR ITS SOLVENTS, CORRESPONDING COMPOSITIONS AND / OR TREATMENT PROCEDURES |
US20050261355A1 (en) * | 2002-06-27 | 2005-11-24 | Sb Pharmco Puerto Rico Inc., | Carvedilol hydobromide |
JP5072364B2 (ja) * | 2003-11-25 | 2012-11-14 | スミスクライン ビーチャム (コーク) リミテッド | カルベジロール遊離塩基、カルベジロール塩、無水形態またはその溶媒和物、対応する医薬組成物、制御放出処方および治療またはデリバリー方法 |
WO2005051325A2 (en) * | 2003-11-25 | 2005-06-09 | Sb Pharmco Puerto Rico Inc. | Carvedilol compositions methods of treatment and delivery |
US7750036B2 (en) * | 2003-11-25 | 2010-07-06 | Sb Pharmco Puerto Rico Inc. | Carvedilol salts, corresponding compositions, methods of delivery and/or treatment |
CN1991364A (zh) * | 2005-12-26 | 2007-07-04 | 中国科学院上海生命科学研究院 | 预防和治疗阿尔兹海默症的g蛋白偶联受体拮抗剂 |
US20100029654A1 (en) * | 2006-03-23 | 2010-02-04 | Mount Sinai School Of Medicine | Cardiovascular compositions and use of the same for the treatment of alzheimer's disease |
WO2008021552A2 (en) * | 2006-08-18 | 2008-02-21 | Duke University | Biased ligands and methods of identifying same |
US20090076116A1 (en) * | 2007-09-13 | 2009-03-19 | Protia, Llc | Deuterium-enriched carvediolo |
DK2247558T4 (da) | 2008-02-14 | 2024-07-29 | Lilly Co Eli | Nye billeddannelsesmidler til detektering af neurologisk dysfunktion |
US8932557B2 (en) | 2008-02-14 | 2015-01-13 | Eli Lilly And Company | Imaging agents for detecting neurological dysfunction |
CN103172643B (zh) * | 2011-12-26 | 2016-03-02 | 中国医学科学院药物研究所 | 黄皮咔唑生物碱及其制备方法和其药物组合物与用途 |
CN102816107B (zh) * | 2012-08-20 | 2015-06-03 | 东南大学 | 咔唑衍生物及其制备方法与用途 |
JP2016523918A (ja) | 2013-06-27 | 2016-08-12 | シーダーズ−サイナイ メディカル センター | 神経変性状態の予防および治療のためのアドレナリン受容体拮抗薬 |
CA3192905A1 (en) * | 2020-09-17 | 2022-06-23 | Sui Rong Wayne CHEN | Methods of treating and/or preventing alzheimer's disease with r-carvedilol |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2815926A1 (de) * | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DE3319027A1 (de) * | 1983-05-26 | 1984-11-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten |
DK662687A (da) * | 1986-12-17 | 1988-06-18 | Glaxo Group Ltd | Anvendelse af tricycliske carbazoloner |
US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
US4983608A (en) | 1989-09-05 | 1991-01-08 | Hoechst-Roussell Pharmaceuticals, Inc. | N-substituted-4-pyrimidinamines and pyrimidinediamines |
JPH0558998A (ja) * | 1991-09-06 | 1993-03-09 | Taisho Pharmaceut Co Ltd | カルバゾール誘導体 |
MX9700696A (es) * | 1994-07-27 | 1997-04-30 | Sankyo Co | Compuestos heterociclicos, utiles como productores de efecto aloesterico en receptores muscarinicos. |
FR2724933A1 (fr) * | 1994-09-22 | 1996-03-29 | Pf Medicament | Nouveaux ethers aromatiques derives d'indoles utiles comme medicaments |
US5760069A (en) * | 1995-02-08 | 1998-06-02 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 | Method of treatment for decreasing mortality resulting from congestive heart failure |
FR2731222A1 (fr) * | 1995-03-02 | 1996-09-06 | Pf Medicament | Nouveaux derives de piperazine aminoindoles cycliques, leur procede de preparation et leur utilisation a titre de medicaments |
EP1110945A3 (en) * | 1995-05-01 | 2003-05-07 | University Of Pittsburgh | Azocompounds for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
-
1998
- 1998-10-14 ZA ZA989365A patent/ZA989365B/xx unknown
- 1998-10-15 HU HU0100024A patent/HUP0100024A3/hu unknown
- 1998-10-15 BR BR9814075-2A patent/BR9814075A/pt not_active IP Right Cessation
- 1998-10-15 US US09/529,526 patent/US6358990B1/en not_active Expired - Fee Related
- 1998-10-15 IL IL13558498A patent/IL135584A/en not_active IP Right Cessation
- 1998-10-15 JP JP2000515438A patent/JP2001519364A/ja active Pending
- 1998-10-15 AU AU10897/99A patent/AU751526B2/en not_active Ceased
- 1998-10-15 CN CN98812171A patent/CN1281334A/zh active Pending
- 1998-10-15 PL PL98339910A patent/PL339910A1/xx unknown
- 1998-10-15 TR TR2000/01018T patent/TR200001018T2/xx unknown
- 1998-10-15 CA CA002305262A patent/CA2305262A1/en not_active Abandoned
- 1998-10-15 KR KR1020007003990A patent/KR100573352B1/ko not_active IP Right Cessation
- 1998-10-15 WO PCT/US1998/021789 patent/WO1999018794A1/en not_active Application Discontinuation
- 1998-10-15 NZ NZ504419A patent/NZ504419A/xx unknown
- 1998-10-15 EP EP98953558A patent/EP1024697A4/en not_active Withdrawn
-
2000
- 2000-04-11 NO NO20001869A patent/NO20001869L/no unknown
Also Published As
Publication number | Publication date |
---|---|
EP1024697A1 (en) | 2000-08-09 |
PL339910A1 (en) | 2001-01-15 |
TR200001018T2 (tr) | 2000-08-21 |
CA2305262A1 (en) | 1999-04-22 |
WO1999018794A1 (en) | 1999-04-22 |
HUP0100024A2 (hu) | 2001-07-30 |
NZ504419A (en) | 2002-11-26 |
BR9814075A (pt) | 2000-09-26 |
US6358990B1 (en) | 2002-03-19 |
HUP0100024A3 (en) | 2002-12-28 |
KR20010031108A (ko) | 2001-04-16 |
AU751526B2 (en) | 2002-08-22 |
EP1024697A4 (en) | 2007-05-02 |
NO20001869L (no) | 2000-06-14 |
NO20001869D0 (no) | 2000-04-11 |
JP2001519364A (ja) | 2001-10-23 |
IL135584A0 (en) | 2001-05-20 |
ZA989365B (en) | 1999-04-15 |
KR100573352B1 (ko) | 2006-04-25 |
AU1089799A (en) | 1999-05-03 |
CN1281334A (zh) | 2001-01-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FF | Patent granted | ||
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |