IL133731A0 - Certain diarylimidazole derivatives, a new class of npy specific ligands - Google Patents
Certain diarylimidazole derivatives, a new class of npy specific ligandsInfo
- Publication number
- IL133731A0 IL133731A0 IL13373198A IL13373198A IL133731A0 IL 133731 A0 IL133731 A0 IL 133731A0 IL 13373198 A IL13373198 A IL 13373198A IL 13373198 A IL13373198 A IL 13373198A IL 133731 A0 IL133731 A0 IL 133731A0
- Authority
- IL
- Israel
- Prior art keywords
- certain
- new class
- specific ligands
- npy
- diarylimidazole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5171197P | 1997-07-03 | 1997-07-03 | |
| PCT/US1998/013861 WO1999001128A1 (fr) | 1997-07-03 | 1998-07-02 | Certains derives diarylimidazoles; nouvelle classe de ligands specifiques de neuropeptide y (npy) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL133731A0 true IL133731A0 (en) | 2001-04-30 |
Family
ID=21972909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13373198A IL133731A0 (en) | 1997-07-03 | 1998-07-02 | Certain diarylimidazole derivatives, a new class of npy specific ligands |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6121260A (fr) |
| EP (1) | EP0996443A1 (fr) |
| JP (1) | JP2002515400A (fr) |
| KR (1) | KR20010020610A (fr) |
| CN (1) | CN1265033A (fr) |
| AU (1) | AU744297B2 (fr) |
| BR (1) | BR9810651A (fr) |
| CA (1) | CA2294898A1 (fr) |
| HU (1) | HUP0003934A3 (fr) |
| IL (1) | IL133731A0 (fr) |
| NO (1) | NO996573L (fr) |
| PL (1) | PL337887A1 (fr) |
| WO (1) | WO1999001128A1 (fr) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6590106B2 (en) * | 1997-05-09 | 2003-07-08 | Pharm-Eco Laboratories, Inc. | Amino acid derivatives and methods of making the same |
| CA2294898A1 (fr) * | 1997-07-03 | 1999-01-14 | Neurogen Corporation | Certains derives diarylimidazoles; nouvelle classe de ligands specifiques de neuropeptide y (npy) |
| US6989379B1 (en) | 1999-04-22 | 2006-01-24 | H. Lundbick A/S | Selective NPY (Y5) antagonists |
| US6340683B1 (en) | 1999-04-22 | 2002-01-22 | Synaptic Pharmaceutical Corporation | Selective NPY (Y5) antagonists (triazines) |
| WO2000064880A1 (fr) | 1999-04-22 | 2000-11-02 | Synaptic Pharmaceutical Corporation | Antagonistes selectifs npy (y5) |
| WO2000066578A1 (fr) | 1999-04-30 | 2000-11-09 | Pfizer Products Inc. | Composes pour le traitement de l'obesite |
| AR024077A1 (es) * | 1999-05-25 | 2002-09-04 | Smithkline Beecham Corp | Compuestos antibacterianos |
| AU773892B2 (en) * | 1999-06-30 | 2004-06-10 | H. Lundbeck A/S | Selective NPY (Y5) antagonists |
| US7273880B2 (en) | 1999-06-30 | 2007-09-25 | H. Lunbeck A/S | Selective NPY (Y5) antagonists |
| ATE257827T1 (de) | 1999-07-21 | 2004-01-15 | Hoffmann La Roche | Triazolderivate |
| DE60022386T2 (de) | 1999-12-16 | 2006-06-22 | Schering Corp. | Substituierte imidazole als neuropeptide y y5 rezeptor antagonisten |
| ES2236178T3 (es) * | 2000-02-22 | 2005-07-16 | Banyu Pharmaceutical Co., Ltd. | Nuevos compuestos de imidazolina. |
| HUP0303829A3 (en) | 2001-04-16 | 2006-02-28 | Tanabe Seiyaku Co | Large conductance calcium-acitvated k channel opener compounds, use thereof and pharmaceutical compositions containing them |
| KR20040004705A (ko) * | 2001-06-08 | 2004-01-13 | 시토비아 인크. | 카스파제의 활성제 및 아폽토시스의 유도제로서의 치환된3-아릴-5-아릴-[1,2,4]-옥사디아졸과 유사체 및 이의 용도 |
| US7124183B2 (en) | 2001-09-26 | 2006-10-17 | Bell Security Solutions Inc. | Method and apparatus for secure distributed managed network information services with redundancy |
| US20050165011A1 (en) * | 2002-05-15 | 2005-07-28 | Gellibert Francoise J. | Benzoxazine and benzoxazinone substituted triazoles |
| US7884120B2 (en) | 2002-08-19 | 2011-02-08 | Lorus Therapeutics Inc. | 2,4,5-trisubstituted imidazoles and their use as anti-microbial agents |
| US6958347B2 (en) | 2002-12-18 | 2005-10-25 | Pfizer Inc. | Aminophenanthridinone and aminophenanthridine as NPY-5 antagonists |
| US6949564B2 (en) * | 2002-12-18 | 2005-09-27 | Pfizer Inc. | NPY-5 antagonists |
| WO2004058253A1 (fr) * | 2002-12-18 | 2004-07-15 | Cytovia, Inc. | 3,5-disubstitues-[1,2,4]-oxadiazoles et analogues servant d'activateurs des caspases et de promoteurs de l'apoptose, et leur utilisation |
| DK1692113T3 (en) | 2003-11-14 | 2018-01-08 | Lorus Therapeutics Inc | ARYLIMIDAZOLES AND USE THEREOF AS ANTICANCES |
| JP4694251B2 (ja) * | 2004-06-10 | 2011-06-08 | 四国化成工業株式会社 | 無鉛半田付け用の銅または銅合金の表面処理剤及びその利用 |
| CN101624374B (zh) * | 2004-06-10 | 2012-03-21 | 四国化成工业株式会社 | 在焊接过程中用于铜表面上的苯基萘基咪唑 |
| KR101074640B1 (ko) * | 2004-06-10 | 2011-10-19 | 시코쿠가세이고교가부시키가이샤 | 납땜 동안 구리 표면에 사용하기 위한 페닐나프틸이미다졸 |
| AU2006250809B2 (en) | 2005-05-25 | 2011-05-12 | Lorus Therapeutics Inc. | 2-indolyl imidazo(4,5-D)phenanthroline derivatives and their use in the treatment of cancer |
| TWI387592B (zh) * | 2005-08-30 | 2013-03-01 | Novartis Ag | 經取代之苯并咪唑及其作為與腫瘤形成相關激酶之抑制劑之方法 |
| US9447049B2 (en) * | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
| TR201903981T4 (tr) | 2008-06-16 | 2019-04-22 | Univ Ohio State Res Found | Kanser tedavisi için bileşikler. |
| JP5361316B2 (ja) * | 2008-10-02 | 2013-12-04 | 株式会社タムラ製作所 | 表面処理剤、プリント回路基板およびその製造方法 |
| JP5615227B2 (ja) * | 2011-05-23 | 2014-10-29 | 四国化成工業株式会社 | 銅または銅合金の表面処理剤及びその利用 |
| JP5858884B2 (ja) * | 2012-08-16 | 2016-02-10 | 四国化成工業株式会社 | チオフェン環を有するイミダゾール化合物 |
| JP5892605B2 (ja) * | 2012-08-17 | 2016-03-23 | 四国化成工業株式会社 | ４−（２−チエニル）イミダゾール化合物 |
| US9309247B2 (en) | 2013-03-20 | 2016-04-12 | Lorus Therapeutics Inc. | 2-substituted imidazo[4,5-D]phenanthroline derivatives and their use in the treatment of cancer |
| WO2015051302A1 (fr) | 2013-10-04 | 2015-04-09 | Aptose Biosciences Inc. | Compositions et procédés de traitement de cancers |
| ES2815374T3 (es) | 2014-05-06 | 2021-03-29 | Oncternal Therapeutics Inc | Compuestos para el tratamiento del cáncer |
| CN104974095B (zh) * | 2015-06-30 | 2017-09-15 | 浙江大学 | 2,4,5‑多取代咪唑类化合物及制备方法 |
| JP2021501203A (ja) | 2017-10-30 | 2021-01-14 | アプトース バイオサイエンシズ インコーポレイテッド | がん治療用のアリールイミダゾール |
| WO2022236253A1 (fr) * | 2021-05-03 | 2022-11-10 | Nuvation Bio Inc. | Composés hétérocycliques en tant qu'inhibiteurs de kinase |
| EP4173485A1 (fr) * | 2021-10-27 | 2023-05-03 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Composés inhibant l'agrégation de protéine pour la lutte contre les maladies des plantes |
| CN115043779B (zh) * | 2022-06-14 | 2024-06-25 | 广东金柏化学有限公司 | 一种2,4-二苯基咪唑化合物及其制备方法与应用 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE297816C (fr) * | ||||
| US3297710A (en) * | 1963-04-09 | 1967-01-10 | Du Pont | Oxoarylidene-imidazoles |
| US3657441A (en) * | 1970-07-30 | 1972-04-18 | Merck & Co Inc | Method of inhibiting the formation of phenylethanolamine n-methyl transferase with imidazoles |
| US3707475A (en) * | 1970-11-16 | 1972-12-26 | Pfizer | Antiinflammatory imidazoles |
| US4134983A (en) * | 1975-03-03 | 1979-01-16 | Merck & Co., Inc. | 3-amino-2-or-propoxyaryl substituted imidazoles |
| US4853383A (en) * | 1975-03-03 | 1989-08-01 | Merck & Co., Inc. | β-blocking substituted imidazoles |
| SU1051076A1 (ru) * | 1982-04-09 | 1983-10-30 | Алтайский политехнический институт | Способ получени производных имидазола |
| IT1206498B (it) | 1983-07-18 | 1989-04-27 | Angeli Inst Spa | Derivati amidinici del4-fenilmidazolo 2-sostituto processi per la loro preparazione e loro uso farmaceutico. |
| DE3411997A1 (de) * | 1984-03-31 | 1985-10-17 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue redox-indikatoren |
| IN165525B (fr) * | 1984-07-23 | 1989-11-04 | Shinetsu Chemical Co | |
| PT80975B (pt) * | 1984-08-17 | 1987-11-11 | Shinetsu Chemical Co | Processo para a preparacao de um polimero de vinilo |
| IL83467A0 (en) * | 1986-08-15 | 1988-01-31 | Fujisawa Pharmaceutical Co | Imidazole derivatives,processes for their preparation and pharmaceutical compositions containing the same |
| JP2630432B2 (ja) * | 1987-08-24 | 1997-07-16 | コニカ株式会社 | 新規なシアンカプラーを含有するハロゲン化銀カラー写真感光材料 |
| JP2700475B2 (ja) * | 1988-07-30 | 1998-01-21 | コニカ株式会社 | 非線形光学材料および非線形光学素子 |
| DE3835195A1 (de) * | 1988-10-15 | 1990-04-19 | Basf Ag | Verfahren zur herstellung von p-nitrophenyl-imidazolen |
| AU621245B2 (en) * | 1989-10-17 | 1992-03-05 | Boehringer Mannheim Gmbh | Hydrolase substrates, a process for the preparation thereof and agents containing them |
| ATE109979T1 (de) * | 1990-03-30 | 1994-09-15 | Heumann Pharma Gmbh & Co | Verwendung von guanidinderivaten zur herstellung eines arzneimittels mit npy-antagonistischer wirkung. |
| US5296609A (en) * | 1993-04-09 | 1994-03-22 | Syntex Pharmaceuticals, Ltd. | Process for the preparation of 1,2,4-substituted imidazoles and related aminoalkylimidazole derivatives |
| TW270944B (fr) * | 1993-05-10 | 1996-02-21 | Shikoku Kakoki Co Ltd | |
| US5620999A (en) * | 1994-07-28 | 1997-04-15 | Weier; Richard M. | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation |
| AU7692996A (en) * | 1995-12-01 | 1997-06-27 | Ciba-Geigy Ag | Receptor antagonists |
| CA2294898A1 (fr) * | 1997-07-03 | 1999-01-14 | Neurogen Corporation | Certains derives diarylimidazoles; nouvelle classe de ligands specifiques de neuropeptide y (npy) |
-
1998
- 1998-07-02 CA CA002294898A patent/CA2294898A1/fr not_active Abandoned
- 1998-07-02 BR BR9810651-1A patent/BR9810651A/pt not_active IP Right Cessation
- 1998-07-02 HU HU0003934A patent/HUP0003934A3/hu unknown
- 1998-07-02 EP EP98933135A patent/EP0996443A1/fr not_active Withdrawn
- 1998-07-02 KR KR1019997012624A patent/KR20010020610A/ko not_active Application Discontinuation
- 1998-07-02 IL IL13373198A patent/IL133731A0/xx unknown
- 1998-07-02 PL PL98337887A patent/PL337887A1/xx not_active Application Discontinuation
- 1998-07-02 JP JP2000500894A patent/JP2002515400A/ja active Pending
- 1998-07-02 AU AU82868/98A patent/AU744297B2/en not_active Ceased
- 1998-07-02 WO PCT/US1998/013861 patent/WO1999001128A1/fr not_active Application Discontinuation
- 1998-07-02 US US09/109,558 patent/US6121260A/en not_active Expired - Fee Related
- 1998-07-02 CN CN98807669A patent/CN1265033A/zh active Pending
-
1999
- 1999-12-30 NO NO996573A patent/NO996573L/no not_active Application Discontinuation
-
2000
- 2000-03-10 US US09/523,328 patent/US6515133B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BR9810651A (pt) | 2000-10-03 |
| HUP0003934A2 (hu) | 2001-11-28 |
| AU744297B2 (en) | 2002-02-21 |
| KR20010020610A (ko) | 2001-03-15 |
| WO1999001128A1 (fr) | 1999-01-14 |
| HUP0003934A3 (en) | 2002-01-28 |
| EP0996443A1 (fr) | 2000-05-03 |
| PL337887A1 (en) | 2000-09-11 |
| US6515133B1 (en) | 2003-02-04 |
| AU8286898A (en) | 1999-01-25 |
| CN1265033A (zh) | 2000-08-30 |
| JP2002515400A (ja) | 2002-05-28 |
| CA2294898A1 (fr) | 1999-01-14 |
| NO996573L (no) | 2000-02-23 |
| NO996573D0 (no) | 1999-12-30 |
| US6121260A (en) | 2000-09-19 |
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