IL133265A0 - Heparanase specific molecular probes and their use in research and medical applications - Google Patents
Heparanase specific molecular probes and their use in research and medical applicationsInfo
- Publication number
- IL133265A0 IL133265A0 IL13326599A IL13326599A IL133265A0 IL 133265 A0 IL133265 A0 IL 133265A0 IL 13326599 A IL13326599 A IL 13326599A IL 13326599 A IL13326599 A IL 13326599A IL 133265 A0 IL133265 A0 IL 133265A0
- Authority
- IL
- Israel
- Prior art keywords
- heparanase
- specific molecular
- research
- molecular probe
- medical applications
- Prior art date
Links
- 102100024025 Heparanase Human genes 0.000 title abstract 10
- 108010037536 heparanase Proteins 0.000 title abstract 10
- 239000003068 molecular probe Substances 0.000 title abstract 7
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 238000011002 quantification Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01166—Heparanase (3.2.1.166)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/988—Lyases (4.), e.g. aldolases, heparinase, enolases, fumarase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
- G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- General Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Anesthesiology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/071,739 US6177545B1 (en) | 1997-09-02 | 1998-05-01 | Heparanase specific molecular probes and their use in research and medical applications |
PCT/US1999/009255 WO1999057153A1 (en) | 1998-05-01 | 1999-04-29 | Heparanase specific molecular probes and their use in research and medical applications |
Publications (1)
Publication Number | Publication Date |
---|---|
IL133265A0 true IL133265A0 (en) | 2001-04-30 |
Family
ID=22103268
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL13326599A IL133265A0 (en) | 1998-05-01 | 1999-04-29 | Heparanase specific molecular probes and their use in research and medical applications |
Country Status (11)
Country | Link |
---|---|
US (6) | US6177545B1 (xx) |
EP (2) | EP1734133A2 (xx) |
JP (1) | JP2002512533A (xx) |
AT (1) | ATE328008T1 (xx) |
AU (1) | AU754228B2 (xx) |
CA (1) | CA2295323A1 (xx) |
DE (1) | DE69931624T2 (xx) |
ES (1) | ES2267266T3 (xx) |
IL (1) | IL133265A0 (xx) |
NO (1) | NO996229L (xx) |
WO (1) | WO1999057153A1 (xx) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6699672B1 (en) * | 1997-09-02 | 2004-03-02 | Insight Biopharmaceuticals Ltd. | Heparanase specific molecular probes and their use research and medical applications |
US20010006630A1 (en) * | 1997-09-02 | 2001-07-05 | Oron Yacoby-Zeevi | Introducing a biological material into a patient |
US6562950B2 (en) * | 1997-09-02 | 2003-05-13 | Insight Strategy & Marketing Ltd. | Heparanase activity neutralizing anti-heparanase monoclonal antibody |
US5968822A (en) * | 1997-09-02 | 1999-10-19 | Pecker; Iris | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells |
US20020088019A1 (en) * | 1997-09-02 | 2002-07-04 | Oron Yacoby-Zeevi | Methods of and pharmaceutical compositions for improving implantation of embryos |
US20030161823A1 (en) * | 1998-08-31 | 2003-08-28 | Neta Ilan | Therapeutic and cosmetic uses of heparanases |
US6177545B1 (en) * | 1997-09-02 | 2001-01-23 | Insight Strategy & Marketing Ltd. | Heparanase specific molecular probes and their use in research and medical applications |
US20040213789A1 (en) * | 1997-09-02 | 2004-10-28 | Oron Yacoby-Zeevi | Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies |
US20030217375A1 (en) * | 1998-08-31 | 2003-11-20 | Eyal Zcharia | Transgenic animals expressing heparanase and uses thereof |
EP1157118A4 (en) * | 1999-03-01 | 2002-07-17 | Insight Strategy & Marketing | POLYNUCLEOTID ENCODING A POLYPEPTIDE WITH HEPARANASE ACTIVITY AND ITS EXPRESSION IN GENETICALLY MODIFIED CELLS |
CN1370178A (zh) * | 1999-06-25 | 2002-09-18 | 洞察战略及销售有限公司 | 多核苷酸及其编码的与乙酰肝素酶同源较远的多肽 |
EP1244778A2 (en) * | 1999-12-23 | 2002-10-02 | Schering Aktiengesellschaft | Human heparanase-related polypeptide and nucleic acid |
JP2004529606A (ja) | 2000-09-15 | 2004-09-30 | レディ ユーエス セラピューティクス インコーポレイテッド | グリコシダーゼアッセイのための方法及び組成物 |
CA2432157A1 (en) * | 2000-12-19 | 2002-06-27 | Insight Strategy And Marketing Ltd. | The use of ecm degrading enzymes for the improvement of cell transplantation |
CA2446962A1 (en) * | 2001-05-09 | 2002-11-14 | Insight Biopharmaceuticals Ltd. | Methods and kits utilizing heparanase as a diagnostic marker for haemostatic disorders |
WO2003006645A2 (en) * | 2001-07-13 | 2003-01-23 | Imclone Systems Incorporated | Method and composition for inhibiting heparanase activity |
AU2002322862A1 (en) * | 2001-07-31 | 2003-02-17 | Reddy Us Therapeutics, Inc. | Methods and compositions for diagnosis and treatment of vascular conditions |
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WO2004043989A2 (en) * | 2002-11-07 | 2004-05-27 | Medarex, Inc. | Human monoclonal antibodies to heparanase |
EP1582584A4 (en) * | 2002-12-26 | 2006-05-31 | Nippon Shinyaku Co Ltd | PROCESS FOR PRODUCING PNPASE |
US20060269552A1 (en) * | 2003-06-09 | 2006-11-30 | Oron Yacoby-Zeevi | Heparanase activity neutralizing anti-heparanase monclonal antibody and other anti-heparanase antibodies |
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WO2009075774A2 (en) * | 2007-12-05 | 2009-06-18 | Massachusetts Institute Of Technology | Glycosaminoglycan-coated particles and uses thereof |
EP2295028A4 (en) * | 2008-03-31 | 2013-11-13 | Shiseido Co Ltd | PREPARATION FOR PREVENTING OR REDUCING WRINKLES FOR ORAL INJECTION, FOR INJECTION OR FOR EXTERNAL APPLICATION TO THE SKIN AND COSMETIC PROCEDURE |
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US9428586B2 (en) * | 2009-12-01 | 2016-08-30 | Compugen Ltd | Heparanase splice variant |
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WO2013190582A1 (en) | 2012-06-22 | 2013-12-27 | Gentium S.P.A. | Euglobulin-based method for determining the biological activity of defibrotide |
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EP3026122A1 (en) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
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US10349968B2 (en) * | 2016-05-02 | 2019-07-16 | Covidien Lp | Devices, systems, and methods for establishing electrical and fluid connections to surgical instruments |
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-
1998
- 1998-05-01 US US09/071,739 patent/US6177545B1/en not_active Expired - Lifetime
-
1999
- 1999-04-29 AT AT99921513T patent/ATE328008T1/de not_active IP Right Cessation
- 1999-04-29 EP EP06009462A patent/EP1734133A2/en not_active Withdrawn
- 1999-04-29 EP EP99921513A patent/EP1073682B1/en not_active Expired - Lifetime
- 1999-04-29 WO PCT/US1999/009255 patent/WO1999057153A1/en active IP Right Grant
- 1999-04-29 ES ES99921513T patent/ES2267266T3/es not_active Expired - Lifetime
- 1999-04-29 CA CA002295323A patent/CA2295323A1/en not_active Abandoned
- 1999-04-29 DE DE69931624T patent/DE69931624T2/de not_active Expired - Lifetime
- 1999-04-29 IL IL13326599A patent/IL133265A0/xx unknown
- 1999-04-29 JP JP55552899A patent/JP2002512533A/ja active Pending
- 1999-04-29 AU AU38706/99A patent/AU754228B2/en not_active Ceased
- 1999-06-01 US US09/322,977 patent/US6531129B2/en not_active Expired - Lifetime
- 1999-12-15 NO NO996229A patent/NO996229L/no not_active Application Discontinuation
-
2001
- 2001-01-16 US US09/759,207 patent/US7049407B2/en not_active Expired - Fee Related
- 2001-09-04 US US09/944,602 patent/US6800441B2/en not_active Expired - Fee Related
-
2004
- 2004-02-26 US US10/786,149 patent/US6986996B2/en not_active Expired - Fee Related
- 2004-05-24 US US10/851,135 patent/US7790376B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6800441B2 (en) | 2004-10-05 |
US20020102619A1 (en) | 2002-08-01 |
AU3870699A (en) | 1999-11-23 |
DE69931624D1 (de) | 2006-07-06 |
US20020114801A1 (en) | 2002-08-22 |
US20020004585A1 (en) | 2002-01-10 |
EP1734133A2 (en) | 2006-12-20 |
US20040229834A1 (en) | 2004-11-18 |
DE69931624T2 (de) | 2007-05-03 |
NO996229L (no) | 2000-02-24 |
US7049407B2 (en) | 2006-05-23 |
EP1073682B1 (en) | 2006-05-31 |
US6531129B2 (en) | 2003-03-11 |
ES2267266T3 (es) | 2007-03-01 |
WO1999057153A1 (en) | 1999-11-11 |
AU754228B2 (en) | 2002-11-07 |
CA2295323A1 (en) | 1999-11-11 |
US20040146925A1 (en) | 2004-07-29 |
US6177545B1 (en) | 2001-01-23 |
US7790376B2 (en) | 2010-09-07 |
NO996229D0 (no) | 1999-12-15 |
ATE328008T1 (de) | 2006-06-15 |
EP1073682A4 (en) | 2001-02-07 |
JP2002512533A (ja) | 2002-04-23 |
EP1073682A1 (en) | 2001-02-07 |
US6986996B2 (en) | 2006-01-17 |
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