IL132747A - Identification of objects by means of multiple imaging - Google Patents
Identification of objects by means of multiple imagingInfo
- Publication number
- IL132747A IL132747A IL13274798A IL13274798A IL132747A IL 132747 A IL132747 A IL 132747A IL 13274798 A IL13274798 A IL 13274798A IL 13274798 A IL13274798 A IL 13274798A IL 132747 A IL132747 A IL 132747A
- Authority
- IL
- Israel
- Prior art keywords
- image
- cytoplasm
- regions
- images
- sample
- Prior art date
Links
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1429—Signal processing
- G01N15/1433—Signal processing using image recognition
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/012—Red blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
Landscapes
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Signal Processing (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Table Devices Or Equipment (AREA)
- Testing Of Coins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Image Processing (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4647097P | 1997-05-14 | 1997-05-14 | |
| US09/072,502 US6169816B1 (en) | 1997-05-14 | 1998-05-04 | Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images |
| PCT/US1998/009689 WO1998052018A1 (fr) | 1997-05-14 | 1998-05-12 | Identification d'objets par formation d'images multiples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL132747A0 IL132747A0 (en) | 2001-03-19 |
| IL132747A true IL132747A (en) | 2002-12-01 |
Family
ID=26723956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13274798A IL132747A (en) | 1997-05-14 | 1998-05-12 | Identification of objects by means of multiple imaging |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6169816B1 (fr) |
| EP (1) | EP0981732B1 (fr) |
| JP (1) | JP2002514304A (fr) |
| AT (1) | ATE308747T1 (fr) |
| AU (1) | AU739834B2 (fr) |
| CA (1) | CA2289930C (fr) |
| DE (1) | DE69832167T2 (fr) |
| HK (1) | HK1029170A1 (fr) |
| IL (1) | IL132747A (fr) |
| NO (1) | NO995542L (fr) |
| WO (1) | WO1998052018A1 (fr) |
Families Citing this family (108)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6320697B2 (en) * | 1931-08-07 | 2001-11-20 | Nikon Corporation | Illuminating light selection device for a microscope |
| US6718053B1 (en) * | 1996-11-27 | 2004-04-06 | Chromavision Medical Systems, Inc. | Method and apparatus for automated image analysis of biological specimens |
| CA2236268A1 (fr) * | 1995-11-30 | 1997-06-05 | Chromavision Medical Systems, Inc. | Procede et appareil permettant d'effectuer l'analyse d'images automatisee d'echantillons biologiques |
| US6259807B1 (en) | 1997-05-14 | 2001-07-10 | Applied Imaging Corp. | Identification of objects of interest using multiple illumination schemes and finding overlap of features in corresponding multiple images |
| KR100303608B1 (ko) * | 1997-05-22 | 2001-11-22 | 박호군 | 혈구세포자동인식방법및장치 |
| JP2002514762A (ja) * | 1998-05-09 | 2002-05-21 | アイコニシス，インコーポレーテッド | コンピュータによって制御された、胎児細胞を含む希少細胞に基づく診断のための方法および装置 |
| GB2361996B (en) * | 1998-10-29 | 2004-05-12 | Cell Works Inc | Multiple marker characterization of single cells |
| US6539106B1 (en) * | 1999-01-08 | 2003-03-25 | Applied Materials, Inc. | Feature-based defect detection |
| JP4624513B2 (ja) * | 1999-01-19 | 2011-02-02 | オリンパス株式会社 | 顕微鏡用撮像装置 |
| WO2000047998A1 (fr) | 1999-02-10 | 2000-08-17 | Cell Works Inc. | Caracterisation de classes de cellules cancereuses circulantes isolees a partir de fluides corporels et methodes d'utilisation |
| DE19911988C2 (de) * | 1999-03-17 | 2003-07-31 | Siemens Ag | Medizinische Magnetresonanzanlage |
| US6876760B1 (en) | 2000-12-04 | 2005-04-05 | Cytokinetics, Inc. | Classifying cells based on information contained in cell images |
| US7151847B2 (en) * | 2001-02-20 | 2006-12-19 | Cytokinetics, Inc. | Image analysis of the golgi complex |
| DE19932870A1 (de) * | 1999-07-09 | 2001-04-05 | Friedrich Schiller Uni Jena Bu | Vorrichtung zur optischen Partikel- und Partikelströmungsanalyse |
| DE60020986T2 (de) * | 1999-09-01 | 2006-05-11 | Hamamatsu Photonics K.K., Hamamatsu | Farbbildaufnahmegerät für schwaches licht |
| WO2001033196A2 (fr) * | 1999-10-29 | 2001-05-10 | Veracel Inc. | Reexamen commande d'echantillon medical |
| US6692952B1 (en) * | 1999-11-10 | 2004-02-17 | Massachusetts Institute Of Technology | Cell analysis and sorting apparatus for manipulation of cells |
| US20060073509A1 (en) * | 1999-11-18 | 2006-04-06 | Michael Kilpatrick | Method for detecting and quantitating multiple subcellular components |
| US6542180B1 (en) * | 2000-01-07 | 2003-04-01 | Mitutoyo Corporation | Systems and methods for adjusting lighting of a part based on a plurality of selected regions of an image of the part |
| US7518652B2 (en) | 2000-05-03 | 2009-04-14 | Aperio Technologies, Inc. | Method and apparatus for pre-focus in a linear array based slide scanner |
| US6711283B1 (en) | 2000-05-03 | 2004-03-23 | Aperio Technologies, Inc. | Fully automatic rapid microscope slide scanner |
| US7668362B2 (en) | 2000-05-03 | 2010-02-23 | Aperio Technologies, Inc. | System and method for assessing virtual slide image quality |
| US20020049544A1 (en) * | 2000-06-23 | 2002-04-25 | Cytokinetics, Inc. | Image analysis for phenotyping sets of mutant cells |
| US7218764B2 (en) * | 2000-12-04 | 2007-05-15 | Cytokinetics, Inc. | Ploidy classification method |
| US6956961B2 (en) * | 2001-02-20 | 2005-10-18 | Cytokinetics, Inc. | Extracting shape information contained in cell images |
| US7016787B2 (en) * | 2001-02-20 | 2006-03-21 | Cytokinetics, Inc. | Characterizing biological stimuli by response curves |
| SE517626C3 (sv) * | 2001-04-12 | 2002-09-04 | Cellavision Ab | Förfarande vid mikroskopering för att söka av och positionera ett objekt, där bilder tas och sammanfogas i samma bildkoordinatsystem för att noggrant kunna ställa in mikroskopbordet |
| US20040157211A1 (en) * | 2001-06-08 | 2004-08-12 | Ole Skyggebjerg | Method and a system for counting cells from a plurality of species |
| US7133543B2 (en) * | 2001-06-12 | 2006-11-07 | Applied Imaging Corporation | Automated scanning method for pathology samples |
| EP1406081A4 (fr) * | 2001-07-03 | 2011-10-05 | Hitachi Ltd | Procede de mesure optique de prelevement biologique et appareil de mesure optique de prelevement biologique |
| US7336988B2 (en) * | 2001-08-08 | 2008-02-26 | Lucent Technologies Inc. | Multi-photon endoscopy |
| WO2003042788A2 (fr) * | 2001-11-13 | 2003-05-22 | Chromavision Medical Systems, Inc. | Systeme de suivi d'echantillons biologiques |
| US7272252B2 (en) * | 2002-06-12 | 2007-09-18 | Clarient, Inc. | Automated system for combining bright field and fluorescent microscopy |
| US20050037406A1 (en) * | 2002-06-12 | 2005-02-17 | De La Torre-Bueno Jose | Methods and apparatus for analysis of a biological specimen |
| JP2004163413A (ja) * | 2002-08-28 | 2004-06-10 | Carl-Zeiss-Stiftung Trading As Carl Zeiss | 顕微鏡システムおよび顕微鏡検査方法 |
| CA2500392C (fr) * | 2002-09-27 | 2012-11-27 | The General Hospital Corporation | Dispositif microfluidique pour la separation de cellules et utilisations de ce dispositif |
| US9487823B2 (en) * | 2002-12-20 | 2016-11-08 | Qiagen Gmbh | Nucleic acid amplification |
| US8043834B2 (en) * | 2003-03-31 | 2011-10-25 | Qiagen Gmbh | Universal reagents for rolling circle amplification and methods of use |
| US20040202357A1 (en) | 2003-04-11 | 2004-10-14 | Perz Cynthia B. | Silhouette image acquisition |
| JP2007503597A (ja) * | 2003-06-13 | 2007-02-22 | ザ ジェネラル ホスピタル コーポレーション | 血液から赤血球および血小板をサイズに基づいて除去するための微少流体システム |
| US20050009032A1 (en) * | 2003-07-07 | 2005-01-13 | Cytokinetics, Inc. | Methods and apparatus for characterising cells and treatments |
| US7235353B2 (en) | 2003-07-18 | 2007-06-26 | Cytokinetics, Inc. | Predicting hepatotoxicity using cell based assays |
| US20050014217A1 (en) | 2003-07-18 | 2005-01-20 | Cytokinetics, Inc. | Predicting hepatotoxicity using cell based assays |
| EP1646926A2 (fr) * | 2003-07-18 | 2006-04-19 | Cytokinetics, Inc. | Caracterisation de stimuli biologiques par courbes de reponse |
| US7251363B2 (en) * | 2003-07-29 | 2007-07-31 | Ventana Medical Systems, Inc. | Method and system for creating an image mask |
| US7440101B2 (en) * | 2004-01-23 | 2008-10-21 | Beckman Coulter, Inc. | System and method for multiple laser triggering |
| JP4271054B2 (ja) * | 2004-02-12 | 2009-06-03 | オリンパス株式会社 | 細胞画像解析装置 |
| US20050273271A1 (en) * | 2004-04-05 | 2005-12-08 | Aibing Rao | Method of characterizing cell shape |
| EP1756750A4 (fr) | 2004-05-27 | 2010-10-20 | Aperio Technologies Inc | Systemes et procedes destines a creer et a visualiser des diapositives virtuelles tridimensionnelles |
| US7653260B2 (en) * | 2004-06-17 | 2010-01-26 | Carl Zeis MicroImaging GmbH | System and method of registering field of view |
| US8582924B2 (en) * | 2004-06-30 | 2013-11-12 | Carl Zeiss Microimaging Gmbh | Data structure of an image storage and retrieval system |
| US7323318B2 (en) * | 2004-07-15 | 2008-01-29 | Cytokinetics, Inc. | Assay for distinguishing live and dead cells |
| US20070031818A1 (en) * | 2004-07-15 | 2007-02-08 | Cytokinetics, Inc., A Delaware Corporation | Assay for distinguishing live and dead cells |
| US7612769B2 (en) * | 2004-09-14 | 2009-11-03 | E.I. Du Pont De Nemours And Company | Computer-implemented methods for organizing image data produced by resonant Mie scattering of light from microparticles and resulting data structures |
| CA2580961A1 (fr) * | 2004-09-22 | 2006-04-06 | Ikonisys, Inc. | Procede de detection et de quantification de multiples composants subcellulaires |
| EP1863908B1 (fr) * | 2005-04-01 | 2010-11-17 | Qiagen GmbH | Transcription inverse et amplification d'arn avec degradation simultanee d'adn |
| US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
| US8164622B2 (en) | 2005-07-01 | 2012-04-24 | Aperio Technologies, Inc. | System and method for single optical axis multi-detector microscope slide scanner |
| US8921102B2 (en) | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US20070031043A1 (en) * | 2005-08-02 | 2007-02-08 | Perz Cynthia B | System for and method of intelligently directed segmentation analysis for automated microscope systems |
| EP1762627A1 (fr) | 2005-09-09 | 2007-03-14 | Qiagen GmbH | Procédé pour l'activation d'acides nucléiques pour effectuer une réaction d'une polymérase |
| WO2007080583A2 (fr) * | 2006-01-10 | 2007-07-19 | Applied Spectral Imaging Ltd. | Procédés et systèmes pour analyser des échantillons biologiques |
| DE102006020885A1 (de) * | 2006-05-05 | 2007-11-08 | Qiagen Gmbh | Einführung von Sequenzelementen in Nukleinsäuren |
| EP2034349B2 (fr) | 2006-06-08 | 2023-07-19 | Nikon Corporation | Appareil d'observation et procédé d'observation |
| JP4678601B2 (ja) * | 2006-08-15 | 2011-04-27 | 横河電機株式会社 | 創薬スクリーニング装置 |
| NZ578077A (en) * | 2007-02-12 | 2012-04-27 | Stefan Hansson | Diagnosis of preeclampsia using free foetal haemoglobin |
| ES2374686T3 (es) | 2007-05-14 | 2012-02-21 | Historx, Inc. | Separación en compartimentos por caracterización de píxel usando agrupamiento de datos de imágenes. |
| CA2690633C (fr) * | 2007-06-15 | 2015-08-04 | Historx, Inc. | Procede et systeme pour normaliser des instruments de microscope |
| CA2604317C (fr) | 2007-08-06 | 2017-02-28 | Historx, Inc. | Methodes et systeme permettant de valider des echantillons d'images pour dosages immunologiques quantitatifs |
| CA2596204C (fr) * | 2007-08-07 | 2019-02-26 | Historx, Inc. | Procede et systeme de determination de la dilution optimale d'un reactif |
| US7936913B2 (en) * | 2007-08-07 | 2011-05-03 | Nextslide Imaging Llc | Network image review in clinical hematology |
| WO2009029810A1 (fr) * | 2007-08-31 | 2009-03-05 | Historx, Inc. | Sélection de temps d'exposition automatique pour un tissu d'imagerie |
| DE102007062067A1 (de) * | 2007-12-21 | 2009-07-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Optisches Verfahren und Vorrichtung zur Klassifizierung von Partikeln |
| US8346574B2 (en) | 2008-02-29 | 2013-01-01 | Dako Denmark A/S | Systems and methods for tracking and providing workflow information |
| US8081303B2 (en) * | 2008-03-21 | 2011-12-20 | Abbott Point Of Care, Inc. | Method and apparatus for analyzing individual cells or particulates using fluorescent quenching and/or bleaching |
| WO2009124997A1 (fr) | 2008-04-11 | 2009-10-15 | Universität Leipzig | Procédé et kit pour l’évaluation ex vivo de la réponse d’une tumeur à des conditions à évaluer |
| JP5407015B2 (ja) | 2008-07-10 | 2014-02-05 | 国立大学法人徳島大学 | 画像処理装置、画像処理方法、コンピュータ実行可能な画像処理プログラム、及び顕微鏡システム |
| US20100159506A1 (en) * | 2008-07-25 | 2010-06-24 | Cellscape Corporation | Methods and systems for genetic analysis of fetal nucleated red blood cells |
| CA2737116C (fr) * | 2008-09-16 | 2019-01-15 | Historx, Inc. | Quantification reproductible de l'expression de biomarqueurs |
| WO2010048584A2 (fr) | 2008-10-24 | 2010-04-29 | Aperio Technologies, Inc. | Scanner à fluorescence de coupe entière |
| JP4997255B2 (ja) * | 2009-01-05 | 2012-08-08 | オリンパス株式会社 | 細胞画像解析装置 |
| FR2942899B1 (fr) * | 2009-03-03 | 2011-09-23 | Jose Balbuena | Dispositif et procede d'analyse optique de documents |
| US8187979B2 (en) * | 2009-12-23 | 2012-05-29 | Varian Semiconductor Equipment Associates, Inc. | Workpiece patterning with plasma sheath modulation |
| JP5846609B2 (ja) | 2010-01-21 | 2016-01-20 | バイオセップ リミテッド | 希少細胞の磁気分離 |
| US8774488B2 (en) | 2010-03-11 | 2014-07-08 | Cellscape Corporation | Method and device for identification of nucleated red blood cells from a maternal blood sample |
| JP5495934B2 (ja) * | 2010-05-18 | 2014-05-21 | キヤノン株式会社 | 画像処理装置、その処理方法及びプログラム |
| CN105445170B (zh) * | 2010-08-05 | 2018-06-05 | 艾博特健康公司 | 识别生物样品目标组分的方法和分析生物流体样品的装置 |
| JP5668436B2 (ja) * | 2010-12-01 | 2015-02-12 | ソニー株式会社 | 検体領域検出方法、検体領域検出装置及び検体領域検出プログラム |
| CN104094099B (zh) | 2011-04-15 | 2017-05-03 | 罗氏血液诊断股份有限公司 | 测量细胞体积和成份 |
| JP5413408B2 (ja) * | 2011-06-09 | 2014-02-12 | 富士ゼロックス株式会社 | 画像処理装置、プログラム及び画像処理システム |
| JP6014590B2 (ja) * | 2011-06-27 | 2016-10-25 | シスメックス株式会社 | 細胞分析装置および細胞分析方法 |
| CN104246479B (zh) * | 2012-04-18 | 2016-10-19 | 奥林巴斯株式会社 | 利用光分析的单个粒子检测装置、单个粒子检测方法以及单个粒子检测用计算机程序 |
| US9690976B2 (en) | 2013-03-11 | 2017-06-27 | Roche Diagnostics Hematology, Inc. | Imaging blood cells |
| JP6128998B2 (ja) * | 2013-07-09 | 2017-05-17 | 富士フイルム株式会社 | 遺伝毒性又は骨髄毒性評価方法及び遺伝毒性又は骨髄毒性評価キット |
| WO2015013605A1 (fr) * | 2013-07-26 | 2015-01-29 | Abbott Point Of Care, Inc. | Procédé et appareil de production d'une image d'un échantillon de sang total non dilué coloré avec un colorant de wright |
| EP3178942A4 (fr) * | 2014-08-05 | 2017-08-23 | Fujifilm Corporation | Procédé de test des chromosomes f taux |
| WO2016138064A1 (fr) * | 2015-02-24 | 2016-09-01 | Nanoscopia (Cayman), Inc. | Champ sombre hors-axe et éclairage par fluorescence |
| DE102016109945A1 (de) * | 2015-11-05 | 2017-05-11 | Leica Microsystems Cms Gmbh | Mikroskop für die Durchlicht- und Fluoreszenzmikroskopie |
| US10255511B2 (en) * | 2016-01-04 | 2019-04-09 | Texas Instruments Incorporated | Real time traffic sign recognition |
| US10324041B2 (en) | 2016-12-21 | 2019-06-18 | Abbott Japan Co., Ltd. | Optical imaging system using lateral illumination for digital assays |
| US11047854B2 (en) | 2017-02-06 | 2021-06-29 | Abbott Japan Llc | Methods for reducing noise in signal-generating digital assays |
| DE102017107348B4 (de) | 2017-04-05 | 2019-03-14 | Olympus Soft Imaging Solutions Gmbh | Verfahren zur zytometrischen Analyse von Zellproben |
| CN110914674B (zh) * | 2017-04-28 | 2023-02-24 | 迈克维斯公司 | 用于量化活生物体的方法和器件以及器件的使用 |
| WO2020006129A1 (fr) | 2018-06-28 | 2020-01-02 | The Regents Of The University Of California | Production d'une image composite d'un échantillon de tissu coloré par combinaison de données d'image |
| WO2020039520A1 (fr) * | 2018-08-22 | 2020-02-27 | オリンパス株式会社 | Dispositif de traitement d'image, système d'image, procédé et programme d'exploitation de dispositif de traitement d'image |
| EP3644044B1 (fr) | 2018-10-24 | 2020-12-23 | Leica Biosystems Imaging, Inc. | Commande d'exposition de caméra lors de l'acquisition des images d'hybridation in situ en fluorescence |
| EP3948221A4 (fr) * | 2019-03-27 | 2022-12-21 | Becton, Dickinson and Company | Systèmes de tri de cellules basés sur des images codées en fréquence et leurs procédés d'utilisation |
| US11808703B2 (en) * | 2019-10-03 | 2023-11-07 | The Regents Of The University Of California | Fluorescence imitating brightfield imaging |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4125828A (en) * | 1972-08-04 | 1978-11-14 | Med-El Inc. | Method and apparatus for automated classification and analysis of cells |
| US3999047A (en) * | 1972-09-05 | 1976-12-21 | Green James E | Method and apparatus utilizing color algebra for analyzing scene regions |
| US5093866A (en) | 1990-02-09 | 1992-03-03 | Hamilton Equine Associates Limited | Fluorescence and motility characterization system for cells, bacteria, and particles in fluids |
| US5162990A (en) | 1990-06-15 | 1992-11-10 | The United States Of America As Represented By The United States Navy | System and method for quantifying macrophage phagocytosis by computer image analysis |
| US5629147A (en) * | 1992-07-17 | 1997-05-13 | Aprogenex, Inc. | Enriching and identifying fetal cells in maternal blood for in situ hybridization |
| GB9215710D0 (en) | 1992-07-23 | 1992-09-09 | Inst Of Cancer The Research | Analysis of cells |
| US5294799A (en) | 1993-02-01 | 1994-03-15 | Aslund Nils R D | Apparatus for quantitative imaging of multiple fluorophores |
| US5432054A (en) | 1994-01-31 | 1995-07-11 | Applied Imaging | Method for separating rare cells from a population of cells |
| US5662813A (en) * | 1994-10-21 | 1997-09-02 | Bioseparations, Inc. | Method for separation of nucleated fetal erythrocytes from maternal blood samples |
| US5863504A (en) | 1995-03-16 | 1999-01-26 | Bio-Rad Laboratories, Inc. | Fluorescence imaging instrument utilizing fish |
| US5642433A (en) | 1995-07-31 | 1997-06-24 | Neopath, Inc. | Method and apparatus for image contrast quality evaluation |
| US5764792A (en) | 1996-01-19 | 1998-06-09 | Oncor, Inc. | Method and apparatus for processing images |
| US5989835A (en) * | 1997-02-27 | 1999-11-23 | Cellomics, Inc. | System for cell-based screening |
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1998
- 1998-05-04 US US09/072,502 patent/US6169816B1/en not_active Expired - Lifetime
- 1998-05-12 IL IL13274798A patent/IL132747A/en not_active IP Right Cessation
- 1998-05-12 DE DE69832167T patent/DE69832167T2/de not_active Expired - Lifetime
- 1998-05-12 WO PCT/US1998/009689 patent/WO1998052018A1/fr active IP Right Grant
- 1998-05-12 AU AU74828/98A patent/AU739834B2/en not_active Expired
- 1998-05-12 JP JP54945198A patent/JP2002514304A/ja active Pending
- 1998-05-12 AT AT98922230T patent/ATE308747T1/de not_active IP Right Cessation
- 1998-05-12 EP EP98922230A patent/EP0981732B1/fr not_active Expired - Lifetime
- 1998-05-12 CA CA002289930A patent/CA2289930C/fr not_active Expired - Lifetime
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1999
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Also Published As
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|---|---|
| DE69832167T2 (de) | 2006-07-20 |
| HK1029170A1 (en) | 2001-03-23 |
| DE69832167D1 (de) | 2005-12-08 |
| IL132747A0 (en) | 2001-03-19 |
| ATE308747T1 (de) | 2005-11-15 |
| CA2289930A1 (fr) | 1998-11-19 |
| JP2002514304A (ja) | 2002-05-14 |
| WO1998052018A1 (fr) | 1998-11-19 |
| AU7482898A (en) | 1998-12-08 |
| EP0981732B1 (fr) | 2005-11-02 |
| EP0981732A1 (fr) | 2000-03-01 |
| CA2289930C (fr) | 2007-08-07 |
| NO995542D0 (no) | 1999-11-12 |
| NO995542L (no) | 2000-01-14 |
| AU739834B2 (en) | 2001-10-18 |
| US6169816B1 (en) | 2001-01-02 |
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