IL132176A0 - Method for oral delivery of proteins - Google Patents

Method for oral delivery of proteins

Info

Publication number
IL132176A0
IL132176A0 IL13217698A IL13217698A IL132176A0 IL 132176 A0 IL132176 A0 IL 132176A0 IL 13217698 A IL13217698 A IL 13217698A IL 13217698 A IL13217698 A IL 13217698A IL 132176 A0 IL132176 A0 IL 132176A0
Authority
IL
Israel
Prior art keywords
proteins
oral delivery
oral
delivery
Prior art date
Application number
IL13217698A
Other languages
English (en)
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of IL132176A0 publication Critical patent/IL132176A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
IL13217698A 1997-04-02 1998-04-02 Method for oral delivery of proteins IL132176A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4228097P 1997-04-02 1997-04-02
US6136797P 1997-10-08 1997-10-08
PCT/US1998/006563 WO1998043615A1 (en) 1997-04-02 1998-04-02 Method for oral delivery of proteins

Publications (1)

Publication Number Publication Date
IL132176A0 true IL132176A0 (en) 2001-03-19

Family

ID=26719055

Family Applications (1)

Application Number Title Priority Date Filing Date
IL13217698A IL132176A0 (en) 1997-04-02 1998-04-02 Method for oral delivery of proteins

Country Status (14)

Country Link
EP (1) EP0975328A1 (sh)
JP (1) JP2002512607A (sh)
KR (1) KR20010005952A (sh)
CN (1) CN1259045A (sh)
AU (1) AU727053B2 (sh)
BR (1) BR9808466A (sh)
CA (1) CA2285457A1 (sh)
IL (1) IL132176A0 (sh)
NO (1) NO994757L (sh)
NZ (1) NZ500075A (sh)
PL (1) PL335974A1 (sh)
TR (1) TR199903240T2 (sh)
WO (1) WO1998043615A1 (sh)
YU (1) YU49699A (sh)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
DE10040592A1 (de) * 2000-08-15 2002-03-07 Aventis Res & Tech Gmbh & Co Formulierung zur verbesserten Aufnahme von Wirkstoffen und deren Verwendung
US6878384B2 (en) 2001-03-13 2005-04-12 Microvention, Inc. Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use
ES2300568T3 (es) 2002-03-20 2008-06-16 Mannkind Corporation Aparato de inhalacion.
CA2575692C (en) 2004-08-20 2014-10-14 Mannkind Corporation Catalysis of diketopiperazine synthesis
BR122019022692B1 (pt) 2004-08-23 2023-01-10 Mannkind Corporation Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo
US8110212B2 (en) 2005-04-07 2012-02-07 Drexel University Bioactive thermogelling polymer systems and methods of their use
PL1916995T5 (pl) 2005-07-29 2022-10-31 Stichting Groningen Centre For Drug Research Kontrolowany wartością ph impulsowy układ podawczy, sposoby przygotowania i zastosowanie
DK1915171T3 (da) * 2005-08-01 2013-12-09 Mannkind Corp Fremgangsmåde til bevarelse af funktionen af insulin-producerende celler
HUE028691T2 (en) 2005-09-14 2016-12-28 Mannkind Corp A method for formulating a drug based on increasing the affinity of crystalline microparticle surfaces towards active ingredients
EP1986679B1 (en) 2006-02-22 2017-10-25 MannKind Corporation A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
CN101500623B (zh) 2006-06-15 2016-08-24 微温森公司 一种由可膨胀聚合物构成的栓塞器械
CA2709379C (en) 2007-12-21 2016-08-16 Microvention, Inc. Hydrogel filaments for biomedical uses
AR072114A1 (es) 2008-06-13 2010-08-04 Mannkind Corp Un inhalador de polvo seco y sistema para suministro de farmacos
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
BRPI0914308B8 (pt) 2008-06-20 2021-06-22 Mannkind Corp sistema de inalação
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
CA2754595C (en) 2009-03-11 2017-06-27 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
KR101875969B1 (ko) 2009-06-12 2018-07-06 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
HUP0900482A2 (en) 2009-08-03 2011-03-28 Cera Med Kft Pharmaceutical formulation for oral administration
US9114200B2 (en) 2009-09-24 2015-08-25 Microvention, Inc. Injectable hydrogel filaments for biomedical uses
CA2777171C (en) 2009-10-26 2017-09-19 Microvention, Inc. Embolization device constructed from expansile polymer
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
RU2571331C1 (ru) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
JP6133270B2 (ja) 2011-04-01 2017-05-24 マンカインド コーポレイション 薬剤カートリッジのためのブリスター包装
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
JP6018640B2 (ja) 2011-10-24 2016-11-02 マンカインド コーポレイション 疼痛を緩和するのに有効な鎮痛組成物並びに当該組成物を含む乾燥粉末及び乾燥粉末薬剤輸送システム
US9011884B2 (en) 2012-04-18 2015-04-21 Microvention, Inc. Embolic devices
SG11201500218VA (en) 2012-07-12 2015-03-30 Mannkind Corp Dry powder drug delivery systems and methods
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
WO2014144895A1 (en) 2013-03-15 2014-09-18 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
AU2014290438B2 (en) 2013-07-18 2019-11-07 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
WO2015021044A1 (en) * 2013-08-05 2015-02-12 University Of Rochester Compositions and methods for stimuli-responsive release of a therapeutic agent
WO2015021064A1 (en) 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
WO2015153996A1 (en) 2014-04-03 2015-10-08 Micro Vention, Inc. Embolic devices
US10092663B2 (en) 2014-04-29 2018-10-09 Terumo Corporation Polymers
US10226533B2 (en) 2014-04-29 2019-03-12 Microvention, Inc. Polymer filaments including pharmaceutical agents and delivering same
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10265405B2 (en) 2014-11-18 2019-04-23 Board Of Regents, The University Of Texas System Polymers for delivery of factor VIII and/or factor IX
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2976576A (en) * 1956-04-24 1961-03-28 Wichterle Otto Process for producing shaped articles from three-dimensional hydrophilic high polymers
US3220960A (en) * 1960-12-21 1965-11-30 Wichterle Otto Cross-linked hydrophilic polymers and articles made therefrom
DE1617393C2 (de) * 1966-01-06 1982-11-11 Československá akademie věd, Praha Verfahren zur Herstellung von biologisch aktive Stoffe enthaltenden hydrophilen vernetzten Copolymeren
US3607848A (en) * 1967-08-07 1971-09-21 Ceskoslovenska Akademie Ved Method for preparing insoluble,cross-linked organic hydrogels comprising copolymers of glycol monoesters with diesters
US3885078A (en) * 1968-03-06 1975-05-20 Ceskoslovenska Akademie Ved Hydrogel laminates and method of manufacturing thereof
US4071508A (en) * 1975-02-11 1978-01-31 Plastomedical Sciences, Inc. Anionic hydrogels based on hydroxyalkyl acrylates and methacrylates
FR2601026B1 (fr) * 1986-04-15 1988-09-16 Rhone Poulenc Chimie Matiere seche hydratable en un gel aqueux contenant des particules de polymeres dispersees, procede pour sa preparation et son application en biologie

Also Published As

Publication number Publication date
CA2285457A1 (en) 1998-10-08
TR199903240T2 (xx) 2000-05-22
AU727053B2 (en) 2000-11-30
EP0975328A1 (en) 2000-02-02
PL335974A1 (en) 2000-06-05
NO994757L (no) 1999-11-29
YU49699A (sh) 2002-12-10
AU6880998A (en) 1998-10-22
BR9808466A (pt) 2001-08-07
KR20010005952A (ko) 2001-01-15
JP2002512607A (ja) 2002-04-23
CN1259045A (zh) 2000-07-05
NZ500075A (en) 2001-03-30
NO994757D0 (no) 1999-09-30
WO1998043615A1 (en) 1998-10-08

Similar Documents

Publication Publication Date Title
IL132176A0 (en) Method for oral delivery of proteins
IL113456A0 (en) Modified amino acids for oral drug delivery
AUPO066096A0 (en) Oral delivery of peptides
HUP9701554D0 (en) Pharmaceutical composition containing plazma proteins
IL134633A0 (en) Process for preparing glufosinate and intermediates therefor
IL134699A0 (en) Protein composition and process for isolating a protein composition from a muscle source
AU5705398A (en) Method for automatic dosing of drugs
EP0725145A4 (en) PROTEIN MODIFICATION PROCESS
NZ324642A (en) Composition for delivery of nucleic acids
GB9710800D0 (en) Pharmaceutical composition and method of preparing it
HUP0105460A3 (en) Hemiasterlin analogs and process for preparation thereof
EP0950663A4 (en) USEFUL PROTEIN STABILIZATION AND USEFUL PROTEIN COMPOSITIONS
PL341559A1 (en) Method of obtaining polyamides
ZA983065B (en) Inhibitors of protein farnesyltranferase
GB9719161D0 (en) New therapeutic method
ZA981885B (en) Method for the preparation of alpha-bromo-lactam derivatives
AU1328599A (en) Apparatus for placement of dental fillings
HK1022695A1 (en) Method for debenzylation of dibenzylbiotin
EP0976380A4 (en) METHOD FOR RECALCIFYING THE TEETH
IL136878A0 (en) Method for inhaling powdery substances
EP0987942A4 (en) PHARMACEUTICAL COMPOSITION AND METHOD OF USE
GB9724786D0 (en) Oral delivery system
AP9700964A0 (en) Phenyl peptides method for preparing same and pharmaceutical compositions containing said peptides
GB9704499D0 (en) Method of manufacture
GB9720059D0 (en) Method of bonding