IL131171A0 - Factor x deletion mutants and analogues thereof and preparations containing the same - Google Patents

Factor x deletion mutants and analogues thereof and preparations containing the same

Info

Publication number
IL131171A0
IL131171A0 IL13117198A IL13117198A IL131171A0 IL 131171 A0 IL131171 A0 IL 131171A0 IL 13117198 A IL13117198 A IL 13117198A IL 13117198 A IL13117198 A IL 13117198A IL 131171 A0 IL131171 A0 IL 131171A0
Authority
IL
Israel
Prior art keywords
analogues
factor
same
preparations containing
deletion mutants
Prior art date
Application number
IL13117198A
Other languages
English (en)
Original Assignee
Baxter Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Ag filed Critical Baxter Ag
Publication of IL131171A0 publication Critical patent/IL131171A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
IL13117198A 1997-02-27 1998-02-27 Factor x deletion mutants and analogues thereof and preparations containing the same IL131171A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0033697A AT405517B (de) 1997-02-27 1997-02-27 Faktor x-deletionsmutanten und analoge davon
PCT/AT1998/000046 WO1998038318A1 (de) 1997-02-27 1998-02-27 Faktor x-deletionsmutanten und analoge davon

Publications (1)

Publication Number Publication Date
IL131171A0 true IL131171A0 (en) 2001-01-28

Family

ID=3487892

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13117198A IL131171A0 (en) 1997-02-27 1998-02-27 Factor x deletion mutants and analogues thereof and preparations containing the same
IL131171A IL131171A (en) 1997-02-27 1999-07-29 Factor x deletion mutants and analogues thereof and preparations containing the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL131171A IL131171A (en) 1997-02-27 1999-07-29 Factor x deletion mutants and analogues thereof and preparations containing the same

Country Status (17)

Country Link
US (2) US6562598B1 (pl)
EP (1) EP1012303B1 (pl)
JP (1) JP4108761B2 (pl)
AR (1) AR010119A1 (pl)
AT (2) AT405517B (pl)
AU (1) AU732953B2 (pl)
BR (1) BR9807618A (pl)
CA (1) CA2282728A1 (pl)
CZ (1) CZ298296B6 (pl)
DE (1) DE59813745D1 (pl)
ES (1) ES2273405T3 (pl)
HU (1) HU225247B1 (pl)
IL (2) IL131171A0 (pl)
NO (1) NO328022B1 (pl)
PL (1) PL191778B1 (pl)
SK (1) SK282369B6 (pl)
WO (1) WO1998038318A1 (pl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT405517B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
GB9826747D0 (en) * 1998-12-05 1999-01-27 Zeneca Ltd Chemical compounds
AT410216B (de) 1999-08-10 2003-03-25 Baxter Ag Faktor x-analogon mit verbesserter aktivierbarkeit
WO2001070763A1 (en) * 2000-03-22 2001-09-27 The Children's Hospital Of Philadelphia Modified blood clotting factors and methods of use
AU2004238843B2 (en) * 2003-05-09 2009-04-23 Research Development Foundation Insertion of furin protease cleavage sites in membrane proteins and uses thereof
EP1728798A1 (en) * 2005-06-01 2006-12-06 ZLB Behring GmbH Coagulation factor X polypeptides with modified activation properties
MX336958B (es) 2005-11-15 2016-02-05 Philadelphia Children Hospital Metodos y composiciones para modular la hemostasia.
GB2433592A (en) 2005-12-23 2007-06-27 Pentapharm Ag Assay for thrombin inhibitors
EP1820508A1 (en) * 2006-02-21 2007-08-22 CSL Behring GmbH Coagulation factor X polypeptides with modified activation properties
US20080050776A1 (en) * 2006-05-26 2008-02-28 Kenneth Neet Stable mutated pro nerve growth factors
BRPI0816837B1 (pt) 2007-09-28 2022-10-18 Portola Pharmaceuticals, Inc Composições farmacêuticas, polipeptídeo isolado de duas cadeias e uso de uma composição farmacêutica
KR101649770B1 (ko) 2008-11-14 2016-08-19 포톨라 파마슈티컬스, 인코포레이티드 인자 ｘａ 저해제에 대한 해독제 및 혈액 응고제와 조합된 그의 사용 방법
EP2414517B1 (en) 2009-03-30 2016-09-21 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same
US9056106B2 (en) 2009-07-15 2015-06-16 Portola Pharmaceuticals, Inc. Unit dose formulation of antidotes for factor Xa inhibitors and methods of using the same
US9371522B2 (en) 2011-09-30 2016-06-21 The Children's Hospital Of Philadelphia Compositions and methods for modulating hemostasis
KR20140131957A (ko) * 2012-02-14 2014-11-14 포톨라 파마슈티컬스, 인코포레이티드 Xa 인자 억제제에 대한 재조합 해독제를 제조하는 방법
JP6363600B2 (ja) 2012-07-25 2018-07-25 カタリスト・バイオサイエンシーズ・インコーポレイテッドＣａｔａｌｙｓｔ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． 修飾第ｘ因子ポリペプチドおよびその使用
CN104994868A (zh) 2013-01-31 2015-10-21 辉瑞公司 用于抵消因子Xa抑制的组合物和方法
AU2014326257B2 (en) 2013-09-24 2017-08-10 Pfizer Inc. Compositions comprising heterogeneous populations of recombinant human clotting factor Xa proteins
WO2016028872A2 (en) 2014-08-19 2016-02-25 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor ix function
AU2018366110A1 (en) 2017-11-07 2020-06-04 Rani Therapeutics, Llc Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT366916B (de) 1980-04-02 1982-05-25 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
US4501731A (en) 1983-06-27 1985-02-26 Tishkoff Garson H Treatment of disparate bleeding disorders with factor X zymogen
AT382783B (de) 1985-06-20 1987-04-10 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
US5028424A (en) 1987-10-16 1991-07-02 University Of Georgia Research Foundation Antibodies to receptor and antigen for natural killer and non-specific cytotoxic cells
US5597799A (en) * 1990-09-04 1997-01-28 Cor Therapeutics, Inc. Recombinant agents affecting thrombosis
EP0574402B2 (en) 1990-11-26 2012-08-01 Genetics Institute, LLC Expression of pace in host cells and methods of use thereof
US5621039A (en) 1993-06-08 1997-04-15 Hallahan; Terrence W. Factor IX- polymeric conjugates
DE4325872C1 (de) 1993-08-02 1994-08-04 Immuno Ag Virusinaktivierte Faktor Xa-Präparation
AT401270B (de) 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
AT404838B (de) 1995-11-24 1999-03-25 Immuno Ag Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
AT405517B (de) 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon
AT405516B (de) 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
US6582598B2 (en) * 2000-12-14 2003-06-24 Hubert Patrovsky Wave filter for rotary filter

Also Published As

Publication number Publication date
AU6080898A (en) 1998-09-18
HUP0000826A3 (en) 2002-01-28
AU732953B2 (en) 2001-05-03
ATA33697A (de) 1999-01-15
JP4108761B2 (ja) 2008-06-25
BR9807618A (pt) 2000-02-15
PL335379A1 (en) 2000-04-25
WO1998038318A1 (de) 1998-09-03
NO994136L (no) 1999-10-27
IL131171A (en) 2007-05-15
CA2282728A1 (en) 1998-09-03
AT405517B (de) 1999-09-27
PL191778B1 (pl) 2006-07-31
SK117099A3 (en) 2000-05-16
AR010119A1 (es) 2000-05-17
SK282369B6 (sk) 2002-01-07
US20030138914A1 (en) 2003-07-24
EP1012303A1 (de) 2000-06-28
EP1012303B1 (de) 2006-09-27
HU225247B1 (en) 2006-08-28
ATE340862T1 (de) 2006-10-15
NO994136D0 (no) 1999-08-26
ES2273405T3 (es) 2007-05-01
NO328022B1 (no) 2009-11-09
DE59813745D1 (de) 2006-11-09
US6562598B1 (en) 2003-05-13
US6905846B2 (en) 2005-06-14
CZ298296B6 (cs) 2007-08-22
JP2001513632A (ja) 2001-09-04
HUP0000826A1 (en) 2000-07-28
CZ303199A3 (cs) 2000-01-12

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Legal Events

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KB20 Patent renewed for 20 years