GB2309224B - Tamoxifen and analogues thereof - Google Patents

Tamoxifen and analogues thereof

Info

Publication number
GB2309224B
GB2309224B GB9618775A GB9618775A GB2309224B GB 2309224 B GB2309224 B GB 2309224B GB 9618775 A GB9618775 A GB 9618775A GB 9618775 A GB9618775 A GB 9618775A GB 2309224 B GB2309224 B GB 2309224B
Authority
GB
United Kingdom
Prior art keywords
tamoxifen
analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9618775A
Other versions
GB9618775D0 (en
GB2309224A (en
Inventor
John Double
Derek Maitland
Ioana Popa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Bradford
Original Assignee
University of Bradford
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Bradford filed Critical University of Bradford
Publication of GB9618775D0 publication Critical patent/GB9618775D0/en
Priority to EP97900379A priority Critical patent/EP0883587A1/en
Priority to JP9525793A priority patent/JP2000503315A/en
Priority to PCT/GB1997/000134 priority patent/WO1997026234A1/en
Priority to AU13953/97A priority patent/AU725286B2/en
Priority to CA002243330A priority patent/CA2243330A1/en
Priority to HU9900951A priority patent/HUP9900951A3/en
Publication of GB2309224A publication Critical patent/GB2309224A/en
Priority to NO19983346A priority patent/NO311346B1/en
Priority to US09/118,836 priority patent/US6172263B1/en
Application granted granted Critical
Publication of GB2309224B publication Critical patent/GB2309224B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/20—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB9618775A 1996-01-20 1996-09-09 Tamoxifen and analogues thereof Expired - Fee Related GB2309224B (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA002243330A CA2243330A1 (en) 1996-01-20 1997-01-20 Tamoxifen and analogues thereof
JP9525793A JP2000503315A (en) 1996-01-20 1997-01-20 Tamoxifen and its congeners
PCT/GB1997/000134 WO1997026234A1 (en) 1996-01-20 1997-01-20 Tamoxifen and analogues thereof
AU13953/97A AU725286B2 (en) 1996-01-20 1997-01-20 Tamoxifen and analogues thereof
EP97900379A EP0883587A1 (en) 1996-01-20 1997-01-20 Tamoxifen and analogues thereof
HU9900951A HUP9900951A3 (en) 1996-01-20 1997-01-20 Process for producing tamoxifen and analogues thereof
NO19983346A NO311346B1 (en) 1996-01-20 1998-07-20 Tamoxifen and analogues thereof
US09/118,836 US6172263B1 (en) 1996-01-20 1998-07-20 Tamoxifen and analogues thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9601167.1A GB9601167D0 (en) 1996-01-20 1996-01-20 Tamoxifen and analogues thereof

Publications (3)

Publication Number Publication Date
GB9618775D0 GB9618775D0 (en) 1996-10-23
GB2309224A GB2309224A (en) 1997-07-23
GB2309224B true GB2309224B (en) 2000-06-28

Family

ID=10787311

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB9601167.1A Pending GB9601167D0 (en) 1996-01-20 1996-01-20 Tamoxifen and analogues thereof
GB9618775A Expired - Fee Related GB2309224B (en) 1996-01-20 1996-09-09 Tamoxifen and analogues thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GBGB9601167.1A Pending GB9601167D0 (en) 1996-01-20 1996-01-20 Tamoxifen and analogues thereof

Country Status (1)

Country Link
GB (2) GB9601167D0 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997026234A1 (en) 1996-01-20 1997-07-24 Bradford University Tamoxifen and analogues thereof
GB9715479D0 (en) * 1997-07-23 1997-10-01 Univ Bradford Tamoxifen and analogues thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127128A1 (en) * 1983-05-24 1984-12-05 Bristol-Myers Company Process for the conversion of the E isomer of 1,2-diphenyl-1-(4-(2-dimethylaminoethoxy)-phenyl)-1-butene to tamoxifen HCl
EP0287690A1 (en) * 1987-04-21 1988-10-26 HEUMANN PHARMA GMBH & CO Stable solvent adducts of Z-1-(p-beta-dimethylamino-ethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenylbut-1-ene
WO1995011879A1 (en) * 1993-10-25 1995-05-04 Taiho Pharmaceutical Co., Ltd. Process for producing acid-addition salt of z-isomer of triphenylethylene compound
WO1995018786A1 (en) * 1994-01-03 1995-07-13 Klinge Pharma Gmbh Method for the production of e-1-[4'-(2-dimethylaminoethoxy)-phenyl]-1-(3'-hydroxyphenyl)-2-phenyl-1-butene

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127128A1 (en) * 1983-05-24 1984-12-05 Bristol-Myers Company Process for the conversion of the E isomer of 1,2-diphenyl-1-(4-(2-dimethylaminoethoxy)-phenyl)-1-butene to tamoxifen HCl
EP0287690A1 (en) * 1987-04-21 1988-10-26 HEUMANN PHARMA GMBH & CO Stable solvent adducts of Z-1-(p-beta-dimethylamino-ethoxyphenyl)-1-(p-hydroxyphenyl)-2-phenylbut-1-ene
US4973755A (en) * 1987-04-21 1990-11-27 Heumann Pharma Gmbh & Co. Stable solvent adducts of Z-1-(p-β-dimethylaminoethoxy-phenyl)-1-(p-hydroxyphenyl)-2-phenyl-but-1-ene
WO1995011879A1 (en) * 1993-10-25 1995-05-04 Taiho Pharmaceutical Co., Ltd. Process for producing acid-addition salt of z-isomer of triphenylethylene compound
WO1995018786A1 (en) * 1994-01-03 1995-07-13 Klinge Pharma Gmbh Method for the production of e-1-[4'-(2-dimethylaminoethoxy)-phenyl]-1-(3'-hydroxyphenyl)-2-phenyl-1-butene

Also Published As

Publication number Publication date
GB9601167D0 (en) 1996-03-20
GB9618775D0 (en) 1996-10-23
GB2309224A (en) 1997-07-23

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20060909