IL130037A - Use of Sphingomilinas for the preparation of preparations for raising the levels of cormorants in the skin and tissue, mucus and dermatologists and cosmetics suitable for use on the skin containing the above - Google Patents
Use of Sphingomilinas for the preparation of preparations for raising the levels of cormorants in the skin and tissue, mucus and dermatologists and cosmetics suitable for use on the skin containing the aboveInfo
- Publication number
- IL130037A IL130037A IL13003797A IL13003797A IL130037A IL 130037 A IL130037 A IL 130037A IL 13003797 A IL13003797 A IL 13003797A IL 13003797 A IL13003797 A IL 13003797A IL 130037 A IL130037 A IL 130037A
- Authority
- IL
- Israel
- Prior art keywords
- lactobacillus
- bifidobacterium
- agents
- sphingomyelinase
- skin
- Prior art date
Links
- 229940106189 ceramide Drugs 0.000 title claims abstract description 40
- 239000000203 mixture Substances 0.000 title claims abstract description 35
- 108010061312 Sphingomyelin Phosphodiesterase Proteins 0.000 title claims abstract description 26
- 102000011971 Sphingomyelin Phosphodiesterase Human genes 0.000 title claims abstract description 23
- 239000002537 cosmetic Substances 0.000 title claims abstract description 16
- 150000001783 ceramides Chemical class 0.000 title claims abstract description 14
- 230000000699 topical effect Effects 0.000 title description 5
- 241000894006 Bacteria Species 0.000 claims abstract description 30
- 241000192125 Firmicutes Species 0.000 claims abstract description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 31
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims description 27
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims description 27
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims description 27
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims description 27
- 241000186000 Bifidobacterium Species 0.000 claims description 17
- 239000006071 cream Substances 0.000 claims description 17
- 241000186660 Lactobacillus Species 0.000 claims description 13
- 229940039696 lactobacillus Drugs 0.000 claims description 13
- 150000002632 lipids Chemical class 0.000 claims description 12
- -1 sphingomyelines Natural products 0.000 claims description 12
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 8
- 241000186840 Lactobacillus fermentum Species 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 6
- 241000186018 Bifidobacterium adolescentis Species 0.000 claims description 4
- 241000186020 Bifidobacterium dentium Species 0.000 claims description 4
- 241000186015 Bifidobacterium longum subsp. infantis Species 0.000 claims description 4
- 241001134772 Bifidobacterium pseudocatenulatum Species 0.000 claims description 4
- 208000001840 Dandruff Diseases 0.000 claims description 4
- 206010012438 Dermatitis atopic Diseases 0.000 claims description 4
- 241001430190 Eggerthia catenaformis Species 0.000 claims description 4
- 240000001046 Lactobacillus acidophilus Species 0.000 claims description 4
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims description 4
- 241000186679 Lactobacillus buchneri Species 0.000 claims description 4
- 244000199866 Lactobacillus casei Species 0.000 claims description 4
- 235000013958 Lactobacillus casei Nutrition 0.000 claims description 4
- 241000218492 Lactobacillus crispatus Species 0.000 claims description 4
- 241001561398 Lactobacillus jensenii Species 0.000 claims description 4
- 241001134654 Lactobacillus leichmannii Species 0.000 claims description 4
- 241001438705 Lactobacillus rogosae Species 0.000 claims description 4
- 241000194037 Lactococcus raffinolactis Species 0.000 claims description 4
- 201000008937 atopic dermatitis Diseases 0.000 claims description 4
- 229940004120 bifidobacterium infantis Drugs 0.000 claims description 4
- 235000012000 cholesterol Nutrition 0.000 claims description 4
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims description 4
- 229940017800 lactobacillus casei Drugs 0.000 claims description 4
- 239000000344 soap Substances 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 241000193815 Atopobium minutum Species 0.000 claims description 3
- 241000186014 Bifidobacterium angulatum Species 0.000 claims description 3
- 241000186016 Bifidobacterium bifidum Species 0.000 claims description 3
- 241000186011 Bifidobacterium catenulatum Species 0.000 claims description 3
- 241001134659 Lactobacillus curvatus Species 0.000 claims description 3
- 241000186673 Lactobacillus delbrueckii Species 0.000 claims description 3
- 240000006024 Lactobacillus plantarum Species 0.000 claims description 3
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims description 3
- 241000194020 Streptococcus thermophilus Species 0.000 claims description 3
- 229940002008 bifidobacterium bifidum Drugs 0.000 claims description 3
- 229940012969 lactobacillus fermentum Drugs 0.000 claims description 3
- 229940072205 lactobacillus plantarum Drugs 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 102100022548 Beta-hexosaminidase subunit alpha Human genes 0.000 claims description 2
- 241000186148 Bifidobacterium pseudolongum Species 0.000 claims description 2
- 206010007882 Cellulitis Diseases 0.000 claims description 2
- 102000004201 Ceramidases Human genes 0.000 claims description 2
- 108090000751 Ceramidases Proteins 0.000 claims description 2
- 201000004624 Dermatitis Diseases 0.000 claims description 2
- 206010048768 Dermatosis Diseases 0.000 claims description 2
- 239000004150 EU approved colour Substances 0.000 claims description 2
- 208000010201 Exanthema Diseases 0.000 claims description 2
- 208000024720 Fabry Disease Diseases 0.000 claims description 2
- 208000015872 Gaucher disease Diseases 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 241000194017 Streptococcus Species 0.000 claims description 2
- 208000022292 Tay-Sachs disease Diseases 0.000 claims description 2
- 206010048222 Xerosis Diseases 0.000 claims description 2
- 150000007513 acids Chemical class 0.000 claims description 2
- 230000002225 anti-radical effect Effects 0.000 claims description 2
- 230000001153 anti-wrinkle effect Effects 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 239000003212 astringent agent Substances 0.000 claims description 2
- 208000010668 atopic eczema Diseases 0.000 claims description 2
- 239000002585 base Substances 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 239000002781 deodorant agent Substances 0.000 claims description 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims description 2
- 239000003974 emollient agent Substances 0.000 claims description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims description 2
- 239000007920 enema Substances 0.000 claims description 2
- 201000005884 exanthem Diseases 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 238000009499 grossing Methods 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 239000002955 immunomodulating agent Substances 0.000 claims description 2
- 229940121354 immunomodulator Drugs 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 239000002502 liposome Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 239000002324 mouth wash Substances 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 claims description 2
- 239000011049 pearl Substances 0.000 claims description 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims description 2
- 239000000049 pigment Substances 0.000 claims description 2
- 230000000485 pigmenting effect Effects 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 239000003380 propellant Substances 0.000 claims description 2
- 230000001012 protector Effects 0.000 claims description 2
- 206010037844 rash Diseases 0.000 claims description 2
- 239000006254 rheological additive Substances 0.000 claims description 2
- 239000002453 shampoo Substances 0.000 claims description 2
- 208000017520 skin disease Diseases 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims description 2
- 239000003381 stabilizer Substances 0.000 claims description 2
- 239000003351 stiffener Substances 0.000 claims description 2
- 239000000021 stimulant Substances 0.000 claims description 2
- 230000000475 sunscreen effect Effects 0.000 claims description 2
- 239000000516 sunscreening agent Substances 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 235000015961 tonic Nutrition 0.000 claims description 2
- 230000001256 tonic effect Effects 0.000 claims description 2
- 229960000716 tonics Drugs 0.000 claims description 2
- 229940034610 toothpaste Drugs 0.000 claims description 2
- 239000000606 toothpaste Substances 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 208000031439 Striae Distensae Diseases 0.000 claims 1
- 239000007854 depigmenting agent Substances 0.000 claims 1
- 206010021198 ichthyosis Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 description 19
- 210000004027 cell Anatomy 0.000 description 11
- 230000000694 effects Effects 0.000 description 11
- 239000010410 layer Substances 0.000 description 10
- 210000002615 epidermis Anatomy 0.000 description 9
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
- 210000000245 forearm Anatomy 0.000 description 7
- 230000032683 aging Effects 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 5
- 108040005466 neutral sphingomyelin phosphodiesterase activity proteins Proteins 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 150000003408 sphingolipids Chemical class 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 101710124951 Phospholipase C Proteins 0.000 description 3
- 102100024550 Sphingomyelin phosphodiesterase 2 Human genes 0.000 description 3
- 101710166827 Sphingomyelinase Proteins 0.000 description 3
- 101710122751 Sphingomyelinase C Proteins 0.000 description 3
- 102000010126 acid sphingomyelin phosphodiesterase activity proteins Human genes 0.000 description 3
- 239000000556 agonist Substances 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 230000004069 differentiation Effects 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000007935 neutral effect Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 238000004809 thin layer chromatography Methods 0.000 description 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
- 241000186012 Bifidobacterium breve Species 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- DHCLVCXQIBBOPH-UHFFFAOYSA-N Glycerol 2-phosphate Chemical compound OCC(CO)OP(O)(O)=O DHCLVCXQIBBOPH-UHFFFAOYSA-N 0.000 description 2
- 239000007995 HEPES buffer Substances 0.000 description 2
- 208000010346 Sphingolipidoses Diseases 0.000 description 2
- 201000001307 Sphingolipidosis Diseases 0.000 description 2
- MIUIRGGKIICMBP-NFOZDHADSA-N [27-oxo-27-[[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]amino]heptacosyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC MIUIRGGKIICMBP-NFOZDHADSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 238000000376 autoradiography Methods 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 229940048864 ceramide 1 Drugs 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 239000003623 enhancer Substances 0.000 description 2
- 239000000469 ethanolic extract Substances 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 210000002510 keratinocyte Anatomy 0.000 description 2
- 229910001629 magnesium chloride Inorganic materials 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 238000000527 sonication Methods 0.000 description 2
- XZKIHKMTEMTJQX-UHFFFAOYSA-N 4-Nitrophenyl Phosphate Chemical compound OP(O)(=O)OC1=CC=C([N+]([O-])=O)C=C1 XZKIHKMTEMTJQX-UHFFFAOYSA-N 0.000 description 1
- 241001608472 Bifidobacterium longum Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000011107 Diacylglycerol Kinase Human genes 0.000 description 1
- 108010062677 Diacylglycerol Kinase Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 241000186869 Lactobacillus salivarius Species 0.000 description 1
- GDBQQVLCIARPGH-UHFFFAOYSA-N Leupeptin Natural products CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCN=C(N)N GDBQQVLCIARPGH-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- BBAFBDLICMHBNU-MFZOPHKMSA-N N-(2-hydroxyoctadecanoyl)-4-hydroxysphinganine Chemical compound CCCCCCCCCCCCCCCCC(O)C(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC BBAFBDLICMHBNU-MFZOPHKMSA-N 0.000 description 1
- BLTCBVOJNNKFKC-QUDYQQOWSA-N N-acetylsphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)NC(C)=O BLTCBVOJNNKFKC-QUDYQQOWSA-N 0.000 description 1
- YDNKGFDKKRUKPY-TURZORIXSA-N N-hexadecanoylsphingosine Chemical compound CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)\C=C\CCCCCCCCCCCCC YDNKGFDKKRUKPY-TURZORIXSA-N 0.000 description 1
- ZQQLMECVOXKFJK-NXCSZAMKSA-N N-octadecanoylsphingosine 1-phosphate Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@@H](COP(O)(O)=O)[C@H](O)\C=C\CCCCCCCCCCCCC ZQQLMECVOXKFJK-NXCSZAMKSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010048676 Sjogren-Larsson Syndrome Diseases 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 239000013504 Triton X-100 Substances 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102100040247 Tumor necrosis factor Human genes 0.000 description 1
- 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 description 1
- 108050002568 Tumor necrosis factor ligand superfamily member 6 Proteins 0.000 description 1
- 102000014384 Type C Phospholipases Human genes 0.000 description 1
- 108010079194 Type C Phospholipases Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940009291 bifidobacterium longum Drugs 0.000 description 1
- 239000011449 brick Substances 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229940099417 ceramide 2 Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 210000001047 desmosome Anatomy 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 210000000224 granular leucocyte Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 210000003093 intracellular space Anatomy 0.000 description 1
- 238000000021 kinase assay Methods 0.000 description 1
- 210000001821 langerhans cell Anatomy 0.000 description 1
- GDBQQVLCIARPGH-ULQDDVLXSA-N leupeptin Chemical compound CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCN=C(N)N GDBQQVLCIARPGH-ULQDDVLXSA-N 0.000 description 1
- 108010052968 leupeptin Proteins 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 230000009456 molecular mechanism Effects 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 229950000964 pepstatin Drugs 0.000 description 1
- 108010091212 pepstatin Proteins 0.000 description 1
- FAXGPCHRFPCXOO-LXTPJMTPSA-N pepstatin A Chemical compound OC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C FAXGPCHRFPCXOO-LXTPJMTPSA-N 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 description 1
- 229950004354 phosphorylcholine Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/04—Phosphoric diester hydrolases (3.1.4)
- C12Y301/04012—Sphingomyelin phosphodiesterase (3.1.4.12)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
- Y10S435/854—Lactobacillus acidophilus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
- Y10S435/855—Lactobacillus brevis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
- Y10S435/856—Lactobacillus casei
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/853—Lactobacillus
- Y10S435/857—Lactobacillus plantarum
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/885—Streptococcus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Birds (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Cosmetics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96RM000799A IT1296148B1 (it) | 1996-11-22 | 1996-11-22 | Uso di batteri lattici per accrescere il livello delle ceramidi della pelle e delle mucose, e composizioni dermatologiche e cosmetiche atte |
| PCT/IT1997/000278 WO1998022082A1 (en) | 1996-11-22 | 1997-11-14 | Sphingomyelinase compositions and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL130037A0 IL130037A0 (en) | 2000-02-29 |
| IL130037A true IL130037A (en) | 2004-06-01 |
Family
ID=11404547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13003797A IL130037A (en) | 1996-11-22 | 1997-11-14 | Use of Sphingomilinas for the preparation of preparations for raising the levels of cormorants in the skin and tissue, mucus and dermatologists and cosmetics suitable for use on the skin containing the above |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US6258355B1 (de) |
| EP (1) | EP0941056B1 (de) |
| JP (2) | JP4965008B2 (de) |
| KR (1) | KR100508407B1 (de) |
| CN (2) | CN1840183A (de) |
| AR (1) | AR009626A1 (de) |
| AT (1) | ATE218850T1 (de) |
| AU (1) | AU732203B2 (de) |
| BR (1) | BR9713287A (de) |
| CA (1) | CA2271762C (de) |
| DE (1) | DE69713379T2 (de) |
| DK (1) | DK0941056T3 (de) |
| EA (1) | EA001741B1 (de) |
| ES (1) | ES2176795T3 (de) |
| IL (1) | IL130037A (de) |
| IT (1) | IT1296148B1 (de) |
| MX (1) | MX216017B (de) |
| PT (1) | PT941056E (de) |
| WO (1) | WO1998022082A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1296148B1 (it) * | 1996-11-22 | 1999-06-09 | Renata Maria Anna Ve Cavaliere | Uso di batteri lattici per accrescere il livello delle ceramidi della pelle e delle mucose, e composizioni dermatologiche e cosmetiche atte |
| RO113114B1 (ro) * | 1997-08-05 | 1998-04-30 | Rodica Teodorescu | Produs eubiotic natural, pentru intretinerea si tratamentul tegumentelor |
| JP3618296B2 (ja) * | 1998-10-09 | 2005-02-09 | 株式会社ヤクルト本社 | 皮膚外用剤 |
| US8697051B2 (en) | 1999-06-09 | 2014-04-15 | Vsl Pharmaceuticals Inc. | Composition comprising alkaline sphingomyelinase for use as a dietetic preparation, food supplement or pharmaceutical product |
| IT1311495B1 (it) * | 1999-06-09 | 2002-03-13 | Mendes S U R L | Composizione comprendente sfingomielinasi alcalina, utilizzabile qualeprodotto dietetico, integratore alimentare o medicamento. |
| DE10037046A1 (de) * | 2000-07-29 | 2002-02-21 | Jean Krutmann | Verwendung von N-Oleoylethanolamin zur Behandlung der Schuppenflechte (Psoriasis) |
| EP1287815A1 (de) * | 2001-08-31 | 2003-03-05 | Cosmoferm B.V. | Verwendung einer Sphingoidbase zur Inhibierung von Ceramidase-Aktivität |
| US6869519B2 (en) * | 2001-09-27 | 2005-03-22 | National Institute Of Advanced Industrial Science And Technology | Electrolytic process for the production of metallic copper and apparatus therefor |
| US7585518B2 (en) * | 2002-11-19 | 2009-09-08 | Kimberly-Clark Worldwide, Inc. | Products and methods for maintaining or increasing ceramide levels in skin |
| US7037535B2 (en) * | 2002-11-19 | 2006-05-02 | Kimberly-Clark Worldwide, Inc. | Method and composition for neutralizing house dust mite feces |
| US20050019379A1 (en) * | 2003-07-22 | 2005-01-27 | Kimberly-Clark Worldwide, Inc. | Wipe and methods for improving skin health |
| US7510734B2 (en) * | 2004-03-04 | 2009-03-31 | E-L Management Corporation | Skin treatment method with Lactobacillus extract |
| US7374750B2 (en) * | 2004-05-14 | 2008-05-20 | Jennifer Albano | Probiotic containing anhydrous hair care composition |
| MXPA06015184A (es) * | 2004-06-23 | 2007-11-22 | Nestec Sa | Procedimiento y composiciones utiles para prevenir y/o tratar pieles sensibles y/o secas. |
| ITMI20041550A1 (it) * | 2004-07-29 | 2004-10-29 | Proge Farm Srl | Uso di batteri probiotici per la preparazione di composizioni topiche per la protezione dell'epidermide |
| US20060045894A1 (en) * | 2004-09-01 | 2006-03-02 | Vera Brown | Compound for neck skin firming |
| US20080124306A1 (en) * | 2006-11-28 | 2008-05-29 | Kiminobu Sugaya | Vigor Enhancement Via Administration of Pyrimidine Derivatives |
| KR20090085084A (ko) * | 2006-12-01 | 2009-08-06 | 오르가노발란스 게엠베하 | 병원성 미생물에 대해 피부를 보호하기 위한 조성물, 키트 및 용도 |
| JP2010047504A (ja) * | 2008-08-20 | 2010-03-04 | Nippon Meat Packers Inc | アトピー性皮膚炎緩和剤 |
| FR2937536B1 (fr) * | 2008-10-28 | 2016-07-01 | Oreal | Utilisation cosmetique d'un lysat de bifidobacterium species pour le traitement du cuir chevelu gras |
| US20100260695A1 (en) * | 2009-04-09 | 2010-10-14 | Mary Kay Inc. | Combination of plant extracts to improve skin tone |
| US8506952B2 (en) * | 2009-07-03 | 2013-08-13 | James Madison Innovations, Inc. | Probiotic compositions and process thereof |
| CN102648003B (zh) * | 2009-10-09 | 2016-01-13 | 儿童医疗中心有限公司 | 选择性裂解的全细胞疫苗 |
| AU2011262840B2 (en) * | 2010-06-08 | 2015-02-05 | Asahi Group Holdings, Ltd. | Lipid metabolism-improving agent |
| CN102626424A (zh) * | 2012-04-28 | 2012-08-08 | 王飞 | 一种活性抑菌胶囊 |
| CN104232537B (zh) * | 2014-09-03 | 2017-04-12 | 中国科学院微生物研究所 | 一株弯曲乳杆菌及其应用 |
| TW201630596A (zh) * | 2015-01-06 | 2016-09-01 | Meiji Co Ltd | 鞘脂質吸收促進劑 |
| MX2018004616A (es) * | 2015-10-15 | 2019-06-20 | Natura Cosmeticos Sa | Cosmetica qie tiene bacterias probioticas. |
| US10238597B2 (en) * | 2015-11-19 | 2019-03-26 | Beauty Biolabs Llc | Probiotic treatment of skin diseases, disorders, and infections: formulations, methods and systems |
| KR101917497B1 (ko) | 2017-02-18 | 2018-11-09 | 박병희 | 신규한 락토바실러스 부크네리 및 이의 용도 |
| KR101912380B1 (ko) * | 2017-03-15 | 2018-10-26 | (주)바이오일레븐 | 프로바이오틱스의 방출 및 프로바이오틱스 효소 활성의 유지를 위한 점막점착성 장치 |
| KR102311725B1 (ko) * | 2017-09-27 | 2021-10-13 | (주)아모레퍼시픽 | 락토바실러스 크러스토룸의 배양물 또는 이의 추출물을 포함하는 조성물 |
| RU2681545C1 (ru) * | 2017-11-27 | 2019-03-11 | Федеральное государственное бюджетное учреждение науки "Институт морских биологических исследований имени А.О. Ковалевского РАН" | Способ получения крем-маски (варианты) |
| IT201800002052A1 (it) * | 2018-01-26 | 2019-07-26 | Girolamo Stefano Di | Probiotico per il trattamento della psoriasi |
| CN110151672B (zh) * | 2018-02-12 | 2022-04-05 | 景岳生物科技股份有限公司 | 一种植物乳杆菌gmnl-6组合物用于皮肤保养的用途 |
| KR20220003539A (ko) | 2019-04-09 | 2022-01-10 | 덤바이온트, 인코포레이티드 | 피부 건강을 개선하기 위한 그리고 병원성 미소생물과 연관된 질환, 장애 및 병태의 치료 및 예방을 위한 조성물 및 방법 |
| FR3117340B1 (fr) * | 2020-12-15 | 2024-01-05 | Basf Beauty Care Solutions France Sas | Utilisation cosmétique, nutraceutique ou dermatologique d’une souche deLactobacillus crispatus et / ou d’une composition la comprenant |
| FR3134010B1 (fr) | 2022-03-30 | 2026-01-09 | Basf Beauty Care Solutions France Sas | Utilisation cosmétique, nutraceutique et/ou dermatologique d’une souche de Lactobacillus crispatus et/ou d’une composition la comprenant |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4085228A (en) * | 1976-08-18 | 1978-04-18 | Leprino Cheese Co. | Preparation of pizza cheese |
| PL193146A1 (pl) * | 1976-10-19 | 1978-04-24 | Inst Przemyslu Mleczarskiego | Preparat enzymatyczny do dojrzewania bialkowych produktow mleczarskich |
| GB2037160B (en) * | 1978-12-08 | 1983-02-09 | Dso Pharmachim | Milk derived products |
| KR800001462B1 (ko) * | 1979-05-01 | 1980-12-10 | 강원명 | 탈지유로부터 화장품 원료를 제조하는 방법 |
| JPS63216813A (ja) * | 1987-03-05 | 1988-09-09 | Noebia:Kk | 皮膚用組成物 |
| JP3112983B2 (ja) * | 1991-05-31 | 2000-11-27 | 御木本製薬株式会社 | 化粧料 |
| KR950014592B1 (ko) * | 1991-10-22 | 1995-12-11 | 주식회사태평양 | 화장료용 유산균제재 |
| US5716615A (en) * | 1992-02-10 | 1998-02-10 | Renata Maria Anna Cavaliere Vesely | Dietary and pharmaceutical compositions containing lyophilized lactic bacteria, their preparation and use |
| JP3413220B2 (ja) * | 1992-08-17 | 2003-06-03 | 株式会社コーセー | 肌荒れ改善剤 |
| FR2729079A1 (fr) | 1995-01-09 | 1996-07-12 | Sederma Sa | Nouvelles compositions cosmetiques contenant des ceramides et autres lipides complexes |
| JP3122333B2 (ja) * | 1995-02-28 | 2001-01-09 | 株式会社薬理学中央研究所 | 赤血球を原料とするスフィンゴミエリンおよびセラミドの新規製造方法とセラミド配合治療剤又は化粧品 |
| US5830916A (en) * | 1996-05-23 | 1998-11-03 | Duke University | Inhibitor of ceramidase |
| IT1296148B1 (it) * | 1996-11-22 | 1999-06-09 | Renata Maria Anna Ve Cavaliere | Uso di batteri lattici per accrescere il livello delle ceramidi della pelle e delle mucose, e composizioni dermatologiche e cosmetiche atte |
| IT1298918B1 (it) * | 1998-02-20 | 2000-02-07 | Mendes Srl | Uso di batteri dotati di arginina deiminasi per indurre apoptosi e/o ridurre una reazione infiammatoria e composizioni farmaceutiche |
-
1996
- 1996-11-22 IT IT96RM000799A patent/IT1296148B1/it active IP Right Grant
-
1997
- 1997-11-14 EA EA199900486A patent/EA001741B1/ru not_active IP Right Cessation
- 1997-11-14 WO PCT/IT1997/000278 patent/WO1998022082A1/en not_active Ceased
- 1997-11-14 CN CNA2006100049282A patent/CN1840183A/zh active Pending
- 1997-11-14 CA CA2271762A patent/CA2271762C/en not_active Expired - Fee Related
- 1997-11-14 KR KR19997004543A patent/KR100508407B1/ko not_active Expired - Fee Related
- 1997-11-14 AT AT97946038T patent/ATE218850T1/de active
- 1997-11-14 IL IL13003797A patent/IL130037A/en not_active IP Right Cessation
- 1997-11-14 EP EP97946038A patent/EP0941056B1/de not_active Expired - Lifetime
- 1997-11-14 MX MX9904749A patent/MX216017B/es unknown
- 1997-11-14 CN CNB971806470A patent/CN1243536C/zh not_active Expired - Fee Related
- 1997-11-14 JP JP52343198A patent/JP4965008B2/ja not_active Expired - Fee Related
- 1997-11-14 AU AU51340/98A patent/AU732203B2/en not_active Ceased
- 1997-11-14 DE DE69713379T patent/DE69713379T2/de not_active Expired - Lifetime
- 1997-11-14 US US09/308,366 patent/US6258355B1/en not_active Ceased
- 1997-11-14 DK DK97946038T patent/DK0941056T3/da active
- 1997-11-14 ES ES97946038T patent/ES2176795T3/es not_active Expired - Lifetime
- 1997-11-14 BR BR9713287-0A patent/BR9713287A/pt active Search and Examination
- 1997-11-14 PT PT97946038T patent/PT941056E/pt unknown
- 1997-11-21 AR ARP970105454A patent/AR009626A1/es active IP Right Grant
-
2001
- 2001-05-22 US US09/861,774 patent/US6582695B2/en not_active Expired - Lifetime
-
2002
- 2002-12-03 US US10/307,935 patent/US6962697B2/en not_active Expired - Fee Related
-
2005
- 2005-08-03 US US11/195,673 patent/US20050265986A1/en not_active Abandoned
-
2009
- 2009-02-04 JP JP2009023731A patent/JP2009138006A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0941056B1 (de) | Zusammensetzungen auf basis von sphingomyelinase und ihre verwendung | |
| MXPA99004749A (en) | Sphingomyelinase compositions and use thereof | |
| JP5744405B2 (ja) | 微生物とフィトスフィンゴシン誘導体との化粧的組合せ | |
| WO2008004165A2 (en) | Use of c-glycoside derivatives as pro-desquamating active agents | |
| JP3129646B2 (ja) | セラミド合成促進剤 | |
| KR20210133390A (ko) | 피부 및 점막 세라미드를 증가시키는 스핑고미엘리나제 함유 국소부위용 화장품 조성물 | |
| JPH11322534A (ja) | セラミド合成促進剤 | |
| USRE39118E1 (en) | Sphingomyelinase compositions and use thereof | |
| JPH10259135A (ja) | セラミド合成促進剤 | |
| HK1096851A (en) | Use of sphingomyelinase to increase the levels of skin and mucosal ceramides | |
| HK1024636B (en) | Use of sphingomyelinase for producing dermatological and cosmetic compositions for increasing the levels of skin and mucosal ceramides | |
| WO2023249017A1 (ja) | 抗老化剤、育毛剤および抗男性ホルモン剤 | |
| BRPI1001814B1 (pt) | Cosmetic composition, cosmetic use of a combination, use of at least one smooth at least a microorganism, and, cosmetic treatment method | |
| HK1095283A1 (en) | Use of a sunflower oil product for skin treatments | |
| HK1095283B (en) | Use of a sunflower oil product for skin treatments |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| MM9K | Patent not in force due to non-payment of renewal fees |